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All Journal JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Ilmu Kefarmasian Indonesia Jurnal Riset Kesehatan Poltekkes Depkes Bandung Jurnal Ners Pharmaceutical Sciences and Research (PSR) Eduvest - Journal of Universal Studies Media Penelitian dan Pengembangan Kesehatan Holistik Jurnal Kesehatan
Atika Wahyu Puspitasari
Fakultas Farmasi Universitas Indonesia
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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THE EFFECTIVENESS ANALYSIS OF MEDICATION BOOKLET ON ADHERENCE RATE IN TYPE 2 DIABETES MELLITUS PATIENTS Atika Wahyu Puspitasari; Retnosari Andrajati; Anton Bahtiar
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 2, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.84

Abstract

Diabetes Mellitus (DM) is a chronic metabolic disorder characterized by elevation of blood glucose concentration. Non-adherence to diabetes treatment in type 2 DM patients leads to poor glucose control and increases the risk of disease complications. Education is one of the ways to increase medication adherence. Limitation of pharmacists in public primary health care in Indonesia led to education could not be done effectively so that it was necessary to find other alternatives education such as medication booklet. This study was undertaken to evaluate the effect of a medication booklet on adherence rate parameters, in type 2 diabetic patients. This was pre-experimental and prospective study conducted at Bakti Jaya primary care, Depok from January to June 2012. A convenience sample of 30 type 2 diabetic patients was studied to receive medication booklet. The value of The 8-item Morisky Medication Adherence Scale (MMAS-8) and percentage of glycosylated haemoglobin (HbA1C) were measured before and after the 8-week intervention. The results were analyzed by paired t-test for HbA1C and Wilcoxon test for MMAS-8. The research result  showed that there were significant differences (p < 0.05) of the value of HbA1C and MMAS-8 between before and after the 8-week intervention. It indicated that a diabetes education by medication booklet, was effective enhancing their medication adherence. This study also found that patients with a lower score on the Morisky scale had a lower HbA1C measurement.Keywords : MMAS-8, HbA1C, adherence, blood glucose, type 2 diabetes mellitus, booklet, pharmacist
Analisis Potensi Interaksi Obat Golongan Antidepresan pada Pasien Skizofrenia di Rumah Sakit Jiwa Dr. Soeharto Heerdjan Tahun 2016 Puspitasari, Atika Wahyu; Angeline, Loranda
Pharmaceutical Sciences and Research Vol. 6, No. 1
Publisher : UI Scholars Hub

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Abstract

Schizophrenic patients who used antidepressant combination drug therapy in their treatment can cause drug interaction. This study aimed to determine the potential drug interactions of antidepressant in schizophrenic patients. The study designed was cross-sectional by random sampling. The samples were secondary data from outpatient prescriptions and medical record of schizophrenic patients in Psychiatric Hospital Dr. Soeharto Heerdjan during 2016. From 743 drug prescriptions, it was found that 694 (91.41%) drug prescriptions having 1286 (61.24%) cases of drug interaction. The most common interaction were fluoxetine and risperidone in 376 cases (29.24%). The proportion based on interaction level was 1246 cases (96.89%) for severe, 34 cases (2.64%) for moderate, and 6 cases (0.47%) for minor. The study concluded that antidepressant prescribing needs to be closely monitored because of high incidence in drug interactions or modified when the negative impact was greater than the positive impact.
Evaluation of Potential Drug Interaction of Analgesic in Cancer Patient Receiving Palliative Care in Dharmais Cancer Hospital Sitepu, Eme Stepani; Puspitasari, Atika Wahyu; Azmi, Nuriza Ulul; Sari, Lila Nilam
Pharmaceutical Sciences and Research Vol. 7, No. 1
Publisher : UI Scholars Hub

