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All Journal Jurnal Kesehatan Hesti Wira Sakti Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Kesehatan Islam : Islamic Health Journal Jurnal Riset Kesehatan Poltekkes Depkes Bandung Borneo Journal Of Pharmascientech PROFESSIONAL HEALTH JOURNAL Pharmademica: Jurnal Kefarmasian dan Gizi Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan RESLAJ: Religion Education Social Laa Roiba Journal Jurnal Sains dan Kesehatan Journal of Medicine and Clinical Pharmacy
Wardana, Fendi Yoga
Program Studi Vokasi Farmasi, Institut Teknologi, Sains, Dan Kesehatan RS Dr. Soepraoen Kesdam V/BRW, Malang, 65147, Indonesia
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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UJI ANTIBAKTERI FRAKSI DAUN CIPLUKAN (Physalis angulata L.) TERHADAP BAKTERI Staphylococcus aureus DAN Escherichia coli Puspitasari, Meyrika Dwi; Wardana, Fendi Yoga; Widara, Ratih Tyas; Ibrahim, Kevvy Buana
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 16 No 1 (2024): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/juriskesbdg.v16i1.2452

Abstract

Penyakit infeksi merupakan gangguan yang dapat menyebabkan atau menularkan penyakit. Pada 2019 diperkirakan 13,7 juta kematian berasal dari penyakit infeksi, 5 bakteri yang paling sering menyebabkan penyakit infeksi adalah Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Klebsiella pneumoniae, dan Pseudomonas aeruginosa. Ciplukan (Physalis angulata L.) diperkirakan dapat digunakan sebagai antibakteri. Tujuan penelitian ini menguji aktivitas fraksi daun ciplukan terhadap Staphylococcus aureus dan Escherichia coli. Penelitian ini dilakukan pada Agustus - Oktober 2023 di Laboratorium Farmakognosi dan Laboratorium Mikrobiologi ITSK RS DR. Soepraoen. Penelitian ini merupakan kuantitatif eksperimental dengan sampel daun ciplukan yang dimaserasi kemudian dilanjutkan fraksinasi menggunakan n-heksana, etil asetat, dan etanol. Uji aktivitas antibakteri menggunakan metode difusi cakram dengan kontrol negatif DMSO 50% dan kontrol positif kloramfenikol 30 μg. Aktivitas antibakteri ditandai dengan diameter zona bening pada sekitar cakram kemudian hasilnya dianalisis dengan One Way ANOVA. Hasil uji aktivitas antibakteri yang paling tinggi fraksi etanol 20% yaitu 8,4725 mm pada Staphylococcus aureus dan 11,6225 mm pada Escherichia coli. Pada fraksi n-heksana terhadap Escherichia coli tidak ditemukan aktivitas antibakteri. Berdasarkan hasil diketahui bahwa fraksi etanol konsentrasi 20% merupakan fraksi yang memiliki aktivitas antibakteri paling efektif terhadap Staphylococcus aureus dan Escherichia coli. Berdasarkan uji One Way ANOVA pada setiap kelompok bakteri didapatkan perbedaan signifikan. Disarankan bagi peneliti selanjutnya untuk melakukan penelitian yang sama namun menggunakan metode difusi sumuran.
IDENTIFIKASI PENETAPAN KADAR FLAVONOID DAN TOTAL FENOL PADA FRAKSI KULIT BUAH MELINJO (GNETUM GNEMON L.) Prasetyo, Bagus Dadang; Wardana, Fendi Yoga; Indahyati, Krisna; Wardani, Dhea Aliyyul
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 16 No 1 (2024): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/juriskesbdg.v16i1.2477

