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All Journal Jurnal Natur Indonesia Pharmaciana: Jurnal Kefarmasian Jurnal Sains dan Teknologi Kimia Prosiding KOVALEN: Jurnal Riset Kimia Indonesian Journal of Chemistry Molekul: Jurnal Ilmiah Kimia Dinamika Journal : Pengabdian Masyarakat Molekul: Jurnal Ilmiah Kimia Indonesian Journal of Chemical Science JURNAL REKAYASA KIMIA & LINGKUNGAN
Senny Widyaningsih
Universitas Jenderal Soedirman
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Energy Engineering Environmental Science Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Physics Other

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Formulasi Deterjen Berbahan Aktif Etil Ester Sulfonat dari Minyak Biji Ketapang (Terminalia cattapa) dengan Penambahan Enzim Papain Chasani, Moch.; -, Purwati; Widyaningsih, Senny; Larasati, Bina
Jurnal Sains dan Teknologi Kimia Vol 4, No 2 (2013): Jurnal Sains dan Teknologi Kimia
Publisher : Program Studi Kimia Jurusan Pendidikan Kimia FPMIPA UPI

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Abstract

Enzim papain merupakan salah satu enzim protease yang dapat dijadikan sebagai additive pada formulasi deterjen. Protease dalam deterjen secara spesifik membantu menghilangkan protein yang menodai pakaian. Penelitian ini bertujuan untuk mengkaji pengaruh penambahan enzim papain terhadap karakteristik deterjen berbahan aktif etil ester sulfonat dari minyak biji ketapang (Terminalia cattapa).    Karakteristik  deterjen  yang  ditentukan  meliputi:  Bahan  tidak  larut dalam  air,  Stabilitas  emulsi,  dan  Stabilitas  busa.  Hasil  penelitian  merupakan bahan tidak larut dalam air dari deterjen   tanpa papain dan deterjen dengan konsentrasi papain  1, 3, 5, 7, dan 9% (b/b)  berturut-turut sebesar 6; 6; 5; 4; 5, dan 4%. Stabilitas emulsi deterjen tanpa papain dan deterjen dengan konsentrasi papain 1, 3, 5, 7, dan 9% (b/b) berturut-turut adalah 93,05; 90,20; 90,70; 94,55; 94,60 dan 96,05% dan Stabilitas busa deterjen tanpa penambahan papain dan deterjen enzimatik dengan penambahan konsentrasi papain 1, 3, 5, 7, dan 9% (b/b) berturut-turut adalah 83,33; 70,00; 78,33; 78,59; 73,64, dan 77,50%.  Penambahan enzim papain pada deterjen hasil formulasi menggunakan surfaktan etil ester sulfonat dari minyak biji ketapang berpengaruh terhadap karakteristik deterjen yang meliputi bahan tidak larut dalam air, stabilitas emulsi, dan stabilitas busaKata kunci: Deterjen, Terminalia cattapa, papain.
DINAMIKA HIDRASI CERIUM (III) DALAM LARUTAN BERDASARKAN SIMULASI DINAMIKA MOLEKUL Iswanto, Ponco; Widyaningsih, Senny
Prosiding Vol 3, No 1 (2012)
Publisher : Prosiding

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Abstract

Penelitian tentang sifat dinamika hidrasi ion Ce3+ berdasarkan simulasi dinamika molekul telah dilakukan. Metode simulasi yang digunakan adalah simulasi dinamika molekul ab initio Quantum Mechanical Charge Field (QMCF). Metode ini membagi kotak simulasi menjadi 2 bagian. Bagian pertama yang meliputi lapisan hidrasi pertama dan kedua, dihitung dengan metode mekanika kuantum ab initio pada tingkatan teori Hartree–Fock (HF). Himpunan basis yang digunakan pada perhitungan mekanika kuantum untuk ion Ce3+ dan molekul air adalah SBKJC VDZ ECP dan DZP Dunning secara berurutan. Bagian kedua, di luar bagian pertama, dihitung dengan metode perhitungan mekanika klasik. Hasil penelitian menunjukkan bahwa ion Ce3+ memiliki lapisan hidrasi yang fleksibel pada lapisan hidrasi pertama dan kedua.
Konsentrasi Katalis dan Suhu Optimum pada Reaksi Esterifikasi menggunakan Katalis Zeolit Alam Aktif (ZAH) dalam Pembuatan Biodiesel dari Minyak Jelantah Kartika, Dwi; Widyaningsih, Senny
Jurnal Natur Indonesia Vol 14, No 3 (2012)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (208.189 KB) | DOI: 10.31258/jnat.14.3.219-226