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Abstract

Analgesics are mostly used in cancer patients receiving palliative care to improve the quality of life of patients. Besides analgesics, cancer patients receiving palliative care were also given other drugs in combination to overcome other symptoms of cancer, and this combination could potentially cause drug interactions. This study was aimed to analyze the potential of drug interactions with analgesics in cancer patients. The study design was cross-sectional with a retrospective method and descriptive study. The sample of this study was cancer palliative care patient’s prescription at Dharmais Cancer Hospital in the period of January – December 2017. The sample analyzed in this study consisted of 273 prescriptions. This study found that there were 191 prescriptions (69.9%) of analgesics which potential- ly interacted with 316 interaction cases. Fentanyl and morphine with 61 cases (19.3%), morphine and gabapentin with 60 cases (18.9%) and morphine and amitriptyline with 33 cases (10.4%) were observed as the three most analgesics-other drugs interaction. Based on severity levels, there were 73.5% of major interaction, 26.3% of moderate interaction, and 0.2% of minor interaction. This study concluded that high occurrence of drug interactions was observed in analgesic drugs, therefore close monitoring is needed in cancer patient receiving palliative care.
Analisis obat yang berpotensi tidak tepat terhadap reaksi obat yang tidak diinginkan (ROTD) pada pasien lansia Fauziah, Nur; Andrajati, Retnosari; Puspitasari, Atika Wahyu
Holistik Jurnal Kesehatan Vol. 19 No. 7 (2025): Volume 19 Nomor 7
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/hjk.v19i7.1103

Abstract

Background: The elderly population is a vulnerable group due to physiological changes, including decreased organ function. In Depok City, the number of elderly people is expected to increase to 202,194 by 2023. Potentially inappropriate medication use (PDR) in the elderly is associated with an increased risk of adverse drug reactions (ADRs). STOPP_INA is a tool for identifying PDRs and can help reduce the incidence of PDRs. Purpose: To analyze potentially inappropriate medication use associated with adverse drug reactions (ADRs) in elderly patients. Method: This was a descriptive observational study with a cross-sectional design. Data were collected retrospectively from electronic prescriptions and electronic medical records of elderly inpatients at RSUI. The minimum sample size was 52. Results: Of 528 medications prescribed to 52 patients, 90 PDRs (17.04%) were identified. The most common medications included in the STOPP_INA criteria were aspirin, ramipril, clopidogrel, spironolactone, clonidine, and amlodipine. Twenty-two patients (42.3%) experienced ADRs, with the most common adverse effects being hypotension (12 cases), followed by cognitive impairment, gastric ulcer recurrence, bleeding, and decreased renal function (3 cases each). Conclusion: There was a very strong correlation between the number of PIMs and ADRs (r = 0.758; p < 0.01) in patients with polypharmacy.   Keywords: Adverse Drug Reactions (ADRs); Elderly; Potentially Inappropriate Medications.   Pendahuluan: Populasi lanjut usia merupakan kelompok rentan karena mengalami perubahan fisiologis, termasuk penurunan fungsi organ. Di Kota Depok, jumlah lansia meningkat mencapai 202,194 jiwa pada tahun 2023. Penggunaan obat yang berpotensi tidak tepat atau potentially inappropriate medications (PIMs) pada lansia dikaitkan dengan peningkatan risiko reaksi obat yang tidak diinginkan (ROTD). STOPP_INA merupakan salah satu instrumen untuk mengidentifikasi PIMs dan dapat membantu mengurangi kejadian ROTD. Tujuan: Untuk menganalisis obat yang berpotensi tidak tepat terhadap reaksi obat yang tidak diinginkan (ROTD) pada pasien lansia. Metode: Studi observasional deskriptif dengan desain cross-sectional. Data dikumpulkan secara retrospektif dari resep elektronik dan catatan rekam medis elektronik pasien lansia rawat inap di RSUI. Jumlah sampel minimal berdasarkan perhitungan adalah 52 sampel. Hasil: Dari total 528 obat yang diresepkan kepada 52 pasien, ditemukan 90 PIMs (17.04%). Obat yang paling sering termasuk dalam kriteria STOPP_INA adalah aspirin, ramipril, klopidogrel, spironolakton, klonidin, dan amlodipin. Sebanyak 22 pasien (42.3%) mengalami kejadian ROTD, dengan efek samping terbanyak berupa hipotensi (12 kasus), diikuti gangguan kognitif, kekambuhan tukak peptik, perdarahan, dan penurunan fungsi ginjal (masing-masing 3 kasus). Simpulan: Terdapat korelasi yang sangat kuat antara jumlah PIMs dan ROTD (r = 0.758; p < 0.01) pada pasien dengan polifarmasi.   Kata Kunci: Lansia; Obat yang Berpotensi Tidak Tepat; Reaksi Obat yang tidak Diinginkan (ROTD).
ERYTHROPOIESIS-STIMULATING AGENT THERAPY IN HEMODIALYSIS FOR KIDNEY DISEASE RELATED ANEMIA: A SYSTEMATIC REVIEW Sinabutar, Reniati; Andrajati, Retnosari; Puspitasari, Atika Wahyu
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 4 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i4.3323

