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Efektivitas Sediaan Salep yang Mengandung Ekstrak Ikan Gabus (Channa striata) pada Proses Penyembuhan Luka Akut Stadium II Terbuka pada Tikus Jantan Galur Wistar Andrie, Mohamad; Sihombing, Dies
Pharmaceutical Sciences and Research Vol. 4, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

The snakehead (Channa striata) extract contains albumin (in its water phase) and omega-3 and omega-6 (in its oil phase) which have been proven to be effective in wound healing process. This research was aimed to determine wound healing effect of snakehead extract-containing ointment on 6 groups of male Wistar rats. The rat’s skin was wounded to produce acute stage II opened wound, the ointment was applied for sixteen days, and wound healing process was observed. The width of the wound was measured by using Macbiophotonic Image J program. The AUC results of each groups from smallest to largest were normal group (702.84% x day), negative group (749.56% x day), positive group (765.146% x day), water phase-containing ointment 10% group (795.146% x day), oil phase-containing ointment 10% (837.282% x day), and water-oil-phase combination ointment 10% (874.901% x day). The data were analyzed using One-Way ANOVA and Post-Hoc LSD test. The result of this research showed significant differences (p<0.05) between groups of water-oil phase combination of snakehead extract ointment with a negative control group. This research result showed that ointment containing water-oil phase combination of snakehead extract had wound healing effect on acute stage II opened wound.

KARAKTERISASI SIMPLISIA MADU KELULUT (Heterotrigona itama) SEBAGAI BAHAN BAKU SEDIAAN OBAT PENYEMBUHAN LUKA Nurlaila Afriliah; Wintari Taurina; Mohamad Andrie
Majalah Farmasi dan Farmakologi Vol. 26 No. 3 (2022): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v26i3.20969

Karakterisasi bahan alam merupakan langkah untuk mengetahui kejelasan identitas bahan alam. Identitas bahan alam merupakan aspek penting pada produksi suatu obat herbal. Madu kelulut (Heterotrigona itama) adalah salah satu bahan alam yang diperoleh dari lebah kelulut. Madu kelulut berkhasiat sebagai obat penyembuhan luka karena bersifat antiinflamasi, antibakteri, dan antioksidan. Penelitian ini bertujuan untuk mengetahui karakterisasi proses pembuatan simplisia dan simplisia madu kelulut yang berasal dari Desa Pangkalan 2, Kabupaten Bengkayang, sebagai bahan baku sediaan obat penyembuhan luka. Simplisia dikarakterisasi secara biologi meliputi habitat dan morfologi, secara fisika meliputi organoleptis, kadar air, kadar abu total, pH, dan bobot jenis, serta secara kimia meliputi skrining fitokimia. Proses pembuatan simplisia madu kelulut terdiri dari pengumpulan sampel, penyaringan, pengemasan, dan penyimpanan. Rendemen simplisia madu kelulut yang diperoleh sebesar 89,6%. Hasil karakterisasi yaitu lebah kelulut (Heterotrigona itama) hidup di daerah dataran rendah dengan iklim tropis, wilayah yang hangat dan lembap, serta memiliki sistem vegetasi yang didominasi 60% pohon kelapa (Cocos nucifera L.), 5% pohon kaliandra (Calliandra haematocephala), 5% tanaman air mata pengantin (Antigonon leptopus), serta 30% terdiri atas pisang (Musa paradisiaca L.), pinang (Areca catechu), rambutan (Nephelium lappaceum L), durian (Durio zibethinus), ceri (Prunus cerasus), buah naga (Selenicereus polyrhizus), dan beberapa tanaman liar. Morfologi lebah kelulut terbagi menjadi bagian kepala, dada, dan perut, berukuran panjang 6 mm, dan berwarna hitam. Simplisia madu kelulut memiliki rasa asam sedikit manis, berwarna hitam, beraroma khas madu kelulut, kadar air 27,11%, kadar abu total 0,28%, pH 3,07, bobot jenis 1,34 g/mL, serta mengandung senyawa alkaloid, flavonoid, dan triterpenoid. Berdasarkan hasil karakterisasi yang telah dilakukan, dapat disimpulkan simplisia madu kelulut yang diperoleh memiliki kualitas yang baik.

