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All Journal Idea Nursing Journal Jurnal Kedokteran Syiah Kuala Jurnal Bioleuser Majalah Patologi Indonesia Budapest International Research in Exact Sciences (BirEx Journal) Jurnal Natural Cakradonya Dental Journal Trends in Infection and Global Health
. Vera Dewi Mulia, Troef Soemarno
Bagian Patologi Anatomi, Fakultas Kedokteran, Universitas Syiah Kuala
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Dentistry Earth & Planetary Sciences Energy Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Transportation

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Acute toxicity evaluation of ethanolic extract of the leaves of Anredera cordifolia in wistar rats (Rattus Norvegicus) SURYAWATI SURYAWATI; NISSA SEURUNIE; DAMAR DITA KIRANA; VERA DEWI MULIA; HIJRA NOVIA SUARDI
Jurnal Natural Volume 22 Number 2, June 2022
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v22i2.22285

Abstract

Anredera cordifolia (Binahong) is one of the medicinal plants that has been widely used for its properties of inhibiting the growth of microorganisms, decreasing blood uric acid, and healing wounds. This study was conducted to evaluate the acute toxicity effects of ethanolic extract of binahong to support its use as a medicinal plant. Ethanolic extracts of binahong leaves were prepared. Twenty-five white male rats (Rattus norvegicus) were divided into 5 groups and administered with a single dose of Na-CMC suspension or a dose of 300, 600, 1200, or 2400 mg/kg BW of binahong ethanolic leaf extract, respectively. Toxicity symptoms were monitored at three-time intervals: ½-1, 1½-2, and 3-6 hours after the administration. A macroscopic evaluation of the rat’s liver was carried out to identify any lesion. The rat’s liver and whole-body weights were determined to assess the weight reduction. The results showed that there was no dead rat in any of the groups, indicating that no LD50 was identified. Also, there were several toxic effects observed including a decrease in movements, somatic response, insensitivity, and stool consistency. There was no evidence of a lesion on liver macroscopy. However, the weights of rats’ livers increased in tandem with the reduction in their body weights. The findings from this study reveal that single dose of binahong ethanolic extract ranging from 300 to 2400 mg/kg BW are safe, while minimal toxic effects were observed.
TRIGONELLA FOENUM : A REVIEW OF HYPOGLYCEMIC ACTIVITY Suryawati Suryawati; Safrida Safrida; Firdausa Sarah; Azizah Vonna; Vera Dewi Mulia
Jurnal Natural Volume 19 Number 3, October 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v19i3.13405

Abstract

Treatment of diabetes mellitus is intended to reduce the risk of blindness, kidney failure, neuropathy and heart disease that can develop due to the chronic increase in the blood glucose level. The selected hypoglycemic agents should be effective, safe and readily available. The widely used agents work by interrupting enzymes responsible for glucose regulation. Those enzymes are α-amilase, α-glucosidase, dipeptidyl peptidase-IV, aldose reductase and angiotensin converting enzyme. A medicinal plant, fenugreek (Trigonella foenum-graecum) has been used as an antidiabetic folk medicine. This review provides information related to in vitro studies showing antihyperglycemic activity of fenugreek along with an in vivo study in animals. In addition, potential phytochemicals that have been isolated from this plant are described and play a role in the searching for the most potent agents for diabetes mellitus therapy.
The use of herbal medicines by the elderly in rural area in Indonesia: A cross-sectional study among Acehnese Suryawati Suryawati; Sarah Firdausa; T. Hidayat Syah; Vera Dewi Mulia; Hijra Novia Suardi; Zahratul Aini; Fauzul Husna; Hafni Andayani
Trends in Infection and Global Health Vol 3, No 1 (2023): June 2023
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v3i1.31438

Abstract

The use of herbal medicines has become increasingly popular worldwide. Elderly has been associated with higher consumption of many medications, including herbal medicines. However, there is a lack of documentation of medicinal herbs use among Acehnese population. Our study aimed at evaluating the profile of herbals use among the elderly population in a rural area of Aceh Province, Indonesia. A cross-sectional study was conducted from October to November 2021 in Nagan Raya Regency of Aceh. To collect information on the use of herbs, a set of structured questionnaires was utilized. The data were presented in percentage (%). A total of 100 respondents were included comprising 54.0% female and most of the respondents aged between 60–64 years (43.0%). The largest percentage of the participants made their own herbal medicines (45.0%) and used them routinely as a habit (36.0%). About 75.0% of the elderly felt better and almost all of them (96.0%) reported no adverse reaction following herbs consumption. A total of 39 plant species were used by the respondents with Annona muricate L. was the most frequently used medicinal plant (16.0%) and leaves were the most commonly used parts (68.4%). Most of the herbs were prepared through boiling and squeezing (32.6%), and mainly used in the form of a drink (77.3%). Cough treatment with herbs made up 19.3%, followed by hypertension (18.0%), flatulence (7.6%), dyspepsia (5.8%), and fever (5.8%). Our investigation revealed consistency in the use of some medicinal herbs in the present study with published experimental data. However, since elderlies are often considered vulnerable individuals, the practice of herbal self-remedies among this population should be well-monitored.
Sitologi Tumor Odontogenik: Ameloblastoma Vera Dewi Mulia
Cakradonya Dental Journal Vol 7, No 2 (2015): Desember 2015
Publisher : FKG Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Ameloblastoma adalah tumor odontogenik jinak dan bersifat agresif secara lokal. Angka kejadian tumor ini sekitar 1% dari seluruh tumor pada tulang rahang. Biasanya terjadi pada regio mandibula, dan hanya sedikit kasus di maksila. Ameloblastoma mempunyai kecendrungan untuk rekurensi, karena itu sangat diperlukan diagnosis yang akurat sebelum menentukan teknik pembedahan. Gejala klinis dan radiologis ameloblastoma dapat menunjukkan gambaran yang tidak spesifik, gambarannya bisa menyerupai odontogenic cyst dan tumor lain. Fine Needle Aspiration Cytology (FNAB) merupakan suatu teknik yang mudah dan tidak invasif dalam menegakkan diagnosis sebelum tindakan pembedahan dilakukan pada ameloblastoma. Teknik ini juga merupakan suatu tindakan yang dapat dilakukan dengan cepat dan menghasilkan diagnosis yang akurat, serta dapat membedakan antara tumor jinak dan ganas. Sitologi dari ameloblastoma terdiri atas kelompok-kelompok sel basaloid dengan single spindle and stellate shaped cells. Bahan pemeriksaan bisa tidak memadai bila diperoleh dari tumor dengan area kista yang luas, dan dapat menyebabkan diagnosis menjadi tidak akurat, sehingga bisa keliru dalam menentukan keganasan yang bisa terdiagnosis sebagai suatu ameloblastoma konvensional.
Co-Authors Aini, Zahratul Amida Jannatus Saleha Anak Agung Gede Sugianthara Azizah Vonna Benny Kurnia DAMAR DITA KIRANA Dina Alia Fauzul Husna Firdausa, Sarah Ghina Raudathul Jannah Hafni Andayani Hanifah Yusuf Hijra Novia Suardi Hijra Novia Suardi Indra Gunawan Mirfandi Amirsyah MUHAMMAD AGUS SUPRAYUDI Muhammad Jailani NISSA SEURUNIE Nurrahmah Latifa Reno Keumalazia Kamarlis Safrida Safrida Suryawati Suryawati Suryawati Suryawati Suryawati Suryawati Suryawati Suryawati T. Hidayat Syah Zahratul Aini