Abstract

Anemia merupakan komplikasi umum pada pasien penyakit ginjal kronik (PGK) yang menjalani hemodialisis dan berdampak pada kualitas hidup serta prognosis. Tinjauan sistematis ini dilakukan berdasarkan kerangka Arksey dan O’Malley serta panduan PRISMA untuk mengevaluasi efektivitas dan keamanan erythropoiesis-stimulating agents (ESA) konvensional. Dari 539 artikel yang teridentifikasi pada periode 2015–2025, sebanyak 9 studi memenuhi kriteria inklusi. Sebagian besar ESA terbukti efektif meningkatkan hemoglobin (Hb) ke kisaran target 10–12 g/dL, meskipun terdapat variasi antar agen. Epoetin alfa menunjukkan peningkatan Hb yang lebih besar (2,3 g/dL) dibanding epoetin beta (1,2 g/dL), dengan efek samping ringan seperti pusing dan pruritus. Darbepoetin alfa mencapai proporsi pasien tertinggi yang berada dalam target Hb (88–90%), meskipun pada sebagian kasus ditemukan hipertensi dan komplikasi akses vaskular. C.E.R.A. menawarkan keuntungan interval dosis bulanan dan stabilitas Hb, namun hanya 55,9% pasien yang mencapai target Hb. Kejadian efek samping serius dengan C.E.R.A. relatif rendah (12%) dan sebagian besar terkait komorbiditas pasien. Kesimpulannya, terapi ESA efektif dalam mengoreksi anemia pada pasien PGK dengan hemodialisis, tetapi perbedaan efektivitas dan keamanan antar agen menekankan pentingnya pemilihan yang terindividualisasi. Epoetin alfa lebih sesuai untuk koreksi Hb yang cepat, darbepoetin alfa unggul dalam pencapaian target Hb, sementara C.E.R.A. bermanfaat pada pasien yang memerlukan regimen sederhana dengan penyesuaian dosis minimal. Pemilihan terapi ESA perlu mempertimbangkan kondisi klinis, komorbiditas, kepatuhan pasien, serta kapasitas sistem pelayanan kesehatan untuk mengoptimalkan luaran.
Faktor Gaya Hidup sebagai Prediktor Kualitas Hidup pada Pasien Luka Kaki Diabetik: Studi Cross-Sectional di Indonesia Restu Anisa Putri; Rani Sauriasari; Atika Wahyu Puspitasari
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.53487

