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All Journal Dentika Dental Journal Pro-Life Dental Journal (Majalah Kedokteran Gigi) Jurnal Pengabdian UntukMu NegeRI Best Journal (Biology Education, Sains and Technology) Indonesian Journal of Pharmaceutical and Clinical Research Journal of Functional Food and Nutraceutical Journal of Pharmaceutical and Health Research International Journal Of Science, Technology & Management (IJSTM) Jurnal Sains dan Teknologi Proceeding ISETH (International Summit on Science, Technology, and Humanity) Herbal Medicine Journal
Denny Satria
Department Of Pharmaceutical Biology, Faculty Of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
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Effects of 1% and 3% Mobe Leaf Extract Gel on Socket Wound Healing after Tooth Extraction: Efek Gel Ekstrak Daun Mobe 1% dan 3% pada Penyembuhan Luka Soket Pasca Pencabutan Gigi Hanafiah, Olivia Avriyanti; Satria, Denny; Avi Syafitri
Dentika: Dental Journal Vol. 24 No. 1 (2021): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/dentika.v24i1.5327

Abstract

Tooth extraction is a process of removing teeth from the alveolar bone. In wound healing, fibroblast are very important cells. The main purpose of this study was to determine the effect of mobe leaf 1% and 3% extract gel (Artocarpus lakoocha) on fibroblast proliferation in post extraction tooth socket wound healing. This research used 16 samples of wistar rats, divided into 4 groups, a positive control group, a negative control group and a 1% and 3% mobe leaf extract gel group. The left mandibular incisors were extracted, then 1% and 3% gels of mobe leaf extract were applied on day 1 to day 7. Data analysis was calculated using the Kruskal-Wallis test on clinical data and one way ANOVA test for microscopic. The result of the socket wound healing activity test for a good concentration of mobe leaf extract gel was 3%. This research shows significant resultith p-value of 0.018 (< 0.05) on the closure of the socket wound clinically which means the closure of the wound accelerates because of the mobe leaf 3% extract gel treatment. The distance of fibroblast on microscopically shows significant resultith a p-value of 0.002 (< 0.05), which means that there was an enlargement of the distance fibroblast at the socket wound closure with application of mobe leaf 3% extract gel. From the results of the study it can be concluded that mobe leaf 3% extract gel has the best ability to show acceleration the closure of the socket wound either clinically or microscopically.
Sosialisasi Pembuatan Virgin Coconut Oil Sebagai Suplemen Peningkat Imunitas Untuk Menghadapi Covid-19 Di Kelurahan Gedung Johor Medan Rosidah Rosidah; Mahatir Muhammad; Effendy De Lux Putra; Denny Satria; Panal Sitorus; M. Fauzan Lubis
Jurnal Pengabdian UntukMu NegeRI Vol 5 No 1 (2021): Pengabdian Untuk Mu negeRI
Publisher : LPPM UMRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jpumri.v5i1.2263

Abstract

Pengabdian kepada masyarakat ini bertujuan untuk memberikan pengetahuan mengenai pembuatan Virgin Coconut Oil secara sederhana dan memberikan pengetahuan bahwa Virgin Coconut Oil dalam meningkatkan imunitas tubuh sehingga dapat menangani atau mencegah semakin berkembangnya pasien positif Covid-19. Melalui kegiatan pengabdian kepada masyarakat yang ditujukan kepada masyarakat di Kelurahan Gedung Johor, Kecamatan Medan Johor, Medan. Pemahaman masyarakat terhadap manfaat dan kandungan VCO serta cara pembuatan VCO yang benar, sederhana dan dengan tetap memperhatikan kualitas dari VCO yang dibuat, dilihat berdasarkan mutu fisik meliputi warna, bau dan rasa yang dihasilkan VCO buatan sendiri dan VCO dari Palm Mustika yaitu normal untuk bau dan rasa serta berwarna putih hingga kuning pucat. Mutu kimia VCO buatan sendiri yang didominasi asam laurat yaitu 53,2% sedangkan VCO dari Mustika Palem yaitu 49,4%. asam lemak bebas (FFA) VCO buatan sendiri yaitu 0,38% sedangkan asam lemak bebas (FFA) VCO Mustika Palem yaitu 0,08%, bilangan peroksida VCO buatan sendiri yaitu 0,06 meq/kg sedangkan bilangan peroksida VCO Mustika Palem yaitu 0,00 meq/kg dan bilanga penyabunan VCO buatan sendiri yaitu 252,74 mg KOH/gram sedangkan bilangan penyabunan VCO Mustika Palem yaitu 253,13 mg KOH/gram.
Aktivitas Antibakteri Ekstrak Etanol Daun Pepaya (Carica papaya Linn.) Terhadap Bakteri Pseudomonas aeruginosa Nasri Nasri; Vera Estefania Kaban; Kasta Gurning; Hariyadi Dharmawan Syahputra; Denny Satria
INSOLOGI: Jurnal Sains dan Teknologi Vol. 1 No. 3 (2022): Juni 2022
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (376.277 KB) | DOI: 10.55123/insologi.v1i3.438