WATER PHASE CONCENTRATE SOLUBILITY TEST SNAKEHEAD FISH EXTRACT (Channa Striata) IN ORGANIC COSOLVENT Mohamad Andrie; Wintari Taurina
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.658

Snakehead fish extract has been recognized for its potential in healing postoperative wounds and burns. The extract contains albumin, which aids in tissue formation and healing processes. To create a high-quality wound healing drug, the extract needs to be formulated into a concentrated form and combined with a solvent that can effectively dissolve its active substances. Understanding the solubility profile of the extract and the composition of the solvent is crucial for this purpose. This study aims to determine the solubility profile of the aqueous phase concentrate of snakehead fish extract in an organic co-solvent. Solubility is an important parameter as it can impact the release rate and therapeutic effectiveness of the drug. A solubility test was conducted to assess the solubility of the aqueous phase concentrate in various solvents. The results of the solubility test indicated that the aqueous phase concentrate of snakehead fish extract exhibited good solubility in aquadest (20%), slight solubility in propylene glycol (8.5%) and honey (2%), and was insoluble in ethanol, glycerin, mannitol, and sorbitol (0%). These findings provide valuable information for formulating the extract into a wound healing drug with an appropriate solvent composition, ensuring optimal solubility and therapeutic efficacy according to pharmacopeial standards. Keywords: Concentrate; Aqueous phase of snakehead fish extract; Solubility; Solvent; Polarity Properties

WATER PHASE CONCENTRATE SOLUBILITY TEST SNAKEHEAD FISH EXTRACT (Channa Striata) IN ORGANIC COSOLVENT Mohamad Andrie; Wintari Taurina
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.658

Snakehead fish extract has been recognized for its potential in healing postoperative wounds and burns. The extract contains albumin, which aids in tissue formation and healing processes. To create a high-quality wound healing drug, the extract needs to be formulated into a concentrated form and combined with a solvent that can effectively dissolve its active substances. Understanding the solubility profile of the extract and the composition of the solvent is crucial for this purpose. This study aims to determine the solubility profile of the aqueous phase concentrate of snakehead fish extract in an organic co-solvent. Solubility is an important parameter as it can impact the release rate and therapeutic effectiveness of the drug. A solubility test was conducted to assess the solubility of the aqueous phase concentrate in various solvents. The results of the solubility test indicated that the aqueous phase concentrate of snakehead fish extract exhibited good solubility in aquadest (20%), slight solubility in propylene glycol (8.5%) and honey (2%), and was insoluble in ethanol, glycerin, mannitol, and sorbitol (0%). These findings provide valuable information for formulating the extract into a wound healing drug with an appropriate solvent composition, ensuring optimal solubility and therapeutic efficacy according to pharmacopeial standards. Keywords: Concentrate; Aqueous phase of snakehead fish extract; Solubility; Solvent; Polarity Properties

Gambaran Penyimpanan Obat-Obat LASA (Look A like Sound A like) Di Apotek Kecamatan Pontianak Selatan Anggareni, Anggareni; Nurmainah, Nurmainah; Andrie, Mohamad
Jurnal Ilmu Kedokteran dan Kesehatan Vol 11, No 6 (2024): Volume 11 Nomor 6
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v11i6.15030

Pengelolaan obat LASA (Look A like Sound A like) perlu dilakukan untuk meningkatkan keamanan dan mencegah terjadinya medication error. Tujuan penelitian ini ialah untuk mengkaji penyimpanan obat LASA di Apotek Kecamatan Pontianak Selatan berdasarkan Petunjuk Teknis Standar Pelayanan Kefarmasian di Apotek dan mengkaji pelayanan obat LASA di Apotek Kecamatan Pontianak Selatan. Metode penelitian yang digunakan yakni observasional melalui wawancara mendalam disertai pengamatan secara langsung. Sampel dalam penelitian ini ialah seluruh Apotek di Kecamatan Pontianak Selatan yang memenuhi kriteria inklusi dan ekslusi. Pengambilan sampel dilakukan secara purposive sampel, pada periode Januari-Februari 2024. Hasil penelitian ini menunjukkan bahwa dari 10 apotek penyimpanan obat LASA di Apotek Kecamatan Pontianak Selatan tergolong cukup baik dengan persentase 71% berdasarkan Petunjuk Teknis Standar Pelayanan Kefarmasian di Apotek sedangkan pelayanan obat LASA tergolong baik dengan persentase 93%. Kesimpulan dari penelitian ini bahwa beberapa apotek belum melakukan penyimpanan obat LASA berdasarkan Petunjuk Teknis Standar Pelayanan Kefarmasian dan sebagian besar apotek telah melakukan pelayanan obat LASA dengan baik.

