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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Sains dan Komunitas Jurnal Pengabdian Pada Masyarakat Bubungan Tinggi: Jurnal Pengabdian Masyarakat Jurnal Pengabdian Pada Masyarakat

Wisnu Kundarto

Department Of Pharmacy, Sekolah Vokasi, Universitas Sebelas Maret. Jl. Ir. Sutami 36A Surakarta

Author-ID : 2387479

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STUDY OF KINETICS MODEL OF FLAVONOID TOTAL RELEASE IN PATCH OF ANTIHYPERTENSIVE HERBS Dian Eka Ermawati; Anif Nur Artanti; Dyah Ayu Ambarwati; Niken Rosyana Dewi Septini; Sholichah Rohmani; Wisnu Kundarto
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 18, No 1 (2021)
Publisher : Sanata Dharma University

The liquid extract of antihypertensive herbs could reduce blood pressure equivalent to Hydrochlorothiazide 25 mg based on research conducted in “Hortus Medicus” clinic, Tawangmangu, Central Java, but parameters of herbal medicine taste, design, and packaging had the lowest scores. Transdermal patch was chosen as an alternative to resolve those problems. Polymers determined the effectiveness of the active substance release from the formula. Patch was formulated from combination of hydrophilic hydroxy methylcellulose (HPMC) and carboxymethylcellulose natrium (CMC-Na) polymer which would produce a fast release profile. The objective of this research was to study the kinetics models of total flavonoid release and to study the total number of flavonoids released from the antihypertensive herbs patch for 5 hours, as well as to determine the optimum formula for observing the weight, pH and loss on drying. Herbs were infused with distilled water at 90 ° C for 15 minutes, filtered then evaporated. Release kinetics model used a modified type-5 dissolution apparatus equipment with a cellophane membrane. The optimum proportion of HPMC and CMC-Na was 220:180 mg. Patch was dark brown, circle shaped, moist and flexible. It had pH value of 7.29 ± 0.09, folding endurance of 350, and thickness of 0.64 ± 0.05 mm. The average percentage of total flavonoids released from the matrix patch was 37.23% for 5 hours. The release kinetics followed the Higuchi kinetics model with a diffusion mechanism.

Cox-2 inhibition activities of creams containing anguilla bicolor and sea cucumbers extract on croton oil induced inflammation in mice Heru Sasongko; Waliyyin Razan Qanit; Raka Sukmabayu W.S; Agung Putu S.P.Kristyawan; Nining Sugihartini; Wisnu Kundarto; Dian Eka Ermawati
Pharmaciana Vol 10, No 3 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The fatty acids, like EPA and DHA, were known as anti-inflammation. It works on inflammatory tissue, brought by edema plasma, and changed into resolvins, protectins, and maresins by the enzyme reaction. Anguilla bicolor and Sea cucumber fish are known to contain EPA and DHA. This study analyzes the inhibition Cox-2 effect of the combination of Anguilla bicolor oil with Sea cucumber extract as an active ingredient in a cream preparation. This experiment used 7 groups of male BALB/C strain mice: normal control; negative control; positive control; A. bicolor oil cream; H. leucospilota extract cream; a combination of A. bicolor : H. leucospilota (2:1) cream; a combination of A. bicolor : H. leucospilota (1:2) cream. The anti-inflammatory activity was evaluated by the amount of inflammatory cell, the thickness epidermis, and the amount of cell expression COX-2Â on mice's back skin tissue induced by croton oil (0,1 %). After 3 days, histopathological skin tissues were made. The data were analyzed statistically by One Way ANOVA followed by LSD to know each group's differences at a significance level of 0.05. The experiment results showed that the formula with the best anti-inflammatory activities is the combination of A. bicolor and H. leucospilota (2:1) cream.Â The decrease of the amount of inflammatory cell (75.97%), the thickness of the epidermis (43.88%), and the amount of COX-2 cell expressions (60.52%) from the formula did not differ significantly with the positive control (p>0,05). It can be concluded that A. bicolor and H. leucospilota have anti-inflammation activity based on the experiment results.

