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All Journal Indonesian Journal of Chemistry Molekul: Jurnal Ilmiah Kimia
Habibie, Ranti Kamila
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology

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Formulation, Characterization, and Sunscreen Potential Evaluation of Nutmeg Leaf Essential Oil Nanoemulsions (Myristica fragrans Houtt.) Rastuti, Undri; Widyaningsih, Senny; Chasani, Mochammad; Habibie, Ranti Kamila; Elly, Vani Fitria Rosita; Zia, Sity Khalidah
Molekul Vol 18 No 3 (2023)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2023.18.3.6872

Abstract

Nutmeg leaf essential oil (Myristica Fragrans Houtt.) is one of the natural ingredients which have antioxidant activity and potential as a sunscreen. The research aims to formulate nutmeg leaf essential oil nanoemulsion, characterize, and determine its potency as a sunscreen. Nutmeg leaf essential oil nanoemulsion was formulated with 1; 3; and 5 mL of oil content with two variations of surfactant. The characterization included organoleptic, pH, viscosity, %T, nanoemulsion type, droplet size, thermodynamic and centrifugation stability tests. Evaluation was conducted using UV-Vis spectrophotometer at a wavelength range of 290-400 nm with ethanol as a blank and non-nano-emulsified as a comparison. The result showed that the nutmeg leaf essential oil nanoemulsion had clear and stable appearance, safe for skin, viscosity values of <200 mPas, %T values of near 100%, nanoemulsions type of o/w, and particles size of <200 nm. The evaluation showed that the sunscreen activities of nutmeg leaf oil nanoemulsion was higher than non-nano-emulsified. The highest sunscreen activity was the formula A nanoemulsion which an oil content of 5 mL and had an SPF value of 1.475; %Te value of 50.571%; and %Tp value of 77.218%. The nanoemulsion sunscreen activity of formula A was categorized as a regular suntan
Antibacterial Test of The Essential Oil Fractions of Citronella (Cymbopogon nardus L.) Against Escherichia coli and Application as Hand Sanitizer Formulation Rastuti, Undri; Lestari, Puji; Hidayatullah, Rafly; Habibie, Ranti Kamila
Molekul Vol 19 No 2 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.2.9773

Abstract

ABSTRACT. Hand sanitizer is an essential item during the COVID-19 pandemic, posing potential side effects when containing synthetic ingredients. Therefore, this study aimed to replace hand sanitizer formulation with Citronella essential oil (Cymbopogon nardus L.). Essential oil was fractioned into 3 components, namely F1 (67.07% of limonene), F2 (92.39% of citronellal), and F3 (62.41% of geraniol) while evaluation was conducted on antibacterial properties against E. coli. Antibacterial test was performed using the well diffusion method, showing inhibition zone diameters of 7.40, 10.76, and 8.30 mm for F1 to F3 fractions, respectively. The results showed that F2, selected as the reference for hand sanitizer formulation, had the most potential antibacterial activity and a MIC of 3.125%. Comparative test with commercial alternatives, including hedonic, characteristic, and antibacterial activity test, were conducted to assess the formulated hand sanitizer. F2 was discovered to have an inhibition zone diameter of 29.56 mm as opposed to 9.06 mm of commercial hand sanitizer. Based on hendonic test, hand sanitizer formulated with citronella oil had a distinct smell, which was less preferred than lime fragrance. Keywords: Antibacterial, Escherichia coli, and sanitizer, citronella essential oil.
Toxicity Test of Nanoemulsions of Nutmeg Fruits and Leaves Essential Oil against Artemia salina Leach and Its Cytotoxicity Test against Breast Cancer Cells T47D Rastuti, Undri; Diastuti, Hartiwi; Widyaningsih, Senny; Chasani, Moch; Sheiliyani, Cindi; Rahmasari, Anisa; Fajriyah, Bunga Sita Roihanul; Mesayu, Puspa Rahma; Habibie, Ranti Kamila
Indonesian Journal of Chemistry Vol 24, No 5 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.91077

Abstract

Nutmeg (Myristica fragrans Houtt) is a widely known spice plant, which has been reported to offer several benefits. Therefore, this study aims to develop and analyze nanoemulsions of nutmeg leaves and fruit essential oil, as well as determine their toxicity and cytotoxicity. Nanoemulsions were formulated with varying concentrations of essential oil, including 0, 1, 2, 4, and 6%. Characterization included organoleptic assessment, pH measurement, type examination, viscosity testing, transmittance analysis, particle size distribution measurement, centrifugation, and freeze-thaw cycle test. Toxicity testing results using the brine shrimp lethality test (BSLT) showed that nanoemulsions were toxic except NF F4 with high toxicity. Cytotoxicity testing on T47D breast cancer cells showed moderate activity for NF F4 nanoemulsions (IC50: 34.363 ppm), while NL nanoemulsions were deemed inactive (IC50: 33576.430 ppm). In addition, the organoleptic characteristics of all nanoemulsions were stable, and most parameters met the desired standards. Based on the results, further studies exploring nanoemulsions with natural products must be carried out to determine their advantages, specifically in the development of sciences.
Co-Authors Chasani, Moch Elly, Vani Fitria Rosita Fajriyah, Bunga Sita Roihanul Hartiwi Diastuti Hidayatullah, Rafly Mesayu, Puspa Rahma Mochammad Chasani PUJI LESTARI Rahmasari, Anisa Senny Widyaningsih Sheiliyani, Cindi Undri Rastuti Zia, Sity Khalidah