Hubungan Senam Dan Kepatuhan Minum Obat Terhadap Penurunan Tekanan Darah Pada Pasien Hipertensi Prolanis Di Wilayah Kerja Puskesmas Samalantan Hedaya, Angelina Putri; Nurmainah, Nurmainah; Andrie, Mohamad
Jurnal Ilmu Kedokteran dan Kesehatan Vol 11, No 6 (2024): Volume 11 Nomor 6
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v11i6.15046

Hipertensi sebagai salah satu penyakit penyebab morbiditas terbesar didunia. Peningkatan prevalensi hipertensi perlu ditekan melalui berbagai intervensi secara farmakologi dan non farmakologi. Tujuan penelitian ini adalah menganalisis dan mengetahui hubungan kegiatan senam rutin dan kepatuhan minum obat terhadap penurunan tekanan darah pada pasien hipertensi Prolanis di wilayah kerja Puskesmas Samalantan. Metode penelitian yang digunakan adalah metode kuasi eksperimen secara kuantitatif dengan teknik purposive sampling. Penelitian ini dilakukan pada bulan Februari-Maret 2024 dengan jumlah 60 responden yang dibagi menjadi dua kelompok, kelompok pertama diberikan intervensi senam dengan frekuensi 1 kali seminggu selama 4 minggu dan kelompok kedua yang diminta mengisi kuesioner ARMS. Hasil penelitian menggunakan analisis secara terpisah menggunakan uji wilcoxon signed ranks dan uji spearman menunjukkan hasil ρ value < α = 0,05 yang menunjukkan pencapaian tekanan darah yang optimal pada responden. Kesimpulan dari penelitian ini yaitu senam dan kepatuhan minum obat memiliki hubungan yang signifikan terhadap penurunan tekanan darah.

Standardization of Golden Sea Cucumber (Stichopus hermanii) Extracts from Pelapis Island, Kayong Regency, West Kalimantan Rusmini, Rusmini; Taurina, Wintari; Andrie, Mohamad
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.539-545

Stichopus hermanii can be used as a medicinal material, a source of animal protein, and wound healing medicine products. Extracts as raw materials for products must go through a standardization process to ensure pharmaceutical reproducibility, a therapeutic quality, and to ensure a consistent and uniform final composition. The purpose of this research was to determine the test results of the standardization parameters of Stichopus hermanii extract from Pelapis Island, West Kalimantan as raw material for wound healing herbal medicinal preparations. Preparation of extracts using the maceration method with 96% ethanol. The extract was standardized with specific parameters, including organoleptic, water and ethanol soluble content, phytochemical screening, and protein content, and non-specific parameters, including drying shrinkage, water content, ash content, and acid insoluble ash content. The test results obtained were a water-soluble content of 61.89%, ethanol-soluble content of 41.81%, protein content of 7.62%, drying shrinkage of 38.81%, water content of 20.58%, ash content of 37.95%, and acid insoluble ash content of 2.07%.

