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All Journal bionature JURNAL TAMALANREA : Media Inspirasi Karya Mahasiswa Narra J Bionature
Amru, Khaeriah
Hasanuddin University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Evaluasi Rasio Netrofil Limfosit (RNL) untuk diagnosis COVID-19 pada Pasien di RS Tadjuddin Chalid, Makassar, Indonesia Yusuf, Yenni; Nurisyah, Sitti; Hasyim, Ammar Abdurrahman; Amru, Khaeriah; Kadir, Atifatul Qalbi; Mutia, Azizah Nurul; Zuhair, Muhammad Naufal; Paramita, Kartika
bionature Vol 22, No 2 (2021): Oktober
Publisher : Fakultas MIPA UNM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/bionature.v22i2.27644

Abstract

Abstract. The neutrophil lymphocyte ratio (NLR) is one of the variables related to the severity of COVID-19 disease. Therefore, we evaluated the value of NLR in COVID-19 patients and its relation to the symptoms and severity of COVID-19 at Tadjuddin Chalid Hospital, Makassar. We recruited patients visiting Tadjuddin Chalid Hospital Makassar who were willing to take part in the study in April to August 2021. Demographic, clinical and laboratory data were recorded through interviews and medical records. The severity of the disease is classified according to the guidelines from the association of Indonesian pulmonary doctors, Indonesian internal medicine doctors, Indonesian pediatricians, anesthesiologists and intensive care doctors, and the Indonesian cardiologist association. NLR data was obtained by calculating the ratio between neutrophil levels and lymphocyte levels in the blood. A total of 130 patients took part in the study, between 19-72 years old. There were 77 subjects (59.2%) with mild symptoms, 28 (21.6%) with moderate symptoms, and 25 (19.2%) with severe symptoms. There were 89 subjects with NLR <3.5 (68.5%) and 41 (10.8%) with NLR > 3.5. NLR values in patients with severe and moderate disease were significantly different from NLR in patients with mild disease (p =0.0002 dan p<0.0001, respectively). However, no significant difference was found in NLR between patients who neither have cough nor fever with those who had one or both of those symptoms. The presence of clinical or radiological symptoms of pneumonia accompanied by an NLR > 3.5 can be used as an indicator for a suspected moderate or severe COVID-19 diagnosis.Keywords: COVID-19, neutrophil lymphocyte ratio (NLR), pneumonia, disease severity, diagnostic tool
The Effects of Avocado Extract (Persea americana mill), Papaya Seed (Carica papaya l.), and Celery (Apigium graveolens l.) Combination on The Skin and Hair of Mice (Rattus novergicus) Khaeriah Amru; Itzar Chaidir Islam; Andi Radiah Permatasari
Hasanuddin Student Journal VOLUME 2 NOMOR 1, JUNI 2018
Publisher : Hasanuddin University

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Abstract

Aging is a physiological process that causes changes in various body structures. One of them is hair follicle depigmentation that occurs due to the inability of the body to produce a substance that is melanin. By modern society, this is overcome by the development of hair synthetic dyes which are believed to be mutagenic and carcinogenic. Therefore, research from a combination of papaya seed extract, celery leaf and avocado fruit aims to produce natural hair dye which is also expected to give a good influence on the surrounding cells. This study used a true experimental design in vivo, using 4 treatment groups. The control group (P0) was only applied aquades, the treatment group1 (P1) was applied with a combination of extract with a concentration of 0.1%, the treatment group 2 (P2) was applied with a combination of 1% extract and the treatment group 3 (P3) smeared with a 10% extract combination. The preparation of a combination of extracts was done by maceration method. The results obtained from this study there are 3, namely (1) obtained changes in the color of animal hair try varying from dark brown to dark-brown depending on the concentration of substances given. (2) found the growth of hair follicles but not with melanin-producing cells of melanocytes. (3) the discovery of hyperkeratosis and hypergranulosis in tissue epidermis experimental animals due to regeneration of epithelial cells that continue to divide. From these results obtained the conclusion that the combination of three nutritious extracts to grow hair follicles and as a natural hair dye
Exploring links between visuospatial ability and anatomy learning in education: A bibliometric analysis and scientific mapping Rahmani, Muhammad Z.; Bukhari, Agussalim; Wiyono, Nanang; Amru, Khaeriah; Baharuddin, Baharuddin; Nurhadi, Asty A.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1095

Abstract

The field of medical education faces a significant challenge in teaching human anatomy, a fundamental aspect of medical science that is often perceived as complex and demanding. Understanding the shapes and anatomical structure locations is crucial for students to master the intricacies of anatomy. Visuospatial ability, which involves comprehending three-dimensional structures and their spatial relationships, plays a pivotal role in anatomy learning. The aim of this study was to examine keywords, territories/countries, the number of publications, institutions, authors, and associated journals related to visuospatial ability in anatomy learning through extensive bibliometric analysis. Data were gathered from the Scopus database, and VOSviewer was employed to conduct a bibliometric analysis. Approximately 552 eligible articles were examined in their entirety. The findings indicated that the most significant research growth occurred in 2012, with the United States of America emerging as the leading country in the field.  Furthermore, Anatomical Science Education was recognized as the most esteemed journal in this field, with Wilson, T.D. being credited as the most influential author. The bibliometric data also demonstrated various approaches to improve visuospatial capacity in anatomy learning, such as utilizing virtual reality or other computer-assisted learning modalities and their integration into medical education practice. In conclusion, these findings highlight the critical role of visuospatial ability in facilitating the acquisition of anatomical knowledge and offer direction for future research in this area.
Evaluation of an E. coli-expressed spike protein-based in-house ELISA system for assessment of antibody responses after COVID-19 infection and vaccination Nurisyah, Sitti; Iyori, Mitsuhiro; Hasyim, Ammar A.; Amru, Khaeriah; Itani, Kei; Nakamura, Kurumi; Zainal, Kartika H.; Halik, Handayani; Djaharuddin, Irawaty; Bukhari, Agussalim; Asih, Puji BS.; Syafruddin, Din; Yoshida, Shigeto; Idris, Irfan; Yusuf, Yenni
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1250

