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All Journal Jurnal Pengajaran MIPA Dimas: Jurnal Pemikiran Agama untuk Pemberdayaan Jurnal Kimia dan Kemasan Biology, Medicine, & Natural Product Chemistry Al-Kimia Walisongo Journal of Chemistry Jambura Journal of Chemistry Reswara: Jurnal Pengabdian Kepada Masyarakat Jurnal Kimia dan Kemasan Prosiding Seminar Nasional Pendidikan dan Agama Dinamika Sosial: Jurnal Pengabdian Masyarakat Dan Transformasi Kesejahteraan
Hafshah, Mutista
Program Studi Kimia Fakultas Sains Dan Teknologi UIN Walisongo Semarang
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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DESAIN TURUNAN KALKON BARU SEBAGAI ANTIKANKER PAYUDARA BERDASARKAN MOLECULAR DOCKING Karlina, Lilis; Hafshah, Mutista
Walisongo Journal of Chemistry Vol 2, No 2 (2019): Walisongo Journal of Chemistry
Publisher : Department of Chemistry Faculty of Science and Technology Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1085.393 KB) | DOI: 10.21580/wjc.v2i2.6025

Abstract

Penelitian ini dilakukan untuk menentukan senyawa turunan kalkon yang berpotensi sebagai antikanker payudara berdasarkan Molecular Docking. Protein yang digunakan yaitu 17?-hidroksisteroid dehydrogenase. Adapun ligan yang digunakan adalah 20 senyawa turunan kalkon yang dibandingkan dengan senyawa obat pembanding. Posisi pusat grid pada sisi aktif protein kanker payudara yang telah dilakukan pada penelitian sebelumnya yaitu pada leusin 149.X CB, serin 142.X OG, dan asparagine 152.X OD1. Software yang digunakan yaitu hyperchem, Gaussian03, Molden, Autodock Tools, Autodock4, dan chimera 1.5.3. Penelitian ini dilakukan dengan empat langkah yaitu pencarian kompleks protein-ligan 17?-hidroksisteroid dehydrogenase dengan kode PDB 3HB4, optimasi struktur ligan dengan metode perhitungan AM1, molecular docking, dan pemilihan senyawa turunan kalkon sebagai antikanker payudara. Hasil docking turunan kalkon memiliki akivitas daya hambat terhapat protein 17?-hidroksisteroid dehydrogenase dengan nilai sebesar 4,41 × 10-6M sampai 2,4783 × 10-7M. Hasil molecular docking didapatkan senyawa turunan kalkon sebagai antikanker payudara yaitu kalkon X memiliki tetapan inhibisi 2,4783 × 10-7M.
DEGRADASI POLIETILEN TEREFTALAT DENGAN RADIASI SINAR MATAHARI DAN METANOLISIS Mutista Hafshah; Titin Kartin
Jurnal Kimia dan Kemasan Vol. 43 No. 2 Oktober 2021
Publisher : Balai Besar Kimia dan Kemasan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24817/jkk.v43i2.6824

Abstract

Telah dilakukan penelitian mengenai degradasi polietilen tereftalat (PET) menjadi dibenzil tereftalat. Degradasi polietilen tereftalat (PET) pada penelitian ini didahului dengan pemanasan sampel limbah botol PET di bawah sinar matahari kemudian dilanjutkan secara metanolisisis dengan katalis seng asetat. Degradasi dengan sinar matahari dilakukan dengan cara menjemur botol plastik di bawah sinar matahari selama 0, 30, dan 60 hari. Botol plastik kemudian dipotong-potong ukuran 2x2 mm. Degradasi kemudian dilanjutkan secara metanolisisis menggunakan pelarut benzil alkohol dan seng asetat sebagai katalis. Katalis seng asetat yang digunakan divariasikan sebanyak 0; 0,3; 0,6; dan 0,9 g. Degradasi metanolisisis dilakukan secara refluks pada suhu     145-150 °C. Produk hasil degradasi dikarakterisasi titik leleh dan gugus fungsinya dengan spektrum FTIR. Hasil penelitian menunjukkan bahwa pemanasan di bawah sinar matahari selama 0, 30 dan 60 hari tidak dapat mendepolimerisasi PET yang dibuktikan dengan data titik leleh dari masing-masing sampel limbah plastik PET yang masih sama dengan rentang titik leleh PET yaitu 250-260 °C. Depolimerisasi PET dengan radiasi sinar matahari yang dilanjutkan dengan metanolisis menghasilkan produk akhir berupa dibenzil tereftalat. Adapun variasi jumlah katalis seng asetat pada tahap metanolisis tidak mempengaruhi produk akhir yang terbentuk.
DEGRADASI POLIETILEN TEREFTALAT DENGAN RADIASI SINAR MATAHARI DAN METANOLISIS Mutista Hafshah; Titin Kartin
Jurnal Kimia dan Kemasan Vol. 43 No. 2 Oktober 2021
Publisher : Balai Besar Kimia dan Kemasan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24817/jkk.v43i2.6824

