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All Journal Journal of Pharmaceutics and Pharmacology Indonesian Journal of Pharmaceutical Science and Technology Pro-Life Jurnal Pengabdian UntukMu NegeRI Journal of Pharmaceutical and Health Research Jurnal Farmanesia
Panal Sitorus
Department Of Pharmaceutical Biology, Faculty Of Pharmacy, Universitas Sumatera Utara, Jl. Tri Dharma No. 5, Kampus USU, Medan. Sumatera Utara, Indonesia 20155.
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Sosialisasi Pembuatan Virgin Coconut Oil Sebagai Suplemen Peningkat Imunitas Untuk Menghadapi Covid-19 Di Kelurahan Gedung Johor Medan Rosidah Rosidah; Mahatir Muhammad; Effendy De Lux Putra; Denny Satria; Panal Sitorus; M. Fauzan Lubis
Jurnal Pengabdian UntukMu NegeRI Vol 5 No 1 (2021): Pengabdian Untuk Mu negeRI
Publisher : LPPM UMRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jpumri.v5i1.2263

Abstract

Pengabdian kepada masyarakat ini bertujuan untuk memberikan pengetahuan mengenai pembuatan Virgin Coconut Oil secara sederhana dan memberikan pengetahuan bahwa Virgin Coconut Oil dalam meningkatkan imunitas tubuh sehingga dapat menangani atau mencegah semakin berkembangnya pasien positif Covid-19. Melalui kegiatan pengabdian kepada masyarakat yang ditujukan kepada masyarakat di Kelurahan Gedung Johor, Kecamatan Medan Johor, Medan. Pemahaman masyarakat terhadap manfaat dan kandungan VCO serta cara pembuatan VCO yang benar, sederhana dan dengan tetap memperhatikan kualitas dari VCO yang dibuat, dilihat berdasarkan mutu fisik meliputi warna, bau dan rasa yang dihasilkan VCO buatan sendiri dan VCO dari Palm Mustika yaitu normal untuk bau dan rasa serta berwarna putih hingga kuning pucat. Mutu kimia VCO buatan sendiri yang didominasi asam laurat yaitu 53,2% sedangkan VCO dari Mustika Palem yaitu 49,4%. asam lemak bebas (FFA) VCO buatan sendiri yaitu 0,38% sedangkan asam lemak bebas (FFA) VCO Mustika Palem yaitu 0,08%, bilangan peroksida VCO buatan sendiri yaitu 0,06 meq/kg sedangkan bilangan peroksida VCO Mustika Palem yaitu 0,00 meq/kg dan bilanga penyabunan VCO buatan sendiri yaitu 252,74 mg KOH/gram sedangkan bilangan penyabunan VCO Mustika Palem yaitu 253,13 mg KOH/gram.
Aktivitas Antimikroba Fraksi n-Heksan dan Fraksi Air Clerodendrum paniculatum L. Terhadap Pseudomonas aeruginosa dan MRSA Dewi Pertiwi; Panal Sitorus; Ihsanul Hafiz
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.30659

Abstract

Ada banyak tanaman obat-obatan yang berasal dari alam terbukti memiliki senyawa antimikroba yang digunakan sebagai alternatif yang berpotensi secara efektif pada penanganan bakteri. Clerodendrum telah diteliti aktivitas antimikrobanya pada beberapa bakteri. Tujuan dari penelitian ini adalah untuk mengetahui aktifitas antimikroba dari fraksi n-heksan dan fraksi air dari daun pagoda (Clerodendrum paniculatum) terhadap bakteri Pseudomonas aeruginosa and Metichilin Resistant Staphylococcus Aureus (MRSA). Aktivitas antimikroba dari senyawa yang diisolasi diukur dengan metode difusi cakram. Fraksi n-heksan dari Clerodendrum paniculatum memiliki aktivitas antimikroba terhadap Pseudomonas aeruginosa dengan inhibisi 9,43 ± 0,057; 8,76 ± 0,057; 8,17 ± 0,115; 7,03 ± 0,057 dan terhadap MRSA 6,07 ± 0,057; 6,03 ± 0,057; 6,03 ± 0,115; 6,03 ± 0,057 pada konsentrasi 300 ppm, 200 ppm, 100 ppm dan 50 ppm. Fraksi air dari Clerodendrum paniculatum memiliki aktivitas antimikroba terhadap Pseudomonas aeruginosa dengan inhibisi 9,13 ± 0,057; 8,30 ± 0,100; 7,86 ± 0,057; 6,53 ± 0,057 dan terhadap MRSA 8.50 ± 0,100; 7,73 ± 0,057; 6,87 ± 0,057; 6,47 ± 0,057 pada konsentrasi 300 ppm, 200 ppm, 100 ppm dan 50 ppm. Hal ini menunjukkan fraksi n-heksan dan fraksi air dari Clerodendrum paniculatum memiliki potensi sebagai antimikroba yang baru.
Uji Ekstrak Etanol Kulit Buah Manggis (Garcinia mangostana L.) Terhadap Penurunan Kadar Glukosa Darah Fidayani Pasaribu; Panal Sitorus*; Saiful Bahri
Journal of Pharmaceutics and Pharmacology Vol 1, No 1 (2012)
Publisher : Journal of Pharmaceutics and Pharmacology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (220.797 KB)