Standardization of Snakehead Fish (Channa striata) Concentrates Obtained from Sungai Itik Village, Kubu Raya District, West Kalimantan Aulia, Yunita Hananda; Andrie, Mohamad; Wintari , Wintari
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 2: September 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i2.26746

Standardization is the method of identifying properties based totally on superb parameters to advantage the identical diploma of satisfaction. it has been proven that vitamins decided in snakehead fish (Channa striata) from herbal assets can be implemented as a possibility to hasten the recuperation of wounds. With the assistance of the techniques of freeze drying, this examination sought to set up the standardization of snakehead fish pay attention from Sungai Itik Village in Kubu Raya Regency, West Kalimantan as an uncooked material for prescribed drugs that treat wounds. Standardization carried out on concentrate samples consisted of specific and non-specific parameters. Specific parameters consist of organoleptic, water-soluble essence content, protein, and albumin. While the non-specific parameters tested were moisture content, ash content, acid-insoluble ash content, and drying shrinkage. The test results showed that the water content contained in snakehead fish was 7.21% ± 0.165, ash content was 10.47% ± 1.06, acid insoluble ash content was 1.40% ± 0.115, water-soluble essence content was 77.10% ± 0.54, dry shrinkage rate was 13.973% ± 0.193, the protein was 99.49% and albumin was 7.03 g/dl. The standardization parameters have not met all the tests so it can be said that snakehead fish concentrate has not met the standard and has not been standardized for natural wound healing medicinal ingredients.

The Effect of BHA as an Antioxidant to the Accelerated Stability Test of Snakehead Fish and Kelulut Honey Ointment Taurina, Wintari; Andrie, Mohamad; Mukkaromah, Siti
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.37776

The ointment of snakehead fish extract and kelulut honey has a synergistic potential to boost the wound recuperation process. This ointment is formulated for topical use to be easily applied to the wound area. The ointment base used in this preparation is adeps lanae. Adeps lanae is an easily oxidized substance that can cause the preparation to become unstable. The addition of antioxidants is one way to prevent the oxidation process in the preparation. This has a look at aims to decide the impact of the addition of BHA as an antioxidant in the ointments of snakehead fish extract (Channa striata) and kelulut honey (Heterotrigona itama) at 28 days of storage with an accelerated stability test method with a temperature 40 ± 20C and RH 75 ± 5%. The ointment was made with various concentrations of BHA 0.005% (F1), 0.01% (F2), and 0.02% (F3) then tested the physical properties of the ointment and analyzed by SPSS. Results of spreadability test analysis showed an increase of the spread and significant differences between F1, F2, and F3 to F0. The adhesion test analysis results showed a decrease in the stickiness of time bonding strength and a significant difference. The test results showed a decrease in acid number on the acid number F2 and F3. Results of the organoleptic test, homogeneity, and power protection showed that all formulas have good stability. F2 is the best formula to prevent oxidization of the dosage indicated by the smallest value of the acid number.

THE ANALYSIS OF PATIENT CHARACTERISTICS OF COMPLIANCE IN THE USE OF METADONE THERAPY IN THE BANGKONG RIVER REGIONAL MENTAL HEALTH CLINIC OF PONTIANAK IN THE PERIOD OF 2020-2021 Prisilla, Salma; Nurmainah, Nurmainah; Andrie, Mohamad
Journal Pharmacy Of Tanjungpura Vol 1, No 1 (2023): Oktober
Publisher : Universitas Tanjungpura

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ABSTRACT Compliance with Injecting Drug Users (IDUs) in Methadone Maintenance Therapy is crucial during rehabilitation. However, many IDUs still do not comply with methadone therapy. As a result, the patient may once more experience withdrawal symptoms. The purpose of this study was to examine the percentage of patient compliance and the impact of patient's age, education, and occupation on compliance with the use of methadone therapy at Sungai Bangkong Region Psychiatric Hospital, Pontianak. The research method used is observational research with an analytical cohort study design. The data were taken from patient's medical record, which includes the patient's medical record number and patient characteristics such as age, gender, last education, occupation, and the number of days the patient received the drug. The collected medical record data is then analyzed using the Chi-Square analysis method. The results showed that the respondents had a high level of compliance with a percentage of 85.7%. Compliant patients are dominated by patients in the 20-40 age range, with college as their last education, and working as laborers. The results of the Chi-square test analysis showed the impact of age, education, and occupation on compliance, with values of p = 0.462; p=1,000; p=1,000, respectively. This study concludes that characteristics like age, education, and occupation had no impact on patient compliance in undergoing Methadone Maintenance Therapy. Keywords: Compliance, Injecting Drug Users, Methadone Maintenance Therapy

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