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All Journal Jurnal Kesehatan Hesti Wira Sakti Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Kesehatan Islam : Islamic Health Journal Jurnal Riset Kesehatan Poltekkes Depkes Bandung Borneo Journal Of Pharmascientech PROFESSIONAL HEALTH JOURNAL Pharmademica: Jurnal Kefarmasian dan Gizi Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan RESLAJ: Religion Education Social Laa Roiba Journal Jurnal Sains dan Kesehatan Journal of Medicine and Clinical Pharmacy
Wardana, Fendi Yoga
Program Studi Vokasi Farmasi, Institut Teknologi, Sains, Dan Kesehatan RS Dr. Soepraoen Kesdam V/BRW, Malang, 65147, Indonesia
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Pemanfaatan Ekstrak Buah Bit Merah (Beta vulgaris) sebagai Sensor Anion Fendi Yoga Wardana
Jurnal Kesehatan Hesti Wira Sakti Vol. 9 No. 2 (2021): Jurnal Kesehatan Hesti Wira Sakti
Publisher : Institut Teknologi, Sains, dan Kesehatan RS dr. Soepraoen Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47794/jkhws.v9i2.336

Abstract

Pendahuluan: Keberadaan senyawa beracun terdiri dari ion-ion senyawa anorganik yang dapat mengontaminasi lingkungan dan sangat berbahaya bagi kehidupan perairan dan kesehatanmanusia. Senyawa betalain yang berasal dari ekstrak buah bit merah (Beta vulgaris) adalah contoh dari senyawa kimia yang diprediksi memiliki sifat sebagai senyawa sensor terhadap nion beracun. Metode: Buah bit merah diekstraksi dengan metode maserasi menggunakanpelarut etanol. Ekstrak etanol buah bit diujikan terhadap larutan anion NO3-, SO42-, CN- dan Cl dengan konsentrasi 1.000 ppm dan 10.000 ppm. Hasil: Hasil pengujian ekstrak buah bit merah sebagai sensor anion pada konsentrasi 10.000 ppm, didapatkan perubahan warna menjadi ungu pada larutan ion CN-. Berdasarkan hasil analisis spektrofotometer UV-Visible diketahui bahwa larutan ion CN- yang ditambahkan ekstrak buah bit merah menunjukkan nilai λmaks 575 nm, sedangkan ekstrak buah bit merah menunjukkan nilai λmaks 525 nm. Sedangkan untuk hasil pengujian anion yang lain tidak menunjukkan perubahan warna yang berbeda dibandingkandengan ekstrak buah bit merah. Kesimpulan: Ekstrak buah bit merah dapat digunakan untuk mendeteksi kandungan anion CN- pada konsetrasi 10.000 ppm. Kata kunci: Beta vulgaris, bit merah, sensor anoin, spektrofotometer UV-Visible.
Analisis Kadar Asam Retinoat dalam Krim Pemutih Malam di Kota Malang Fendi Yoga Wardana; Yunida Senja Lestari; Rakhmadani Gadis Aprilianti
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 1 No 2 (2022): Oktober - Maret
Publisher : LPPMKI - AKAFARMA AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (644.087 KB) | DOI: 10.54445/pharmademica.v1i2.17

Abstract

Whitening cream is a product that is used on the outside of the body to lighten or change the color of the skin. Whitening cream contains chemicals that are harmful to the skin, such as mercury, hydroquinone, and retinoic acid. Retinoic acid belongs to a group of drugs that are prohibited because it can cause dry skin, burning and teratogenicity. Therefore, it is necessary to analyze the retinoic acid in whitening cream. This study aims to determine the content of retinoic acid in night whitening cream. The samples in this study were 5 night whitening cream products marketed in Malang. Qualitative test of retinoic acid was performed by Thin Layer Chromatography (TLC) with silica gel 60F 254 nm as a stationary phase and n-hexane: acetone (6:4) as a mobile phase, and quantitative test using UV-Vis spectrophotometry. The observation result on TLC shows dark blue spots when viewed under UV light at 254 nm with Rf values for samples B, D, and E of 0.487; sample C of 0.425; while the Rf value of the comparison standard is 0.500. The quantitative test indicates 4 samples of night whitening cream contain retinoic acid; 0.165% in sample B, 0.060% in sample C, 0.125% in sample D, and 0.151% in sample E. In conclusion, samples B, C, D and E do not meet the BPOM requirements because they are sold freely without a doctor's supervision.
Identifikasi Kandungan Asam Salisilat dalam Produk Krim Anti Jerawat di Pasar Tajinan Kabupaten Malang Fendi Yoga Wardana; Nurul Fadila; Mayang Aditya Ayuning Siwi
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 1 No 2 (2022): Oktober - Maret
Publisher : LPPMKI - AKAFARMA AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (542.429 KB) | DOI: 10.54445/pharmademica.v1i2.18