Abstract

Background: Patients with diabetes mellitus are increasing with levels of affluence and the changing of lifestyles. Treatments of diabetes mellitus using conventional drugs are quite expensive and causing unwanted side effects. Therefore, it is necessary to find an effective drug with small side effect and low price. One of the alternative drugs that have an effect as anti-diabetic is mangosteen rind.Objective: The objective of this study was to determine the characteristics of mangosteen rind, phytochemical screening and the effect of ethanol extract of mangosteen rind to decrease blood glucose levels in male mice with glucose tolerance test.Method: This study was done using glucose tolerance test and ethanol extract of mangosteen rind with doses of 50, 100 and 200 mg/kg BW.Results: The results of the characterization of mangosteen rind were moisture content 7.96%, watersoluble extract concentration 12.98%, soluble in ethanol extract concentration 20.14%, total ash content 9.40% and insoluble ash content in acid 0.42%. The results of phytochemical screening of mangosteen rind and ethanol extract of mangosteen rind were alkaloids, flavonoids, glycosides, saponins, tannins and steroid/triterpenoid. The decreasing blood glucose level test of the ethanol extract of mangosteen rind doses of 50, 100 and 200 mg/kg BW gave a significant difference with control group (CMC 0.5%) and did not show significant difference with glibenclamide dose of 0.65 mg/kg BW (p > 0.05). Ethanol exctract of mangosteen rind dose of 100 mg/kg BW gave the best effect to decrease blood glucose level than dose 50 mg/kg BW and 200 mg/kg BW.Conclusion: It is concluded that ethanol extract of mangosteen rind has antidiabetic effect to the mice.Key words: mangosteen, ethanol extract, plasma glucose ABSTRAK Latar Belakang: Penderita diabetes mellitus dewasa ini terus meningkat seiring dengan meningkatnya tingkat kemakmuran dan berubahnya gaya hidup. Pengobatan diabetes mellitus menggunakan obat konvensional, harganya relatif mahal dan dapat menimbulkan efek samping yang tidak diinginkan. Oleh karena itu, perlu dicari obat yang efektif, efek samping yang relatif kecil dengan harga yang murah. Salah satu obat sebagai alternatif yang berefek sebagai antidiabetes mellitus adalah kulit buah manggis. Tujuan: Tujuan penelitian ini untuk mengetahui karakteristik simplisia kulit buah manggis, skrining fitokimia dan efek ekstrak etanol kulit buah manggis terhadap penurunan kadar glukosa darah. Metode: Pada penelitian ini dilakukan dengan menggunakan metode toleransi glukosa. Dosis ekstrak etanol kulit buah manggis yang digunakan adalah dosis 50, 100 dan 200 mg/kg BB. Hasil: Hasil karakteristik simplisia kulit buah manggis adalah kadar air 7,96%, kadar sari larut air 12,98%, kadar sari larut etanol 20,14%, kadar abu total 9,40%, dan kadar abu tidak larut asam 0,42%. Hasil skrining fitokimia simplisia dan ekstrak etanol kulit buah manggis adalah  alkaloida, flavonoida, glikosida, saponin, tanin, dan steroid/triterpenoid. Data hasil pengujian KGD dengan dosis 50, 100 dan 200 mg/kg BB memberikan penurunan kadar glukosa darah yang signifikan dan berbeda bermakna dibandingkan kelompok kontrol (CMC 0,5%) dan tidak memberikan perbedaan yang nyata dengan glibenklamid dosis 0,65 mg/kg BB (p > 0,05). Pemberian ekstrak etanol kulit buah manggis dengan dosis 100 mg/kg BB memberikan hasil yang lebih baik  terhadap penurunan kadar glukosa darah dibandingkan dengan dosis 50 mg/kg BB dan 200 mg/kg BB. Kesimpulan: Disimpulkan bahwa ekstrak etanol kulit buah manggis mempunyai efek sebagai antidiabetes terhadap mencit. Kata Kunci: manggis, ekstrak etanol, kadar glukosa darah *Korespondensi penulis: panal@usu.ac.id
UJI AKTIVITAS ANTIJAMUR EKSTRAK ETANOL KULIT BAWANG PUTIH (Allium sativum) DENGAN METODE DIFUSI CAKRAM Panal Sitorus; Eka Margaret Sinaga; Jon Kenedy Marpaung; Ayu Vevariantina
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (242.636 KB) | DOI: 10.51544/jf.v5i2.2734

