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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences The Journal of Experimental Life Sciences (JELS) Biotropika
Yuyun Ika Christina
Graduate Program of Biology, Faculty of Mathematics and Natural Sciences, University of Brawijaya, Malang, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Immunology & microbiology Medicine & Pharmacology Neuroscience

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Journal : Biotropika

 1 
Aktivitas Ekstrak Etanol Umbi Uwi Ungu (Dioscorea alata L.) terhadap Sel B220+IgE+ pada Mencit BALB/c Model Alergi Pencernaan Christina, Yuyun Ika
Biotropika: Journal of Tropical Biology Vol 2, No 2 (2014)
Publisher : Biotropika: Journal of Tropical Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (490.845 KB)

Abstract

Uwi ungu (Dioscorea alata L.) merupakan famili Dioscoreaceae yang mengandung diosgenin yang diketahui bermanfaat sebagai agen imunomodulator. Tujuan dari penelitian ini adalah untuk mengetahui adanya perubahan kuantitas sel B220+IgE+ pada organ lymph node mencit BALB/c model alergi pencernaan pasca pemberian ekstrak etanol umbi uwi ungu dan dosis optimum ekstrak etanol umbi uwi ungu. Pemberian ekstrak etanol umbi uwi ungu dilakukan pada hari ke 1-28. Hari ke-15 dilakukan injeksi ovalbumin (OVA) secara intraperitoneal. Kemudian 3 hari setelah injeksi OVA mencit dibedah. Hari ke-22 dilakukan challenge OVA secara intraperitoneal. Hari ke-23 sampai 28 mencit dilakukan injeksi OVA kembali secara oral. Kemudian dilakukan pembedahan pada hari ke-29. Limfosit diisolasi pada organ lymph node dan dilihat profil sel B220+ dan B220+IgE+ melalui analisis flow cytometry. Data dianalisis menggunakan One-way ANOVA (p<0,05) dan uji Tukey menggunakan SPSS 16  for Windows. Jumlah sel B220+IgE+ menurun signifikan pada dosis 0,167 g/kg BB dibandingkan pada dosis 2,008 g/kg BB dan 10,039 g/kg BB. Variasi dosis ekstrak etanol umbi uwi ungu berbeda secara signifikan. Ekstrak etanol umbi uwi ungu (Dioscorea alata L.) mampu menurunkan jumlah relatif sel B220+IgE+ pada dosis 0,167 g/kg BB. Dosis optimum untuk menurunkan level B220+IgE+ adalah pada dosis rendah yaitu 0,167 g/kg BB.Kata kunci : Alergi pencernaan, B220+IgE+, Dioscorea alata L., immunomodulator
CaCO3-Reformulated Interlocking Bricks: Physical Characterization and Their Antibacterial and Anti-Inflammatory Potential for Healthy Housing Djati, Muhammad Sasmito; Rachmawati, Turniningtyas Ayu; Anggraini, Retno; Zacoeb, Achfas; Rifa`i, Muhaimin; Minang, Bony Zulkarnaen; Kusuma, Kavana Hafil; Prima, Alex; Christina, Yuyun Ika
Biotropika: Journal of Tropical Biology Vol. 13 No. 1 (2025)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2025.013.01.01

