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All Journal Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Biology, Medicine, & Natural Product Chemistry Majalah Obat Tradisional Pharmascience Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Ilmu Kefarmasian Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Medical Sains : Jurnal Ilmiah Kefarmasian Media Farmasi Indonesia Pharmaceutical Sciences and Research (PSR) Medical Sains : Jurnal Ilmiah Kefarmasian Journal Pharmacy of Tanjungpura
Mohamad Andrie
Departement Of Pharmacy, Faculty Of Medicine, Tanjungpura University, Pontianak, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Other

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Formulasi Sediaan Salep Kombinasi Fase Air Ekstrak Ikan Gabus (Channa striata) Dan Madu Kelulut (Heterotrigona itama) dengan Penambahan Alfa Tokoferol Sebagai Antioksidan Arifani, Nata Hadiati; Andrie, Mohamad; Taurina, Wintari
Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN Vol 5, No 1 (2021): Jurnal Farmasi Kalbar
Publisher : Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN

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Abstract

Ekstrak ikan gabus dan madu kelulut memiliki kemampuan untuk mempercepat proses penyembuhan luka sehingga diformulasikan menjadi salep dengan basis adeps lanae. Adeps lanae dapat terdegradasi akibat proses oksidasi sehingga dapat menyebabkan pembentukan senyawa volatil sehingga menyebabkan ketengikan. Penambahan alfa tokoferol sebagai antioksidan pada salep dapat mencegah ketengikan basis adeps lanae. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan alfa tokoferol sebagai antioksidan pada sediaan salep ekstrak ikan gabus (Channa striata) dan madu kelulut (Heterotrigona itama) terhadap uji sifat fisik dan bilangan asam. Variasi alfa tokoferol yang digunakan adalah 0,001%, 0,01% dan 0,05% kemudian diuji sifat fisik dan bilangan asam dari sediaan. Pengujian daya sebar menunjukkan bahwa sediaan tidak memenuhi syarat 5-7 cm. Hasil analisis pada daya sebar menunjukan perbedaan yang signifikan antara F0, F1, F2, dan F3 sehingga dapat disimpulkan bahwa sediaan mengalami ketidakstabilan. Hasil analisis daya lekat menunjukkan tidak terdapat perbedaan signifikan pada tiap formula. Hasil uji stabilitas menunjukkan semua formula memiliki stabilitas fisik yang baik, memberikan proteksi. Sediaan juga mengalami penurunan oksidasi pada F3 dibandingkan dengan F0 dan F2 yang ditunjukkan dengan penurunan bilangan asam.
UJI STABILITAS PROTEIN SEDIAAN SALEP KOMBINASI FASA AIR EKSTRAK IKAN GABUS (Channa striata) DAN EKSTRAK ETANOL DAUN SIRIH (Piper betle L.) MENGGUNAKAN METODE BIURET Wulandari, Dwi; Andrie, Mohamad; Taurina, Wintari
Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN Vol 4, No 1 (2019): Jurnal Farmasi Kalbar
Publisher : Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN

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Abstract

Ikan gabus mengandung kadar albumin yang sangat tinggi. Albumin sendiri merupakan salah satu jenis protein yang sangat penting untuk proses penyembuhan luka di tubuh. Penelitian sebelumya telah dilakukan uji aktivitas salep fase air maupun fase minyak pada luka akut stadium II terbuka dan hasilnya menunjukkan daya penyembuhan yang signifikan terhadap kontrol negatif. Pada penelitian ini diujikan ke hewan penelitian dan luka mengalami infeksi, sehingga diperlukan antibakteri alami. Salah satu antibakteri alami adalah daun sirih. Daun sirih (Piper betle L.) hijau merupakan bahan alam yang memiliki kandungan aktif seperti tannin, minyak atsiri, flavonoid, dan fenol yang mempunyai kemampuan untuk membantu proses penyembuhan luka. Senyawa fenol cenderung bereaksi dengan kelompok sulfhidril protein. Reaksi tersebut dapat mengakibatkan protein terdenaturasi dan menyebabkan turunnya nilai protein. Penelitian dilakukan untuk mengetahui stabilitas protein fasa air ekstrak ikan gabus dalam sediaan salep yang dikombinasi dengan ekstrak etanol daun sirih hijau (Piper betle L.) Stabilitas obat penting untuk diperhatikan karena akan berdampak pada efektifitas, keamanan dan mutu obat. Pengukuran kadar protein ditentukan dengan menggunakan metode Biuret. Uji stabilitas protein fasa air ekstrak ikan gabus dalam sediaan salep kombinasi maupun tunggal dilakukan selama 28 hari. Sediaan salep disimpan di dalam lemari yang telah dimodifikasi dengan suhu dan kelembaban yang terjaga (30?C, 75%). Hasil dari penelitian terdapat selisih penurunan kadar antara salep tunggal tanpa ekstrak etanol daun sirih (F1) dan sediaan salep kombinasi dengan ekstrak etanol daun sirih (F2) sebesar 16,345 ppm. Berdasarkan hasil spss pada uji statistic one way anova penurunan kadar protein sediaan salep tunggal maupun salep kombinasi terjadi secara signifikan pada hari ke 28. Pada uji Independent sample t-test terdapat perbedaan signifikan kadar protein salep tunggal dan salep kombinasi ditandai dengan nilai signifikansi 0,008 < 0,05. Hal ini mengindikasikan bahwa adanya pengaruh dari ekstrak etanol daun sirih dalam menjaga stabilitas protein. Kata kunci : Protein, Ikan gabus, Ekstrak daun sirih hijau, Salep, Metode Biuret.
Profil Proteinuria dan Tekanan Darah pada Pasien Preeklampsia Berat yang menggunakan Antihipertensi Nurmainah Nurmainah; Firda M. Hadad; Mohamad Andrie
Indonesian Journal of Clinical Pharmacy Vol 10, No 2 (2021)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2021.10.2.79