Abstract

Fungal infections rarely cause dangerous conditions, one of which is Candida albicans. The use of antifungal drugs for the treatment of infectious diseases caused by fungi is now quite a lot, but the problem faced now is the occurrence of side effects for users, such as allergies, to other toxic hazards. Garlic (Allium sativum) since antiquity has shown broad antibiotic properties against gram-positive and gram-negative bacteria, including against multi-antibiotic-resistant strains. The purpose of this study was to determine the antifungal activity and effectiveness of ethanol extract of garlic peel against the fungus Candida albicans. The results showed that the yield of fresh simplicia was 10%, the extract yield was 8%. Examination of simplicia characteristics resulted in water content of 7.98%, water-soluble extract content of 18.11%, ethanol-soluble extract content of 7.30%, ash content of 1.06%, and acid insoluble ash content of 0.27%. Phytochemical screening results stated that garlic peel simplicia contained secondary metabolites of alkaloids, flavonoids, and saponins. The results of the inhibition test against the fungus candida Albicans using ethanol extract of garlic peel found antifungal effectiveness on the fungus candida Albicans. The conclusion of this study is that the ethanolic extract of garlic peel at concentrations of 500%, 400%, 300%, 200%, and 100% was less effective against the fungus Candida albicans.
ISOLASI DAN IDENTIFIKASI PEKTIN DARI KULIT PISANG MAS (Musa acuminata Colla) Panal Sitorus; Supartiningsih Supartiningsih; Jon Kenedy Marpaung; Bernadetta R. Munthe
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (565.14 KB)

Abstract

Pectin is one of the types of carbohydrate from polysacharide compound derivatives found in plan cell walls. pectin can be used in the viscosity, stability, texture and appearance of the food. The use of pectin in pharmacy is used for diarrhea, where pectin works as absordent in the intestine and also used as wound medicine as the hemostatic agent. The purpose of this research is utilize the mas banana peel as the source of pectin. This research was conducted by using the reflux extraction method using 1N hydrochloric acid as a solvent. Pectin isolation at pH 2, temperature 70-80-C for 60 minutes. The result of the precipitate is then added ethanol into the filtrate to precipitate the pectin and the final process is drying to obtain dry pectin which is 2.2975 gr. Dried pectin is obtained in the form of a fine powder, reddish brown in color and practically insoluble in ethanol. From the result of the identification that was carried out positive for the reaction with the addition of 96% ethanol and 2N NaOH, there was a gel which when added with 3N HCI and heated it formed brownish yellow lumps and had a distinctive odor. Physical specific characterization of pectin was also carried out, including moisture content (31.37%) and ash content (38.79%). Pure pectin standard for maximum moisture content of 12%, and maximum ash content of 10%. Pectin from mas banana (Musa acuminataColla) does not meet IPPA (International Pectin Producers Association) quality standards. Keywords: Banana peel, pectin, extraction, Reflux
KARAKTERISASI DAN SKRINING FITOKIMIA SERTA ANALISIS FLAVONOID DARI BUAH MENGKUDU (Morindacitrifolia L) SECARA KROMATOGRAFI LAPIS TIPIS Panal Sitorus; Suharyanisa Suharyanisa; Devina Chandra; Berton Sitanggang
Jurnal Farmanesia Vol 8 No 2 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (456.727 KB) | DOI: 10.51544/jf.v8i2.2793