Abstract

Diabetic foot ulcers (DFUs) are a serious complication of diabetes mellitus (DM) that significantly impacts patients' quality of life. Lifestyle factors, particularly smoking status and physical activity, are important modifiable factors to support improvement of this condition. This study aims to analyze the relationship between these two factors and the quality of life of DFU patients in Indonesia. A predictive cross-sectional study was conducted on 70 patients undergoing treatment at six branches of the Diabetic Wound Care Home Clinic in the Greater Jakarta area during March–May 2025. Quality of life was measured using the Indonesian version of the Diabetic Foot Ulcer Scale-Short Form (DFS-SF). Analysis was performed using the chi-square test for bivariate associations and multivariate logistic regression, controlling for confounding variables. The results showed that most patients did not smoke (74.3%) and did not exercise regularly (70.0%). Smoking status was significantly associated with quality of life (p=0.042), while physical activity showed a trend towards significance (p=0.060). Multivariate analysis identified physical activity as a predictor of quality of life (OR=5.30; 95% CI: 0.96–29.14; p=0.055), with patients who did not exercise being 5.3 times more likely to experience low quality of life. Smoking status showed a paradoxical result (OR=0.12; 95% CI: 0.02–0.82; p=0.030), which requires cautious interpretation. Physical activity also significantly impacted the domains of dependency/activities of daily living (p=0.001) and physical health (p=0.002). These findings emphasize the importance of integrating physical activity promotion and healthy lifestyle interventions in the holistic management of patients with LKD to support improved quality of life.
Translation and Validation of the Indonesian Version of Oral Chemotherapy Adherence Scale (OCAS) Puspitasari, Atika Wahyu; Kristina, Susi Ari; Satibi, Satibi; Prabandari, Yayi Suryo
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 16, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.105128

Abstract

Background: Medication adherence is essential for oral anticancer agents (OAAs) to succeed and maintain the optimal therapeutic outcomes. However, there are no well-established instruments in Indonesia to evaluate adherence to oral chemotherapy by cancer patients.Objectives: This study aimed to validate and translate the Oral Chemotherapy Adherence Scale (OCAS) for cancer patients in Indonesia.Methods: Data were collected from patients taking oral chemotherapy for at least a month at Dharmais Cancer Hospital in Jakarta. OCAS was translated into Indonesian using a forward-backward translation method. Content validity was assessed through expert review to calculate Content Validity Index (CVI), while face validity was evaluated to confirm cultural relevance and readability. Internal consistency was measured using Cronbach's alpha.Results: A total of 131 patients participated from August to December 2021. Content validation by seven experts showed that the mean I-CVI of the items was above 0.79, with an S-CVI of 0.985, reflecting the validity of the items. Furthermore, face validity confirmed the readability and clarity of Indonesian version of OCAS. Reliability testing showed a Cronbach alpha of 0.871, suggesting strong internal consistency.Conclusion: Indonesian OCAS was a valid instrument for evaluating medication adherence in Indonesian cancer patients taking oral chemotherapy. Therefore, it can be used for adherence monitoring in healthcare settings.
Predictors of drug-related problems among psychiatric patients with anxiety disorders: a systematic review Andi Ayulestari; Atika Wahyu Puspitasari; Nadia Farhanah Syafhan
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.2080

Abstract

Anxiety disorders are a major component of mental health conditions and are commonly managed with long-term pharmacotherapy, including the use of antidepressants and anxiolytics. The complexity of these regimens increases the risk of drug-related problems (DRPs), which may compromise treatment effectiveness, patient safety, and adherence to medication. This systematic review aimed to identify and synthesize the risk factors associated with DRPs in patients with anxiety disorders. A comprehensive systematic search was conducted across electronic databases according to the PRISMA guidelines. Observational studies were included to reflect real-world clinical practice, and the methodological quality of the included studies was assessed using the Newcastle-Ottawa Scale (NOS). Studies published between 2016 and 2026 were considered; however, only eligible studies published between 2022 and 2025 were included in the final analysis. Ten studies involving 151,331 participants from inpatient and outpatient settings were analyzed. Polypharmacy was the most consistently reported predictor of DRPs (7/10 studies). Other commonly identified risk factors included comorbidities (7/10), older age (6/10), use of multiple psychotropic medications (6/10), longer treatment duration or hospitalization (5/10), poor medication adherence (5/10), and inappropriate dosing (4/10). Patients with anxiety disorders are at considerable risk of DRPs, with polypharmacy being the most critical predictor. These findings highlight the importance of targeted pharmaceutical care interventions, including medication reviews, deprescribing, and adherence optimization, as well as the key role of pharmacists in improving pharmacotherapy outcomes.
Inpatient therapy profile for coronary heart disease patients at Universitas Indonesia Hospital Khoirun Nisak; Retnosari Andrajati; Atika Wahyu Puspitasari
Media Penelitian dan Pengembangan Kesehatan Vol. 36 No. 1 (2026): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v36i1.3264

