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All Journal Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Pharmaceutical Reports Altifani Journal: International Journal of Community Engagement
Kusuma, Andi Trihadi
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : Pharmaceutical Reports

 1 
Comparison of Antioxidant Activity Based on Temperature Variables of Avocado Seed Extract from Maumere by 1,1-Diphenyl-2-Picrylhdrazy Method Pratama, Mamat; Kusuma, Andi Trihadi; Rahmat, Sri Rahayu; Safitri, Dewi; Efendi, Nurmaya
Pharmaceutical Reports Vol 3, No 2 (2024): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v3i2.308

Abstract

Avocados are plants that can grow well in tropical environments like Indonesia. People love this fruit because of its high antioxidant content and its delicious taste. The aim of this study was to measure the antioxidant activity of three extracts of ethyl acetate of avocado seeds (Percea americana Mill.) using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method. The measurement was done using a quersetin as a reference standard with a maximum wavelength of 516 nm. The results of the study showed that the sample's half inhibitory concentration (IC50) value was 1,653.89 g/mL, 1,202.56 g/ mL, and 903.08 g/mL for two, four, and six hours, respectively.
Determination of Total Flavonoid Content of Red Fruit Juice (Pandanus conoideus Lam) by a UV–Vis Spectrophotometer Sulaeman, Nur Rachmi; Pratama, Mamat; Kusuma, Andi Trihadi
Pharmaceutical Reports Vol 4, No 1 (2025): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v4i1.360

Abstract

Red fruit (Pandanus conoideus Lam) belongs to the pandanacea family. This plant contains compounds such as tannins, flavonoids, steroids, triterpenoids and alkaloids and has properties in curing various diseases such as diabetes, coronary heart disease, hypertension, cancer and HIV/AIDS. This study aims to determine the total flavonoid content of red fruit juice (Pandanus conoideus Lam) using a UV - Vis spectrophotometer. The stages carried out in this research began with sample preparation, qualitative testing of flavonoid compounds and determining the total flavonoid content of red fruit (Pandanus conoideus Lam) samples. The results obtained in this study based on a qualitative test using NaOH reagent stated that red fruit juice (Pandanus conoideus Lam) was positive for containing flavonoids and in a quantitative test using a UV - Vis spectrophotometer the percent concentration obtained in the red fruit juice sample was 8.7258%.
In Silico Evaluation of Bioactive Compounds from Caesalpinia sappan L. as Lipase and Penicillin-Binding Protein Inhibitors for Antibacterial Therapy Kusuma, Andi Trihadi; Arsal, Andi Sitti Fahirah
Pharmaceutical Reports Vol 5, No 1 (2026): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v5i1.404

Abstract

The increasing prevalence of antibiotic-resistant bacteria has created an urgent demand for alternative antibacterial agents with distinct molecular targets. Natural compounds derived from medicinal plants continue to play an important role in early drug discovery. Caesalpinia sappan contains diverse phenolic and flavonoid constituents with potential pharmacological activity. This study investigated selected bioactive compounds from sappan wood, excluding brazilein, as potential inhibitors of bacterial lipase and penicillin-binding protein (PBP) through computational analysis. Molecular docking was employed to examine binding affinity and protein–ligand interactions, while pharmacokinetic and toxicity properties were predicted using pkCSM. The docking results revealed that sappanchalcone showed the strongest interaction with bacterial lipase, whereas protosappanin A demonstrated the highest affinity toward PBP. Both compounds formed stable interactions with important active-site residues associated with enzymatic function. In addition, ADMET prediction indicated favorable pharmacokinetic characteristics, including adequate intestinal absorption, minimal toxicity, and low potential for cytochrome P450 inhibition. Overall, the findings indicate that sappanchalcone and protosappanin A may serve as promising multi-target antibacterial candidates and provide a computational basis for future experimental validation and antibacterial drug development.
Co-Authors AMINAH Aminah Aminah Andi Herwati Andi Sitti Fahirah Arsal Asni Amin Audia Triani Olii, Audia Triani Dewi Safitri Dewi Yuliana Efendi, Nurmaya Hadawiah Hadawiyah, Hadawiyah Mamat Pratama, Mamat Rahmat, Sri Rahayu Rospida, Rospida Sulaeman, Nur Rachmi