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All Journal Indonesian Journal of Medicine Cermin Dunia Kedokteran Journal of General Procedural Dermatology and Venereology Indonesia
Yuliarto, Danu
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Health Professions Medicine & Pharmacology Public Health

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Terapi Kondiloma Akuminata dengan Kombinasi Trichloroacetic Acid (TCA) 80% + Krioterapi Dhamayanti, Marsita Endy; Rahayu, Tutik; Putra Wirawan, Eka; Diana, Rina; Yuliarto, Danu; Sari, Endra Yustin Ellista
Cermin Dunia Kedokteran Vol 46, No 6 (2019): Diabetes Mellitus
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1365.041 KB) | DOI: 10.55175/cdk.v46i6.469

Abstract

Kondiloma akuminata adalah infeksi yang disebabkan Human Papilloma Virus (HPV) di daerah perineum, genitalia; merupakan penyakit menularseksual paling sering di dunia. Kondiloma akuminata dapat disebabkan oleh berbagai subtipe HPV, terutama HPV 6 dan 11. Dilaporkan satu kasuspasien laki-laki, 43 tahun, dengan keluhan muncul kutil di batang penis, skrotum, dan anus sejak kurang lebih 3 bulan, yang bertambah banyakdan gatal. Pada pemeriksaan daerah genital dan perianal tampak papul dan vegetasi dengan permukaan verukosa, sewarna kulit, multipel.Pasien mendapat terapi kombinasi TCA 80% dengan krioterapi dan simetidin.Condyloma acuminatum is an infection caused by the Human Papilloma Virus (HPV) in the perineal region, genitalia; It is the most frequentsexually transmitted disease in the world. Kondiloma akuminata can be caused by various HPV subtypes, especially HPV 6 and 11. One casewas reported, male patient, 43 years, with warts appearing on the penis, scrotum, and anus since 3 months, which multiplied and itchy. Onexamination of the genital area and perianal, there are papules and vegetation with verucous surfaces, skin color, multiple. Patients received80% TCA combination therapy with cryotherapy and cimetidine.
Prevalence and risk factors of bacterial vaginosis among female sex workers in Surakarta Hastuti, Rini; Yuliarto, Danu; Triana, Agung; Damayanti, Willa; Irfanti, Rakhma Tri; Mardiana, Mardiana; Dewi, Putti Fatiharani; Aliwardani, Ambar; Abas, Ervianti; Sulistyo, Sulistyo; Mawardi, Prasetyadi; Ellistasari, Endra Yustin
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 4, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Bacterial vaginosis (BV) is the most common vaginal infection in women of reproductive age and increases the risk of acquiring human immunodeficiency virus (HIV) and other sexually transmitted diseases (STDs). Data regarding the association between sexual activity and BV acquisition is contradictory. Thus, tracking the prevalence and associated risk factors of BV among female sex workers (FSWs) is necessary to improve our understanding and control of STDs and the HIV epidemic. Methods: The subjects of this study were FSWs in Surakarta. This study adopted a cross-sectional design, and diagnosis was established using Amsel criteria. Interviews were conducted using questionnaires to collect data of risk factors, including demographic factors (age, education level, daily income, marital status, location of sex), sociologic factors (age of first intercourse; age of first FSW encounter; duration of work as an FSW; number of clients/day; condom, contraceptive, and vaginal douching use; violence experienced as an FSW; smoking habits; alcohol consumption; and drug use), and knowledge factors (knowledge of STDs and HIV). Statistical analysis was performed by using bivariate analysis. Results: We interviewed 175 FSWs with an average age of 40.66 years. BV was detected in 28 subjects (16%). Risk factors associated with BV include alcohol (p = 0.022) and drug use (p = 0.022). Conclusion: Other than routine screening for STDs and HIV, FSWs should be encouraged to participate in prevention programs aiming to regulate alcohol and drug use to decrease the incidence of BV infection.
A comparison of single-dose versus divided-dose of metronidazole on bacterial vaginosis among female sex workers in Surakarta Damayanti, Willa; Hastuti, Rini; Triana, Agung; Yuliarto, Danu; Ayu, Ardelia Dyah; Ellistasari, Endra Yustin
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 5, No. 2
Publisher : UI Scholars Hub