Abstract

Anti-acne cream is a type of cosmetics that is often used for skin care. Salicylic acid is often used as the active substance in this anti-acne cream. According to the Indonesian National Food and Drug Agency in 2019 on cosmetics, salicylic acid is allowed in cosmetics if it is not more than 2%. In this study, 6 types of anti-acne cream, from Tajinan Market, Malang Regency, were tested with the aim of studying the content of salicylic acid in anti-acne cream products. The test was performed qualitatively using a colour test with FeCl3 reagent (a positive reaction show a purple colour) and a thin layer chromatography (TLC) method using a solvent mixture of ethyl acetate;methanol;ammonia (8:1.90:0.10) as the mobile phase. Quantitative determination of the content was performed using UV-Vis spectrophotometry. The qualitative test with the colour test indicates that samples A and E are positive for containing salicylic acid. The results of the thin layer chromatography (TLC) test indicates that sample A is positive for containing salicylic acid with an Rf value of 0.66, which is the same as the comparison standard. The quantitative test with UV-Vis spectrophotometry indicates that the salicylic acid content in sample A is 2.516%, sample D is 1,400%, and sample E is 1.646%. In conclusion, only cream of sample A do not meet the requirements of the Indonesian National Food and Drug Agency because it has a salicylic acid content of more than 2%.
Oral Subchronic Toxicity Test of Yellow Root Ethanol Extract (Arcangelisia flava Merr.) In Rats (Mus musculus): Uji toksisitas subkronik oral ekstrak etanol akar kuning (Arcangelisia flava Merr.) pada Mencit (Mus musculus) Rakhmadani Gadis Aprilianti; Tsaniaturrizqiah Permataningtyas; Fendi Yoga Wardana
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 8 No. 2 (2022): (October 2022)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2022.v8.i2.15961

Abstract

Background: Yellow root (Arcangelisia flava Merr.) is a native Indonesian plant that contains alkaloids, phenolics, flavonoids, saponins, tannins and berberine. This plant is proven to have antimicrobial, antioxidant, antihyperlipidemic, and anticancer activity. However, the effect on body weight, clinical symptoms and toxic symptoms has not been studied yet. Objectives: Accordingly, the objective of this research was to determine the effect of Arcangelisia flava Merr. extract with the multilevel maceration method on parameters of body weight, clinical symptoms and toxic symptoms in male rats. Material and Methods: A total of 16 male rats aged 6-8 weeks weighing 20-40 grams were divided into 4 groups. The control group was only given 1% sodium-carboxymethyl cellulose (CMC-Na), while the treatment group was given Arcangelisia flava Merr. extract at doses of 800, 900, and 1000 mg/kgBW orally for 28 days. At week 1 to week 4, body weight, clinical symptoms and toxic symptoms were observed for male rats. Result: Observations of toxic symptoms and symptoms showed that there were several symptoms that appeared in male rats and changes in body weight there were no significant differences from t0 to t1, t0 to t2, t0 to t3, and t0 to t4 for each treatment (p>0,05). Conclusions: The administration of Arcangelisia flava Merr. extract at doses of 800, 900, and 1000mg/kgBW for 28 days did not affect weight gain or loss, but these extracts did have an effect on symptoms in test animals such as straight fur and strange behavior.
Analisis Kandungan Formalin dalam Bumbu Giling Instan di Pasar Besar Kota Malang Fendi Yoga Wardana
PROFESSIONAL HEALTH JOURNAL Vol 4 No 2 (2023): Juni
Publisher : Pusat Penelitian dan Pengabdian Masyarakat (PPPM) STIKES Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54832/phj.v4i2.336