Abstract

Background: Coronary heart disease (CHD) was the second-highest cause of death in Indonesia. West Java is one of the provinces with a high prevalence of heart disease in Indonesia. Objective: This study aimed to determine the inpatient therapy profile for CHD patients at Universitas Indonesia Hospital (RSUI). Methods: This study was a descriptive study using data from medical records of inpatients with CHD who were registered as BPJS Kesehatan participants at RSUI from January to September 2024. Results: The results showed that 84 patients met the inclusion and exclusion criteria from a total study population of 208 patients, with the majority of patients being male (59,5%), aged <60 years (56,0%), and having a primary complaint of chest pain (79,8%). Based on laboratory characteristics, most patients had normal troponin T levels (86,9%), normal blood creatinine levels (54,8%), and random blood glucose levels <200 mg/dL (77,4%). The length of hospitalization was ≤5 days (82,1%) with improved clinical outcomes (97,6%). Most patients had ≥3 comorbidities (53,6%), with the most common comorbidities being HHD (38,1%), hypertension (35,7%), and CHF (33,3%). In addition, most patients received  ≥5 drugs (97,6%), with the commonly used therapeutic profiles being platelet aggregation inhibitors (79,8%), HMG CoA reductase inhibitors (78,6%), organic nitrates (67,9%), selective beta-blocking agents (56,0%), and ACE inhibitors (45,2%). Conclusion: The predominant therapeutic profile of CHD inpatients at RSUI included platelet aggregation inhibitors, HMG CoA reductase inhibitors, organic nitrates, selective beta-blocking agents, and ACE inhibitors.
Analysis of Predictors Associated with Acid Suppressant Drug Related Problems (DRPs) among Inpatients at Dr. Mintohardjo Naval Hospital Deki Yuliya Putra; Atika Wahyu Puspitasari; Siti Fauziyah
Eduvest - Journal of Universal Studies Vol. 6 No. 4 (2026): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v6i4.53073

Abstract

The use of gastric acid suppressants such as Proton Pump Inhibitors (PPI) and Histamine-2 Receptor Antagonists (H2RA) is very common in inpatient settings, but inappropriate use is often found, posing risks to patient safety and cost efficiency. This study aims to analyze the relationship of predictors (age, number of drugs, number of comorbidities, and length of stay) to the occurrence of Drug-Related Problems (DRPs) in inpatients using gastric acid suppressants. This study was an observational study with a cross-sectional design was conducted retrospectively using patient medical record data at Rumkital Dr. Mintohardjo from January to December 2024. A sample of 432 patients was taken using a simple random sampling technique based on inclusion criteria. DRPs were identified using the Pharmaceutical Care Network Europe (PCNE) V9.0 instrument. Data analysis used the chi-square test for bivariate analysis and binary logistic regression for multivariate analysis. DRP characteristics were dominated by treatment safety issues (49.1%), particularly adverse drug events, with the most frequent drug interaction being ranitidine and ketorolac. Bivariate analysis showed that length of stay (p=0.105), and number of drugs (p=0.001) significantly influenced the number of DRPs. Multivariate analysis identified the number of drugs as the most influential predictor; inpatients receiving ≥10 drugs had a 2.580 times higher risk of experiencing DRPs (p=0.003; OR 2,580; 95% CI 1.396-4.779)
Co-Authors Andi Ayulestari Angeline, Loranda Anton Bahtiar Azmi, Nuriza Ulul Deki Yuliya Putra Khoirun Nisak Kusumawardani, Larasati Arrum Loranda Angeline Nadia Farhanah Syafhan Nur Fauziah Rani Sauriasari, Rani Restu Anisa Putri Retnosari Andrajati Retnosari Andrajati Retnosari Andrajati Sari, Lila Nilam Satibi Satibi Sinabutar, Reniati Sitepu, Eme Stepani Siti Fauziyah Susi Ari Kristina Syifa Fauziah Yayi Suryo Prabandari