Abstract

Gnetum gnemon L atau sering dikenal dengan nama melinjo merupakan tanaman yang banyak tumbuh di daerah tropis seperti Asia Tenggara. Selain kandungan purin yang tinggi pada biji melinjo, ternyata kulit melinjo yang selama ini kurang dimanfaatkan ternyata memiliki banyak manfaat, diantaranya adalah kandungan polifenol dan flavonoid yang dapat membantu mencegah penyakit asam urat yang sering terjadi. Penelitian ini bertujuan untuk penetapan kadar metabolit fenol dan flavonoid pada fraksi kulit buah melinjo merah. Diselenggarakan pada bulan Agustus hingga September 2023 di Laboratorium Farmakognosi dan Kimia ITSK RS Dr Soepraoen Malang. Jenis penelitian yang digunakan adalah eksperimen laboratorium dengan desain Quasi Experimental Design pada fraksi etanol, fraksi etil asetat dan fraksi n-heksana kulit melinjo. Populasi yang digunakan adalah kulit buah melinjo yang ada di RT 15 RW 03 Desa Bantur Kabupaten Malang Jawa Timur. Sampel penelitian menggunakan kulit buah melinjo yang kondisinya baik dan berwarna merah. Penelitian menunjukkan bahwa kandungan total flavonoid dalam etanol adalah 96%; etil asetat; fraksi n-heksana sebesar 14,2143 mgQE/g; 13,4707 mg QE/g; 31,1703 mg QE/g sedangkan total fenol dalam etanol 96%; etil asetat; fraksi n-heksana sebesar 10,4904 mgGAE/g; 5,5366 mgGAE/g; 9,6911mgGAE/g. Kesimpulan penelitian adalah kulit melinjo mengandung antioksidan seperti total fenol dan flavonoid yang cukup tinggi, sehingga berpotensi untuk dijadikan sebagai alternatif sumber obat alami untuk menurunkan kadar purin pada penyakit asam urat, dimana biji melinjo memiliki kandungan yang cukup tinggi Direkomendasikan uji penetapan kadar total fenol, flavonoid fraksi etil asetat pada fraksi kulit buah melinjo.
Antioxidant Activity and Body Scrub Formulation from Yellow Dragon Fruit Peel (Selenicereus megalanthus) Extract. Yoga Wardana, Fendi; Islamiyah, Tufa Nur; Arifin, Irnandhea Putri
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 1 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i1.542

Abstract

Antioxidant agents are substances that repress oxidation responses due to free radicals which can cause harm to unsaturated greasy acids in cell divider films, blood vessel cells and lipid tissue. Dragon fruit has been reported to have high antioxidant activity. The aim of the research was to determine the antioxidants in yellow dragon fruit peel (Selenicereus megalanthus) extract and formulate them as body scrub. Research design of laboratory experiments, the yellow dragon fruit peel was extracted by maceration using 96% ethanol. Antioxidant activity testing was carried out using 2,2-diphenyl-1-picrylhydrazyl (DPPH). Preparation of the formula using extract concentration variations of 1% and 3%. The evaluation of body scrub preparation include homogeneity, organoleptic, pH and dispersive power. The yellow dragon fruit peel extract showed antioxidant activity with IC50 value of 2.7 ppm (strong antioxidant). The results of the evaluation of the two formulas did not provide a significant difference. Both body scrub preparations were homogeneous, organoleptic evaluation showed a yellowish-white color and does not become rancid, pH range of 7.7-7.8 and dispersive power range of 4.3-4.4 cm. The yellow dragon fruit peel extract has very strong antioxidant activity and can be formulated as a scrub product.
GAMBARAN TINGKAT PENGETAHUAN IBU HAMIL TERHADAP PENTINGNYA ASAM FOLAT PADA KEHAMILAN DI RSIA MUHAMMADIYAH MALANG Wardana, Fendi Yoga; Mukholifah, Siti; Sekti, Beta Herilla
Journal Medicine And Clinical Pharmacy Vol. 1 No. 1 (2024): MedClip Vol 1 No 1, 2024
Publisher : Institut Teknologi, Sains, dan Kesehatan RS.DR. Soepraoen Kesdam V/BRW

