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All Journal Jurnal Berkala Epidemiologi Health Notions Jurnal Aisyah : Jurnal Ilmu Kesehatan AKSONA Neurona Jurnal Widya Medika

Sudibyo, Devi Ariani

Department Of Neurology, Faculty Of Medicine, Universitas Airlangga Dr. Soetomo General Academic Hospital, Surabaya

Author-ID : 2410307

Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Injeksi Cairan Dekstrosa Hipertonik (Proloterapi) pada Osteoarthritis Lutut Kronis Muhammad Reza Fathoni; Devi Ariani Sudibyo
AKSONA Vol. 1 No. 2 (2021): JULY 2021
Publisher : Universitas Airlangga

Pendahuluan: Proloterapi juga dikenal sebagai terapi injeksi regeneratif atau skleroterapi adalah terapi yang menggunakan zat kimia atau biologi untuk kondisi nyeri muskuloskeletal kronis, termasuk osteoartritis lutut. Osteoartritis(OA) lutut adalah bentuk paling umum dari osteoarthritis kronis di seluruh dunia serta merupakan penyebab utama nyeri dan kecacatan dalam beberapa tahun terakhir, hasilbeberapa uji klinis yang dipublikasikan telah menunjukkan efek positif proloterapi pada osteoartritis lutut. Kasus: Wanita,51 tahun dengan nyeri lutut kanan sejak 1 tahun lalu, semakin memberat dalam 3 bulan. Numeric Rating Scale (NRS) adalah 7. Didapatkan tenderness, krepitasi, dan range of movement (ROM) normal tanpa adanya deformitaslutut kanan. Dari pemeriksaan radiologis didapatkan osteoarthritis femorotibial joint grade 1 dan osteoarthritis femoropatellar joint kanan. Injeksi dekstrosa hipertonik 25% dilakukan setiap 2 minggu. Sebelumnya pasien mendapat injeksi steroid intraartikuler (triamsinolon) namun nyeri kembali muncul setelah tiga minggu. Nilai Numeric Rating Scale (NRS) menurun menjadi 4 setelah dilakukan injeksi dekstrosa hipertonik yang keempat. Kesimpulan: Injeksi dekstrosa hipertonik (proloterapi) dapat dijadikan sebagai modalitas terapi alternatif yang menghasilkan perubahan klinis pada osteoarthritis lutut dengan resiko minimal, biaya terjangkau dan penggunaan yang mudah.

Azathioptrine in Refractory Tolosa-Hunt Syndrome: Two Case Report Devi Ariani Sudibyo; Mohammad Saiful Ardhi
AKSONA Vol. 2 No. 1 (2022): JANUARY 2022
Publisher : Universitas Airlangga

Introduction: Tolosa-Hunt syndrome (THS) is an inflammatory disease with painful ophthalmoplegia and unilateral periorbital headache as detailed by the International Classification of Headache Disorders, 3rd edition (ICHD-3). Azathioprine has been suggested as a second-line treatment in refractory THS when oral corticosteroid only gives a partial response. Case: Two cases of THS, 45-year-old and 41-year-old women with unilateral headache, drooping of the left upper eyelid, and diplopia. They presented with complete ophthalmoplegia and ophthalmic division of trigeminal nerve disturbance. Magnetic resonance imaging (MRI) showed thickening of the left cavernous sinus, suggesting THS, while the other was normal. Corticosteroid (prednisone 1-1,5 mg/day) was given orally for the first two weeks, and according to the Numeric Pain Rating Scale (NPRS), pain intensity was reduced from severe to moderate. As a second-line treatment, azathioprine (2 mg/kg/day) was given afterward, with a significant reduction in pain intensity and remission of ophthalmoplegia within seven days. Azathioprine was used as an immunosuppressive agent and was continued for another three months without any deterioration in neurological deficits. The levels of complement 3, 4 (C3, C4), and C-reactive protein (CRP) were normal in both patients, with a slight increase in erythrocyte sedimentation rate (ESR) and equivocal values on antinuclear antibody (ANA) results. Other differentials of THS were eliminated from history-taking, physical examination, and proper investigations. Conclusion: Azathioprine as a second-line treatment can be used instead of an oral corticosteroid for refractory cases of THS with fewer side effects. Complete remission of ophthalmoplegia and a significant reduction in pain intensity was obtained.

Pain Type and Quality of Life in Cervicogenic Headache Patients Sudibyo, Devi Ariani; Fathoni, M Reza; Puti, Nazla Ananda Rachmi
AKSONA Vol. 5 No. 1 (2025): JANUARY 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v5i1.52075

Highlight: Cervicogenic headache is the most incapacitating type, leading to significant physical impairment. Based on the data, there were 15 subjects in the nociceptive pain group and 15 subjects in the neuropathic pain group. There was a statistically significant correlation between the type of pain and the mental quality of life. In patients with cervicogenic headaches and neuropathic pain, there was a stronger relationship than those with nociceptive pain. ABSTRACT Introduction: Cervicogenic headache is classified as a secondary headache under the International Classification of Headache Disorders, third edition (ICHD-3). Significant neuropathic and nociceptive pain components are believed to be present in this condition, which eventually lowers quality of life by causing problems like anxiety, depression, and sleep disruptions. Objective: This study aimed to correlate pain types with quality of life in those suffering from cervicogenic headaches. Methods: A cross-sectional observational study was conducted at the Neurology Outpatient Clinic of Dr. Soetomo General Academic Hospital in Surabaya from June to August 2020. Quality of life and pain types were evaluated using the painDETECT and SF-36 questionnaires. A painDETECT score of 12 or less indicated nociceptive pain, but a score of more than 12 indicated neuropathic pain. An SF-36 score below 50 indicated a poor quality of life. Conclusion:Patients with cervicogenic headaches and neuropathic pain exhibited a lower quality of life compared to those experiencing nociceptive pain. These findings emphasize the importance of evaluating pain types to support the maintenance of a good quality of life.

Co-Authors Ardhi, Mohammad Saiful Dyah Kencono Wungu, Citrawati Fathoni, M Reza Fathoni, Muhammad Reza Florentina Sustini Imas Resa Palupi Inez Anabela Suprijadi Suprijadi Isti Suharjanti Machin, Abdulloh Maridsky, Aldilla Afifie Putri Marlon Yutimma Roestam Moenaf Muhammad Hamdan Muhammad Reza Fathoni Paulus Sugianto Pawana, I Putu Alit Puti, Nazla Ananda Rachmi Qurnianingsih, Ema Rochmanti, Maftuchah Rochmanti

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