Abstract

Ground spices are food ingredients that can enrich the taste, aroma and taste of dishes and have a very limited service life. Many manufacturers use formalin as a preservative to overcome the short shelf life of ground spices. Formalin is a clear, colorless or almost colorless liquid with a pungent odor. The use of formalin as a food preservative is prohibited in the Regulation, because formaldehyde is toxic (poisonous). This study identified the formalin content in instant ground spices in the market of Malang City. The purpose of this study was to determine the content and levels of formaldehyde contained in five traders of instant ground spices in Market of Malang City. Five samples of instant ground spices that were analyzed were taken using the Purposive Sampling technique. Qualitative testing was carried out using the Test Kit and quantitative testing for the determination of formalin levels was carried out using the Spectrophotometry UV-VIS . The results showed that based on observations and qualitative tests, two samples of instant ground spices sold in Market were positive for formaldehyde. Meanwhile, the quantitative test results using the Spectrophotometry UV-Vis showed that of the five samples tested, two of them contained 0.378% formalin in Rendang instant ground spice and 0.516% instant curry spice. So the curry and rendang samples are not suitable for consumption because formaldehyde cannot be added to food at all.
Formulasi Lotion dari Ekstrak Buah Bit (Beta vulgaris) dengan Perbedaan Komposisi Asam Stearat Fendi Yoga Wardana; Riska , Riska Milani
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 12 No. 2 (2023): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v12i2.20826

Abstract

Abstract. Lotion is a skin moisturizing cosmetic preparation that has non-greasy properties and is easily applied to the skin. This study aims to make a lotion formulation from beetroot (Beta vulgaris) extract according to the physical stability properties. In this study, three lotion preparation formulas were made with differences in stearic acid with a composition of 5%, 10% and 15%. Determination of the physical stability of the product is determined according to organoleptic, homogeneity, spreadability, pH and preference tests. The results showed that beetroot extract produced a yield percentage of 8.34%. Phytochemical screening showed that beetroot extract contains flavonoids, tannins, saponins and steroids or triterpenoids. Beetroot extract lotion was evaluated for 16 days. The results of the organoleptic evaluation on lotions F1, F2 and F3 showed no change. In the lotion homogeneity test F1, F2 and F3 produced a homogeneous lotion. Spreadability tests on F1, F2 and F3 had a spreading diameter of 4.5 – 5.5 g.cm/s. The pH test of lotions F1, F2 and F3 produced the same as a pH value of 7. F1 was the most preferred formula because all parameters give good results. Based on this study, it can be concluded that differences in stearic acid concentrations have no effect on the physical quality test of beetroot extract lotion preparations. Kata Kunci Buah bit, Lotion, Uji mutu fisik
Karakteristik Organoleptik dan Kandungan Formalin Pada Ikan Asin DI Pasar Kota Malang Carmenita Maharani Aditiya; Ratih Tyas Widara; Fendi Yoga Wardana; Ita Handayani
An-Najat Vol. 2 No. 4 (2024): NOVEMBER - An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v2i3.1638

Abstract

The use of formalin as a food additive has been prohibited by the Ministry of Health as stipulated in The Indonesia Ministry of Health Regulation No.1168/MENKES/PER/X/1988 regarding the food additive. However, there is still widespread use of formaldehyde as a preservative in food such as salted fish persists. This research aims to identify the formaldehyde content in salted fish sold by vendors at Pasar Gadang, Malang City. The samples are tested qualitatively using organoleptic tests, KMnO4 test method, formalin kit, and Tollens reagent and then continued with the UV-visible spectrophotometry test to determine the formalin levels in the samples. Qualitative test results showed that all test samples contained formalin. Quantitative test results showed that the average level of formalin in the sample was 200 mg/kg. All test samples contained formalin at levels exceeding 0.2 mg/kg.
UJI AKTIVITAS ANTIOKSIDAN DAN PENENTUAN NILAI SUN PROTECTION FACTOR (SPF) DARI FRAKSI DAUN VIOLET (Viola odorata L.) Anjani, Marshela; Wardana, Fendi Yoga; Ardianto, Nanang; Istiqomah, Maria
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 16 No 2 (2024): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/juriskesbdg.v16i2.2494