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47794/medclip.v1i1.4

Abstract

Asam folat (vitamin B9) sangat penting selama kehamilan, dan merupakan satu-satunya vitamin yang kebutuhannya selama hamil berlipat dua. Pemberian asam folat pada ibu hamil diketahui untuk mencegah terjadinya cacat tabung saraf terutama tulang belakang tidak menutup sempurna otak janin tidak terbentuk. Penelitian ini merupakan penelitian deskriptif menggunakan metode observasional cross-sectional dengan pengamatan pada bulan Juni 2023. Pengumpulan data pada penelitian ini dilakukan dengan membagikan lembar kuesioner pada responden yang berkenan menjadi responden, sebelum analisis data melakukan data tabulating yaitu dengan memasukan data dalam tabel berdasarkan tujuan penelitian agar memudahkan data tabulating, maka perlu dibuat dummy tabel yaitu tabel kosong yang akan digunakan untuk mengkajikan hasil penelitian. Pengetahuan ibu hamil tentang pentingnya asam folat dalam kehamilan sebagian besar termaksud dalam kategori cukup dengan persentase sebesar 47,82% (33 orang) sisanya tergolong dalam kategori pengetahuan baik sebesar 47,82% (34 orang) dan pengetahuan kurang sebesar 2,90% (2 orang).
Analisis Bahan Kimia Obat dalam Sediaan Jamu Pegal Linu dengan Metode KLT dan Spektrofotometri Uv-Vis Ita Handayani; Ratih Tyas Widara; Fendi Yoga Wardana; Carmenita Maharani Aditiya
Reslaj: Religion Education Social Laa Roiba Journal Vol. 6 No. 8 (2024): RESLAJ: Religion Education Social Laa Roiba Journal 
Publisher : Intitut Agama Islam Nasional Laa Roiba Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47467/reslaj.v6i8.4358

Abstract

One of the traditional medicines widely consumed by the Indonesian people is herbal medicine for aches and pains with the requirement that it should not contain medicinal chemicals. Paracetamol, ibuprofen, and mefenamic acid are medicinal chemicals that are often added to herbal medicine for aches and pains. The purpose of this study was to determine the content and levels of paracetamol, ibuprofen, and mefenamic acid in herbal medicine for aches and pains circulating in Batu City. The samples used were 10 herbal medicine for aches and pains both branded and unbranded circulating in Batu City. The content of medicinal chemicals was identified qualitatively by KLT test method with stationary phase used GF254 and mobile phase chloroform: ethanol (9:1), chloroform: methanol (8:1), and ethyl acetate: methanol: ammonia (85:10:5), as well as color reaction test (FeCl3, methyl red, and vitali morin). Meanwhile, quantitative tests were carried out using the UV-Vis spectrophotometric method. The results of qualitative analysis with KLT there are 3 samples that can be seen in UV light 254 nm, namely SJ2, SJ3, and SJ5. In the color reaction test with FeCl3 reagent there was 1 positive sample, namely SJ3, methyl red reagent with all samples showing positive results except SJ6, and for vitali morin reagent only SJ2 was positive. The results of quantitative analysis by UV-Vis spectrophotometry showed that all samples contained BKO (paracetamol, ibuprofen, and mefenamic acid). The highest concentration of BKO was found in SJ2 (PCT 5.31%, IP 12%, and AM 5.75%) and SJ3 (PCT 5.33%, IP 14.8%, and AM 4.45%).
Analisis Kandungan Formalin dalam Bumbu Giling Instan di Pasar Besar Kota Malang Fendi Yoga Wardana; Arnis Riawati; Beta Herilla Sekti
PROFESSIONAL HEALTH JOURNAL Vol. 4 No. 2 (2023): Juni
Publisher : Pusat Penelitian dan Pengabdian Masyarakat (PPPM) STIKES Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54832/phj.v4i2.336