Menjaga Kualitas Jamu Kunyit Asam Segar Industri Rumah Tangga X Yogyakarta dengan Penyimpanan Suhu yang Tepat Berdasarkan Kadar Kurkuminoid Dian Eka Ermawati; Villian Septiana; Wisnu Kundarto; Anif Nur Artanti; Sholichah Rohmani; Heru Sasongko
Jurnal Pengabdian Pada Masyarakat Vol 6 No 2 (2021)
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30653/002.202162.617

IMPROVING THE QUALITY OF FRESH ACID TURMERIC JAMU OF HOME INDUSTRY X AT THE RIGHT TEMPERATURE STORAGE BASED ON CURCUMINOID CONCENTRATION. Tamarind turmeric herbal medicine contains about 10% curcuminoids, consisting of: 1-5% curcumin, demectosicurcumin and bisdemethoxy-curcumin. Curcuminoids are a group of phenolic compounds as antibacterial, anticholesterol and antioxidants. Home Industry (IRT) X in Yogyakarta produces fresh turmeric and sour herbal medicine and is sold via delivery via an online application. Handling and storage at inappropriate temperatures can affect curcuminoid levels in herbal medicine, so it is necessary to do research on curcuminoid levels at various temperatures to provide information on IRT X in particular and herbal medicine manufacturers in general. Samples of herbal turmeric acid IRT X Yogyakarta stored at room temperature (25±2°C), refrigerator temperature (4±2°C), and freezer temperature (-10±2°C), analyzed the levels of curcuminoids on variations in storage temperature manually. quantitative method with UV-Vis Spectrophotometry. The analysis begins with the manufacture of standard curves and assays which are replicated three times. The results showed that curcuminoid levels were affected by storage temperature. Samples of herbal turmeric acid IRT X Yogyakarta which were analyzed by UV-Vis spectrophotometry method obtained a standard curve of y = 0.009x + 0.025 with a value of r = 0.997. The results of curcuminoid levels at room temperature were 4.74±0.13; refrigerator temperature 4.85±0.22; and freezer temperature 5.18±0.22. The optimum temperature in the handling and storage of the tamarind turmeric herbal medicine is at low temperatures, namely the refrigerator temperature and freezer temperature to maintain the curcuminoid content in the herbal medicine.

Pelatihan Pemanfaatan Minyak Atsiri sebagai Bahan Aktif Balsam Aromaterapi kepada Warga Kelurahan Mojosongo M Fiqri Zulpadly; Dian Eka Ermawati; Heru Sasongko; Anif Nur Artanti; Sholichah Rohmani; Wisnu Kundarto; Diyah Tri Utami
Bubungan Tinggi: Jurnal Pengabdian Masyarakat Vol 4, No 4 (2022)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/btjpm.v4i4.6684

Pandemi Covid-19 yang melanda hampir seluruh negara di dunia khususnya di Indonesia membuat banyak masyarakat cemas, stres, dan frustasi akibat ketidakpastian dari berbagai aspek kehidupan. Stres pada umumnya merupakan kondisi normal dan tidak menimbulkan masalah pada kesehatan. Balsam aromaterapi dengan bahan utama dari minyak atsiri dapat digunakan sebagai alternatif untuk dapat merelaksasikan tubuh serta berperan dalam pengaturan emosional. Pengabdian kepada masyarakat ini adalah transfer pengetahuan dan pendampingan pelatihan pembuatan balsam aromaterapi. Kegiatan yang dilakukan mencakup pemberian informasi terkait pembuatan balsam yang dilanjutkan dengan demo pelatihan pembuatan balsam aromaterapi. Kegiatan pengabdian yang dilaksanakan pada tanggal 25 Oktober 2022 menghasilkan sebuah produk balsam aromaterapi hasil karya tangan para warga yang turut hadir yang didampingi oleh tim dari D3 Farmasi UNS. Kegiatan ini telah mencapai sasaran yang diinginkan yaitu kemampuan warga Kelurahan Mojosongo dalam membuat suatu produk skala kecil menengah namun memiliki nilai yang tinggi baik dari aspek guna maupun finansial. Kegiatan pendampingan ini merupakan langkah awal dalam membentuk kemandirian masyarakat setempat untuk memproduksi balsam aromaterapi secara mandiri ataupun kelompok yang berada dalam lingkup UMKM.The Covid-19 pandemic that hit almost all countries, especially in Indonesia, made many people anxious, stressed, and frustrated due to the uncertainty of various aspects of life. Stress is generally a normal condition and does not cause health problems. Aromatherapy balms with the main ingredients of essential oils can be used as an alternative to relax the body and play a role in emotional regulation. This community service is the transfer of knowledge and assistance in training on making aromatherapy balm. The activities included providing information on making balm, followed by a training demonstration on aromatherapy balm. The service activity, carried out on October 25, 2022, resulted in an aromatherapy balm product that was handmade by the present residents, accompanied by a team from UNS Pharmacy D3. This activity has achieved the desired target, namely the ability of the residents of Mojosongo Village to make a small-medium-scale product that has a high value both in terms of use and finances. This mentoring activity is the first step in establishing the independence of the local community to produce aromatherapy balm independently or in groups within the scope of Micro Small and Medium Enterprises (MSME).