Abstract

Paparan radiasi sinar UV dalam waktu lama dapat memicu efek berbahaya pada kulit manusia, seperti kerutan dan kanker kulit. Dampak buruk tersebut dapat diminimalisir dengan penggunaan tabir surya sebagai pelindung sinar UV. Daun violet (Viola odorata L.)  mempunyai kandungan senyawa flavonoid yang berpotensi sebagai antioksidan sekaligus zat aktif tabir surya. Tujuan penelitian ini adalah untuk mengetahui aktivitas antioksidan dan mengukur nilai Sun Protection Factor (SPF) pada fraksi daun violet (Viola odorata L.). Penelitian ini dilakukan di Laboratorium Farmakognosi dan Kimia  ITSK RS dr. Soepraoen pada bulan Agustus sampai September 2023. Metode ekstraksi yang digunakan adalah maserasi yang kemudian dilanjutkan dengan fraksinasi. Penentuan aktivitas antioksidan menggunakan metode DPPH (1,1-diphenyl-2-picrylhydrazyl) dan penentuan aktivitas tabir surya menggunakan perhitungan Sun Protection Factor (SPF). Pengukuran nilai IC50 sebagai pengukur aktivitas antioksidan dengan spektrofotometri UV-Vis yang panjang gelombangnya 517 nm, sedangkan spektrofotometri UV-Vis yang digunakan untuk menentukan nilai SPF pada rentang panjang gelombang 290-320 nm. Hasil penelitian menunjukkan aktivitas antioksidan yang rendah dari fraksi-fraksi daun violet (Viola odorata L.), dengan nilai IC50 sebesar 1690 µg/mL untuk fraksi n-heksana, 1880 µg/mL untuk fraksi etil asetat dan 2130 µg/mL untuk fraksi etanol. Kategori perlindungan minimal pada konsentrasi 250 ppm ditunjukkan oleh nilai SPF fraksi n-heksana dan etil asetat, yaitu masing-masing 2,142 dan 2,807. Pada konsentrasi 250 ppm, nilai SPF fraksi etanol adalah 12,589, masuk dalam kategori perlindungan maksimal.
Analisis Bahan Kimia Obat dalam Sediaan Jamu Pegal Linu dengan Metode KLT dan Spektrofotometri Uv-Vis Ita Handayani; Ratih Tyas Widara; Fendi Yoga Wardana; Carmenita Maharani Aditiya
Reslaj: Religion Education Social Laa Roiba Journal Vol. 6 No. 8 (2024): RESLAJ: Religion Education Social Laa Roiba Journal 
Publisher : Intitut Agama Islam Nasional Laa Roiba Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47467/reslaj.v6i8.4358

Abstract

One of the traditional medicines widely consumed by the Indonesian people is herbal medicine for aches and pains with the requirement that it should not contain medicinal chemicals. Paracetamol, ibuprofen, and mefenamic acid are medicinal chemicals that are often added to herbal medicine for aches and pains. The purpose of this study was to determine the content and levels of paracetamol, ibuprofen, and mefenamic acid in herbal medicine for aches and pains circulating in Batu City. The samples used were 10 herbal medicine for aches and pains both branded and unbranded circulating in Batu City. The content of medicinal chemicals was identified qualitatively by KLT test method with stationary phase used GF254 and mobile phase chloroform: ethanol (9:1), chloroform: methanol (8:1), and ethyl acetate: methanol: ammonia (85:10:5), as well as color reaction test (FeCl3, methyl red, and vitali morin). Meanwhile, quantitative tests were carried out using the UV-Vis spectrophotometric method. The results of qualitative analysis with KLT there are 3 samples that can be seen in UV light 254 nm, namely SJ2, SJ3, and SJ5. In the color reaction test with FeCl3 reagent there was 1 positive sample, namely SJ3, methyl red reagent with all samples showing positive results except SJ6, and for vitali morin reagent only SJ2 was positive. The results of quantitative analysis by UV-Vis spectrophotometry showed that all samples contained BKO (paracetamol, ibuprofen, and mefenamic acid). The highest concentration of BKO was found in SJ2 (PCT 5.31%, IP 12%, and AM 5.75%) and SJ3 (PCT 5.33%, IP 14.8%, and AM 4.45%).
Analisis Kandungan Natrium Siklamat pada Jamu Sinom di Pasar Besar Malang: Analysis of Sodium Cyclamate Content in Jamu Sinom at Malang Market Fendi Yoga Wardana; Vita Mariah
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1620