Abstract

Pseudomonas aeruginosa is a Gram-negative bacterium that can cause nosocomial infections. The use of antibiotics in the treatment of non-adherent P. aeruginosa infections increases the risk of antibiotic resistance. Efforts to find new antibiotic compounds from plants continue to be carried out. Papaya leaves are widely spread among the public, which are often used as ingredients for vegetables and have antibacterial potential because they contain papain enzymes and a class of flavonoid compounds. The purpose of this study was to analyze the antibacterial activity of the ethanol extract of papaya leaves (Carica papaya Linn.) against P. aeruginosa by finding the value of the Minimum Inhibitory Concentration (MIC) and calculating the index activity value against the positive control. The method used in this research is Kirby-Bauer (disc diffusion method) with several variations of the test concentration. The results showed that the diameter of the inhibition zone at a concentration of 500 mg/mL was in the strong category with an inhibition zone diameter of 10.87 ± 0.06 mm. MIC at a concentration of 3.125 mg/mL. The index activity value was greatest at a concentration of 500 mg/mL with a value of 0.668. So it can be concluded that the ethanol extract of papaya leaves (Carica papaya Linn.) has inhibitory activity against Pseudomonas aeruginosa.
Antibacterial Potential Ethanol Extract of Papaya Leaves (Carica papaya Linn.) Towards Salmonella typhi Mahatir Muhammad; Nasri Nasri; Vera Estefania Kaban; Denny Satria; Henni Cintya
BEST Journal (Biology Education, Sains and Technology) Vol 5, No 2 (2022): September 2022
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v5i2.5717

Abstract

Infectious diseases are a problem of great concern throughout the world. Bacterial infections such as Salmonella typhi often attack children and cause diarrhea and typhoid fever. Salmonella typhi is a beflagellated Gram negative bacteria that can be transmitted through contaminated food, drink, or water. Treatment of infections using antibiotics, where often the use of antibiotics is not achieved on the therapeutic target due to lack of patient compliance in taking antibiotics, will cause new problems, namely problems related to antibiotic resistance. Papaya leaf is a plant originating from the Caricaceae family which, based on studies, has been reported to have antimicrobial, antidiabetic, and immunomodulatory effects. The purpose of this study was to examine the antibacterial potential of ethanol extract of papaya leaves (Carica papaya Linn.) against Salmonella typhi bacteria. This research method uses the agar diffusion method (Kirby-Bauer) with various concentrations to determine the minimum inhibitory concentration (MIC) and the streaking method to determine the minimum killing concentration (MBC). The minimum inhibitory concentration was obtained at a concentration of 3.125 mg/mL with an inhibitory zone diameter of 6.70 ± 0.20 mm and a minimum killing concentration of 50 mg/mL. The index activity value at a concentration of 300 mg/mL was 0.688 ± 0.05. So it can be concluded that the ethanol extract of papaya leaves has potential antibacterial activity against Salmonella typhi bacteria.
Sosialisasi serta Edukasi Aplikasi Pengolahan Pangan Fungsional dalam Pencegahan Stunting Di Kecamatan Tanjung Morawa Henni Cintya; Denny Satria; Mahatir Muhammad
Jurnal Pro-Life Vol. 9 No. 3 (2022): November
Publisher : Program Studi Pendidikan Biologi Fakultas Keguruan dan Ilmu Pendidikan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/jpvol6Iss2pp102

