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All Journal Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Biology, Medicine, & Natural Product Chemistry Majalah Obat Tradisional Pharmascience Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Ilmu Kefarmasian Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Medical Sains : Jurnal Ilmiah Kefarmasian Media Farmasi Indonesia Pharmaceutical Sciences and Research (PSR) Medical Sains : Jurnal Ilmiah Kefarmasian Journal Pharmacy of Tanjungpura
Mohamad Andrie
Departement Of Pharmacy, Faculty Of Medicine, Tanjungpura University, Pontianak, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Other

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The Effectiveness Test of Oil Phase Ointment Containing Snakehead Fish (Channa striata) Extract on Open Stage II Acute Wounded Wistar Strain Male Rats Fransisca Daisa; Mohamad Andrie; Wintari Taurina
Majalah Obat Tradisional Vol 22, No 2 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (435.142 KB) | DOI: 10.22146/tradmedj.27920

Abstract

The snakehead (Channa striata) contained fatty acids omega-3 and omega-6 are useful as nutrients in accelerating the wound healing process. This study aims to determine the effectiveness of the oil phase extract ointment snakehead in the healing of acute wounds open stage II. Testing the effectiveness of wound healing using 6 groups: normal, gel bioplacenton (positive control), ointment base (negative control), ointments snakehead extract oil phase concentration of 10; 20 and 40% of the 4 rats with acute wounds open stage II and observation until day 16 injury. The area of the wound was measured with the image J program Macbiophotonic, calculated% healing power, and AUC values. A statistical test to the total AUC values per rat with SPSS for Windows 22.0 program using One Way ANOVA and Post-hoc LSD test. The results showed a significant difference in the negative group with ointment concentration of 20% (p <0.05). The treatment group phase ointment fish oil extract is effective for wound healing is best to have a concentration of 20% for percentage of wound healing power of 97.157% and the average AUC value of 865.683% of the day.
Accelerated Stability Test of Snakehead Fish Extract (Channa striata) and Kelulut Honey (heterotrigona itama) Ointment Combination with Tween 80 and Span 80 as an Emulsifying Agent Wintari Taurina; Mohamad Andrie; Taufik Nanda Pratama
Majalah Obat Tradisional Vol 26, No 2 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.66608

Abstract

The combination of Snakehead Fish and Kelulut Honey has activity in accelerating the wound healing process. The ointment with active ingredients of Snakehead Fish extract and Kelulut Honey showed separation from the active ingredient and its base. The addition of tween 80 and span 80 is expected to increase the stability of the ointment preparation by keeping the water-phase droplets distributed uniformly on the ointment base. This study aimed to determine the effect of adding Tween 80 and Span 80 on the stability of the ointment preparation. The ointment was made by varying Tween 80 and span 80 by 2,5%: 5%: 7,5% and control (active ingredients without the addition of tween 80 and Span 80) as a comparison. The preparation was subjected to an accelerated stability test using a temperature of 40 ° ± 2 ° C / Relative humidity 75% ± 5% for 28 days by observing the organoleptic test, adhesion, spreadability, homogeneity test, pH test, and protection power. The data obtained were analyzed statistically using One Way Anova. The analysis showed that the addition of tween 80 and span 80 with a total concentration of 5% and 7,5% had a significant effect in increasing the spreadability, decreasing adhesion, and reducing the pH of the preparation. Formulas that meet the requirements in this study are F2 and F3, which have an average spreadability of 5,11 cm and 5,25 cm, adhesion of 96 seconds and 51 seconds, and pH of 6,02 and 5,02.
Accelerated Stability Test of Snakehead Fish Extract (Channa striata) and Kelulut Honey (Heterotrigona itama) Ointment Combination with BHT as an Antioxidant Mohamad Andrie; Wintari Taurina; Dyah Ayuningtias
Majalah Obat Tradisional Vol 27, No 1 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.68861

Abstract

The oil phase of adeps lanae was used as a basis in the ointment formulation with snakehead fish extract and kelulut honey, which influences wound healing. Adeps lanae has the potential to become rancid due to the high water content in it (25-30%). The use of oil-soluble antioxidants such as Butyl Hydroxy Toluene (BHT) can overcome the rancidity in oil. This study aimed to see how adding BHT as an antioxidant affects the ointment's stability. The ointment is prepared in three different BHT concentrations: F1 (0.0075%), F2 (0.05%), F3 (0.1%), and a control for comparison. Organoleptic tests, homogeneity, spreadability, adhesion, protection power, and acid number were used to evaluate the stability of the preparation over 28 days at 40 ± 2°C / RH 75 ± 5%. The data obtained were analyzed statistically using One Way ANOVA. The addition of BHT affected the preparation's spreadability, adhesion, and acid number but did not affect the organoleptic, homogeneity, or protective power. At F3, there is a significant difference in spreadability (5.57 ± 0.21 cm) and adhesion (89.00±2.00 seconds) based on statistical analysis. F3 is the best ointment based on the physical characteristics test results and the minimum increase in acid number (8.83 mg KOH/g).
Uji Stabilitas Protein Salep Kombinasi Ikan Gabus (Channa striata) dan Ekstrak Etanol Daun Sirih (Piper betle L.) Menggunakan Metode Kjeldahl Mohamad Andrie; Wintari Taurina; Maya Widya Astuti Wulandari
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.799