Abstract

Telah dilakukan penelitian mengenai degradasi polietilen tereftalat (PET) menjadi dibenzil tereftalat. Degradasi polietilen tereftalat (PET) pada penelitian ini didahului dengan pemanasan sampel limbah botol PET di bawah sinar matahari kemudian dilanjutkan secara metanolisisis dengan katalis seng asetat. Degradasi dengan sinar matahari dilakukan dengan cara menjemur botol plastik di bawah sinar matahari selama 0, 30, dan 60 hari. Botol plastik kemudian dipotong-potong ukuran 2x2 mm. Degradasi kemudian dilanjutkan secara metanolisisis menggunakan pelarut benzil alkohol dan seng asetat sebagai katalis. Katalis seng asetat yang digunakan divariasikan sebanyak 0; 0,3; 0,6; dan 0,9 g. Degradasi metanolisisis dilakukan secara refluks pada suhu     145-150 °C. Produk hasil degradasi dikarakterisasi titik leleh dan gugus fungsinya dengan spektrum FTIR. Hasil penelitian menunjukkan bahwa pemanasan di bawah sinar matahari selama 0, 30 dan 60 hari tidak dapat mendepolimerisasi PET yang dibuktikan dengan data titik leleh dari masing-masing sampel limbah plastik PET yang masih sama dengan rentang titik leleh PET yaitu 250-260 °C. Depolimerisasi PET dengan radiasi sinar matahari yang dilanjutkan dengan metanolisis menghasilkan produk akhir berupa dibenzil tereftalat. Adapun variasi jumlah katalis seng asetat pada tahap metanolisis tidak mempengaruhi produk akhir yang terbentuk.
Desain Turunan Kalkon Baru Sebagai Antikanker Payudara Berdasarkan Molecular Docking Mutista Hafshah; Lilis Karlina
Walisongo Journal of Chemistry Vol 2, No 2 (2019): Walisongo Journal of Chemistry
Publisher : Department of Chemistry Faculty of Science and Technology Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/wjc.v2i2.6025

Abstract

Penelitian ini dilakukan untuk menentukan senyawa turunan kalkon yang berpotensi sebagai antikanker payudara berdasarkan Molecular Docking. Protein yang digunakan yaitu 17β-hidroksisteroid dehydrogenase. Adapun ligan yang digunakan adalah 20 senyawa turunan kalkon yang dibandingkan dengan senyawa obat pembanding. Posisi pusat grid pada sisi aktif protein kanker payudara yang telah dilakukan pada penelitian sebelumnya yaitu pada leusin 149.X CB, serin 142.X OG, dan asparagine 152.X OD1. Software yang digunakan yaitu hyperchem, Gaussian03, Molden, Autodock Tools, Autodock4, dan chimera 1.5.3. Penelitian ini dilakukan dengan empat langkah yaitu pencarian kompleks protein-ligan 17β-hidroksisteroid dehydrogenase dengan kode PDB 3HB4, optimasi struktur ligan dengan metode perhitungan AM1, molecular docking, dan pemilihan senyawa turunan kalkon sebagai antikanker payudara. Hasil docking turunan kalkon memiliki akivitas daya hambat terhapat protein 17β-hidroksisteroid dehydrogenase dengan nilai sebesar 4,41 × 10-6M sampai 2,4783 × 10-7M. Hasil molecular docking didapatkan senyawa turunan kalkon sebagai antikanker payudara yaitu kalkon X memiliki tetapan inhibisi 2,4783 × 10-7M.
UNDERSTANDING MOLECULAR BONDING AND GEOMETRY THROUGH FLIPPED CLASSROOM IMPLEMENTATION Sri Mulyanti; Mutista Hafshah; Nana Misrochah
Jurnal Pengajaran MIPA Vol 26, No 1 (2021): JPMIPA: Volume 26, Issue 1, 2021
Publisher : Faculty of Mathematics and Science Education, Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18269/jpmipa.v26i2.32868

