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Hepatoprotective Effect of Corn Silk Infusion in Male Wistar Rats Arba Pramundita Ramadani; Hady Anshory Tamhid; Tika Luthfi Sadrina; Jasno Jasno; Mabrurotul Mustafidah
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 1, ISSUE 1, February 2020
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/EKSAKTA.vol1.iss1.art8

The use of medicinal plants in treating various disease has been reported since long time ago, including for hepatic disease. Corn silk contains phytochemicals of medical benefit such as flavonoids compounds which act as antioxidant agents and has been widely reported possess hepatoprotective effect. Using a model of carbon tetrachloride (CCl4)-induced hepatotoxicity in 36 male Wistar rats, this study investigated the effect of corn silk infusion and assessed using enzymes produced by the liver in plasma [alkaline phosphatase (ALP) and liver glutathione (GSH)]. The corn silk infusion (in 50, 100, and 200 mg/kg BW doses) were administered 24 hours after CCl4-induction liver damage with 3ml/kg BW CCl4 in olive oil (1:1, v/v), intraperitoneally for seven days. Along with corn silk groups, distilled water (0.2 mL/kg BW) and Curcumin (100 mg/kg BW) were given for induction and drug control, respectively. In the end of the study (8th day), the level of both ALP dan GSH were measured. The differences among groups for GSH and ALP level were statistically calculated using ANOVA method. The result showed that the corn silk infusion is active at 200 mg/kg BW based on both ALP (18.74% decreased) and GSH (5-7% increased) level. Moreover, the flavonoid compound was detected on the infusion that may contribute on its hepatoprotective activity. In conclusion, corn silk infusion owned hepatoprotective effect in male Wistar rats.

Asuhan Kebidanan Komprehensif Pada Ny. S 24 Th G1P0A0 Dengan Ketuban Pecah Dini Bercampur Meconium Nova Purmahardini; Mabrurotul Hasanah
Ovary Midwifery Journal Vol 4 No 1 (2022): August 2022
Publisher : Akademi Kebidanan Aifa Husada Madura

Show Abstract | Download Original | Original Source | Check in Google Scholar

Asuhan kebidanan Komprehensif adalah salah satu upaya yang dilakukan oleh tenaga kesehatan untuk memantau ibu mulai dari hamil, bersalin, nifas, bbl, dan KB. Kematian Ibu dan Bayi merupakan salah satu indikator keberhasilan asuhan yang diberikan pada ibu maupun bayi baru lahir. Jumlah kematian ibu Ketuban pecah dini merupakan dengan meconium merupakan salah satu penapisan persalinan normal yang ditolong oleh bidan. Ketuban pecah dini adalah pecahnya ketuban sebelum persalinan mulai pada tahapan kehamilan manapun. Tujuan dalam penelitian ini untuk melakukan Asuhan kebidanan Komprehensif pada Ny.”S” G1P0A0 . Penelitian ini dilakukan mulai bulan Januari sampai April 2019 di BPM Bidan Titiek Listyowati S.ST. Jenis studi kasus ini observasional deskriptif dengan cara pendekatan studi kasus dengan cara continuity of care mulai dari kehamilan, persalinan, nifas, BBL, dan KB. Hasil asuhan dianalisa dengan membandingkan teori dengan kasus yang ditemukan dengan menggunakan pendekatan asuhan kebidanan komprehensif Varney dan SOAP pada ibu hamil, ibu bersalin , ibu nifas dan bayi serta KB. Ketuban pecah dini dengan meconial dilakukan rujukan untuk penanganan yang lebih lanjut.

Aplikasi FTIR sebagai Deteksi Cepat Bahan Non-Halal dalam Campuran Produk Olahan Mabrurotul Mustafidah; Arif Nur Ikhsan
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 1 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i1.24426

The trend of Halal is not about label processed products, but also to become a necessity in products to gain public trust. Indonesia as the country with the most Muslims in Asia, has its own market for halal products. Consumer confidence increases for goods that have included halal in their products. The unknown material in this case is the material that makes the product non-halal, such as the presence of a mixture of pork. Many irresponsible producers use a mixture of non-halal ingredients to increase profits. To detect halal, various methods have been developed, one of which is FTIR. FTIR is a fast and easy to use instrument capable of analyzing mixtures in a product. Various studies for product authentication were analyzed using FTIR and showed results that FTIR was able to detect the presence of a mixture of unwanted ingredients in the product and could be used as a method to detect counterfeiters in processed products.