Abstract

Ground spices are food ingredients that can enrich the taste, aroma and taste of dishes and have a very limited service life. Many manufacturers use formalin as a preservative to overcome the short shelf life of ground spices. Formalin is a clear, colorless or almost colorless liquid with a pungent odor. The use of formalin as a food preservative is prohibited in the Regulation, because formaldehyde is toxic (poisonous). This study identified the formalin content in instant ground spices in the market of Malang City. The purpose of this study was to determine the content and levels of formaldehyde contained in five traders of instant ground spices in Market of Malang City. Five samples of instant ground spices that were analyzed were taken using the Purposive Sampling technique. Qualitative testing was carried out using the Test Kit and quantitative testing for the determination of formalin levels was carried out using the Spectrophotometry UV-VIS . The results showed that based on observations and qualitative tests, two samples of instant ground spices sold in Market were positive for formaldehyde. Meanwhile, the quantitative test results using the Spectrophotometry UV-Vis showed that of the five samples tested, two of them contained 0.378% formalin in Rendang instant ground spice and 0.516% instant curry spice. So the curry and rendang samples are not suitable for consumption because formaldehyde cannot be added to food at all.
Aktivitas Antibakteri dan Antioksidan Kulit Apel Rome Beauty (Malus sylvestris Mill) Fitri, Aldesra; Silya, Ardika Amanda; Ryhasanda, Olafiani; Wardana, Fendi Yoga; Siwi, Mayang Aditya Ayuning
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 2 (2026): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i2.165

Abstract

Rome beauty apple (Malus sylvestris Mill) is an apple variety that is widely grown in Batu City. The skin of this apple is known to contain flavonoid compounds such as quercetin, catechin, procyanidin and caffeic acid which are useful as antibacterial, antioxidant, and antiproliferative. This study was conducted to determine the total flavonoid content and antibacterial activity in the ethanol extract of macerated Roma beauty apple peel. In addition, this study also aims to determine the antioxidant activity of the ethyl acetate extract and the ethanol extract of Roma beauty apple from multistage extraction. The ethanol extract of macerated Rome beauty apple was tested for total flavonoid content and antibacterial activity using the well diffusion method, then the diameter of the inhibition zone was measured against Propionibacterium acnes and Staphylococcus aureus bacteria, while the ethyl acetate extract and the ethanol extract of Rome beauty apple from multistage extraction were tested for antioxidant activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. Based on the research, it is known that the ethanol extract of Rome Beauty apple peel from maceration contains flavonoids of 47.10 mgQE/g with an inhibition zone diameter against Propionibacterium acnes and Staphylococcus aureus of 8.70 mm and 11.67 mm respectively with a concentration of 20% w/v. The results of the antioxidant activity test of the ethyl acetate extract obtained IC50 3026 ppm and the ethanol extract from multistage extraction of 4702 ppm. The test results can be concluded that the ethanol extract of Rome Beauty apple has a total flavonoid content and antibacterial activity with a moderate category against P. acnes bacteria and strong against S. aureus bacteria. The ethyl acetate extract and the ethanol extract of Rome Beauty apple peel from multistage extraction have antioxidant activity with a very weak category.
Co-Authors Aldesra Fitri Anjani, Marshela Ardianto, Nanang Arifin, Irnandhea Putri Arnis Riawati Ayuning Siwi, Mayang Aditya Beta Herilla Sekti Carmenita Maharani Aditiya Ibrahim, Kevvy Buana Indahyati, Krisna Islamiyah, Tufa Nur Istiqomah, Maria ita handayani Mukholifah, Siti Nurul Fadila Prasetiyo, Bagus Dadang Prasetyo, Bagus Dadang Puspitasari, Meyrika Dwi Ratih Tyas Widara Riska , Riska Milani Ryhasanda, Olafiani Silya, Ardika Amanda Tsaniaturrizqiah Permataningtyas Vita Mariah Wardani, Dhea Aliyyul Yunida Senja Lestari