Abstract

Understanding molecule bonding and geometry are essential requirements in learning organic chemistry. Studies found that students cannot fully grasp the meaning of these abstract concepts, and pandemic conditions become an added challenge for learning organic chemistry virtually. In this study, We implement flipped classroom model for teaching organic chemistry, particularly for molecule bonding and geometry. Results indicated the benefit of the flipped classroom for students' improved understanding, and advanced analysis for several learning aspects also corroborated this finding.
Potential of Secang Wood (Caesalpinia sappan L.) Ethanol Extractas Anti-Oxidant and Sun-Protection Hafshah, Mutista; Rohmah, Alfiatu; Mardliyah, Ana
Al-Kimia Vol 10 No 2 (2022): DECEMBER
Publisher : Study Program of Chemistry - Alauddin State Islamic University of Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/al-kimia.v10i2.28619

Abstract

Although sunlight has numerous health benefits, prolonged direct exposure to the sun can be harmful to the skin. Among the negative effects of sun exposure are redness and burning of the skin, as well as dullness, wrinkles, dryness, and premature aging, as well as skin cancer. The use of sunscreen to protect the skin from the harmful effects of prolonged sun exposure is becoming more widespread. On the other hand, some sunscreens contain potentially harmful chemicals such as isopropyl alcohol, DEA (diethanolamine), TEA (triethanolamine), and MEA (monoethanolamine), which can cause allergic reactions as well as kidney and liver disorders when used for an extended period of time. As a result, this investigation was carried out in order to determine the antioxidant potential of natural ingredients, specifically sappan wood (Caesalpinia sappan L.), using the DPPH method, as well as its potential as a sun-protective agent using an in vitro SPF test using ultraviolet-visible (Uv-Vis) spectrophotometry (Uv-Vis). The results revealed that the maceration method produced a 17.779 percent yield of ethanol extract of sappan wood, which was used in this study. The extract possesses extremely potent antioxidant activity, as evidenced by its IC50 value of 12,611 mg/L. Furthermore, based on the results of tests and the calculation of the SPF (sun protection factor) value, sappan wood extract has been shown to have potential as a sun protection agent. Using an extract concentration of 120 mg/L, the highest SPF value.
Antibacterial Activity Test of Secang Wood (Caesalpinia sappan L.) Ethanol Extract Against Streptococcus mutans Listiani, Febri Intan; Hafshah, Mutista; Latifah, Rais Nur
Al-Kimia Vol 11 No 1 (2023): JUNE
Publisher : Study Program of Chemistry - Alauddin State Islamic University of Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/al-kimia.v11i1.37136

Abstract

Dental caries is caused by the Streptococcus mutans bacteria, which causes a food deposit to harden and adhere to the tooth surface. Cavities will develop if food residue is not removed. Herbal plants, specifically sappan wood, can be used as an antibiotic. The purpose of this study was to look at the secondary metabolite content of sappan wood extract, antibacterial activity, and the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of sappan wood extract against Streptococcus mutans bacteria. This research method includes the maceration of sappan wood extract with 96% ethanol solvent, phytochemical screening of sappan wood extract, inhibition zone test with paper disc method, and MIC and MBC tests. Qualitative testing revealed that the sappan wood extract contained alkaloids, flavonoids, tannins, and saponins. Flavonoids, tannins, and saponins are all constituents of plants. Secang wood extract has antibacterial activity against Streptococcus mutans, as evidenced by the formation of inhibition zones at concentrations of 20%, 40%, 60%, 80%, and 100%, namely 8.75±0.354; 11±1.41;, 12.75±0.354; 16.25±0.354; and 17.5±0.000 mm. Sappan wood ethanol extract had a MIC of 12.5% against Streptococcus mutans and an MBC of 25%.
Modelling of QSAR Equations for Styryl Quinolone Compound Derivatives as HIV-1 Inhibitors Firdaus, Irvan Maulana; Hafshah, Mutista; Amin, Ahmad Faqih; Satriya, Daffa Faiq Aji
Walisongo Journal of Chemistry Vol 7, No 1 (2024): Walisongo Journal of Chemistry
Publisher : Department of Chemistry Faculty of Science and Technology Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/wjc.v7i1.22315