Abstract

Transesterification of waste cooking oil into biodiesel using KOH catalyst with and without esterification process usingactivated natural zeolite (ZAH) catalyst has been carried out. Activation of the zeolite was done by refluxing with HCl 6Mfor 30 min, followed calcining and oxydized at 500oC for 2 hours, consecutively. The transesterification without esterificationprocess were done using KOH catalyst 1% (w/w) from oil and methanol weight and oil/methanol molar ratio 1:6 at 60oC. Theesterification reaction was also done using ZAH catalyst then continued by transesterification using KOH catalyst inmethanol media. In order to study the effect of ZAH catalyst concentration at constant temperature, the catalysts werevaried, i.e. 0, 1, 2, and 3% (w/w). To investigate the effect of temperature, the experiments were done at various temperaturefrom 30, 45, 60, and 70oC at constant catalyst concentration. The conversion of biodiesel was determined by 1H-NMRspectrometer and physical properties of biodiesel were determined using ASTM standard methods. The results showedthat the transesterification using KOH catalyst without esterification produced biodiesel conversion of 53.29%. The optimumcondition of biodiesel synthesis via esterification process were reached at 60oC and concentration of ZAH catalyst of2% (w/w), that could give biodiesel conversion = 100.00%. The physical properties were conformed with biodiesel ASTM2003b and Directorate General of Oil and Gas 2006 specification.
Peningkatan Pendapatan Melalui Pembuatan Nata de Coco di Kelurahan Bancarkembar Purwokerto Utara Senny Widyaningsih; Zusfahair Zusfahair; Purwati Purwati
Dinamika Journal : Pengabdian Masyarakat Vol 1, No 4 (2019)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.dj.2019.1.4.895

Abstract

Peningkatan pendapatan melalui pembuatan nata de coco telah dilakukan di Kelurahan Bancarkembar Kecamatan Purwokerto Utara Kabupaten Banyumas. Sasaran kegiatan ini adalah para pedagang jajanan sekolah. Para pedagang cenderung menggunakan bahan yang murah namun berbahaya sebagai bahan utama jualannya. Hal ini dikarenakan para penjual kebanyakan merupakan masyarakat yang berpenghasilan rendah. Upaya peningkatan pendapatan sangat diperlukan oleh mereka. Salah satu solusinya adalah dengan membina dan melatih mereka membuat makanan sehat yang dibuat dari bahan yang murah. Nata adalah salah satu makanan yang sehat yang dibuat dari bahan yang murah. Produk nata yang paling mudah pembuatannya adalah nata de coco yang dibuat dari air kelapa dengan metode fermentasi menggunakan bakteri Acetobacter xylinum. Kegiatan ini dilakukan melalui dua tahap. Tahap pertama adalah memberikan informasi melalui penyuluhan dan peragaan. Tahap kedua adalah mempraktekkan cara pembuatan nata de coco. Teknologi pembuatan nata ini dapat diterapkan pada para penjual makanan di lingkungan sekolah dasar di Kelurahan Bancarkembar Kabupaten Banyumas.
Liquid Soap from Nyamplung Seed Oil (Calophyllum inophyllum L) with Ketapang (Terminalia catappa L) as Antioxidant and Cardamom (Amomum compactum) as Fragrance Senny Widyaningsih; Mochammad Chasani; Hartiwi Diastuti; Wawan Nur Fredyono
Molekul Vol 13, No 2 (2018)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (270.561 KB) | DOI: 10.20884/1.jm.2018.13.2.461

Abstract

The non-edible oil from nyamplung seed (Callophyllum inophylum L.) has been widely used as a soap ingredient. The soap production from nyamplung seed oil with the addition of antioxidant and fragrance had been carried out in this research. Ketapang (Terminalia catappa L) fruit extract and Cardamom (Amomum compactum) were used as antioxidant and fragrance substances, respectively. The variation of concentration of antioxidant and fragrance has been carried out to obtain the high quality of soap. Characterization was done to know the quality of soap in accordance with SNI 06-4085-1996. The antioxidant activity was analyzed using DPPH (1,1-diphenyl-2-picrylhydrazyl). The results showed that the addition of 1% ketapang fruit extract and 3% cardamom fragrance exhibited the best characteristics. The antioxidant activity test showed that the IC50 value of the best antioxidant soap is 79.51 ppm, indicating that the soap is a strong category
Phytochemicals and toxicity of ketapang fruit flesh (Terminalia catappa. Linn) using the BSLT method Senny Widyaningsih; Mochamad Chasani; Undri Rastuti; Umi Salamah
Pharmaciana Vol 12, No 3 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (309.064 KB) | DOI: 10.12928/pharmaciana.v12i3.22219

