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All Journal Humantech : Jurnal Ilmiah Multidisiplin Indonesia Journal Transformation of Mandalika Prosiding Workshop dan Seminar Nasional Farmasi (WSNF) Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
I Gusti Ngurah Agung Dewantara Putra
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Review: Sterilisasi Produk Farmasi Steril dengan Metode Through Flow Filtration dan Tangential Flow Filtration I Gede Yudistira Perdangga Bandem; Kadek Adisthi Pradipthasari; Kadek Indra Aryani; Ni Luh Dian Senja Pratiwi; Putu Siska Angelina Pramesti; I Gusti Ngurah Agung Dewantara Putra
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 5 (2025): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i5.1675

Abstract

The production of pharmaceutical sterile products requires strict procedures to minimize the risk of microbial, particulate and pyrogen contamination that can be harmful to the user's health. The selection of the right sterilization method is the key to achieving the desired stability of the final product. Filtration sterilization is one of the oldest methods used for pharmaceutical sterile products. There are two types of feed flow in the method, namely through flow filtration and tangential flow filtration. This review article is prepared through literature search and download of national or international journals with inclusion or exclusion criteria that have been set. Literature sources are accessed online from various sites such as Google Scholar and Pubmed in the range of 2014-2024. The keywords used for journal searches are sterilization, through flow filtration, and tangential flow filtration. This review article reviews and compares the two methods to understand the differences, mechanism of action, and research objectives based on the review article on membrane filtration sterilization. This review aims to provide a better insight into the advantages and disadvantages of each membrane filtration sterilization method, as well as guidance in choosing the appropriate method based on the characteristics of the product to be sterilized. The results showed that through flow filtration is more commonly used in small volume and batch processes because of its simple design, but has limitations in reducing membrane fouling. In contrast, tangential flow filtration allows for continuous processing of larger volumes, with the advantage of minimizing particle build-up on the membrane surface, thus extending membrane life. The choice of method is also influenced by factors such as particle size, viscosity of the solution, sensitivity to heat, as well as operating costs. An in-depth understanding of the Working Principle and application of each method is essential for the pharmaceutical industry to ensure the quality, safety and efficiency of the production process. Thus, this review is expected to be a reference for researchers and practitioners in determining the optimal filtration sterilization strategy according to product needs.
Uji Kelarutan Flavonoid Ekstrak Kulit Salak Pondoh dalam Minyak, Surfaktan, dan Kosurfaktan untuk Preformulasi SNEDDS sebagai Nutrasetikal Made Tresia Pramasta Diva; I Gusti Ngurah Agung Dewantara Putra; Florencya; Kadek Desi Laminiati; Putu Haridas Chandra Gayatri; Komang Ayu Ratih Tri Bhuwana Putri
Prosiding Workshop dan Seminar Nasional Farmasi Vol. 2 (2023): Prosiding Workshop dan Seminar Nasional Farmasi 2023
Publisher : Program Studi Farmasi Fakultas MIPA Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/WSNF.2022.v02.p11

Abstract

Kulit salak pondoh, yang biasanya dianggap sebagai limbah, mengandung flavonoid yang memiliki potensi antioksidan. Sifat antioksidan ini dimanfaatkan sebagai sediaan nutrasetikal untuk meningkatkan efektivitas terapi berbagai penyakit, yang diformulasikan dengan SNEDDS (Self-nanoemulsifying Drug Delivery System). Pemilihan pembawa berupa fase minyak, surfaktan, dan kosurfaktan memegang peranan penting dalam pembuatan SNEDDS. Oleh sebab itu, penelitian ini bertujuan untuk mengetahui fase minyak, surfaktan, dan kosurfaktan yang paling optimum untuk melarutkan ekstrak kulit salak pondoh. Jenis minyak yang diuji antara lain, isopropil miristat (IPM), olive oil, dan asam oleat. Surfaktan yang diuji yaitu, tween 20, tween 80, dan PEG-40 HCO (Hydrogenated Castor Oil), sedangkan kosurfaktan yang diuji adalah propilen glikol, gliserin, dan PEG 400. Uji kelarutan dilakukan dengan melarutkan ekstrak ke dalam masing-masing komponen pembawa, kemudian direaksikan dengan metode AlCl3, dan diukur serapannya dengan spektrofotometer pada panjang gelombang maksimumnya. Kelarutan ekstrak kulit salak pondoh dalam fase minyak (IPM, olive oil, dan asam oleat) secara berturut-turut adalah 78,887; 147,138; dan 149,010 (μg/mL), kelarutan ekstrak dalam surfaktan (tween 20, tween 80, dan PEG-40 HCO) secara berturut-turut adalah 28,559; 34,118; dan 42,467 (μg/mL), serta kelarutan ekstrak dalam kosurfaktan (propilen glikol, gliserin, dan PEG 400) secara berturut-turut adalah 65,738; 106,364; dan 47,985 (μg/mL). Berdasarkan hasil tersebut, ekstrak kulit salak pondoh memiliki kelarutan terbesar pada fase minyak asam oleat, surfaktan PEG-40 HCO, dan kosurfaktan gliserin. Bahan-bahan tersebut dapat dipilih sebagai pembawa dalam formulasi SNEDDS ekstrak kulit salak pondoh.
Co-Authors Adam, Denis Tesalonika Ernest Damayanti, Novi Amna Eka Indra Setyawan Florencya I Gede Yudistira Perdangga Bandem Kadek Adisthi Pradipthasari Kadek Desi Laminiati Kadek Indra Aryani Komang Ayu Ratih Tri Bhuwana Putri Made Tresia Pramasta Diva Mahaswari, Anak Agung Istri Rani Mamarimbing, Merlyn Santa Naripradnya, Putu Saradevi Natalie Christanti Sukandar Ni Luh Dian Senja Pratiwi Ni Made Frida Yanti Pratiwi, Elsa Nanda Ayu Putu Haridas Chandra Gayatri Putu Siska Angelina Pramesti Saraswati, Luh Ayu Putri Valentinus Alwen