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All Journal E-Jurnal Medika Udayana Universa Medicina Jurnal Kesehatan Reproduksi WICAKSANA: Jurnal Lingkungan dan Pembangunan Journal of Public Health and Pharmacy Folia Medica Indonesiana
Putu Indah Budi Apsari
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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LUMBAR SPINAL CANAL STENOSIS, DIAGNOSTIC AND MANAGEMENT Putu Indah Budi Apsari; I Ketut Suyasa; Sri Maliawan; Siki Kawiyana
E-Jurnal Medika Udayana vol 2 no 9 (2013):e-jurnal medika udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (160.476 KB)

Abstract

Lumbar spinal canal stenosis is a narrowing of the osteoligamentous vertebral canal and/or the intervertebral foramina causing compression of the thecal sac and/or the caudal nerve roots. The prevalence are five per 1000 person over 50 years old in USA. Male more than female, the most affect L4 -L5 and L3-L4. Low back pain is the most symptom. Routine diagnostic examination can be done plain x-ray lumbosacral, CT scan, and MRI. Management therapy can divide to two conservative and operative therapy. Complication of operative therapy is infection, vacular injury, cardiorespiratory disturbance due to embolization and death. The prognosis related with severity of symptom, degree of stenosis, surgical procedure and comorbid conditions.
In-vivo antimalarial activity of Holothuria scabra simplicia in Plasmodium berghei-infected mice Sri Laksemi, Dewa Ayu Agus; Asri Damayanti, Putu Ayu; Sudarmaja, I Made; Tunas, I Ketut; Ratna Sundari, Luh Putu; Rustini, Ni Luh; Budi Apsari, Putu Indah
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.195-201

Abstract

BACKGROUNDMalaria remains one of the major causes of death worldwide. Holothuria scabra has a high nutritional content and many biological effects. The development of alternative anti-malarial drugs is necessary, considering that resistance to the newest anti-malarial drugs has been reported. This research study aimed to determine the anti-malarial effects of Holothuria scabra in mice infected with Plasmodium berghei. METHODSThis was a post-test only control group study conducted on 24 Balb/c mice. Peter’s four-day suppressive test was employed to ascertain the claimed anti-plasmodial effect of the simplicia. Following inoculation with P. berghei, all 24 mice were infected and randomized into 4 groups, namely 3 treatment groups and 1 control group. The control group was given carboxymethyl cellulose, two of the treatment groups were given doses of 10 and 100 mg/kg BW Holothuria scabra, respectively, using Peter’s four-day suppressive test, while the remaining treatment group received a dose of 100 mg/kgBW using the prophylactic method. Data were analyzed using One way ANOVA. RESULTSThe results showed by using both the four-day suppressive test and the prophylactic method, that Holothuria scabra has antimalarial activity. Holothuria scabra at a dose of 100 mg/kg BW was significantly effective in decreasing the percentage of parasitemia (p=0.000) and tended to inhibit the growth of Plasmodium berghei in mice (p=0.054). CONCLUSIONThis study demonstrated that Holothuria scabra possesses anti-plasmodial activity in mice. Hence, the sea cucumber could serve as a potential source of a newer antimalarial agent.
Efficacy and Safety of Cannabidiol for Anxiety: A Bibliometric Analysis and Systematic Review Fajaryani, Putu Ayu Putri; I Made Agus Gelgel Wirasuta; Pande Made Nova Armita Sari; Dyah Kanya Wati; Putu Indah Budi Apsari; Made Ary Sarasmita
Journal of Public Health and Pharmacy Vol. 5 No. 3 (2025): November 2025
Publisher : Pusat Pengembangan Teknologi Informasi dan Jurnal Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jphp.v5i3.6807