Abstract

Preeklampsia berat sering terjadi pada ibu hamil. Pengobatan preeklampsia berat dapat dilakukan dengan pemberian antihipertensi untuk mencegah penyakit serebrovaskular dan kematian. Penelitian ini bertujuan untuk mendeskripsikan profil penurunan proteinuria, tekanan darah, dan penggunaan antihipertensi pada pasien preeklampsia berat di Instalasi Rawat Inap RSUD dr. Soedarso Pontianak. Metode penelitian yang digunakan adalah observasional dengan rancangan penelitian potong lintang. Pengumpulan data dilakukan secara retrospektif dari rekam medis pasien preeklampsia berat rawat inap selama periode Januari–Desember 2018. Penelitian ini dilakukan selama bulan Oktober–Desember 2019 di RSUD dr. Soedarso Pontianak. Sampel yang memenuhi kriteria inklusi dalam penelitian ini sebanyak 62 pasien. Hasil penelitian menunjukkan bahwa 32,27% pasien mengalami penurunan nilai proteinuria dengan rata-rata penurunan sebesar dipstik (+)1 sedangkan nilai proteinuria dipstik yang tetap terdapat pada 67,73% pasien dengan mayoritas pasien memiliki nilai proteinuria dipstik (+)3. Penurunan rata-rata tekanan darah sistolik/diastolik (TDS/TDD) pada pasien preeklampsia berat sebesar 28,58/17,69 mmHg. Antihipertensi yang digunakan yaitu nifedipin (14,52%), metildopa (8,06%), furosemid (1,61%). Penggunaan antihipertensi kombinasi paling banyak digunakan adalah kombinasi nifedipin dan metildopa sebanyak 40,32%. Simpulan penelitian ini adalah terdapat penurunan tekanan darah dan proteinuria pada pasien preeklampsia berat yang menggunakan antihipertensi.Walaupun demikian, beberapa pasien preeklampsia berat masih memiliki kadar proteinurianya dalam kondisi tetap. Antihipertensi yang paling banyak digunakan pada pasien preeklampsia berat di Instalasi Rawat Inap RSUD dr. Soedarso Pontianak yaitu kombinasi nifedipin dan metildopa.Kata kunci: Antihipertensi, preeklampsia berat, proteinuria, tekanan darah  Proteinuria and Blood Pressure Profiles in Severe Preeclampsia Patients using Antihypertensive MedicationAbstractPreeclampsia is a common occurrence among pregnant women, and in severe cases, the condition is treated using antihypertensive medication to prevent cerebrovascular disease, as well as death. This study, therefore, aimed to describe the proteinuria levels, blood pressure, and antihypertensive profile of patients with severe preeclampsia at Dr. Soedarso General Hospital, Pontianak, using a descriptive observation method with a cross-sectional design. The study was conducted from October–December 2019, however, data were collected retrospectively, based on inpatients with severe preeclampsia medical records from January to December 2018, and a total of 62 participants were selected based on the inclusion, as well as exclusion criteria. According to the results, 32,27% of the respondents experienced a reduction in proteinuria levels, with an average of proteinuria dipstick (+)1, while 67,73% experienced constant proteinuria levels, with most patients having proteinuria dipstick (+)3. Furthermore, the average systolic/diastolic blood pressure (SBP/DBP) reduction in patients with severe preeclampsia was 28,58/17,69 mmHg. The antihypertensive used were nifedipine (14,52%), methyldopa (8,06%), and furosemide (1,61%), alone or in combination, however combination medication, for instance, nifedipine + methyldopa (40,32%), was most prevalent. In conclusion, patients with severe preeclampsia experienced reductions in blood pressure and proteinuria levels after treatment with antihypertensive medication, however, several patients experienced constant proteinuria levels. Also, the most commonly used antihypertensive was discovered to be a combination of nifedipine and methyldopa.Keywords: Antihypertensive medication, blood pressure, proteinuria, severe preeclampsia 
Ointment formulation of snakehead fish (Channa striata) Extract with variations of CMC-Na and carbopol Mohamad Andrie; Wintari Taurina
Pharmaciana Vol 11, No 1 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.595 KB) | DOI: 10.12928/pharmaciana.v11i1.18385