Abstract

Ketapang is widely used in traditional medicine. Parts of ketapang plant, such as roots, leaves, and bark, are known to have biological activities such as antioxidant, antimicrobial, anti-inflammatory, and anticancer. However, no biological activity has been reported on the flesh of the ketapang fruit. This research was conducted to obtain phytochemicals and toxicity information of ketapang fruit flesh as an anticancer medicine. Toxicity indicates the potential for a chemical compound to cause damage to living organisms, while phytochemicals indicate a group of compounds that have biological activity. Extraction of ketapang fruit flesh was carried out using various solvents, both polar and non-polar solvents, methanol, n-hexane, and ethyl acetate. The toxicity test used the Brine Shrimp Lethality Test (BSLT) method, while phytochemicals tests used the thin layer chromatography (TLC), in which identification of bioactive compounds of ketapang pulp extract used UV-Visible and FTIR spectroscopy. The results showed that the ketapang fruit flesh extract was toxic to Artemia salina Leach shrimp larvae. The most toxic was ethyl acetate extract, with an LC50 value was 17,171 ppm. The phytochemicals screening showed that ethyl acetate extract of the ketapang fruit flesh contained flavonoid, alkaloid, phenolic, terpenoid, and saponin compounds. Tracing using UV-Vis shows the presence of conjugated double bonds which refer to flavonoid compounds, as well as the IR spectrum which indicates the presence of a typical functional group of flavonoid compounds.
Sintesis dan Uji Kinerja Membran Selulosa Termodifikasi Polistirena dari Ampas Tebu dengan Aditif Monosodium Glutamate untuk Menurunkan Nilai BOD dan COD Limbah Cair Tahu: Synthesis and Performance Testing of Modified Cellulose Membrane with Polystyrene Derived from Sugarcane Bagasse and Monosodium Glutamate Additive for Decreasing BOD and COD Values in Tofu Wastewater Alvino Jefferson Sianipar; Senny Widyaningsih; Suyata
KOVALEN: Jurnal Riset Kimia Vol. 9 No. 2 (2023): August Edition
Publisher : Chemistry Department, Mathematics and Natural Science Faculty, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/kovalen.2023.v9.i2.16443

Abstract

Tofu liquid waste, which has high BOD and COD values, can contaminate waters if it is directly disposed of without prior treatment. Therefore, waste treatment is necessary before being released into water. One method for treating this waste is by using a cellulose acetate membrane. In this research, a cellulose acetate membrane was synthesized from sugarcane bagasse fibers using the phase inversion method. The membrane was added 6% MSG as an additive to improve its performance. The membrane was applied to treat tofu waste with BOD and COD parameters. The membrane’s flux values obtained in this study were 33.56 L/(m².hour) for water and 26.85 L/(m².hour) for tofu liquid waste. SEM test result showed that the membrane with a 6% MSG additive had more pores and a denser surface compared to the membrane without the additive. The membrane was capable of decreasing BOD and COD values by 62.5% and 75.3% respectively in liquid tofu waste.
Formulation, Characterization, and Sunscreen Potential Evaluation of Nutmeg Leaf Essential Oil Nanoemulsions (Myristica fragrans Houtt.) Rastuti, Undri; Widyaningsih, Senny; Chasani, Mochammad; Habibie, Ranti Kamila; Elly, Vani Fitria Rosita; Zia, Sity Khalidah
Molekul Vol 18 No 3 (2023)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2023.18.3.6872

Abstract

Nutmeg leaf essential oil (Myristica Fragrans Houtt.) is one of the natural ingredients which have antioxidant activity and potential as a sunscreen. The research aims to formulate nutmeg leaf essential oil nanoemulsion, characterize, and determine its potency as a sunscreen. Nutmeg leaf essential oil nanoemulsion was formulated with 1; 3; and 5 mL of oil content with two variations of surfactant. The characterization included organoleptic, pH, viscosity, %T, nanoemulsion type, droplet size, thermodynamic and centrifugation stability tests. Evaluation was conducted using UV-Vis spectrophotometer at a wavelength range of 290-400 nm with ethanol as a blank and non-nano-emulsified as a comparison. The result showed that the nutmeg leaf essential oil nanoemulsion had clear and stable appearance, safe for skin, viscosity values of <200 mPas, %T values of near 100%, nanoemulsions type of o/w, and particles size of <200 nm. The evaluation showed that the sunscreen activities of nutmeg leaf oil nanoemulsion was higher than non-nano-emulsified. The highest sunscreen activity was the formula A nanoemulsion which an oil content of 5 mL and had an SPF value of 1.475; %Te value of 50.571%; and %Tp value of 77.218%. The nanoemulsion sunscreen activity of formula A was categorized as a regular suntan
Toxicity Test of Nanoemulsions of Nutmeg Fruits and Leaves Essential Oil against Artemia salina Leach and Its Cytotoxicity Test against Breast Cancer Cells T47D Rastuti, Undri; Diastuti, Hartiwi; Widyaningsih, Senny; Chasani, Moch; Sheiliyani, Cindi; Rahmasari, Anisa; Fajriyah, Bunga Sita Roihanul; Mesayu, Puspa Rahma; Habibie, Ranti Kamila
Indonesian Journal of Chemistry Vol 24, No 5 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.91077