Abstract

Calcium carbonate (CaCO3) has many benefits for medicine, manufacturing, and nanotechnology due to its antibacterial and anti-inflammatory properties. Interlocking bricks (i-bricks) are widely used in sustainable housing for efficient air circulation and reducing humidity inside the house. If CaCO3 is mixed with interlocking brick, it can inhibit bacterial growth, leading to a healthier indoor environment. Therefore, this study aimed to investigate the physical characterization and antibacterial activity of CaCO3-reformulated i-brick, and its anti-inflammatory potential in mice infected with Salmonella typhimurium. The physical characterization of CaCO3-reformulated i-brick (F1-F10 formulas), including its density, compression, and absorption, was analyzed. The inhibitory activity of CaCO3-reformulated i-brick on S. typhimurium growth was determined using a linear regression equation between culture age and cell density values. BALB/c male mice were randomly divided into four groups (n=4): healthy mice (N), S. typhimurium-infected mice (S), S. typhimurium-infected mice treated with F6 formula (F6) and F7 formula (F7) for 7 days. After 7 days of treatment, lymphocytes were isolated to determine the relative number of TGF-beta, interleukin (IL)-10, and TNF-alpha using flow cytometry analysis. The results showed that formulas 6 and 7 of CaCO3-reformulated i-bricks exhibited optimal physical properties, including density, compression, and water absorption. These formulas also inhibited the growth of S. typhimurium. Furthermore, formulas 6 and 7 possessed anti-inflammatory effects in S. typhimurium-infected mice indicated by the high increase in IL-10 and TGF-beta production and low levels of TNF-alpha. In conclusion, CaCO3 brick formulation can inhibit the growth of S. typhimurium and exert an anti-inflammatory effect. Further investigation is needed to reveal the effect of CaCO3-reformulated i-bricks on another inflammatory marker to further elucidate its anti-inflammatory mechanism.
Antioxidant Properties and Quantification of Phenolic and Flavonoid Compounds in Alpinia purpurata (Viell.) K. Schum Ethanol Extract Djati, Muhammad Sasmito; Azerlyn, Defiona Rensia Naomi; Kusuma, Kavana Hafil; Rosyadah, Nuraini; Kamila, Fairuz Sarah; Annisa, Yuslinda; Christina, Yuyun Ika; Dwijayanti, Dinia Rizqi; Widodo, Nashi
Biotropika: Journal of Tropical Biology Vol. 13 No. 1 (2025)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2025.013.01.02

Abstract

Phenolic and flavonoid compounds have been found to have positive benefits due to their antioxidant activity. Alpinia purpurata (Viell.) K. Schum, or lengkuas merah, is known to have aromatic rhizomes and is rich in active compounds such as flavonoids and phenolics. This research aimed to investigate the total phenolic and flavonoid content of A. purpurata ethanol extract and its antioxidant activity. A. purpurata was extracted using Microwave-Assisted Extraction (MAE) with 97% ethanol solvent. The ethanol extract of A. purpurata was then analyzed for the total phenolic and flavonoid content. The antioxidant activity and nitric oxide (NO) levels were determined by DPPH and NO scavenging assay, respectively. The results showed that A. purpurata ethanol extract had a high phenolic content (148.76 ± 1.03 mg GAE.g-1extract) but weak DPPH scavenging activity (IC50 of 219.06 ± 8.15 µg.mL-1), indicating that high phenolic content does not necessarily correlate with strong antioxidant properties. In contrast, the extract exhibited strong NO scavenging activity with an IC50 of 22.73 ± 7.57 µg.mL-1. Despite its high phenolic content, the weak DPPH activity indicates that total phenolic concentration alone is not always a reliable indicator of antioxidant strength. Further studies should include additional antioxidant assays to comprehensively evaluate the extract’s antioxidant potential.
Co-Authors Achfas Zacoeb Aminullah, Lela - Annisa, Yuslinda Asfi, Nida Azerlyn, Defiona Rensia Naomi Dewi Mustikaningtyas Dinia Rizqi Dwijayanti Grahadi, Rahmat Izzah, Fathiyah Nurul Kamila, Fairuz Sarah Khodijah, Riska Amalia Kusuma, Kavana Hafil Marlita Marlita, Marlita Minang, Bony Zulkarnaen Moch Sasmito Djati Nabilah, Sarah Nahdah Nafisah, Wirdatun Nashi Widodo Prima, Alex Retno Anggraini Rifa'i, Muhaimin Rifa'i, Muhaimin - Rifa`i, Muhaimin Rifa’i, Muhaimin Rohmah, Ilmiana Nurur Rosyadah, Nuraini SRI RAHAYU Susanti, Winda Karina Turniningtyas Ayu Rachmawati Widyananda, Muhammad Hermawan