Abstract

Evaluating long-term immunity after COVID-19 infection and vaccination is critical for managing potential outbreaks. The aim of this study was to develop a cost-effective in-house enzyme-linked immunosorbent assay (ELISA) based on Escherichia coli-expressed SARS-CoV-2 spike protein (E-S1) for antibody detection and to evaluate its performance. The system was validated by comparing the in-house ELISA results with those obtained using a commercial ELISA with HEK293-expressed spike protein (H-S1). Recombinant SARS-CoV-2 spike protein was produced in E. coli, purified, and validated for antigenicity via ELISA. Indirect ELISAs with both E-S1 and H-S1 antigens were performed on 386 serum samples from COVID-19 survivors, vaccinated individuals, and pre-pandemic controls collected at different time points. The E-S1 ELISA showed a statistically significant but weak correlation with H-S1 ELISA across all samples (r=0.205; p=0.0001). Stronger correlations were observed among vaccinated individuals with prior infection on day 90 (r=0.6017; p<0.001) and in naïve vaccine recipients on day 30 (r=0.5361; p=0.0003). Pre-pandemic sera from a rural population in Sumba Island exhibited high background reactivity in E-S1 ELISA, likely due to anti-E. coli antibodies, while urban pre-pandemic sera from Jakarta showed a stronger correlation with H-S1 ELISA. This suggests potential regional or immune background differences influencing assay performance. Although E-S1 retained antigenic properties, its diagnostic utility is limited by non-specific reactivity and reduced sensitivity compared to H-S1. In conclusion, E. coli expression systems may not be ideal for producing spike protein-based ELISA antigens specific to SARS-CoV-2. Alternative expression systems, such as human or baculovirus, could enhance diagnostic accuracy and specificity for COVID-19 antibody detection.
Evaluasi Rasio Netrofil Limfosit (RNL) untuk diagnosis COVID-19 pada Pasien di RS Tadjuddin Chalid, Makassar, Indonesia Yenni Yusuf; Sitti Nurisyah; Ammar Abdurrahman Hasyim; Khaeriah Amru; Atifatul Qalbi Kadir; Azizah Nurul Mutia; Muhammad Naufal Zuhair; Kartika Paramita
Bionature Vol. 22 No. 2 (2021): Oktober 2021
Publisher : Jurusan Biologi Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The neutrophil lymphocyte ratio (NLR) is one of the variables related to the severity of COVID-19 disease. Therefore, we evaluated the value of NLR in COVID-19 patients and its relation to the symptoms and severity of COVID-19 at Tadjuddin Chalid Hospital, Makassar. We recruited patients visiting Tadjuddin Chalid Hospital Makassar who were willing to take part in the study in April to August 2021. Demographic, clinical and laboratory data were recorded through interviews and medical records. The severity of the disease is classified according to the guidelines from the association of Indonesian pulmonary doctors, Indonesian internal medicine doctors, Indonesian pediatricians, anesthesiologists and intensive care doctors, and the Indonesian cardiologist association. NLR data was obtained by calculating the ratio between neutrophil levels and lymphocyte levels in the blood. A total of 130 patients took part in the study, between 19-72 years old. There were 77 subjects (59.2%) with mild symptoms, 28 (21.6%) with moderate symptoms, and 25 (19.2%) with severe symptoms. There were 89 subjects with NLR <3.5 (68.5%) and 41 (10.8%) with NLR > 3.5. NLR values in patients with severe and moderate disease were significantly different from NLR in patients with mild disease (p =0.0002 dan p<0.0001, respectively). However, no significant difference was found in NLR between patients who neither have cough nor fever with those who had one or both of those symptoms. The presence of clinical or radiological symptoms of pneumonia accompanied by an NLR > 3.5 can be used as an indicator for a suspected moderate or severe COVID-19 diagnosis.
Co-Authors Ammar Abdurrahman Hasyim Andi Radiah Permatasari Asih, Puji BS. Atifatul Qalbi Kadir Azizah Nurul Mutia Baharuddin Baharuddin Bukhari, Agussalim Din Syafruddin Djaharuddin, Irawaty Halik, Handayani Hasyim, Ammar A. Hasyim, Ammar Abdurrahman IRFAN IDRIS Itani, Kei Itzar Chaidir Islam Iyori, Mitsuhiro Kadir, Atifatul Qalbi Kartika Paramita Muhammad Naufal Zuhair Mutia, Azizah Nurul Nakamura, Kurumi Nanang Wiyono Nurhadi, Asty A. Nurisyah, Sitti Rahmani, Muhammad Z. Sitti Nurisyah Veithzal Rivai Zainal Yoshida, Shigeto Yusuf Yenni Zainal, Kartika H. Zuhair, Muhammad Naufal