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All Journal Journal of Multidisciplinary Applied Natural Science Prosiding University Research Colloquium
Sumandjar, Tatar
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SCABIES RISK FACTORS IN PATIENTS WITH MENTAL DISORDERS AND THE LONG-TERM TREATMENT OPTIONS IN INDONESIA Astiyani, Roro Flaviana Bayu; Harioputro, Dhani Redhono; Susilo, R. Satriyo Budhi; Sumandjar, Tatar
Prosiding University Research Colloquium Proceeding of The 19th University Research Colloquium 2024: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Abstract

Scabies is still common in Indonesia, although the national prevalence of scabies cannot yet be explained. This study was conducted to assess the prevalence of scabies and risk factors in patients with mental disorders. The patients in this study were patients who received treatment at a mental hospital for scabies infection (n=94) from January 2022 to August 2023. There were 53 male patients (56.38%). There were 41 female patients (43.61%). The patients consisted of 35 patients who had previously been treated at a rehabilitation center (37.23%) and 59 patients who had previously been treated at home (62.76%). A cross-sectional analytical study showed that male patients previously treated at home were more likely to experience scabies attacks. The hospital develops scabies infection control guidelines, provides patient therapy with scabicides, and performs skin examinations on inpatients upon admission. Infection control teams should be aware that scabies can cause outbreaks. Insufficient screening is a risk factor for scabies infection entry to hospital. So preventive action against scabies, such as examining patients when they enter the hospital and treating all suspicious patients, are effective in preventing the infection of scabies.
Caesalpinia bonduc (L) Roxb Seed Extract Dosage and Sex Effects on Pathobiological Changes in A Rat Model of Diabetes Mellitus Sopianti, Densi Selpia; Doewes, Muchsin; Sumandjar, Tatar; Pamungkasari, Eti Poncorini; Dirgahayu, Paramasari; Febrinasari, Ratih Puspita; Nurwati, Ida
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.349

Abstract

Caesalpinia bonduc (L) Roxb is a medicinal plant commonly utilized in traditional Indonesian medicine, particularly for the treatment of diabetes mellitus (DM). This study examined the effects of varying doses C. bonduc extract on fasting blood sugar (FBS), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), and pancreatic histology in male and female wistar rats with diabetes. The study design included six groups of 18 male and female rats (Wistar strain) each. To develop diabetes, nicotinamide (NA) (110 mg/kg) and streptozotocin (STZ) (45 mg/kg) were supplied, followed by oral administration of C. bonduc extract at dosages of 200, 400, and 600 mg/kg for 21 days. We utilized ELISA to analyze biochemical parameters and employed H&E staining to evaluate histological changes. A factorial design was employed for the statistical analysis to examine the effects of both dosage and sex. This study offers a unique comparative examination of the antidiabetic efficacy of C. bonduc across genders, a dimension seldom explored in experimental diabetes research. The findings indicated that C. bonduc markedly reduced levels of FBS, MDA, TNF-α, and TGF-β (p < 0.05) enhanced the structural integrity of the pancreas. There were no significant differences between males and female (p > 0.05). The dosage and sex influenced MDA and TGF-β. The extract of C. bonduc shown the ability to lower blood sugar, fight free radicals, and reduce inflammation; however, the intensity of these benefits depended on the dosage given. This means that it might assist persons with diabetes minimize oxidative stress and damage to the pancreas.
Co-Authors Astiyani, Roro Flaviana Bayu Eti Poncorini Pamungkasari Harioputro, Dhani Redhono Ida Nurwati Muchsin Doewes Paramasari Dirgahayu Ratih Puspita Febrinasari Sopianti, Densi Selpia Susilo, R. Satriyo Budhi