Abstract

HIV-1 (Human Immunodeficiency Virus) inhibitor compounds have been designed using a QSAR analysis approach for 33 styryl quinolone derivative compounds, with descriptors calculated using semi-empirical methods. This research aims to determine the best semi-empirical method and to obtain the best QSAR equation by comparing the Principal Component Regression method with Multiple Linear Regression, as well as modifying the structure of new styryl quinolone derivative compounds to achieve higher predicted theoretical HIV-1 integrase protein inhibitor activity. The analysis results showed that the semi-empirical MINDO3 method was the best. The QSAR MINDO3 equation with Principal Component Regression is as follows: :  pIC50 = 5.046 + 0.515 VL1 with n = 33, r = 0.611, r2 = 0.374, SD = 0.677, Fcount/Ftable = 4.45, PRESS = 20.554, Sig = 0.01.  Meanwhile, with Multiple Linear Regression, the equation is as follows: pIC50 = -11.252 + 88.481 (qC3) + 26.667 (qC4) + 9.156 (qC5) – 1.443 (qC7) + 4.284 (qC8)-0.03 (Surface Area Approx) + 0.033 (Grid) - 0.195 (logP) – 0.007 (Mr) – 2.166 (HOMO) with n = 33; r = 0.870; r2 = 0.758; SD =0.500; Fcount/Ftable =2.995; PRESS =5.505; Sig. 0.01. The design of the new compound was carried out based on the best QSAR equation, namely Multiple Linear Regression. We obtained 10 structural modifications from the equation above with the best theoretical pIC50 values from the reference ligand.
In Vitro Anti-inflammatory Activity of Bamboo Tali Leaf (Gigantochloa apus) Ethanol Extract Hidayah, Nurul; Hafshah, Mutista
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.601-606

Abstract

Inflammation is a physiological process that serves as a defense mechanism for the body against foreign substances, bacteria, or irritants. Inflammation can be cured with anti-inflammatory drugs. One of the plants that has the potential to be an anti-inflammatory agent is the bamboo leaf. This research aims to analyze the content of secondary metabolites, determine the inhibition value and IC50 value of the anti-inflammatory activity of the ethanol extract of bamboo tali leaves. Bamboo tali leaves were macerated using 96% ethanol and subjected to phytochemical screening. The extract was then tested for anti-inflammatory activity in vitro with the Bovine Serum Albumin (BSA) protein denaturation inhibition method. Bamboo tali leaf ethanol extract contains flavonoids, alkaloids, saponins, and phenols. The anti-inflammatory activity of the ethanol extract of bamboo tali leaves with concentrations of 28, 42, 56, 70, and 84 ppm had an inhibition percentage value of 23.14 ± 0.008%; 34.30 0.026%; 54.51 0.060%; 69.07 ± 0.006%; and 87.02 ± 0.021% with an IC50 value of 52.991 ppm. These results indicate that the ethanol extract of bamboo tali leaves has the potential to be an anti-inflammatory with a strong IC50 value below 100 ppm.
Implementation of Educational Care Model for Orphans: Case Study in Kertomulyo Village Mutista Hafshah; Supitayanti Supitayanti; Eka Intansari; Muhammad Faza Nasrullah
PROSIDING SEMINAR NASIONAL PENDIDIKAN DAN AGAMA Vol. 5 No. 1 (2024): PROSIDING SEMINAR NASIONAL PENDIDIKAN DAN AGAMA
Publisher : Sekolah Tinggi Pastoral Kateketik (STPKat) Santo Fransiskus Assisi Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/semnaspa.v5i1.2075

Abstract

The care and education of orphans is a shared responsibility of the community that requires a comprehensive approach. This study aims to analyze the implementation of an educational care model for orphans in Kertomulyo Village, Brangsong District, Kendal Regency, Central Java. The research method uses a qualitative approach with data collection techniques through participatory observation, in-depth interviews, and documentation studies. The results of the study indicate that the educational care model implemented combines formal education at SDN 1 Kertomulyo and non-formal education at TPQ Al Ittihad. The parenting pattern applied tends to be democratic with an emphasis on role models and local wisdom values. Supporting factors include social support from the community and high awareness of the importance of education, while inhibiting factors include limited human resources and psychological constraints of orphans. The implementation of this model plays an important role in meeting the educational needs and developing the potential of orphans in Kertomulyo Village.
Co-Authors Amin, Ahmad Faqih Ana Mardliyah Chusnah, Hudallil Eka Intansari Firdaus, Irvan Maulana Hashona, Achmad Hasmy Ika Nur Fitriani Ismail, Amrizarois Kholidah Kholidah, Kholidah Lilis Karlina Lilis karlina, Lilis Listiani, Febri Intan Muhammad Faza Nasrullah Nana Misrochah NIDA, KHOIRIN NURUL HIDAYAH Rais Nur Latifah Rohmah, Alfiatu Satriya, Daffa Faiq Aji Sri Mulyanti Supitayanti Supitayanti Teguh Wibowo Titin Kartin