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All Journal EKSAKTA: Journal of Sciences and Data Analysis Ovary Midwifery Journal Pharmaceutical And Biomedical Sciences Journal (PBSJ) Jurnal Farmasi Sains dan Praktis
Mustafidah, Mabrurotul
Department Of Pharmacy, Faculty Of Mathematics And Natural Sciences, Universitas Islam Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary

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Hepatoprotective Effect of Corn Silk Infusion in Male Wistar Rats Arba Pramundita Ramadani; Hady Anshory Tamhid; Tika Luthfi Sadrina; Jasno Jasno; Mabrurotul Mustafidah
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 1, ISSUE 1, February 2020
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/EKSAKTA.vol1.iss1.art8

Abstract

The use of medicinal plants in treating various disease has been reported since long time ago, including for hepatic disease. Corn silk contains phytochemicals of medical benefit such as flavonoids compounds which act as antioxidant agents and has been widely reported possess hepatoprotective effect. Using a model of carbon tetrachloride (CCl4)-induced hepatotoxicity in 36 male Wistar rats, this study investigated the effect of corn silk infusion and assessed using enzymes produced by the liver in plasma [alkaline phosphatase (ALP) and liver glutathione (GSH)]. The corn silk infusion (in 50, 100, and 200 mg/kg BW doses) were administered 24 hours after CCl4-induction liver damage with 3ml/kg BW CCl4 in olive oil (1:1, v/v), intraperitoneally for seven days. Along with corn silk groups, distilled water (0.2 mL/kg BW) and Curcumin (100 mg/kg BW) were given for induction and drug control, respectively. In the end of the study (8th day), the level of both ALP dan GSH were measured. The differences among groups for GSH and ALP level were statistically calculated using ANOVA method.  The result showed that the corn silk infusion is active at 200 mg/kg BW based on both ALP (18.74% decreased) and GSH (5-7% increased) level. Moreover, the flavonoid compound was detected on the infusion that may contribute on its hepatoprotective activity. In conclusion, corn silk infusion owned hepatoprotective effect in male Wistar rats.
Asuhan Kebidanan Komprehensif Pada Ny. S 24 Th G1P0A0 Dengan Ketuban Pecah Dini Bercampur Meconium Nova Purmahardini; Mabrurotul Hasanah
Ovary Midwifery Journal Vol 4 No 1 (2022): August 2022
Publisher : Akademi Kebidanan Aifa Husada Madura

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Abstract

Asuhan kebidanan Komprehensif adalah salah satu upaya yang dilakukan oleh tenaga kesehatan untuk memantau ibu mulai dari hamil, bersalin, nifas, bbl, dan KB. Kematian Ibu dan Bayi merupakan salah satu indikator keberhasilan asuhan yang diberikan pada ibu maupun bayi baru lahir. Jumlah kematian ibu Ketuban pecah dini merupakan dengan meconium merupakan salah satu penapisan persalinan normal yang ditolong oleh bidan. Ketuban pecah dini adalah pecahnya ketuban sebelum persalinan mulai pada tahapan kehamilan manapun. Tujuan dalam penelitian ini untuk melakukan Asuhan kebidanan Komprehensif pada Ny.”S” G1P0A0 . Penelitian ini dilakukan mulai bulan Januari sampai April 2019 di BPM Bidan Titiek Listyowati S.ST. Jenis studi kasus ini observasional deskriptif dengan cara pendekatan studi kasus dengan cara continuity of care mulai dari kehamilan, persalinan, nifas, BBL, dan KB. Hasil asuhan dianalisa dengan membandingkan teori dengan kasus yang ditemukan dengan menggunakan pendekatan asuhan kebidanan komprehensif Varney dan SOAP pada ibu hamil, ibu bersalin , ibu nifas dan bayi serta KB. Ketuban pecah dini dengan meconial dilakukan rujukan untuk penanganan yang lebih lanjut.
Aplikasi FTIR sebagai Deteksi Cepat Bahan Non-Halal dalam Campuran Produk Olahan Mabrurotul Mustafidah; Arif Nur Ikhsan
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 1 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i1.24426