Aplikasi FTIR sebagai Deteksi Cepat Bahan Non-Halal dalam Campuran Produk Olahan Mabrurotul Mustafidah; Arif Nur Ikhsan
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 1 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i1.24426

The trend of Halal is not about label processed products, but also to become a necessity in products to gain public trust. Indonesia as the country with the most Muslims in Asia, has its own market for halal products. Consumer confidence increases for goods that have included halal in their products. The unknown material in this case is the material that makes the product non-halal, such as the presence of a mixture of pork. Many irresponsible producers use a mixture of non-halal ingredients to increase profits. To detect halal, various methods have been developed, one of which is FTIR. FTIR is a fast and easy to use instrument capable of analyzing mixtures in a product. Various studies for product authentication were analyzed using FTIR and showed results that FTIR was able to detect the presence of a mixture of unwanted ingredients in the product and could be used as a method to detect counterfeiters in processed products.

ANALYSIS AND VALIDATION OF DETECTION METHOD FOR ETHYLENE AND DIETHYLENE GLYCOL CONTAMINANTS IN SYRUP USING GCMS (GAS CHROMATOGRAPHY-MASS SPECTROMETER) Supandi, Supandi; Mustafidah, Mabrurotul; Yaenap, Siti; Rumblat, Walid
Jurnal Farmasi Sains dan Praktis Vol 11 No 2 (May-August 2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v11i2.11180

Ethylene glycol (EG) and diethylene glycol (DEG) are hazardous compounds if ingested by the human body. Testing conducted by the Indonesian National Agency of Drug and Food Control (BPM) identified contamination of EG and DEG in glycerin and propylene glycol, which are utilized as solubility enhancers in syrup-based pharmaceuticals. This study aims to analyze EG and DEG contamination in children’s syrup drug samples using a Gas Chromatography-Mass Spectrometry (GC-MS) instrument. This study presents an analytical method for detecting EG and DEG contamination. Based on BPOM regulations governing the control a determination of EG and DEG. Several syrup drug samples, which are listed in the BPOM drug withdrawal list under Number HM.01.1.2.11.22.240, were each weighed at 5 grams, transferred into a 50 mL volumetric flask, 30 mL of methanol was added, and the mixture was sonicated for 5 minutes. Subsequently, solvent was added up to the calibration mark. Five out of eight samples were found to contain EG and DEG at concentrations of less than 0.1%. Validation of the GCMS method for EG and DEG compounds yielded accuracy values with recovery rates between 98% and 101%. The acquisition test results produced a relative standard deviation (RSD) value of 0.87. The linearity test showed a correlation coefficient (r) of 0.955. The limit of detection (LOD) for EG was 0.26 ng/mg, and for DEG it was 0.51 ng/mg. The limit of quantification (LOQ) for EG was 0.86 ng/mg, and for DEG it was 1.69 ng/mg. This validation indicates that the analytical method exhibits high accuracy and sensitivity.

Hubungan Sosiodemografi Pasien dengan Pengetahuan Pasien tentang Pelayanan Informasi Obat menggunakan Telefarmasi (E-Pharmacy) Restinia, Mita; Mustafidah, Mabrurotul; Adhamira, Rania; Kinanti, Annisa Putri
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 1 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i1.31900