Peningkatan Pengetahuan Masyarakat dengan Pendampingan Formulasi Handsanitizer Standar WHO di Kelurahan Mojosongo, Surakarta Dian Eka Ermawati; Anif Nur Artanti; Sholichah Rohmani; Wisnu Kundarto
Jurnal Pengabdian Pada Masyarakat Vol 7 No 3 (2022): Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Mathla'ul Anwar Banten

INCREASING PUBLIC KNOWLEDGE WITH ASSISTANCE IN WHO STANDARD HANDSANITIZER FORMULATION IN MOJOSONGO VILLAGE, SURAKARTA. The Applied Pharmacy Research Group has a service roadmap that examines medicinal products, supplements, cosmetic and traditional medicines that can contribute and be adopted by society. One of the issues is liquid dosage form formulation. Alcohol is the one of choice after washing hands with soap. The use of hand sanitizer can deactivate microorganisms that stick to hand. This increase in use because pandemic covid-19 that made many people take preventive action. One way to prevent the spread of the Corona virus is maintain cleanliness such as diligently washing hands with soap and water. In the other hand the use of handsanitizer is also recommended when you cannot reach water and soap. Activity community service in Mojosongo Village, focuses on increasing public knowledge in formulate liquid Handsanitizer that is practical and simple according to the standards requirment by WHO (World Health Organization). The results of the questionnaire conducted before and after assistance in making hand sanitizers stated that most of the respondents had showed an increase in knowledge related to components in the manufacture of handsanitizers

Pengembangan Produk Permen Jelly Jamu Kunyit Asam Industri Rumah Tangga Jamu di Sleman Yogyakarta Dian Eka Ermawati; Wisnu Kundarto; Yeni Farida
Jurnal Pengabdian Pada Masyarakat Vol 7 No 2 (2022): Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Mathla'ul Anwar Banten

PRODUCT DEVELOPMENT OF GUMMY OF TURMERIC ACID JAMU PRODUCTION BY HERBAL HOMINDUSTRY IN SLEMAN YOGYAKARTA. Jamu of turmeric acid is an Indonesian herbal drink made from turmeric and tamarind. The home industry in Sleman Yogyakarta produces turmeric acid jamu and promising to develop as gummy. The Consumers of turmeric acid Jamu are limited, Children who want to consume jamu are rarely, whereas curcumin in turmeric can increase appetite, especially for school-age children. Product innovation is needed to process jamu become more desirable, durable, and still efficacious, for example, jelly candy or gummy. Gummy is made with the addition of gelling agent that made texture is chewy. Carrageenan is a gelling agent made from seaweed and safe for food products. The aims of product development are to develop micro businesses and to improve the economy and public confidence in the quality of herbal medicine especially jamu. Gummy formulation with carrageenan and turmeric acid jamu as the main ingredient. Formula with 8.0% carrageenan is the optimum formula because it meets the quality requirements for gummy and is most preferred by respondents.

Co-Authors Adistyara Nur Faizah Agung Putu S.P.Kristyawan Anif Nur Artanti, Anif Nur Diyah Tri Utami Dyah Ayu Ambarwati ERMAWATI, DIAN EKA Heru Sasongko Heru Sasongko M Fiqri Zulpadly Niken Rosyana Dewi Septini Nining Sugihartini Raka Sukmabayu W.S Riskafiya Ni'matul Faizah Sholichah Rohmani Villian Septiana Waliyyin Razan Qanit Yeni Farida

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