Abstract

 Snakehead fish (Channa striata) and kelulut honey (Trigona sp.) have the potential to accelerate the wound-healing process. These natural ingredients are formulated in the form of ointment because ointment is an external medicine that is easy to apply and has long contact with the skin. Previous research has shown that the snakehead fish extract ointment undergoes phase separation, so it needs a material that can bind the snakehead fish extract and kelulut honey as the active substances in the preparation. This study aimed to determine the effect of variations in the concentration of CMC-Na (3%, 4.5%, 6%) and Carbopol (0.5%, 1%, 2%) as a binder on the ointment physical properties and to determine the best snakehead fish (Channa striata) extract ointment formulation. The ointment of snakehead fish extract was tested for organoleptic, homogeneity, spreadability, and adhesion. The test results were analyzed by One Way ANOVA with a confidence level of 95%. The results showed that the higher the concentrations of CMC-Na and Carbopol used, the greater the adhesive power and the lower the spreadability. Ointment with Carbopol has a wider spreadability and a softer consistency than ointment with CMC-Na. The best formulation is shown by the Carbopol 0.5% (F4) formula, where the average spreadability with a load of 150 g is 5.09 cm and the average adhesion is 229 seconds.
Accelerated stability test of snakehead fish and kelulut honey ointment with CMC-Na as a binder Wintari Taurina; Mohamad Andrie; Nur Firdiena Titian Ratu
Pharmaciana Vol 11, No 3 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (177.873 KB) | DOI: 10.12928/pharmaciana.v11i3.20628

Abstract

The extract of snakehead fish (Channa striata) and kelulut honey (Heterotrigona itama) ointment was proven to have activity in wound healing. However, previous studies showed instability in the ointment as indicated by the occurrence of phase separation. This study used CMC-Na (Carboxymethyl Cellulose Sodium) with a concentration of 3% (F1), 4.5% (F2), and 6% (F3) as a binder. The stabilizer was added to increase the stability of the ointment preparation by binding to the aqueous phase and preventing it from leaving the ointment base. The test was carried out with the accelerated stability method at a temperature of 40° ± 2° C and a humidity of 75% ± 5% for 28 days. The evaluation includes organoleptic tests, homogeneity, spreadability, adhesion, and protection power. The results showed that CMC-Na increased the stability of the ointment. The data obtained show that the higher the CMC-Na concentration used, the higher the consistency and adhesion were, but the lower the spreadability of the preparation. The results of the average spreadability and adhesion power for formulation 1 were 5.09 cm and 1797.33 seconds, formulation 2 were 4.42 cm and 1798.33 seconds, and formulation 3 were 3.69 cm and 1799 seconds. The results of the One-Way ANOVA showed that all formulations experienced a significant decrease in adhesion and increase in spreadability during 28 days of storage. The best ointment that meets the physical stability criteria is shown by the CMC-Na 3% (F1) formulation, with a soft texture, homogeneous, a good spreadability (5-7 cm), a good adhesion (more than 4 seconds), and a good protective power for 28 days of testing.
The gel formulation of the aqueous phase of snakehead fish (Channa striata) extract with various combinations of HPMC K4M and Carbopol 934 Wintari Taurina; Mohamad Andrie; Lea Anjeli
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (171.809 KB) | DOI: 10.12928/pharmaciana.v8i1.8356