Abstract

Introduction: A non-psychoactive substance present in the cannabis plant, cannabidiol (CBD), seems to have potential as an anxiolytic agent. This study systematically reviews the efficacy, safety, dosage, mechanisms, and adverse effects of CBD in treating anxiety. Methods: The PRISMA guideline was used to conduct the review. Results: A total of 64 articles were included in the study. It showed that CBD works at the endocannabinoid receptors CB1 and 5-HT1A, which regulate mood and reduce anxiety. In animal models, a range dosage of 5 – 10 mg/kg showed a significant anxiolytic effect in behavioral tests, while in humans, 300 mg/day was proven to be effective in treating various types of anxiety disorders. However, individual responses to CBD showed varying results, and demographic characteristics affect the efficacy of animal and human studies. CBD was also considered safer to be used in the short term compared to diazepam, although the long-term effect remains lacking evidence Conclusion: This study concludes that CBD has potential as an alternative choice for anxiety. Further research is needed in larger populations with rigorous study design and longer study durations to evaluate its effectiveness and ensure its safety. Recommendations for Future Research: It is hoped that future research can examine the effects of fly resistance and killing on non-target organisms and control environmental conditions.
Larvicidal Effect of Breadfruit (Artocarpus altilis) Flower Extract Against Aedes aegypti Winianti, Ni Wayan; Budi Apsari, Putu Indah; Jayanti, Ni Kadek Meta
Folia Medica Indonesiana Vol. 60, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: 1. This study attempted an experiment on the novel invention of a naturally sourced larvacide, specifically breadfruit (Artocarpus atilis) flower extract, against Aedes aegepti. 2. The findings of this study suggest that breadfruit flower extract can serve as an effective larvacide, as evident by an increased mortality rate of Aedes aegepti larvae. Abstract Dengue hemorrhagic fever remains a major problem in Indonesia. The mosquito that spreads this disease is the Aedes aegypti species. The use of larvicides is a viable method to inhibit the growth of larvae into adult mosquitoes. The flowers of breadfruits (Artocarpus atilis) have long been used as a natural mosquito killer. The objectives of this study were to determine the lethal dose 50 (LC50) of breadfruit flower extract and to analyze its potential as a larvicide against stage 2–3 instar Aedes aegypti larvae. In this true experimental research, each of four treatment groups was administered with breadfruit flower extracts at concentrations of 25, 50, 75, and 90 ppm, respectively. The positive control group was treated with temephos (Abate), while the negative control group received no treatment. Larval mortality was recorded at 1 hour, 2 hours, 3 hours, 4 hours post-intervention. The observed larval deaths were compared among the groups. Quantitative data encompassing the larval mortality in each group were analyzed using the repetitive analysis of variance (ANOVA) and the probit test with minimum p value <0.05. The results indicated that the LC50 value of breadfruit flower extract was 52.67–54.12 ppm. The doses of 50 ppm, 75 ppm and 90 ppm were effective in killing Aedes aegypti larvae. In conclusion, breadfruit flower extract of 50 ppm and higher can effectively kill Aedes aegypti larvae.
Perbandingan Karakteristik Ibu, Indikasi, dan Klasifikasi Robson pada Persalinan Seksio Sesarea Tahun 2013 dan 2018 Partamayani, Putu Devi Gema; Budi Apsari, Putu Indah; Budayasa, Anak Agung Gede Raka
JURNAL KESEHATAN REPRODUKSI Vol 13, No 1 (2026)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.92707