Abstract

The endemic snakehead fish (Channa striata) supposed to speed up wound healing. Antibacterial properties of green betel leaf (Piper betle L.) are well known. Wound healing necessitates moist circumstances and prolonged medication contact. Such the fact that ointment fat-based preparation that can moisturize skin or wound area due to extended contact with the skin, increasing absorbance and effectiveness. Fish protein concentrate high-protein concentrate obtained by eliminating fat and water from fish. One way that can used is freeze drying. Using Kjeldahl method, this study intends investigate protein stability of combination freeze dry ointment extract of snakehead fish (Channa striata) and ethanol extract green betel leaf (Piper betle L.). The data was analyzed using the SPSS version 25 app. On day 28, average protein content of freeze dry ointment and a combination of freeze dry ointment in aqueous phase and ethanol extract of green betel leaf was 6.321 % and 6.630 %, respectively, indicating substantial difference in protein content. As result, the freeze dry ointment including aqueous phase and ethanol extract of green betel leaf more stable and has larger protein content than the freeze dry ointment containing snakehead fish extract.
Efektivitas Analgetik Nanopartikel Kitosan-Ekstrak Etanol Daun Pepaya (Carica Papaya L.) Pada Mencit Putih Jantan (Mus Mucculus) Juliferd Gredi; Wintari Taurina; Mohamad Andrie
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 2 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (256.244 KB) | DOI: 10.35814/jifi.v15i2.524

Abstract

Papaya leaves has been shown to have efficacy as an analgesic. Analgesic effect caused by the flavonoids in leaves of papaya. To enhance the analgesic effi cacy papaya into dosage formulatio of nanoparticles. The purpose of this research was to create and characterized nanoparticles from ethanol extract of papaya leaves then tested for effectiveness as an analgesic. This study used polymer chitosan and NaTPP to created nanoparticles through ionic gelation method and analgesic activity tested using writhing test method and statistical tested. Optimal formula of nanoparticles were produced at concentration of 0.2% chitosan, Na-TPP extract 0.1% and 4% with a ratio of 6: 1: 1. The nanoparticles was formed a size of 255.4 nm with polidispers index of 0.7, the zeta potential of + 11,1mV, the adsorption effi ciency by 87% and rounded morphology (spherical). Analgesic effectiveness tested by comparison between the groups ethanol extract of papaya and the groups nanoparticles of chitosan-ethanol extract papaya statistically using the T-test Independent. The results of this research indicate that there are statistically signifi cant differences (p <0.05). This results shows that the preparation nanoparticles of chitosan-ethanol extract papaya is more effective as an analgesic than the ethanol extract of papaya leaves.
Characterization of the manufacturing process simplicia Syzygium aromaticum as raw material for wound healing drug preparations Naziella Naziella; Wintari Taurina; Mohamad Andrie
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14184

Abstract

Characterization is the first step before standardization. Standardization of a drug substance is a requirement to achieve parameters that will ensure constant quality in a preparation. The main compounds contained in clove leaves have analgesic and antibacterial properties to accelerate wound healing. This study aims to characterize the process of making clove leaf simplicia and Simplicia (Syzygium aromaticum) originating from Lemukutan Island, Bengkayang Regency, West Kalimantan as raw material for wound healing drug preparations. Clove leaf Simplicia was characterized biologically including habitat and morphology, physically including organoleptic, microscopic, moisture content, ash content, and acid insoluble ash content, and chemically, namely phytochemical screening. Making clove leaf Simplicia consists of harvesting, wet sorting, washing, drying, dry sorting, packaging, and storage. The yield of clove leaf Simplicia was obtained as much as 70.90%. The results of the characterization of clove leaves showed that the clove tree grows in the highlands, with a tropical climate, with a temperature range of 25 C-32 C. Clove leaves are oval in shape, tapered tip, pinnate leaf bone, leaf length is approximately 9-12 cm and width 4 cm-4.5 cm. The moisture content, ash content, and insoluble ash content of the clove leaf Simplicia powder were 9.21%, 3.05%, and 0.69%, respectively. The outcomes of the phytochemical screening of clove leaf Simplicia powder have beensuperbfor holding flavonoids, saponins, triterpenoids, and tannins.
Analisis Hubungan Penggunaan Kontrasepsi Hormonal dengan Obesitas dan Hiperkolesterolemia di Puskesmas Pal III Pontianak Annisa Mutia Yusran; Nurmainah Nurmainah; Mohamad Andrie
Jurnal Pharmascience Vol 9, No 1 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.11697

