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All Journal E-Jurnal Medika Udayana Universa Medicina WICAKSANA: Jurnal Lingkungan dan Pembangunan Journal of Public Health and Pharmacy Folia Medica Indonesiana
Putu Indah Budi Apsari
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Journal : Universa Medicina

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In-vivo antimalarial activity of Holothuria scabra simplicia in Plasmodium berghei-infected mice Sri Laksemi, Dewa Ayu Agus; Asri Damayanti, Putu Ayu; Sudarmaja, I Made; Tunas, I Ketut; Ratna Sundari, Luh Putu; Rustini, Ni Luh; Budi Apsari, Putu Indah
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.195-201

Abstract

BACKGROUNDMalaria remains one of the major causes of death worldwide. Holothuria scabra has a high nutritional content and many biological effects. The development of alternative anti-malarial drugs is necessary, considering that resistance to the newest anti-malarial drugs has been reported. This research study aimed to determine the anti-malarial effects of Holothuria scabra in mice infected with Plasmodium berghei. METHODSThis was a post-test only control group study conducted on 24 Balb/c mice. Peter’s four-day suppressive test was employed to ascertain the claimed anti-plasmodial effect of the simplicia. Following inoculation with P. berghei, all 24 mice were infected and randomized into 4 groups, namely 3 treatment groups and 1 control group. The control group was given carboxymethyl cellulose, two of the treatment groups were given doses of 10 and 100 mg/kg BW Holothuria scabra, respectively, using Peter’s four-day suppressive test, while the remaining treatment group received a dose of 100 mg/kgBW using the prophylactic method. Data were analyzed using One way ANOVA. RESULTSThe results showed by using both the four-day suppressive test and the prophylactic method, that Holothuria scabra has antimalarial activity. Holothuria scabra at a dose of 100 mg/kg BW was significantly effective in decreasing the percentage of parasitemia (p=0.000) and tended to inhibit the growth of Plasmodium berghei in mice (p=0.054). CONCLUSIONThis study demonstrated that Holothuria scabra possesses anti-plasmodial activity in mice. Hence, the sea cucumber could serve as a potential source of a newer antimalarial agent.
Co-Authors Dyah Kanya Wati Fajaryani, Putu Ayu Putri I Ketut Suyasa I Ketut Tunas I Made Sudarmaja Jayanti, Ni Kadek Meta Ketut Siki Kawiyana Luh Putu Ratna Sundari Ni Kadek Meta Jayanti Ni Luh Rustini Ni Made Ary Sarasmita Ni Wayan Widhidewi Ni Wayan Widhidewi Ni Wayan Winianti Pande Made Nova Armita Sari, Pande Made Nova Putu Ayu Asri Damayanti Putu Sutisna Sri Laksemi, Dewa Ayu Agus Sri Maliawan Winianti, Ni Wayan