Abstract

Stunting is the impaired growth and development that children experience from poor nutrition, repeated infection, and inadequate psychosocial stimulation. Stunting is an issue that has a big impact. Infants and toddlers may experience morbidity and death in the near term as a result. Low intellectual and cognitive capacities can be caused over the long term, as well as problems with degenerative diseases and the lowest quality adult human resources. The average prevalence of stunting toddler in Indonesia in 2015-2017 was 31.4%, far above the WHO limit of 20%. Based on this idea, this community service was carried out with the aim of educating mothers with the family walfare movement community (FWMC) about the importance of knowledge on how to process food from natural ingredients such as Moringa leaves and pumpkin into cookies as functional food for stunting prevention in childrens in Tanjung Morawa Regency. This activity received a very good response and high enthusiasm from FWMC and headmans. This activity was attended by 35 participants consisting of 25 mothers and 10 people as headman. Furthermore, an observation survey was conducted by providing questionnaires to measure the level of understanding of food processing from natural ingredients as functional foods for the prevention of stunting in children. Observations showed that arround 96% of mothers after participating in this activity knew what stunting was, the causes, prevention of stunting and how to process food as functional foods that could reduce the prevalence of stunting in Buntu Bedimbar Village, so that they could apply in their respective households for the health.
The Immunomodulatory Activities of Saurauia vulcani Korth Leaves towards RAW 264.7 cell R Rosidah; Y Yuandani; Sri Suryani Widjaja; Muhammad Fauzan Lubis; Denny Satria
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2019: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Saurauia vulcani Korth is an actinidiaceae family plant that is used as traditional medicine by the community. Testing the immunomodulatory effect of Saurauia vulcani Korth extract was done in vitro on RAW cells line by stratified extraction using n-hexane, ethyl asetat, and ethanol solvents. Determination of nitric oxide levels by the griess method and inhibition of gene expression TNF-α, IL6, COX-2, IL-1β, and iNOS by RT-PCR method. Saurauia vulcani Korth extract (NESVL, EAESVL, and EESVL) at a concentration of 25 ug / ml was able to reduce the value of nitric oxide in RAW cells 246.7 and was able to inhibit the expression of genes TNF-α, IL-6, COX-2, IL-1β, and iNOS. Where the density value of each band formed by 1.21 ± 0.005; 1.15 ± 0.005; 0.88 ± 0.003 on TNF-α, 1.23 ± 0.003; 1.64 ± 0.005; 0.55 ± 0.003 on IL-6, 0.38 ± 0.003; 0.55 ± 0.003; 0.38 ± 0.003 on COX-2, 0.18 ± 0.003; 0.04 ± 0.003; 0.03 ± 0.003 on IL-1β, and 0.30 ± 0.003; 0.41 ± 0.003; 0.11 ± 0.005 on iNOS.
Toxic Effect Of The Compound {1,3 Bis (P-Hydroxyphenyl) Urea} On Triiodothyronine (T3) Hormone Levels In Pregnant White Rats (Rattus Norvegicus L.) Ziza Putri Aisyia Fauzi; Urip Harahap; Yuandani Yuandani; Syukur Berkat Waruwu; Hari Purnomo; Denny Satria
International Journal of Science, Technology & Management Vol. 4 No. 1 (2023): January 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i1.719

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed drugs for pregnant women to treat fever, pain and inflammation. Specific NSAIDs can displace thyroid hormone from its protein binding sites, causing thyroid hormone measurement problems. {1,3 bis (p-Hydroxyphenyl)urea} is a modified p-aminophenol compound with potent analgesic and anti-inflammatory activity and less toxicity. This study is a follow-up to previous research to observe the toxic effect on triiodothyronine hormone levels after administration of {1,3 bis(p-Hydroxyphenyl)urea} compound in pregnant white rats. The toxic effect test was carried out by giving the test preparation to pregnant rats, which had been divided into five groups, namely the normal control group (CMC-Na 0.5%), the positive control (Gabapentin 50 mg/kg BW), Compound {1.3 bis (p- Hydroxyphenyl)urea} at a dose of 50 mg/kg BW, 500 mg/kg BW and 1000 mg/kg BW. Mice were given the test preparation every day from the 6th to the 15th day of pregnancy. Blood was taken on the 16th day, and T3 hormone levels were measured using the ELISA method. The results showed that the T3 hormone levels in the {1,3 bis(p-Hydroxyphenyl)urea group had no significant difference from the normal control group, so it was concluded that {1,3 bis(p-Hydroxyphenyl)urea) did not have a significant effect on the hormone T3.
Mekanisme Antibakteri Ekstrak Etanol Daun Kemangi (Ocimum basilicum L.) terhadap Salmonella typhi Nasri Nasri; Vera Estefania Kaban; Denny Satria; Hariyadi Dharmawan Syahputra; Zulmai Rani
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.3176

Abstract

Infectious diseases are conditions that can be brought on by a variety of different organisms, including bacteria, viruses, fungi, and parasites. Typhoid fever is an example of an infectious disease that frequently causes the body's defenses to come under attack. The fever associated with typhoid is a leading cause of death around the world. Infection with the bacterium Salmonella typhi is considered to be one of the potential causes of typhoid fever. When antibiotics are used to treat bacterial infections, there is a risk that the bacteria will become resistant to the medication. In day-to-day life, basil leaves are utilized both as a cooked vegetable and as a fresh vegetable. The antibacterial properties of kemangi leaves have yet to be fully uncovered. The purpose of this study was to investigate the various mechanisms that are involved in antibacterial activity. These mechanisms include cell leakage, minimum inhibitory concentration, minimum killing concentration, and antibiofilm activity. The minimum inhibitory concentration (MIC) was determined with the agar diffusion method, the minimum biofilm forming concentration (MBC) was determined with the staining method, and cell leakage was determined with UV-VIS spectrophotometry at wavelengths of 260 nm (DNA) and 280 nm (protein). Additionally, the formation of anti-biofilms was determined with microtiter plates and gentian violet staining. In the moderate category, the MIC value tests showed a concentration of 0.3125% with an inhibition zone value of 6.80 0.05 mm. These results were obtained from the MIC value. Because there was no detectable bacterial growth on the streaked medium, KBM was obtained at a concentration of 10%. At wavelengths of 260 and 280 nanometers, leakage cells show absorbance absorption. The percentage of biofilm activity that is measured when the concentration is increased to 25% is 44.82%. In conclusion, the ethanol extract of basil leaves possesses a possible antibacterial mechanism against Salmonella typhi. This was discovered through testing.
Uji Aktivitas Antibakteri Ekstrak Daun Karenda (Carissa carandas Linn.) Terhadap Bakteri Propionibacterium acne dan Staphylococcus epidermidis Vera Estefania Kaban; Nasri Nasri; Hariyadi Dharmawan Syahputra; Muhammad Fauzan Lubis; Denny Satria
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.3181