Abstract

Pengaturan kehamilan dapat dilakukan dengan menggunakan kontrasepsi. Kontrasepsi hormonal seperti pil dan suntik memiliki efek samping peningkatan berat badan dan kadar kolesterol. Tujuan penelitian ini adalah untuk menganalisis hubungan antara obesitas dan hiperkolesterolemia dengan penggunaan kontrasepsi hormonal pada akseptor di Puskesmas Pal III Pontianak. Metode yang digunakan merupakan penelitian observasional dengan rancangan penelitian potong lintang (cross sectional) yang bersifat analitik. Teknik pengambilan sampel ialah  purposive sampling dengan jumlah sampel yang memenuhi kriteria inklusi sebanyak 40 akseptor. Metode pengumpulan data menggunakan rekam medis akseptor pengguna kontrasepsi hormonal periode Januari-Juni 2020. Pengukuran kadar kolesterol pada akseptor dilakukan dengan menggunakan alat Easy Touch® GCU dengan pengambilan sampel sebanyak satu kali. Analisis data dilakukan dengan menggunakan analisis chi-square. Hasil analisis jenis kontrasepsi hormonal menunjukkan bahwa persentase akseptor pengguna kontrasepsi hormonal yang mengalami obesitas untuk pil KB sebanyak 17,5%, dan suntik sebanyak 32,5%. Persentase akseptor pengguna kontrasepsi hormonal yang mengalami hiperkolesterolemia untuk pil KB sebanyak 20%, dan suntik sebanyak 27,5%. Analisis statistik menunjukkan bahwa tidak terdapat hubungan yang bermakna antara obesitas (p value = 0,058) dan hiperkolesterolemia (p value = 0,342) dengan penggunaan kontrasepsi hormonal. Kesimpulan dari penelitian ini bahwa tidak ada hubungan antara jenis kontrasepsi hormonal dengan risiko obesitas dan hiperkolesterolemia. Kata Kunci: Kontrasepsi Hormonal, Risiko Obesitas, Risiko Hiperkolesterolemia  Pregnancy control can be done using contraception. Hormonal contraceptives such as pills and injections have side effects of increasing weight and cholesterol levels. The purpose of this study was to analyze the relationship between obesity and hypercholesterolemia with the use of hormonal contraceptives in acceptors at the Pal III Public Health Center Pontianak. The method used was an observational study with an analytic cross-sectional design. The sampling technique was purposive sampling with the number of samples that met the inclusion criteria as many as 40 acceptors. The data collection method used medical records of acceptors of hormonal contraceptive users for the period January-June 2020. Measurement of cholesterol levels in acceptors was carried out using the Easy Touch® GCU device by taking samples once. The analysis was carried out using chi-square analysis. The results of the analysis of types of hormonal contraception showed that the percentage of hormonal contraceptive users who were obese was 17.5% for family planning pills, and 32.5% for injections. There was no significant relationship between the use of hormonal contraception at Pal III Public Health Center Pontianak with the risk of obesity (p-value = 0.058) and hypercholesterolemia (p-value = 0.342). This study concludes that there is no relationship between the type of hormonal contraception with the risk of obesity and hypercholesterolemia.
Uji Aktivitas Antioksidan Sediaan Salep Ikan Gabus (Channa Striata) Kombinasi Vitamin C dan Madu Kelulut (Heterotrigona Itama) Risma Dwi Anugerah; Wintari Taurina; Mohamad Andrie
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15271

Abstract

Based on the results of research, snakehead fish extract and kelulut honey have properties to make wounds heal faster. Ointment with an active formulation of snakehead fish extract and extract of kelulut honey showed an oxidation process that could make the preparation rancid. The addition of BHA and Vitamin C is expected to prevent the oxidation process so that the preparation does not become rancid. This study aims to determine the effect of adding Antioxidant BHA and Vitamin C in preventing the oxidation process of the ointment in the aqueous phase of extracts of snakehead fish (Channa Striata)and of kelulut honey (Heterotrigona Itama) at 28 days storage. Stability was accelerated at a temperature of 40 ± 20ºC and a RH of 75 ± 5%. Variations in the concentration ofiBHA and Vitamin C used were BHA.0.02. : Vitamin C 0.1, BHA 0.02 : Vitamin C 0.01, BHA 0.005 : Vitamin C 0.01, and BHA 0.005 : Vitamin C 0.1 then tested the physical properties of the ointment, namely through organoleptic test, homogeneity test, spreadability test, adhesion test, protection test and acid number test which were then analyzed by SPSS. Based on the analysis of the scattering power showed a significant difference between F0, F1, and F3. The results of the adhesion analysis showed that there were significant differences in each formula. Furthermore, the results of the stability test showed that all formulas had good physical stability. Conclusion: F1 is a very good formula to prevent oxidation in the preparation as evidenced by a decreased acid number, which is 9.62 mg KOH/g.
Formulasi Salep Ekstrak Ikan Gabus (Channa striata) dan Madu Kelulut (Heterotrigona itama) sebagai Antioksidan Ely lisnawati; Wintari Taurina; Mohamad Andrie
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15270

