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All Journal Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) CHEESA: Chemical Engineering Research Articles JSFK (Jurnal Sains Farmasi & Klinis) Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Farmasi Sains dan Praktis Indonesian Journal of Pharmacology and Therapy
Arba Pramundita Ramadani
Jurusan Farmasi Universitas Islam Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : Jurnal Ilmiah Farmasi

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UJI IRITASI PRIMER LOTION EKSTRAK ETANOLIK DAUN KEMANGI (Ocimum basilicum Linn) PADA KELINCI JANTAN BERDASARKAN PARAMETER INDEKS IRITASI PRIMER Arba Pramundita Ramadani; Ari Marstiyani
Jurnal Ilmiah Farmasi Vol. 6 No. 1 (2009)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTKemangi (Ocimum basilicum L.) is Lamiaceae family, consists of volatile oil, saponin,flavonoid, tanin, and polifenole. One of its functions is as an antioxidant. The antioxidantmechanism is blocking free radical oxidative bound with LDL (Low Density Lipoprotein) (Udupa,2006). This study explores kemangi as a lotion formulation on its primary iritation effect using malerabbits. Kemangi leaves are extracted with soxhletation method and formulated on lotion. Primaryirritation test is conducted by using patch test on 12 male rabbits. Rabbits are divided into 2 groups,with incision and without incision. Each of it got same treatments normal control aquadest, lotionbase control, and 4 tapering dose of kemangi leaves extract. Each treatment is done 6 times ondifferent rabbits, with incision and without incision group. The treatment is applied on rabbits backafter 3 stage shaving. For incision group, after 3 stages shaving the skin is scratched with minorincision on cell surface. Toxic symptom is observed during 24 hours and 72 hours after lotionapplication. The study result is analyzed qualitatively and quantitatively. Qualitative analysisshowed that any erythema found as reddish spot on the rabbits back skin, but no edema found.Primary irritation index as quantitative analysis showed 0,083 for normal control aquadest; 0,207 forlotion base control; 0,292 for 0,25g/inci2kemangi leaves extract; 0,416 for 0,5g/inci2kemangileaves extract; 0,582 for 1 g/inci2kemangi leaves extract; 0,642 for 2 g/inci2kemangi leaves extract.It means kemangi leaves extract have no primary irritation effect.Keywords: Kemangi, patch test, anti oxidant
Potential advancement utilizing nanotechnology-based delivery system to enhance the therapeutic properties of lavender essential oil: a review article Trianloka, A. M. Bagas; Chabib, Lutfi; Ramadani, Arba Pramundita
Jurnal Ilmiah Farmasi Vol. 20 No. 2 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss2.art6

Abstract

Background: Essential oils (EO), such as lavender (Lavandula spp.), which are derived from its flower, have become a growing trend in recent years as an alternative medicine in therapy. However, the poor physicochemical properties of EOs have several disadvantages for their application. Integrating nanotechnology into the formulation of medicinal dosage forms may provide a viable way to mitigate these limitations and improve the effectiveness of EO utilization.Objective: This literature review aims to gather information on the medicinal benefits of lavender EO and the prospective applications of nanotechnology-based delivery systems for EOs.Method: Online databases such as PubMed, Science Direct, Research Gate, Google Scholar, and other reliable sources were used to find 65 publications between 1991 and 2021, which are assessed in this review.Results: It is revealed that the main constituents of lavender EO are linalool, linalyl acetate, and lavandulyl acetate. Its effectiveness as an antibacterial, antioxidant, anticancer, anti-anxiety, and having effects on the central nervous system, along with other qualities including pain relief, has been demonstrated via numerous studies. Additionally, it was demonstrated to have dermatological properties that helped treat dermatitis and encouraged both hair growth and wound healing. Furthermore, it was also found that the application of nanotechnology in EOs has improved the concentration of active compounds in the blood and produced a stable dosage form while also increasing its efficacy.Conclusion: It is feasible to create nanoparticle dosage forms from lavender EO that can improve the substance's solubility, stability, and pharmacological effects. More research is necessary to formulate lavender EO by applying nanotechnology.
Co-Authors Aisha Nanda Caela Amry Annisa Fitria Annisa Fitria Annisa Fitria Arde Toga Nugraha Ari Marstiyani Arismunandar, Arif Baruna, Renno Ramadhani Ika Cynthia Astiti Putri Diesty Anita Nugraheni Fanny Rahma Maulida Fitra, Romadhonsyah Fuadah, Shofiatul Hakim, Sherina Nabila Putri Hayati, Farida Jasno Jasno Kamarulzaman, Ezatul Ezleen Larysa Fernenda Lutfi Chabib, Lutfi Maria Hilaria Maulidha Amanati Muhammad Sulaiman Zubair Mustafidah, Mabrurotul Nangim Khasanah Poluan, Jesica Carine Priska Ernestina Tenda Rochmy Istikharah Romadhonsyah, Fitra Sherina Nabila Putri Hakim Suryani, Arman Syafira Tri Nurmala Sari Tamhid, Hady Anshory Tika Luthfi Sadrina Trianloka, A. M. Bagas Yandi Syukri