E-pharmacy or telepharmacy is a form of ICT-based health service that facilitates consultation with medical practitioners. Telepharmaceutical services in Indonesia have not been implemented widely. This is because ICT access has not been perfectly spread throughout Indonesia. There is also still little socialization related to telepharmaceuticals, so that the understanding of telepharmaceuticals cannot reach the public, which causes telepharmaceuticals to not being implemented properly. This study aims to determine the relationship between the sociodemographic characteristics of respondents and the level of patient knowledge of drug information services using telepharmacy. This research is a descriptive quantitative correlation research. Respondents in this study amounted to 401 people. Statistical test using Chi Square test obtained p value < 0.05 for age and education test with telepharmaceutical knowledge, which can be concluded that there is a relationship between respondent's age and education with telepharmaceutical knowledge; and p value > 0.05 for the test of gender, occupation, frequency of application use with telepharmaceutical knowledge, which can be concluded that there is no relationship between gender, occupation, frequency of application use and telepharmaceutical knowledge.

Study of Consumer Satisfaction Levels with E-Pharmacy Services Using the Customer Satisfaction Index (CSI) and Importance Performance Analysis (IPA) Mustafidah, Mabrurotul; Shavira, Rurynta Ferly; Adhamira, Rania; Kinanti, Annisa Putri; Citraningsih, Kinanti
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 1 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i1.37922

E-pharmacy is one of the efforts to improve pharmaceutical services to make them easier and more efficient. Customer Satisfaction Index (CSI) is a scale that can describe consumer satisfaction with a product or service. Customer satisfaction with e-pharmacy services can be assessed by the value of customer expectations for service quality and the reality of the service performance received. This study aims to examine the level of consumer satisfaction, expectations, and priorities for attribute improvement in the dimensions of e-pharmacy services so that service providers can evaluate and improve their services. Furthermore, the analytical method in this study uses an analysis of the results of the gap based on the Service Quality (Servqual), Customer Satisfaction Index (CSI), and Importance Performance Analysis (IPA). The results of this study indicate that attributes' performance on the dimensions of e-pharmacy services is not satisfactory. Customer satisfaction in e-pharmacy service is 86.11% or in the 'very satisfied' category. Meanwhile, the service attribute prioritized for service providers is to improve the guarantee that the drugs given are in good condition (by showing the drug's expiration date).

Halal Authentication and Metabolite Mapping of Kombucha Products via Gas Chromatography-Mass Spectrometry (GC-MS) and Chemometric Analysis Hermanto, Sandra; Arginia, Della; Mustafidah, Mabrurotul; Fathoni, Ahmad
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 2, November 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i2.44602

The presence of ethanol in fermented beverages is a critical factor in the halal certification process. One of the key parameters for verifying the halal status of such products is the quantification of ethanol content. Kombucha tea, a fermented beverage produced from sugared tea and a Symbiotic Culture of Bacteria and Yeast (SCOBY), naturally contains ethanol as a byproduct of fermentation. This study aims to determine the ethanol content and differentiate the metabolite profiles of kombucha tea using a non-targeted metabolomics approach, based on variations in tea type, storage temperature, and duration. Ethanol levels were measured by gas chromatography, and metabolite profiling was conducted by gas chromatography–Mass Spectrometry (GC-MS), followed by Principal Component Analysis (PCA) to visualize compositional differences and identify characteristic compounds. The results indicated that tea type significantly influenced ethanol production. The ethanol content of kombucha prepared with black tea, green tea, and white tea was 0.1126% w/w ± 0.0003 v/v, 0.1708% w/w ± 0.0053 v/v, and 0.1301% w/w ± 0.0043 v/v, respectively. Green tea kombucha, which exhibited the highest ethanol content, was selected for storage analysis. During storage, ethanol levels increased slightly to 0.1789% w/w ± 0.0008 v/v in the first week, followed by a gradual decline to 0.1478% w/w ± 0.0071 v/v by the fourth week. Metabolomic profiling revealed distinct differences in secondary metabolite composition among the three tea variants, as evidenced by non-overlapping PCA groupings. Key discriminant compounds identified included ethyl acetate, ethyl octanoate, ethylamine, and (E)-2-decenal, which are proposed as characteristic markers for kombucha derived from black, green, and white teas. These findings contribute to understanding kombucha’s biochemical diversity and support halal verification through ethanol quantification and metabolite-based authentication.

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