Abstract

Nutmeg (Myristica fragrans Houtt) is a widely known spice plant, which has been reported to offer several benefits. Therefore, this study aims to develop and analyze nanoemulsions of nutmeg leaves and fruit essential oil, as well as determine their toxicity and cytotoxicity. Nanoemulsions were formulated with varying concentrations of essential oil, including 0, 1, 2, 4, and 6%. Characterization included organoleptic assessment, pH measurement, type examination, viscosity testing, transmittance analysis, particle size distribution measurement, centrifugation, and freeze-thaw cycle test. Toxicity testing results using the brine shrimp lethality test (BSLT) showed that nanoemulsions were toxic except NF F4 with high toxicity. Cytotoxicity testing on T47D breast cancer cells showed moderate activity for NF F4 nanoemulsions (IC50: 34.363 ppm), while NL nanoemulsions were deemed inactive (IC50: 33576.430 ppm). In addition, the organoleptic characteristics of all nanoemulsions were stable, and most parameters met the desired standards. Based on the results, further studies exploring nanoemulsions with natural products must be carried out to determine their advantages, specifically in the development of sciences.
Kojic Acid from the Ethyl Acetate Fraction of Terminalia catappa Linn Fruit Flesh and its anti-cancer activity against HeLa cells Chasani, Moch.; Widyaningsih, Senny; Rastuti, Undri; Hanafi, Muhammad; Fauzi, Kevin Azhar; Azahra, Silena
Molekul Vol 20 No 1 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.1.13579

Abstract

ABSTRACT. The ethyl acetate fraction of Terminalia catappa Linn. fruit flesh has anti-cancer activity against HeLa cells, with IC50 value is =165.37 ppm. The aim of this research is to isolate active anticancer compound from the ethyl acetate fraction of T. catappa fruit flesh. Anti-cancer active compounds from the ethyl acetate fraction of T. catappa fruit flesh were purified using column chromatography and continued with recrystallization. The compound isolate from the ethyl acetate fraction is clear yellowish crystals and has a melting point 150 ± 2 oC, has anti-cancer activity against HeLa cells of IC50 =413.695 ppm. Results of molecular structure identification using UV spectroscopy; FTIR; 1HNMR, 13CNMR and LC-MS are thought to be the compound 5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4- one (Kojic acid) with a molecular weight of 142.36 gram/mol. The Kojic acid content in T. catappa Linn fruit flesh was found to provide information on the potential use of T. catappa fruit flesh extract in the pharmaceutical and cosmetics industries. Keywords: Anticancer activity, HeLa cells, Kojic acid, T. catappa Linn.
Co-Authors Aditya Mahendra, Ryan Alvino Jefferson Sianipar Azahra, Silena Bina Larasati Chasani, Moch Dwi Kartika Elly, Vani Fitria Rosita Fajriyah, Bunga Sita Roihanul Fauzi, Kevin Azhar Habibie, Ranti Kamila Hartiwi Diastuti Hartiwi Diastuti HENDRA GUNAWAN B11211055 Ismawati Ismawati Khalidah Zia, Sity Mesayu, Puspa Rahma Moch. Chasani Mochamad Chasani Mochammad Chasani Mochammad Chasani Muhammad Hanafi Muhammad Wisnu Nugroho, Muhammad Wisnu Permana, Afri Ponco Iswanto Purwati - Purwati Purwati Rahmasari, Anisa Rizka Ayusnika, Rizka Rizki Nur Apriliani, Rizki Nur Sheiliyani, Cindi Sulaeman, Uyi Suyata Umi Salamah Undri Rastuti Wawan Nur Fredyono Zia, Sity Khalidah Zusfahair Zusfahair