Abstract

Gel is a clear and semi-solid material, translucent and contains active material. The liquid phase of Ekstrak Ikan Gabus contains reactive Albumin benefits to advance the wound-healing process. HPMC and carbopol is the gelling agent uses to form gel material. This research aims to acknowledge the effect of basic combination variety (gelling agent) towards physical and chemical stability of gel material during liquid phase of Ekstrak Ikan Gabus in length of period 28 days.  Variety of HPMC: Carbopol used, 25:75%, 50:50%, and 75:25%. Physical and chemical test conducted they are, organoleptic test, dispersion test, bonding strength test and pH test. The result is analyzed through one-way ANOVA and continued by LSD test with validity 95%. The whole formula is resulted a stable physical and chemical during 28 days. The higher the consentration of HPMC the the better its physic and chemistry stability. The best and optimum formula was shown by F3 (75:25%), with a stable organoleptic result during 28 days, homogen, the result of the dispere power weight 50 g (±14,517 cm2) weight 100 g (±16,169 cm2) weight 150 g (±16,957 cm2 ) and the average weight is (±15,881 cm2), the sticky power (±2301,78 second) and pH (±6,42) in which can be considered safe for skin.
EVALUASI EFEK ANTI-DIABETES MELITUS EKSTRAK TERPURIFIKASI Andrographis paniculata (Burm. f.) Nees DAN ANDROGRAFOLID DENGAN PARAMETER INDEKS HOMA-IR Ignatius Ryan Adriawan; Mohamad Andrie; Rina Susilowati; Suwidjiyo Pramono; Agung Endro Nugroho
Majalah Obat Tradisional Vol 19, No 1 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (748.432 KB) | DOI: 10.22146/tradmedj.8086

Abstract

Diabetes mellitus type 2 was induced by high fat diet and fructose. The insulin resistance and hyperinsulinemia compensatory can be measured by index homeostatic model assessment – insulin resistance (HOMA-IR). Andrographis paniculata (Burm. f.) Nees is a traditional plant can be used to treat diabetes mellitus and the main active compound of this plant is Andrographolide. The objective of this study is to evaluate the effect of purified extract of Andrographis paniculata (Burm. f.) Nees and andrographolide on HOMA-IR index of High fat diet and fructose induced Wistar Rats. This study is quasi-experimental and data analysis was using Kruskal-Wallis test. The result showed that purified extract of Andrographis paniculata and andrographolide decreased HOMA-IR index. Purified extract of Andrographis paniculata 1303,8 mg/kg decreased HOMA-IR index by 82,05 %.
UJI AKTIVITAS JAMU GENDONG KUNYIT ASAM (Curcuma domestica Val.; Tamarindus indica L.) SEBAGAI ANTIDIABETES PADA TIKUS YANG DIINDUKSI STREPTOZOTOCIN Mohamad Andrie; Wintari Taurina; Rizqa Ayunda
Majalah Obat Tradisional Vol 19, No 2 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1133.105 KB) | DOI: 10.22146/tradmedj.8147

Abstract

 Diabetes mellitus is a metabolic disorder characterized by hyperglycemia. “Jamu gendong kunyit asam” (Curcuma domestica Val.; Tamarindus indica L.) is a traditional medicine that has antioxidant activity which can contribute to diabetic because of the phenolic content. This aim of this study is to determine the effect of “jamu gendong kunyit asam” on lowering blood glucose levels and repairing damage of the islet cells. 25 male wistar rats (Rattus norvegicus) were divided into five groups. Group I as a normal group without any treatment, group II, III, IV and V were induced with streptozotocin (7mg/ 200gBB) then treated with  CMC 1%, glibenclamide (0.27mg / 200gBB), “jamu gendong kunyit asam” 1.90mL/ 200gBB and 3.80mL/ 200gBB. The treatment was done for 28 days. Glucometer was used to measure the gloucose blood level on day 4, 8, 12, 16, 20, 24 and 28. The damages on the islet cells were examined under the microscope on the histology sample of pancreas prepared with Hematoxyllin eosin stain. Datas were analyzed statistically with One Way Anova test, T-Test, and the Kruskal-Wallis test using SPSS 17.0 for Windows. Results showed there is a significant difference (p> 0.05) in blood glucose levels and damage to the islets of Langerhans of the pancreas between the glibenclamide group and treatment of “jamu gendong kunyit asam”. From the research it can be concluded that the “jamu gendong kunyit asam” have antidiabetic activity which is  showed by a decrease in blood glucose levels and an improvement of pancreatic islets of Langerhans in streptozotocin-induced diabetic rats with an effective dose of 1.90mL/ 200gBB.
FORMULASI GEL EKSTRAK LENGKUAS (Alpinia galanga L.) SEBAGAI ANTIJAMUR DENGAN BASIS HIDROKSI PROPIL METIL SELULOSA (HPMC) DAN CARBOPOL Wintari Taurina; Mohamad Andrie
Majalah Obat Tradisional Vol 18, No 3 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (212.261 KB) | DOI: 10.22146/tradmedj.8218

