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All Journal Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Majalah Obat Tradisional IJCER (International Journal of Chemistry Education Research) Jurnal Pengabdian Magister Pendidikan IPA IJCR (Indonesian Journal of Chemical Research)
Asih Triastuti
Department Of Pharmacy, Universitas Islam Indonesia, Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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The potential of fungus Ceratobasidium sp. as a source of pharmaceutical bioactive compounds: a scoping review Triastuti, Asih; Wahyu Wardana, Andika; Tsurayya, Faiqoh; Pramisandi, Amila; Ilyas, Muhammad
Jurnal Ilmiah Farmasi Vol. 22 No. 2 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss2.art13

Abstract

Background: Endophytic fungi are considered promising sources of novel bioactive compounds with diverse pharmacological activities, including antimicrobial, antioxidant, and anticancer effects. Among these fungi, Ceratobasidium sp. has attracted growing interest due to its metabolic diversity, although its bioactive potential remains insufficiently explored. Objective: This review aimed to evaluate the potential of secondary metabolites derived from Ceratobasidium sp. based on isolation studies and biological activity assessments. Methods: A narrative scoping review was conducted using literature retrieved from Google Scholar, PubMed, and ScienceDirect databases. Eligible studies included published journal articles and master's thesis manuscripts between 2005 and 2025. Results: Twelve studies met the inclusion criteria. Several Ceratobasidium sp. isolates demonstrated antibacterial activity against Escherichia coli and Staphylococcus aureus, antifungal activity against Candida albicans and Aspergillus niger, and cytotoxic effects against A549, MCF-7, and HeLa cell lines. Identified metabolites included 4-methoxycinnamate, farnesol, benzoic acid, cyclopeptides, and saturated fatty acids, which exhibited antiproliferative, antioxidant, and enzyme-modulating mechanisms. Conclusion: Ceratobasidium sp. shows promising potential as a source of bioactive secondary metabolites with antibacterial, antifungal, and anticancer activities. Nevertheless, the available evidence remains limited, and further studies are required to confirm these findings and evaluate their relevance for pharmaceutical development.
Co-Authors Arde Toga Nugraha Edy Meiyanto Jong Won Choi Juldani Adytia Lolyta Fournia Sari Lutfi Chabib, Lutfi Melinda Dewi M Muhammad Ilyas Pramisandi, Amila Pramundita Ramadani, Arba Putri Ananditia Rischi Dwi Irianti Rischi Dwi Irianti, Rischi Dwi Riyanto Rumiki, Aida Putri Mawaddah Sismindari . Sri harnanik Sri harnanik Sri Mulyaningsih Sri Mulyaningsih Suparmi Suparmi Tatang Shabur Julianto, Tatang Shabur Tsurayya, Faiqoh Uzulul Hikmah Wahyu Wardana, Andika Wintari Taurina Yandi Syukri Yon Haryanto