Abstract

Latar Belakang: Angka persalinan seksio sesarea terus meningkat secara global maupun nasional. Klasifikasi Robson direkomendasikan WHO sebagai metode standar untuk audit dan evaluasi seksio sesarea.Tujuan: Tujuan penelitian ini untuk menganalisis perbandingan karakteristik ibu, indikasi operasi, dan distribusi klasifikasi Robson pada persalinan seksio sesarea di sebuah rumah sakit daerah pada tahun 2013 dan 2018.Metode: Penelitian analitik dengan desain cross-sectional menggunakan data rekam medis ibu bersalin dengan seksio sesarea tahun 2013 dan 2018. Sampel total sebanyak 472 kasus (2013: 260; 2018: 212).Hasil: Terdapat tidak perbedaan distribusi usia ibu, paritas dan usia kehamilan antara tahun 2013 dan 2018. Distribusi indikasi seksio sesarea berbeda signifikan antara kedua tahun, dengan indikasi terbanyak tahun 2013 adalah riwayat seksio sesarea (24,2%), sedangkan tahun 2018 adalah gawat janin (27,4%). Distribusi kelompok Robson tahun 2013 didominasi kelompok Robson 2 (31,9%), sedangkan tahun 2018 didominasi kelompok Robson 4 (24,5%).Kesimpulan: Terdapat perubahan signifikan pada distribusi usia, indikasi, dan klasifikasi Robson persalinan seksio sesarea antara tahun 2013 dan 2018. Audit berkelanjutan menggunakan klasifikasi Robson diperlukan untuk mengendalikan angka seksio sesarea.
MEDITATION FOR A BETTER LIFE AS A POTENTIAL WELLNESS TOURISM IN BALI Putu Indah Budi Apsari
WICAKSANA: Jurnal Lingkungan dan Pembangunan Vol. 3 No. 2 (2019)
Publisher : Lembaga Penelitian, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wicaksana.3.2.2019.71-83

Abstract

Meditasi merupakan teknik latihan konsentrasi yang digunakan untuk dapat meningkatkan taraf kesadaran, yang selanjutnya dapat membawa proses-proses mental dapat lebih terkontrol secara safar. Saat orang melakukan meditasi, frekuensi getaran gelombang otak turun, nafas akan melambat, dan oksigen yang terpakai menjadi hemat. Gelombang otak tersebut akan mencapai alam bawah sadar dan gelombang otak akan mendatar dan berada pada keadaan alpha keadaan ini dinamakan keadaan homeostatis atau seimbang, sehingga otak akan mengeluarkan hormon endorphin dan terjadilah self healing. Meditasi selain bisa digunakan untuk mengurangi stres dan hipertensi tentunya bisa sebagai perkembangan wellness tourism. Wellness tourism saat ini perlahan sudah mulai muncul dan menjadi trend di masyarakat salah satunya yang dilakukan di Thailand dengan walking meditation. Wellness tourism adalah sebuah produk berupa jasa pariwisata yang dapat dikembangkan atau dikreasikan ragamnya sesuai dengan kondisi sebuah destinasi baik dari sisi sosial maupun lingkungan. Wellness tourism memiliki banyak cabang diantaranya spa, yoga, dan meditasi. Banyak negara yang mulai mengembangkan wellness tourism salah satunya di Thailand dan di Bali. Thailand dan Bali memiliki keunggulannya masing-masing. Meditasi di Thailand dimasukkan ke dalam paket tour sehingga wisatawan yang belum pernah mencoba meditasi sebelumnya bisa mencoba hal tersebut. Berbeda dengan di Bali meditasi biasanya jarang dimasukkan ke dalam paket tour sehingga tempat meditasi di Bali membutuhkan pemasaran yang lebih baik. Selain itu untuk masalah akses informasi mengenai meditasi di Bali sendiri masih kurang baik dibandingkan Thailand sehingga perlu ditingkatkan untuk akses informasi sehingga wisatawan akan lebih mudah mengetahui informasi. Harga meditasi di Bali juga cenderung lebih mahal dibandingkan Thailand.
Co-Authors Budayasa, Anak Agung Gede Raka Dyah Kanya Wati Fajaryani, Putu Ayu Putri I Ketut Suyasa I Ketut Tunas I Made Sudarmaja Jayanti, Ni Kadek Meta Ketut Siki Kawiyana Luh Putu Ratna Sundari Ni Kadek Meta Jayanti Ni Luh Rustini Ni Made Ary Sarasmita Ni Wayan Widhidewi Ni Wayan Winianti Pande Made Nova Armita Sari, Pande Made Nova Partamayani, Putu Devi Gema Putu Ayu Asri Damayanti Putu Sutisna Sri Laksemi, Dewa Ayu Agus Sri Maliawan Winianti, Ni Wayan