Abstract

Jamu is a traditional medicine used by people in Indonesia. The use of additional sweeteners such as sodium cyclamate needs to be wary of its use, because it can cause harmful effects to the body in the future. The herbs that have been circulating in the community are allegedly added with additional sweeteners during the manufacturing process. The aim of this study was to determine the content of sodium cyclamate in jamu sinom at Pasar Besar Malang. The design of this study was an experimental laboratory with purposive sampling on 6 samples of jamu sinom. Qualitative analysis was tested by precipitation method, while quantitative analysis was performed by spectrophotometry UV-Vis. The results of the qualitative test showed that there were 2 positive samples containing sodium cyclamate, namely sample B and sample D which were marked by the formation of a white precipitate. Based on the results of the quantitative test with spectrophotometry UV-Vis, it was found that 2 samples did not comply with BPOM standards with sodium cyclamate levels of 5.053% in sample B and 1.959% in sample D. Keywords: Jamu, Sodium Cyclamate, Precipitation, Spectrophotometry UV-Vis Abstrak Jamu merupakan obat tradisional yang banyak dimanfaatkan oleh masyarakat di Indonesia. Penggunaan bahan pemanis buatan seperti natrium siklamat perlu diwaspadai penggunaannya, karena dapat menimbulkan efek yang berbahaya bagi tubuh dikemudian hari. Jamu yang telah beredar di masyarakat disinyalir ditambahkan pemanis buatan saat proses pembuatannya. Tujuan penelitian adalah mengetahui kandungan natrium siklamat dalam jamu sinom yang dipasarkan di Pasar Besar Malang. Desain penelitian ini adalah laboratorium eksperimental dengan teknik purposive sampling pada 6 jenis sampel jamu sinom. Pengujian analisa kualitatif dilakukan dengan metode pengendapan, sedangkan analisa kuantitatif dilakukan dengan spektrofotometri UV-Vis. Hasil uji kualitatif menunjukkan terdapat 2 sampel positif mengandung natrium siklamat yaitu sampel B dan sampel D yang ditandai dengan terbentuknya endapan berwarna putih. Berdasarkan hasil uji kuantitatif dengan spektrofotometri UV-Vis, didapatkan 2 sampel tidak memenuhi standar BPOM dengan kadar natrium siklamat sebesar 5,053% pada sampel B dan 1,959% pada sampel D. Kata Kunci: Jamu, Natrium Siklamat, Pengendapan, Spektrofotometri UV-Vis.
Co-Authors Anjani, Marshela Ardianto, Nanang Arifin, Irnandhea Putri Ayuning Siwi, Mayang Aditya Beta Herilla Sekti Carmenita Maharani Aditiya Carmenita Maharani Aditiya Ibrahim, Kevvy Buana Indahyati, Krisna Islamiyah, Tufa Nur Istiqomah, Maria Ita Handayani ita handayani Mukholifah, Siti Nurul Fadila Prasetiyo, Bagus Dadang Prasetyo, Bagus Dadang Puspitasari, Meyrika Dwi Ratih Tyas Widara Riska , Riska Milani Tsaniaturrizqiah Permataningtyas Vita Mariah Wardani, Dhea Aliyyul Yunida Senja Lestari