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All Journal Qawwam Jurnal Penyakit Dalam Indonesia
Saleh, Imran
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Religion Economics, Econometrics & Finance Education Medicine & Pharmacology Social Sciences

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The Effect of Angiotensin-Converting Enzyme GenePolymorphism and Angiotensin II Levels in Coronary SlowFlow Phenomenon at Mohammad Hoesin General HospitalPalembang Karlina, Arlis; Indrajaya, Taufik; Ghanie, Ali; Sukandi, Erwin; Usnizar, Ferry; Indra, Syamsu; Chodilawati, Rukiah; Saleh, Imran
Jurnal Penyakit Dalam Indonesia Vol. 8, No. 2
Publisher : UI Scholars Hub

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Introduction. The presence of ACE gene polymorphism is expected to have a role in cardiovascular diseases, including coronary slow flow phenomenon (CSFP). Angiotensin converting enzyme (ACE) gene polymorphism also plays an essential role in increasing angiotensin II levels. Therefore, this study aimed to analyze the effect of angiotensin-converting enzyme gene polymorphism and angiotensin II levels in the coronary slow flow phenomenon in Mohammad Hoesin General Hospital Palembang. Methods. This case-control study was started from July 2019 to July 2020 at RSMH Palembang with 32 subjects for each case (CSFP patients) and the control group (non-CSF patients). This study used a pair of primers and onetimed PCR to detect ACE gene polymorphism. Genetic analysis was carried out in the Biotechnology Laboratory Faculty of Medicine, Universitas Sriwijaya. Statistical analysis was performed using the Spearman correlation test. Results. There were 17 subjects with II genotypes (53.1%), 14 subjects with ID genotypes (43.8%), and 1 subject with DD genotypes (3.1 %) in the CSFP group. While in the non-CSFP group, there were 11 subjects with II genotypes (34.4%), 13 subjects with ID genotypes (42.2%), and 9 subjects with DD genotypes (14.1%). The median value of angiotensin II levels in CSFP and Non-CSF group was 58 pg/mL and 32.8 pg/mL, respectively. The results of the analysis showed that there was an effect of angiotensin II levels on the incidence of CSFP (p=0.001). Further analysis showed that there was a correlation between angiotensin II levels and the I/D 287 bp alu repetitive sequence polymorphism in the intron 16 ACE gene (p=0.030, r=0.822). Conclusions. There was a correlation between I/D 287 bp alu repetitive sequence polymorphism in the intron 16 ACE gene and angiotensin II levels in the coronary slow flow phenomenon at Mohammad Hoesin General Hospital Palembang.
THE DUAL SUPERVISION MODEL AS A GOVERNANCE FRAMEWORK FOR ISLAMIC FINANCIAL INSTITUTIONS Khairunnisa, Ashma; Arifin, Zainal; Saleh, Imran; Hermawan, Riko
Qawwam : The Leader's Writing Vol. 7 No. 1 (2026): June
Publisher : Fakultas Ushuluddin Adab dan Dakwah Insitut Agama Islam Negeri Kerinci

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The rapid growth of the Islamic financial industry has not been fully accompanied by the strengthening of ethical integrity and Sharia governance quality. This study examines the concept of dual supervision as an integrative model that combines regulatory oversight and taqwa-based internal control within Islamic economic systems. Using a qualitative library research approach, this study analyzes classical and contemporary Islamic legal thought, particularly drawing on Mausu’ah Qadhaya Fiqhiyyah Mu’ashirah by Dr. Ali al-Salus, along with relevant literature on Islamic governance and financial analysis. The findings indicate that regulatory supervision ensures formal compliance with Sharia standards and institutional procedures, while it remains insufficient in preventing moral hazards and ethical violations. Conversely, taqwa functions as an internal spiritual mechanism that fosters accountability, integrity, and ethical responsibility among economic actors. The integration of both dimensions produces a dual supervision framework that strengthens Sharia compliance, enhances governance effectiveness, and supports sustainable Islamic financial development. Furthermore, the model is relevant to contemporary challenges such as financial technology innovation, regulatory fragmentation, and increasing complexity in Islamic financial transactions. This study contributes to the development of Islamic governance theory and offers a conceptual framework for improving both Sharia compliance and ethical performance in Islamic financial institutions.
Co-Authors Ali Ghanie Ferry Usnizar, Ferry Hermawan, Riko Indra, Syamsu Indrajaya, Taufik Karlina, Arlis Khairunnisa, Ashma Rukiah Chodilawati Sukandi, Erwin Zainal Arifin