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All Journal Health Science Journal of Indonesia Ta´dib Majalah Patologi Indonesia SUPERMAT (JURNAL PENDIDIKAN MATEMATIKA) Ta’wiluna: Jurnal Ilmu Al-Qur’an,Tafsirdan Pemikiran Islam APPA : Jurnal Pengabdian Kepada Masyarakat JURNAL MULTIDISIPLIN ILMU AKADEMIK Sanitas: Journal of Health, Medical, and Psychological Studie
Ahmad Ghozali
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Religion Humanities Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences

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Ekspresi Notch1 dan ALDH1A1 pada Lesi Prostat; Hubungannya dengan Diagnosis Histopatologik, Proliferasi dan Apoptosis Sel Kanker Paranita Ferronika; Ahmad Ghozali; Harij -
Majalah Patologi Indonesia Vol. 22 No. 1, Januari 2013
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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ABSTRAK Latar belakang Kanker prostat di Indonesia menduduki peringkat ketiga di antara penyakit kanker pada laki-laki dan peringkat kelima di antara kematian akibat kanker pada laki-laki. Sangat diperlukan petanda biologis yang dapat mengidentifikasi agresivitas kanker pada lesi awal yang kemudian dapat membantu pemilihan terapi yang tepat, guna mengurangi kematian. Sel punca pada kelenjar prostat telah terbukti memiliki peran dalam inisiasi, progresivitas, dan metastasis sel kanker, meskipun masih dalam kontroversi. ALDH1A1 diusulkan untuk menjadi kandidat petanda sel punca kanker prostat. Sinyal Notch mempunyai peran penting dalam mempertahankan fenotip sel punca. Ekspresi Notch1 yang tinggi dianggap memiliki peran onkogenik pada kanker prostat. Hipotesis kami yaitu ekspresi Notch1 yang tinggi berkaitan dengan tingginya ekspresi ALDH1A1 sebagai petanda sel punca kanker, yang akan meningkatkan progresivitas kanker prostat. Metode Studi ini dilakukan secara cross-sectional selama dua tahun (2009-2010), dengan pewaarnaan IHC pada 79 jaringan blok parafin dengan diagnosis benign prostatic hyperplasia, prostatic intraepithelial neoplasia, dan kanker prostat dengan skor Gleason rendah dan tinggi. Hubungan antara Notch1 dan ALDH1A1 dianalisa dengan Chi-Square menggunakan SPSS 15,0. Hubungan Notch1 dan ALDH1A1 dengan diagnosis patologis dianalisa dengan Chi-square. Hubungan kedua petanda tersebut dengan tingkat proliferasi sel (Ki-67) dan laju apoptosis (cleaved caspase 3) dianalisis dengan uji Mann-Whitney. Statistik dianggap signifikan jika nilai p
Ekspresi C-kit dan Beberapa Faktor Klinokopatologis Karsinoma Payudara Subtipe Basal-like Peter Santosa; Ahmad Ghozali
Majalah Patologi Indonesia Vol. 24 No. 3, September 2015
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Background Prognosis of breast cancer is determined by several factors such as age, tumor size, lymph node status, and histolopathological grade. Based on its molecular profile, breast cancer is divided into several subtypes and the basal-like subtype has the worst prognosis. Up to now, there is no appropriate and spesific therapy for that tumor. C-kit is a tyrosin kinase transmembrane receptor that has important roles in solid cancers development. C-kit can be expressed in normal breast duct epithelium and in breast cancer subtype with poor histopathological grade and prognosis. To find out about c-kit expression and the correlation with some clinicopathological factors in basal-like subtype breast cancer. Methods Paraffin embedded tissue of 301 infiltrating duct breast cancer patients from Anatomical Pathology Department of Sardjito General Hospital Yogyakarta year 2011-2013 were examined with immunohistochemistry staining, using monoclonal antibody anti ER, PR, HER2, CK5/6 and c-kit. The differences and association are analyzed using Independent T-Test, Fisher, and Kruskall Wallis statistics test. Results From January 2011-October 2013, there were 301 breast cancer patients with 87 of them (28,90%) were triple negative subtype (ER-. PR-. HER2-). Forty two triple negative cancers that match with inclusion criterias were stained with CK 5/6 to defined the basal-like subtype. There were 34 patients (81%) positive CK 5/6 expression (basal-like subtype) and 8 patients (19%) negative CK 5/6 expression (non basal-like). Patients with basal-like subtype have younger mean of age (p=0.026) and a bit larger tumor size but not statistically significant (p=0.560) compared with the non basal-like subtype. There were no significant correlation between basal-like subtype with age (p=0.052), tumor size (p=0.521), lymph node status (p=0.243), histopathological grade (p=0.115) and c-kit expression (p=0.118). Among the basal-like subtype group, 25 patients (73%) shared negative c-kit expression and 9 patients (27%) positive c-kit expression. There were no difference between positive and negative c-kit expression groups with age (p=0.434) and tumor size (p=0.267). There were no significant correlation between c-kit expression with age (p=0.544), tumor size (p=0.616), lymph node status (p=0.560), and histopathological grade (p=0.955). Conclusion C-kit expression could not be correlated to clinico-pathologic factor of basal-like subtype breast cancer. Key words : age, basal-like subtype breast cancer, c-Kit, histologic grade, lymph node status, tumor size.
Co-Authors Afni Fauziyah Ahmad Khoirur Roziqi Aspihan, Moch. Aziz, muhamad wahyuniarto Christina Hari Nawangsih Priharsanti Christina Prihharsanti Danang Abiantoro Dessy Afriyani Dian Diana, Aan Ferronika, Paranita Firly Putri Fardhila Harij - Hatip, Ahmad Iffah Fathimatuzzahro Iskim Luthfa Iwan Giri Waluyo Jean Fadli Alenski M. Fadhillah Sidik Mardiansyah Muhajir Muhajir Muhamad Teguh Muhamad Zidan Alfariz Nurniat Halawa Peter Santosa Rahmat Hidayat Sofia Mubarika Haryana Sri Nuryani Wahyuningrum Sri Nuryani Wahyuningrum sudianto Syamsuddin Muir Windi Setiawan