Abstract

Noni fruit (Morindacitrifolia L.) is a medicinal plant that is well known by the people in Indonesia. Noni is efficacious as an immune enhancer, normalizes blood pressure, anti-cancer, analgesic, diabetes mellitus, heart disease, stroke, antimicrobial. To know the characteristics of simplicia and the class of compounds from the noni fruit as well as to analyze the flavonoid compounds contained in the noni fruit using the thin layer chromatography method. The flavonoid compounds were extracted by maceration using ethanol solvent and then the ethanol extract was tested by thin-layer chromatography using 1% HCl mobile phase and spotting with 1 N H2SO4 reagent and methanol pa (1: 1% v/v). Result of simplicia characterization of fruit Noni, obtained 1.32% water content, 38.41 % water soluble extract content, 16.7% ethanol soluble extract content, 6.09% total ash content, and 0.45 acid insoluble ash content. %. Noni fruit simplicia contains chemical compounds of alkaloids, tannins, flavonoids, triterpenoids/steroids, anthraquinones, saponins with phytochemical screening tests. The value of Rf from the analysis of noni fruit flavonoid compounds using the Thin Layer Chromatography method with 3 repetitions is 0.75; 0.68 and 0.62. This indicates the presence of flavonoid compounds in the noni fruit.
Sosialisasi dan Edukasi Kandungan Nitrit dan Nitrat dalam Sayuran serta Dampaknya terhadap Kesehatan Di Desa Buntu Bedimbar Panal Sitorus; Henni Cintya
Jurnal Pro-Life Vol. 9 No. 3 (2022): November
Publisher : Program Studi Pendidikan Biologi Fakultas Keguruan dan Ilmu Pendidikan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/jpvol6Iss2pp102

Abstract

The conversion of nitrates into nitrites in food is not only in vegetables as the main source, but also in drinking water, as well as in other foods such as processed meat products. The amount of consumption allowed by FAO / World Health Organization for a body weight of 60 kilograms is 220 milligrams for nitrates and 8 milligrams for nitrites. This activity received a very good and enthusiastic response from mothers of family walfare movement community (FWMC) members and all village officials. This activity was accompanied by 30 participants consisting of 20 women and 10 people from village features. Next, an observational survey was attempted by distributing questionnaires to measure the level of description of nitrites and nitrates and their effects on health. Next, an observational survey was attempted by distributing questionnaires to measure the level of description of nitrites and nitrates and their effects on health. The results show that 90% of FWMC members mothers after participating in this activity recognize nitrites and nitrates and the negative effects they cause, so they can apply them in their respective households for the health and welfare of the family
Uji Aktivitas ALT, AST dan Histopatologi Ekstrak Etanol Rimpang Temu Kunci (Boesenbergia rotunda (L.) Mansf) pada Tikus Putih Jantan Mawandha Sari Harahap; Urip Harahap; Panal Sitorus
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3262

Abstract

Experimental research in the field of hepatology on the development of traditional medicine into a potential pharmacological solution to protect the liver from cirrhosis. Accordingly, this study investigated the effect of ethanol extract of temu kunci rhizome on liver cirrhosis. The rats were divided into six groups, the normal control group was given nothing but pellets and sufficient water, the negative control group was given orally CMC-Na 0.5%, 200 mg acetylcysteine (dose converted to rat) was given to the positive control group, and the treatment group was given ethanol extract of temu kunci rhizome doses of 250, 500, 750 mg/kg BW, given daily for 10 days. Then on the 10th day after 1 hour of extract administration, induction was carried out with paracetamol 800 mg/kg BW orally; 16 hours after induction, rats were sacrificed, blood was taken for ALT and AST enzyme examination, then liver organs were taken for histopathological examination. The administration of ethanol extract of temu kunci rhizome can prevent liver damage by reducing ALT and AST enzyme levels in rat blood serum. The best dose in reducing ALT and AST enzymes was produced by giving 500 mg/kg BW of temu kunci rhizome ethanol extract every day for 10 days. At a dose of 500 mg/kg BW ethanol extract of temu kunci rhizome morphologically (evaluation with H&E staining) can also repair liver tissue damaged by paracetamol induction. The development of liver damage can be interpended by using ethanol extract of temu kunci rhizome, so that the status of liver morphology, structure and function of the liver can be maintained.
Co-Authors Ayu Vevariantina Bernadetta R. Munthe Berton Sitanggang Cintya, Henni Denny Satria Devina Chandra Dewi Pertiwi Effendy De Lux Putra, Effendy De Lux Eka Margareta Sinaga Fidayani Pasaribu Fikarwin Zuska Ihsanul Hafiz Jon Kenedy Marpaung Jon Kenedy Marpaung M. Fauzan Lubis Mahatir Muhammad Mawandha Sari Harahap Regina Marinta Sinaga Rosidah, Rosidah Saiful Bahri Suharyanisa Supartiningsih Supartiningsih Urip Harahap