Abstract

The trend of Halal is not about label processed products, but also to become a necessity in products to gain public trust. Indonesia as the country with the most Muslims in Asia, has its own market for halal products. Consumer confidence increases for goods that have included halal in their products. The unknown material in this case is the material that makes the product non-halal, such as the presence of a mixture of pork. Many irresponsible producers use a mixture of non-halal ingredients to increase profits. To detect halal, various methods have been developed, one of which is FTIR. FTIR is a fast and easy to use instrument capable of analyzing mixtures in a product. Various studies for product authentication were analyzed using FTIR and showed results that FTIR was able to detect the presence of a mixture of unwanted ingredients in the product and could be used as a method to detect counterfeiters in processed products.
Aplikasi FTIR sebagai Deteksi Cepat Bahan Non-Halal dalam Campuran Produk Olahan Mabrurotul Mustafidah; Arif Nur Ikhsan
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 1 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i1.24426

Abstract

The trend of Halal is not about label processed products, but also to become a necessity in products to gain public trust. Indonesia as the country with the most Muslims in Asia, has its own market for halal products. Consumer confidence increases for goods that have included halal in their products. The unknown material in this case is the material that makes the product non-halal, such as the presence of a mixture of pork. Many irresponsible producers use a mixture of non-halal ingredients to increase profits. To detect halal, various methods have been developed, one of which is FTIR. FTIR is a fast and easy to use instrument capable of analyzing mixtures in a product. Various studies for product authentication were analyzed using FTIR and showed results that FTIR was able to detect the presence of a mixture of unwanted ingredients in the product and could be used as a method to detect counterfeiters in processed products.
ANALYSIS AND VALIDATION OF DETECTION METHOD FOR ETHYLENE AND DIETHYLENE GLYCOL CONTAMINANTS IN SYRUP USING GCMS (GAS CHROMATOGRAPHY-MASS SPECTROMETER) Supandi, Supandi; Mustafidah, Mabrurotul; Yaenap, Siti; Rumblat, Walid
Jurnal Farmasi Sains dan Praktis Vol 11 No 2 (May-August 2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v11i2.11180

Abstract

Ethylene glycol (EG) and diethylene glycol (DEG) are hazardous compounds if ingested by the human body. Testing conducted by the Indonesian National Agency of Drug and Food Control (BPM) identified contamination of EG and DEG in glycerin and propylene glycol, which are utilized as solubility enhancers in syrup-based pharmaceuticals. This study aims to analyze EG and DEG contamination in children’s syrup drug samples using a Gas Chromatography-Mass Spectrometry (GC-MS) instrument. This study presents an analytical method for detecting EG and DEG contamination. Based on BPOM regulations governing the control a determination of EG and DEG. Several syrup drug samples, which are listed in the BPOM drug withdrawal list under Number HM.01.1.2.11.22.240, were each weighed at 5 grams, transferred into a 50 mL volumetric flask, 30 mL of methanol was added, and the mixture was sonicated for 5 minutes. Subsequently, solvent was added up to the calibration mark. Five out of eight samples were found to contain EG and DEG at concentrations of less than 0.1%. Validation of the GCMS method for EG and DEG compounds yielded accuracy values with recovery rates between 98% and 101%. The acquisition test results produced a relative standard deviation (RSD) value of 0.87. The linearity test showed a correlation coefficient (r) of 0.955. The limit of detection (LOD) for EG was 0.26 ng/mg, and for DEG it was 0.51 ng/mg. The limit of quantification (LOQ) for EG was 0.86 ng/mg, and for DEG it was 1.69 ng/mg. This validation indicates that the analytical method exhibits high accuracy and sensitivity.
Co-Authors Arba Pramundita Ramadani Arif Nur Ikhsan Jasno Jasno Nova Purmahardini Rumblat, Walid Supandi Tamhid, Hady Anshory Tika Luthfi Sadrina Yaenap, Siti