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All Journal Medical Journal of Indonesia Oto Rhino Laryngologica Indonesiana Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Indonesian Journal of Cancer Jurnal Penyakit Dalam Indonesia
Rahmat Cahyanur
Faculty of Medicine Universitas Indonesia Cipto Mangunkusumo General Hospital, Jakarta
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Kerentanan dan Kanker pada Usia Lanjut: Sebuah Tantangan Cahyanur, Rahmat
Jurnal Penyakit Dalam Indonesia
Publisher : UI Scholars Hub

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Gambaran Klinis dan Proporsi Hipotiroidisme Sekunder pada Pasien Adenoma Hipofisis di Rumah Sakit Cipto Mangunkusumo Cahyanur, Rahmat; Soewondo, Pradana; Darmowidjojo, Budiman; Aman, Renindra Ananda; Dewiasty, Esthika
Majalah Kedokteran Indonesia Vol 68 No 6 (2018): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.68.6-2018-57

Abstract

Pendahuluan: Adenoma hipofisis merupakan tumor yang berasal dari jaringan hipofisis anterior. Manifestasi klinis timbul akibat pendesakan massa dan gangguan sekresi hormon. Salah satu gangguan hormonal yang ditimbulkan adalah hipotiroidisme sekunder. Hipotiroidisme sekunder terkait dengan penurunan kualitas hidup serta peningkatan risiko kardiovaskular. Tujuan: Mengetahui proporsi hipotiroidisme sekunder dan gambaran klinis pasien adenoma hipofisis. Metode: Penelitian ini adalah studi potong lintang. Data diambil dari rekam medis pasien di Rumah Sakit Cipto Mangunkusumo antara tahun 2007-2012. Data demografis (usia, jenis kelamin), karakteristik klinis, jenis adenoma, data radiologis, pemeriksaan hormon (T4 bebas dan TSH) dievaluasi pada peneltian ini. Hasil: Terdapat 45 pasien yang memenuhi kriteria penelitian ini. Sebagian besar subyek adalah wanita (62,2%). Keluhan utama subyek adalah gangguan penglihatan (55,6%). Gejala yang sering ditemukan adalah sakit kepala (86,7%), gangguan penglihatan (77,8%). Pada subyek wanita manifestasi yang pertama kali muncul adalah gangguan penglihatan dan gangguan fungsi seksual (39,3% dan 32,1%). Pada Usia muda, gejala pertama kali muncul lebih pada kelompok adenoma fungsional dibandingkan non fungsional (32,9 vs. 40,6). Hampir seluruh kasus yang ditemukan adalah makroadenoma (97,8%). Proporsi subyek yang mengalami hipotiroidisme sekunder adalah 40%. Subyek dengan hipotiroidisme sekunder lebih banyak mengeluhkan gangguan penglihatan dan gangguan ereksi. Kesimpulan: Gangguan penglihatan adalah keluhan utama yang sering ditemukan. Pada subyek wanita, keluhan gangguan fungsi seksual bersama dengan gangguan penglihatan adalah manifestasi yang pertama kali muncul. Proporsi hipotiroidisme sekunder pada penelitian ini adalah 40,0%. Subyek dengan hipotiroidisme sekunder lebih banyak mengeluhkan gangguan penglihatan, gangguan ereksi.
Konsumsi Kopi Mengurangi Angka Kematian pada Pasien dengan Infark Miokard Akut Johan, Kenneth; Cahyanur, Rahmat; Resultanti, Resultanti
Majalah Kedokteran Indonesia Vol 70 No 2 (2020): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.70.2-2020-172

Abstract

Aim: Acute myocardial infarction (AMI) is the number one cause of death in 2000. Usually, coffee restriction was advised to patients with cardiovascular diseases. Recent studies indicate coffee might have a cardioprotective effect.Method: Systematic search was done on Pubmed and Cochrane. Title and abstract screening were initiated on 12 articles, followed by selection with inclusion and exclusion criteria, and selected one meta-analysis study to be critically appraised. Result: The meta-analysis study appraised resulted with a good score. Reduction in mortality rate was found, and an inverse relationship was concluded between heavy coffee consumption versus no consumption and mortality in acute myocardial infarction patients. RR = 0.54 95% CI [0.45 – 0.65].Conclusion: Coffee consumption and mortality in myocardial infarction patients have an inverse relationship, with the highest risk reduction found in heavy coffee drinkers.
Peran radioterapi lokoregional pada kasus karsinoma nasofaring dengan metastasis jauh: laporan serial kasus berbasis bukti Mayangsari, Ika Dewi; Rahman, Muhammad Ade; Adham, Marlinda; Prajogi, Gregorius Ben; Cahyanur, Rahmat; Safitri, Eka Dian
Oto Rhino Laryngologica Indonesiana Vol. 53 No. 2 (2023): VOLUME 53, NO. 2 JULY - DECEMBER 2023
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v53i2.638

