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All Journal Indonesian Journal of Pure and Applied Chemistry Molekul: Jurnal Ilmiah Kimia Molekul: Jurnal Ilmiah Kimia
Mochammad Chasani
Chemistry Department, Faculty of Science and Engineering, Universitas Jenderal Soedirman, Karangwangkal, Purwokerto 53122
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology

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SEMI SINTESIS SENYAWA 2,4,6-TRINITROFENILHIDRAZON KALANON DAN UJI AKTIVITAS TERHADAP SEL LEUKIMIA L1210 Chasani, Mochammad; Iswanto, Ponco; Vaulina, Eva; Satria Putra, Winkanda; Hanafi, M
Molekul Vol 6, No 2 (2011)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2011.6.2.94

Abstract

Kalanon adalah senyawa antikanker yang diisolasi dari Calophyllum biflorum Hends dan Ws. Aktivitas kalanon terhadap sel leukemia L1210 masih rendah yakni dengan niali IC50 = 59,4 ug/mL. Suatu senyawa dikatakan aktif sebagai antikanker jjika memiliki nilai IC50 di bawah 10 ug/mL. Penelitian ini ditujukan untuk mensintesis senyawa turunan kalanon dan diharapkan diperoleh senyawa baru yang mempunyai aktivitas lebih tinggi dibandingkan senyawa asal kalanon.Senyawa turunan kalanon diperoleh melalui reaksi antara kalanon dengan 2,4,6-trinitrofenilhidrazin. Reaksi dilakukan pada suhu 78 oC selama delapan jam. Analisis pendahuluan senyawa hasil sintesis dilakukan dengan metode kromatografi lapis tipis (KLT) menggunakan eluen n-heksana dan etil asetat (2:1, v/v). Pemurnian senyawa hasil sintesis menggunakan teknik rekristalisasi dengan pelarut n-heksana dan diklorometan (3:1, v/v). Senyawa hasil sintesis diperoleh dengan Rf = 0,6609 dan rendemen 5,125 % ( b/b) serta berupa kristal berwarna coklat.Identifikasi senyawa hasil sintesis dilakukan dengan spektrometer massa dan spektrofotometer IR. Hasil identifikasi menunjukkan bahwa senyawa hasil sintesis yang diharapkan telah terbentuk. Data spektrometer massa diperoleh ion molekul M+ = 647 dengan lepasnya molekul H2. Fragmen-fragmen yang terbentuk adalah pada m/e = 504, m/e = 479, m/e = 451, m/e = 429, m/e = 405, m/e = 377, m/e = 341, m/e = 316, m/e = 281, m/e = 253, m/e = 233, m/e = 207, m/e = 177, m/e = 156, m/e = 135, m/e = 96, m/e = 73, dan m/e = 41. Hasil spektrofotometer IR menunjukkan pita serapan pada 1654.8 cm-1 yang merupakan daerah regang ikatan rangkap C=N, pita serapan pada 3000 cm-1 ? 3400 cm-1 adalah pita getaran OH fenol dan pita pada 1380 cm-1menunjukkan rentangan simetri gugus nitro (NO2). Hasil uji sitotoksik terhadap sel leukemia L1210 menghasilkan nilai IC50 sebesr 47.69 ?g/ml.
Formulation, Characterization, and Sunscreen Potential Evaluation of Nutmeg Leaf Essential Oil Nanoemulsions (Myristica fragrans Houtt.) Rastuti, Undri; Widyaningsih, Senny; Chasani, Mochammad; Habibie, Ranti Kamila; Elly, Vani Fitria Rosita; Zia, Sity Khalidah
Molekul Vol 18 No 3 (2023)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2023.18.3.6872

Abstract

Nutmeg leaf essential oil (Myristica Fragrans Houtt.) is one of the natural ingredients which have antioxidant activity and potential as a sunscreen. The research aims to formulate nutmeg leaf essential oil nanoemulsion, characterize, and determine its potency as a sunscreen. Nutmeg leaf essential oil nanoemulsion was formulated with 1; 3; and 5 mL of oil content with two variations of surfactant. The characterization included organoleptic, pH, viscosity, %T, nanoemulsion type, droplet size, thermodynamic and centrifugation stability tests. Evaluation was conducted using UV-Vis spectrophotometer at a wavelength range of 290-400 nm with ethanol as a blank and non-nano-emulsified as a comparison. The result showed that the nutmeg leaf essential oil nanoemulsion had clear and stable appearance, safe for skin, viscosity values of <200 mPas, %T values of near 100%, nanoemulsions type of o/w, and particles size of <200 nm. The evaluation showed that the sunscreen activities of nutmeg leaf oil nanoemulsion was higher than non-nano-emulsified. The highest sunscreen activity was the formula A nanoemulsion which an oil content of 5 mL and had an SPF value of 1.475; %Te value of 50.571%; and %Tp value of 77.218%. The nanoemulsion sunscreen activity of formula A was categorized as a regular suntan
NANO ANTIBACTERIAL LIQUID SOAP FORMULATION BASED ON NYAMPLUNG SEED OIL WITH ACTIVE INGREDIENTS METHANOL EXTRACT OF KETAPANG FRUIT Chasani, Mochammad; Riyani, Kapti; Setyaningtyas, Tien; Putri, Prima Dwi Rahma; Saputra, Dimas
Indonesian Journal of Pure and Applied Chemistry Vol 8, No 3 (2025)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v8i3.76190

Abstract

The development of science and technology in cosmetics is shifting towards a natural approach, utilizing natural ingredients with potential benefits. Nyamplung seed oil is an abundant, non-edible oil that contains fatty acid chains with the potential to serve as a base for soap. The optimization of the soap effect is achieved through a nanoformulation using the sonication method to enhance sound delivery. The objective of this study is to produce soap products from a methanol extract of Ketapang flesh with the best characteristics according to SNI and to determine the effect of a liquid soap nanoformula on antibacterial activity. The results of the study showed that SA1 (a 1% methanol extract of Ketapang flesh) is a liquid soap with the best characteristics according to the SNI. The characterization results are as follows: pH 9.185, density 1.0212 g/mL, total fatty acid percentage 66.93%, neutral fatty acids 3.5356%, free fat 2.2533%, and foam stability 88.50%. The antibacterial activity of liquid soap (SA1) of nanoformula was higher than that of non-nano with an inhibition zone against Staphylococcus aureus of 19.97 mm and 18.04 mm.
Co-Authors Elly, Vani Fitria Rosita Habibie, Ranti Kamila Kapti Riyani M Hanafi Ponco Iswanto Putri, Prima Dwi Rahma Saputra, Dimas Satria Putra, Winkanda Senny Widyaningsih Tien Setyaningtyas Undri Rastuti Vaulina, Eva Zia, Sity Khalidah