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All Journal Acta Pharmaciae Indonesia : Acta Pharm Indo Language Circle : Journal of Language and Literature
Citra Andini
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Languange, Linguistic, Communication & Media Medicine & Pharmacology

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In silico analysis of quercetin and its derivatives as potential TRPC6-targeted treatments for diabetic neuropathy Pangestu, Maryo Adjie; Auli, Winni Nur; Saputro, Anjar Hermadi; Pasaribu, Romualdo; Maharani, Gita Putri; Yunita, Nadia Rahma; Choiriah, Ika Putri; Ainun, Hadhistia Nur; Erniningsih, Ni Ketut; Andini, Citra
Acta Pharmaciae Indonesia Vol 12 No 1 (2024): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2024.12.1.12119

Abstract

Background: Diabetic neuropathy is a condition that arises as a complication of diabetes mellitus and often causes pain in patient. Quercetin and its derivatives have antinociceptive activity, making them potential agents for relieving the pain associated with diabetic neuropathy. Objective: This study aims to analyze the interactions between quercetin and its eight derivatives with canonical transient receptor potential channels 6 (TRPC6) as protein target. Method: The TRPC6 structure (PDB ID: 6UZ8) was prepared and validated with redocked to native ligand R0D using Autodock 4.2.6, with the established grid box and grid center settings. The test compounds were then optimized and docked using the same grid box and grid center settings as in the validation process, followed by visualization and analysis of the docking results. Results: The compound with the best affinity for TRPC6 was tamarixetin, with a binding energy value of -3.27 kcal/mol, close to the binding energy value of the native ligand, which was -4.22 kcal/mol. The amino acid residues interacting with tamarixetin at the active site were 702-Asn, 705-Tyr, 706-Val, and 709-Gly. This indicates that tamarixetin and the native ligand bind to the same active site amino acids, resulting in a similar affinity to the native ligand in inhibiting TRPC6. Conclusion: A total of eight quercetin derivatives were predicted to have TRPC6 antagonistic activity against diabetic neuropathy, with tamarixetin exhibiting the highest affinity compared to the other quercetin derivatives.
The Art of Derivation: Noun-to-Verb Transformations in Student-Written Sentences Andini, Citra; Bochari, Siska; Marhum, Muchtar; Darmawan
Language Circle: Journal of Language and Literature Vol. 19 No. 2 (2025): April 2025 Regular Issue
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/lc.v19i2.21584

Abstract

The study investigates the use of affixes in the derivation process from nouns to verbs in sentences produced by EFL students at Tadulako University. This research employed a descriptive quantitative method, with data collected through written tests and questionnaires from 136 fifth-semester students. The data were analyzed using frequency distribution and descriptive statistics. From the written test, a total of 1.370 affixation errors were identified across seven targeted affixes. The prefix de- had the highest number of errors, accounting for 25% of the total. The questionnaire consisted of 50 items and was designed to measure five key variables: semantic clarity, parsing ability, affix frequency, productivity, and pars ability. The responses indicated that 78% of students found affixation confusing due to a lack of semantic transparency, while 65% admitted difficulty in segmenting complex words into base and affix. The reliability test of the questionnaire showed a high Cronbach's Alpha score of 0.988, confirming its internal consistency. The findings revealed that the prefix de- was the most difficult affix for students, with the highest error rate in the noun-to-verb derivation process. Several factors influenced students' difficulties, including semantic aspects, affix frequency, the ability to analyze word structure, affix productivity, and the ease of breaking words into their morphemes. This study highlights the importance of enhancing morphological awareness among EFL students, particularly in applying the derivational process as part of more effective English language learning. This recommendation is based on the observation that students’ limited familiarity with certain affixes, combined with insufficient explicit instruction in morphology, directly impacts their writing proficiency. Therefore, integrating morphological instruction into ELT—through focused affix exercises, contextual application, and parsing training—can significantly enhance students’ vocabulary growth, grammatical accuracy, and confidence in academic writing.
Co-Authors Ainun, Hadhistia Nur Anjar Hermadi Saputro Choiriah, Ika Putri Darmawan Edwi Mahajoeno Erniningsih, Ni Ketut Maharani, Gita Putri Marhum, Muchtar Pangestu, Maryo Adjie Pasaribu, Romualdo RATNA SETYANINGSIH Siska Bochari Winni Nur Auli Yunita, Nadia Rahma