Abstract

Kelulut honey and snakehead fish extract have been demonstrated to improve wound healing, hence the two active components are combined in ointment formulations. Adeps lanae is a base that is included in the oil phase that undergo an oxidation process that causes rancidity in the ointment preparation, so in this study BHA and BHT antioxidants were added to suppress the oxidation process. The ointment was made with 5 concentrations consisting of 1 control group and 4 treatment groups which were given variations of BHA and BHT antioxidants. Organoleptic testing, homogeneity, adhesion, dispersion, protection, and acid numbers were all evaluated. SPSS 24 is used to test data related to adhesion, and dispersion. Results: The addition of antioxidants BHA and BHT based on acid number tests revealed that the higher the combination of antioxidants employed, the less the increase in acid numbers on day 28. The organoleptic test, homogeneity, protection, and adhesion on the preparation fulfilled the test criteria, whereas the adhesion test revealed significant differences in F1, F2, and F4 when compared to the control group. The optimum formula is F4, which fits the test parameters and has the minimum rise in acid number (9.22 mg KOH/g).
PENGARUH JUS BUAH MANGGIS (Garcinia mangostana L.) TERHADAP PROFIL FARMAKOKINETIK PARASETAMOL TIKUS PUTIH JANTAN (Rattus norvegicus) GALUR WISTAR Emy OKTAVIANI; Mohamad ANDRIE; Bambang WIJIANTO
Media Farmasi Indonesia Vol. 8 No. 2 (2013): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (296.685 KB)

Abstract

Drug interaction happens when drugs is given together with foods. This research was aimed to observe the effect of mangosteen juice to the paracetamol pharmacokinetic profile in Wistar male white rats. The study used Wistar rats weight of 200-350g. The animals were divided into three groups with the total of the male rats are 15. Group I (paracetamol) was given a single oral paracetamol 9 mg/200gBW. Group II (treatment 1) was given a single oral paracetamol 9 mg/200gBW together with mangosteen juice 2,88 g/200gBW. Group III(treatment 2) was given a single oral paracetamol 9 mg/200gBW together with mangosteen juice 0,66 g/200gBW. The serial blood was collected from tail vein for 9 hours and was analyzed using spectrophotometer UV for unchanged paracetamol. The pharmacokinetic parameters of paracetamol were calculated by recidual method and were analyzed by One Way ANOVA using 95% confidence interval. The difference between groups were analyzed using Post Hoc LSD-test. The results showed that the group II(paracetamol-mangosteen 1) and group III(paracetamol-mangosteen 2) increased of ka, Cpmaks, tmaks, t½ab, ke, t½el, CL, AUC and decreased of ka, ke, and CL. The research showed that mangosteen juice doses 2 give higher decreased metabolism and decreased elimination of paracetamol in rat.
Co-Authors Agung Endro Nugroho Agung Endro Nugroho Anggareni, Anggareni Anjeli, Lea Annisa Mutia Yusran Argo, Septian Fernando Arifani, Nata Hadiati Aulia, Yunita Hananda Bambang WIJIANTO Dies Sihombing Dies Sihombing, Dies Dwi Wulandari Dyah Ayuningtias Ely lisnawati Emy OKTAVIANI Firda M. Hadad Fransisca Daisa Hedaya, Angelina Putri Ignatius Ryan Adriawan Ignatius Ryan Adriawan, Ignatius Ryan Juliferd Gredi Lea Anjeli Mardiansyah, Furqaan Maya Widya Astuti Wulandari Mukkaromah, Siti Naziella Naziella Nur Firdiena Titian Ratu Nurlaila Afriliah Nurmainah Nurmainah Nurmainah Nurmainah Pinondang Simaremare Pinondang Simaremare, Pinondang Pratama, Taufik Nanda Prisilla, Salma Rahmawati . Rina Susilowati Rinaldy, Iqmal Arfan Risma Dwi Anugerah Rizqa Ayunda Rizqa Ayunda, Rizqa Rusmini Rusmini Saragi, Restian Rony Suprawijaya, Perianus Suwidjiyo Pramono Suwidjiyo Pramono Taufik Nanda Pratama Wintari , Wintari Wintari Taurina