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Background: Bacterial vaginosis (BV) is the most common vaginal infection in sexually active women. Metronidazole (MTZ) is still one of the recommended regimens for BV either as a single-dose or divided-dose. In addition to its affordability and availability, oral metronidazole also produces fewer adverse effects. This study aimedto determine the efficacy of single-dose versus divided-dose metronidazole for BV among female sex workers (FSWs) in Surakarta. Methods: A single-blind randomized clinical trial was conducted in Surakarta. FSWswith BV (⩾3 Amsel criteria) were enrolled. The subjects were grouped into two, and treated with MTZ either as a single-dose of 2 gr (single-dose group) or 500 mg twice daily for one week (divided-dose group). After two weeks, we performed second vaginal swabs and reassessed the Amsel criteria, complaints and adverse events. Results: Out of 75 FSWs, 30 (42%) were diagnosed with BV. The efficacy between two groups was not significantly different. However, patients in the single-dose group were 2 times more likely to develop recurrent BV (OR = 2.000; 95% CI 0.146 – 27.447), and 1.5 times more likely to have vaginal discharge complaints (OR = 1,500; 95% CI 0,181-12,459) than divided-dose group. Conclusion: Single-dose and divided-dose metronidazole produce similar efficacy for treating BV in sexually active women. Single-dose metronidazole has a higher risk of BV recurrence and vaginal discharge complaint. Divided-dose metronidazole is recommended for treating BV.
Comparison of the Effectiveness of the Chemosurgery and Cryosurgery for the Treatment of Patients with Condyloma Acuminatum at Dr. Moewardi Hospital, Surakarta Mawardi, Prasetyadi; Febrianto, Bobby; Yuliarto, Danu
Indonesian Journal of Medicine Vol. 6 No. 3 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Condyloma acuminatum (CA) is one of the most common sexually transmitted infections. Several therapeutic modalities that can be used are chemosurgery with trichloroacetic acid and cryosurgery with liquid nitrogen. Recurrence in CA often occurs, so selecting the right therapeutic modality and eliminating the lesion also prevents recurrence. This study aimed to compare the effectiveness of chemosurgery and cryosurgery therapy in patients with CA who are treated at Dr. Moewardi Hospital, Surakarta.Subjects and Method: A retrospective cross-sectional study was conducted at the Dermatology and Venereology Polyclinic, Dr. Moewardi Hospital, Surakarta, from January 1, 2018, to December 31, 2020. The study subjects were 78 patients diagnosed with CA based on ICD-10 criteria, while chemosurgery and cryosurgery procedures were based on ICD-9. The dependent variable was healing time in weeks. The independent variables were chemosurgery and cryosurgery therapy. The data came from the patient's medical record. Data were analyzed using an independent t-test.Results: Based on univariate analysis, most patients were male (67.9%), and the age group was 20-29 years (51.28%). Most of the CA patients work as private employees (46.15%). The most sexual orientation was heterosexual (53.8%), the most common site of lesions was genital (47.4%), and 52.6% were coinfected with HIV. Most CA patients received chemosurgery (70.5%). Bivariate analysis showed that chemosurgery therapy provided faster clinical improvement (Mean= 23.34; SD= 26.45) than cryosurgery therapy (Mean= 28.69; SD= 19.84), and the difference was statistically significant (p= 0.037).Conclusion: Treatment of CA using chemosurgery provides clinical improvement faster than cryosurgery, so that faster treatment time can reduce treatment costs and improve the patient's quality of life.Keywords: chemosurgery, cryosurgery, HPV, condyloma acuminatumCorrespondence: Prasetyadi Mawardi. Department of Dermatology and Venereology, Faculty of Medicine of Universitas Sebelas Maret/ Dr. Moewardi Hospital, Surakarta, Central Java, Indonesia. Email: prasetyadimawardi@gmail.com/ prasetyadi_m@staff.uns.ac.id. Mobile: +6281229750211.Indonesian Journal of Medicine (2021), 06(03): 290-297https://doi.org/10.26911/theijmed.2021.06.03.06
Co-Authors Abas, Ervianti Aliwardani, Ambar Ayu, Ardelia Dyah Damayanti, Willa Dewi, Putti Fatiharani Dhamayanti, Marsita Endy Diana, Rina Ellistasari, Endra Yustin Febrianto, Bobby Irfanti, Rakhma Tri Mardiana Mardiana Prasetyadi Mawardi Putra Wirawan, Eka Rini Hastuti Sari, Endra Yustin Ellista Sulistyo Sulistyo Triana, Agung TUTIK RAHAYU