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All Journal SALAM: Jurnal Sosial dan Budaya Syar-i Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Prima Medika Sains Indonesian Journal of Health Sciences Research and Development (IJHSRD) Cermin Dunia Kedokteran Eduvest - Journal of Universal Studies Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Jurnal Sakato Ekasakti Law Review
Rudi Chandra
Fakultas Kedokteran Universitas Kristen Maranatha
Religion Aerospace Engineering Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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In Vivo Macroscopic Study of Ziziphus jujuba Extract Ointment in Accelerated Burn Wound Healing in Rats Taniago, Davina; Suandy, Suandy; Chandra, Rudi
Eduvest - Journal of Universal Studies Vol. 5 No. 11 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i11.52394

Abstract

Burns are type of injury that damage the skin which caused by exposure to heat sources that requiring comprehensive management and potentially leading to high morbidity. Limited resources and costs often encourage the use of herbal ingridients as an alternative. Ziziphus jujuba (Chinese date) has been traditionally used in Chinese medicine (TCM) for its healing property. Ziziphus jujuba contains various bioactive compounds such as flavonoids, saponins, and tannins that contribute to wound healing through their anti-inflammatory, antioxidant and regenerative mechanisms. This study aims to test the effectiveness of Ziziphus jujuba extract ointment on burn wound healing in Rattus norvegicus. Ointment preparations were made in concentrations of 10 mg/mL and 20 mg/mL, then tested physically (organoleptic, homogeneity, pH, spreadability). This study used a trueexperimental method with a post-test only control group design, involving four treatment groups, each consisting of six rats with back burns: control (K), MEBO as control positive (P1), 10 mg/mL Ziziphus jujuba extract ointment (P2), and 20 mg/mL Ziziphus jujuba extract ointment (P3). The study was conducted 21-day obervation period to evaluate wound diameter, wound healing percentage, macroscopic and microscopic assesment based on the modified Nagaoka criteria. The group treated with Ziziphus jujuba ointment 20 mg/mL (P3) achieved the best healing outcomes, chracterized by faster wound reduction, minimal adverse local and allergic reactions, and shorter healing period than those observed in the control and other treatment groups.
Co-Authors Abdul Arif, Abdul Alexander, Rico Antonius, Cayadi S Balqis, Nurliya Darmi, Mila Djohan - Djohan Djohan Edy Fachrial Felix Felix Filzah, Cut Echi Razita Sabrina Ida Susilowati Iyah Faniyah, Iyah Jusuf, Nelva K. Lubis, Ramona D Mukhtar, Zulfikri Nasution, Syamsul Arifin Natali, Oliviti Norawati, Lilik Oentari, Widyaningsih Rahimi, Armon Roesyanto-Mahadi, Irma Damayanti Samuel S Putranto Sihombing, Fenny Theresia Sinaga, Marlina Suandy, Suandy Susi Delmiati Taniago, Davina Valensia, Valensia