Abstract

Background: Nasopharyngeal carcinoma (NPC) is a highly metastatic head and neck cancer primarilytreated with platinum-based chemotherapy. The oligometastasis hypothesis proposed by Hellman andWeichselbaum suggested that controlling the primary tumor through locoregional radiotherapy couldsignificantly improve prolonged disease-free survival. Purpose: To evaluate the effectiveness of combining locoregional radiotherapy with chemotherapy for metastatic NPC. Case series report: The first case involved a 57-year-old male with NPC at T4N3M1 (lungs) with partial response to chemotherapy, who then underwent concurrent chemoradiotherapy. However, his condition deteriorated after completing chemoradiation. The second case featured a 56-year-old male with NPC at T4N3M1 (liver), exhibiting partial response to chemotherapy and remaining at a stable condition after concurrent chemoradiotherapy. Method: Using specific keywords based on clinical questions in the PubMed, Cochrane, EBSCOhost, and Proquest databases. Inclusion criteria, exclusion criteria, and critical appraisal were carried out to find relevant studies. Result: Eleven articles were appraised critically based on the Oxford Centre for Evidence-based Medicine (CEBM) worksheet and include the validity, importance, and applicability in clinical scenarios. Conclusion: Metastatic NPC patients had better overall survival outcomes when treated with locoregional radiotherapy and systemic chemotherapy. Predictive factors influencing survival included oligometastasis, locoregional radiotherapy, chemotherapy response, lactate dehydrogenase, C-reactive protein, EBV DNA, total chemotherapy administration, Karnofsky performance score, number of metastatic lesions, and liver metastases. Platinum-based chemotherapy combined with locoregional radiotherapy could be considered as a management approach for cases of oligometastatic NPC.Keywords: nasopharyngeal carcinoma, chemotherapy, metastasis, overall survival, radiotherapy
Association between immune system parameter and clinical characteristics among patients with solid cancer Cahyanur, Rahmat; Widhani, Alvina; Pantoro, Nico Iswanto; Madadika, Annisa Tsana
Medical Journal of Indonesia Vol. 33 No. 2 (2024): June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247272

Abstract

BACKGROUND Lymphopenia has been reported to be a major predictor of chemotherapy-related toxicity. This study aimed to investigate the correlation between neutrophils, lymphocytes, CD4, and CD8 in solid cancer patients and cancer clinical characteristics. METHODS This was a cross-sectional study of patients who will undergo chemotherapy at the Hematology and Medical Oncology Clinic, Cipto Mangunkusumo Hospital, from June to September 2023. Clinical characteristics, CD4 and CD8 levels, and neutrophil and lymphocyte counts were assessed at the first visit. A comparative test was carried out on the patients’ average CD4, CD8, neutrophil, and lymphocyte counts. RESULTS Types of cancer were associated with CD4 levels. Patients with head and neck cancer had lower CD4 levels (411.3 [119.3–1,427.5] cells/mm³) compared with colorectal (514.7 [129.2–861.3] cells/mm³), breast and gynecological (567.5 [180.1–939 cells/mm³), and other cancers (681.4 [175.1–2,056.9] cells/mm³), with p = 0.009. Patients aged ≥40 years had higher CD8 levels than those aged <40 years (376.4 [142.8–1,293.1] cells/mm³ versus 565.3 [185.9–1,944] cells/mm³, p = 0.01). Additionally, lymphocyte count was associated with cancer type, with the lowest number in head and neck cancer (1,380 [280–2,660] μl, p = 0.044). CONCLUSIONS CD4 levels and lymphocyte counts were associated with the cancer type, whereas CD8 levels were influenced by age.
Co-Authors Affadhia, Hanna Lianti Alvina Widhani, Alvina Aman, Renindra Ananda Aman, Renindra Ananda Andhika Rachman Andree Kurniawan Asicha, Nur Budiman Darmowidjojo, Budiman Cosphiadi Irawan Dimas Priantono, Dimas Esthika Dewiasty, Esthika Gurmeet Singh Hasan Maulahela, Hasan Hayatun Nufus Ikhwan Rinaldi Johan, Kenneth Johannes Sarwono Josephine, Jennifer Linda Armelia Madadika, Annisa Tsana Maharani, Sausan Hana Marlinda Adham Maruhum B.H. Marbun Mayangsari, Ika Dewi Mayangsari, Ika Dewi Nadia Ayu Mulansari, Nadia Ayu Nur Atikah Pangestu, Andhika Pantoro, Nico Iswanto Pradana Soewondo Prajogi, Gregorius Ben Pravita, Aravinda Rahman, Muhammad Ade Ramadan, Edwin Ti Resultanti, Resultanti Safitri, Eka Dian Sharfina, Ratuafni Sri Wahdini Teguh Harjono Karjadi, Teguh Harjono Wulyo Rajabto