Abstract

Karenda leaves contain flavonoids, steroids or triterpenoids, saponins, and tannins that act as antimicrobial compounds. The aim of the study was to determine the antibacterial activity of the ethanol extract of Karenda leaves against several acne-causing bacteria. The research method involved characterizing the simplicia of karenda leaves and extract preparation by maceration using 96% ethanol as a solvent. and test the antibacterial activity of the ethanol extract of Karenda leaves using the agar diffusion method. The bacteria used were Propionibacterium acnes and Staphylococcus epidermis. The extract concentrations used were 300, 150, 125, 100, 75, 50, 25, and 5 mg/mL. Based on tests carried out by the ethanol extract of karenda leaves, the diameters of the inhibition zones were 7.2 ± 0.12 respectively; 7.8±0.10; 9.7±0.15; 11.23±0.25; 12.43±0.06; 13.57±0.06; 14.20±0.10; 16.47 ± 0.21 for Propionibacterium acne and 8.17 ± 0.06; 9.37 ± 0.15; 9.80 ± 0.10; 10.73 ± 0.15; 11.27±0.12; 12.43±0.06; 13.77±0.06; 15.47 ± 0.12 for Staphylococcus epidermis. he test results proved that 300 mg/mL was the best concentration for inhibiting the growth of Propionibacterium acnes and Staphylococcus epidermis bacteria.
Aktivitas Antibakteri Ekstrak Etanol Daun Alpukat (Persea americana Mill) Terhadap Escherichia coli, Salmonella typhi, dan Pseudomonas aeruginosa Nasri Nasri; Vera Estefania Kaban; Hariyadi Dharmawan Syahputra; Denny Satria
Herbal Medicine Journal Vol 5 No 1 (2022): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (480.38 KB) | DOI: 10.58996/hmj.v5i1.37

Abstract

Infectious disease is a serious health problem in the world of health. Escherichia coli causes diarrhea, Salmonella typhi causes typhoid fever, and Pseudomonas aeruginosa causes nosocomial infections which are Gram-negative pathogenic bacteria. Treatment with antibiotics is the therapy that is currently used, but other efforts in the use of herbal medicines are also being carried out in various studies. The purpose of this study was to analyze the antibacterial activity of the ethanolic extract of avocado leaves (Persea americana Mill.) against Escherichia coli, Salmonella typhi, and Pseudomonas aeruginosa. The method used is agar diffusion (Kirby-Bauer) with variations in the concentration of the test solution. The results showed that at a concentration of 500 mg/mL the three bacteria had an inhibition zone diameter of Escherichia coli with a value of 12.37±0.15 mm, Salmonella typhi with a value of 11.60±0.20 mm and Pseudomonas aeruginosa with a value of 10.87±0.15 mm. The ethanol extract of avocado leaves (Persea americana Mill.) showed antibacterial activity against three Gram-negative pathogenic bacteria.
Co-Authors Avi Syafitri Cindy Yuwanda Cintya, Henni Damayanti Damayanti Debi Dinha Octora Diana Sofia Hanafiah Dohude, Gostry Aldica Effendy De Lux Putra, Effendy De Lux Hari Purnomo Hariyadi Dharmawan Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Henni Cintya Jansen Silalahi Kasta Gurning M. Fauzan Lubis Maharani Syahnia Putri Mahatir Muhammad Muhammad Fauzan Lubis Muhammad Fauzan Lubis Nasri N Nasri Nasri Nasri Nasri Nurul Izzatunna Jhirah Harahap Olivia Avriyanti Hanafiah Olivia Avriyanti Hanafiah Panal Sitorus* Rosidah, Rosidah Siti Bahirrah Sri Suryani Widjaja Sumaiyah Sumaiyah Syukur Berkat Waruwu Urip Harahap Vera Estefania Kaban Yuandani Ziza Putri Aisyia Fauzi Zulmai Rani