Abstract

Infection of Malassezia furfur on skin can be caused by bad factor. One of the materials that can be used as an antifungal is Lengkuas rhizome extract (Alpinia galanga L.). This study had purpose to determine the antifungal activity and the effectiveness of gels Lengkuas rhizome extract on pathogenic fungi using maseration method with etanol 96%. Gel making is used HPMC and carbopol base. Testing activity of extract and testing the effectiveness of the gel by disc diffusion method (Kirby-Bauer test). Screening result  showed that the extract contains triterpenoids, flavonoids and essential oil. Based on the test results against Malassezia furfur, antifungal activity of the extract in the gel increased compared to extracts without formulated into a gel. But the activity increasing was not significant based on statistical analysis with one-way ANOVA test obtained a significance of 0.234 (p> 0.05). 
PENGARUH JUS BUAH DURIAN (Durio zibethinus Murr.) TERHADAP PROFIL FARMAKOKINETIK PARASETAMOL PADA TIKUS PUTIH (Rattus norvegicus L.) JANTAN GALUR WISTAR Pinondang Simaremare; Mohamad Andrie; Bambang Wijianto
Majalah Obat Tradisional Vol 18, No 3 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (314.704 KB) | DOI: 10.22146/tradmedj.8223

Abstract

Paracetamol is widely used as analgesic and antipyretic agent in treatment of pain and fever. Paracetamol has interaction with carbohydrates and alcohol. Durian is the fruit native of Indonesia, that contain carbohydrates and alcohol. The aims of this research were to study the influence of durian fruit juice to the absorption and elimination kinetics of paracetamol and to know the dose of durian fruit juice that influence the absorption and elimination kinetics of paracetamol. The study was conducted using 16 rats, divided into 4 groups (n=4 per group). Each group was treated the following treatment : control paracetamol (paracetamol 9 mg/200 gBW), dose 1 group (paracetamol 9 mg/200 gBW and 0.675 g/200 gBW of durian fruit juice), dose 2 group (paracetamol 9 mg/200 gBW and 1.350 g/200 gBW of durian fruit juice) and dose 3 group (paracetamol 9 mg/200 gBW and 2.700 g/200 gBW of durian fruit juice). Blood sampling is done from the vein of rat’s tail at minutes 10, 20, 30, 40, 60, 90, 120, 180, 240, 300 and 360. The quantitation of paracetamol in plasma was determined by UV spectrophotometer at 243 nm. Result showed that durian fruit juice changed the absorption kinetics of paracetamol, durian fruit juice decreased Ka,  Cpmaks  and increased  Tmaks  parameter of paracetamol. Durian fruit juice also changed the elimination kinetics of paracetamol, its decreased Vd, Ke, Cl and increased the value of AUC and T1/2 paracetamol. All doses of durian fruit juice can influence the absorption and elimination kinetics of paracetamol includes Ka, Cpmaks, Tmaks, Vd, Cl, Ke, T1/2 and AUC parameters on wistar male rats (Rattus norvegicus L.).
Co-Authors Agung Endro Nugroho Agung Endro Nugroho Anggareni, Anggareni Anjeli, Lea Annisa Mutia Yusran Argo, Septian Fernando Arifani, Nata Hadiati Aulia, Yunita Hananda Bambang WIJIANTO Dies Sihombing Dies Sihombing, Dies Dwi Wulandari Dyah Ayuningtias Ely lisnawati Emy OKTAVIANI Firda M. Hadad Fransisca Daisa Hedaya, Angelina Putri Ignatius Ryan Adriawan Ignatius Ryan Adriawan, Ignatius Ryan Juliferd Gredi Lea Anjeli Mardiansyah, Furqaan Maya Widya Astuti Wulandari Mukkaromah, Siti Naziella Naziella Nur Firdiena Titian Ratu Nurlaila Afriliah Nurmainah Nurmainah Nurmainah Nurmainah Pinondang Simaremare Pinondang Simaremare, Pinondang Pratama, Taufik Nanda Prisilla, Salma Rahmawati . Rina Susilowati Rinaldy, Iqmal Arfan Risma Dwi Anugerah Rizqa Ayunda Rizqa Ayunda, Rizqa Rusmini Rusmini Saragi, Restian Rony Suprawijaya, Perianus Suwidjiyo Pramono Suwidjiyo Pramono Taufik Nanda Pratama Wintari , Wintari Wintari Taurina