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All Journal JURNAL SAINS DAN TEKNOLOGI INDONESIA Indonesian Journal of Forestry Research Jurnal Penelitian Hutan dan Konservasi Alam Jurnal Hasil Penelitian Industri JURNAL PHOTON Indonesian Journal of Jamu Annales Bogorienses
Latifah K. Darusman
Departemen Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Jl. Meranti, Kampus IPB Dramaga, Bogor, 16680, Indonesia Pusat Studi Biofarmaka, Institut Pertanian Bogor, Jl. Taman Kencana No. 3, Bogor, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Energy Environmental Science Health Professions Medicine & Pharmacology Nursing Physics

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BIOLOGICAL ACTIVITIES AFFORDED BY THE EXTRACT FROM RARU BARK TO INHIBIT ACTION OF ALPHA- GLUCOSIDASE ENZYMES Pasaribu, Gunawan; Syafii, Wasrin; Darusman, Latifah K.
Indonesian Journal of Forestry Research Vol 8, No 1 (2011): Journal of Forestry Research
Publisher : Secretariat of Forestry Research and Development Agency

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Abstract

Raru (Shoreabalanocarpoides Sym) signifies one of the tree species that grows widespread in Sumatra Island.  Its bark portion is commonly used by local villagers as additional ingredient mixed to nira (sugar palm juice).  This addition is intended to make the juice more durable and also to enrich its taste after the juice is previously fermented to become traditional toddy beverage or the so-call “tuak”.  Local villagers believe that raru bark can reduce the level of blood sugar. As the relevance, the research was conducted to confirm that the extract from raru bark could afford its biological activities to inhibit alpha-glucosidase enzyme through its characterization, quantification, and isolation of its boactive compound. The extraction was performed using two methods (i.e.reflux and maceration techniques). Result revealed that the bark extract obtained from both techniques contained polyphenol compounds: flavonoid, saponin and tannin. Further, raru-bark extract from the reflux and maceration techniques could inhibit the action of alpha glucosidase enzymes on carbohydrate substrate ( i.e. p -nitrophenil-α-D-glucopyranose), at respectively 90.67% and 97.33%. Meanwhile, the inhibition activities afforded by the patented drug as a control (i.e. glucobay) equaled to 97.05%.  Assesment using UV-VIS spectroscopy, showed that the maximum spectrum of bioactive compound in the extract was at the wave length of 288.6 nm. Scrutiny using FTIR spectroscopy could identif y the presence of aromatic groups in the compound, containing -OH, C-H, C=C, C-O and C-H bond types. Analysis using GC-MS exhibited that the compound had molecular weight of 390 with molecular structure as C20H22O8. Ultimately, data analysis scrutiny with the aid of NMR judged the most plausible compound as bioactive was 4-Glucosyl-3, 4’, 5-trihydroxystilbene.
BIOLOGICAL ACTIVITIES AFFORDED BY THE EXTRACT FROM RARU BARK TO INHIBIT ACTION OF ALPHA- GLUCOSIDASE ENZYMES Pasaribu, Gunawan; Syafii, Wasrin; Darusman, Latifah K.
Indonesian Journal of Forestry Research Vol 8, No 1 (2011): Journal of Forestry Research
Publisher : Secretariat of Forestry Research and Development Agency

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20886/ijfr.2011.8.1.32-49

Abstract

Raru (Shoreabalanocarpoides Sym) signifies one of the tree species that grows widespread in Sumatra Island.  Its bark portion is commonly used by local villagers as additional ingredient mixed to nira (sugar palm juice).  This addition is intended to make the juice more durable and also to enrich its taste after the juice is previously fermented to become traditional toddy beverage or the so-call “tuak”.  Local villagers believe that raru bark can reduce the level of blood sugar. As the relevance, the research was conducted to confirm that the extract from raru bark could afford its biological activities to inhibit alpha-glucosidase enzyme through its characterization, quantification, and isolation of its boactive compound. The extraction was performed using two methods (i.e.reflux and maceration techniques). Result revealed that the bark extract obtained from both techniques contained polyphenol compounds: flavonoid, saponin and tannin. Further, raru-bark extract from the reflux and maceration techniques could inhibit the action of alpha glucosidase enzymes on carbohydrate substrate ( i.e. p -nitrophenil-α-D-glucopyranose), at respectively 90.67% and 97.33%. Meanwhile, the inhibition activities afforded by the patented drug as a control (i.e. glucobay) equaled to 97.05%.  Assesment using UV-VIS spectroscopy, showed that the maximum spectrum of bioactive compound in the extract was at the wave length of 288.6 nm. Scrutiny using FTIR spectroscopy could identif y the presence of aromatic groups in the compound, containing -OH, C-H, C=C, C-O and C-H bond types. Analysis using GC-MS exhibited that the compound had molecular weight of 390 with molecular structure as C20H22O8. Ultimately, data analysis scrutiny with the aid of NMR judged the most plausible compound as bioactive was 4-Glucosyl-3, 4’, 5-trihydroxystilbene.
KARAKTERISTIK HABITAT MIKRO TABAT BARITO (Ficus deltoidea Jack) PADA TUMBUHAN INANGNYA Agustina, Anisa; Zuhud, Ervizal A.M.; Darusman, Latifah K.
Jurnal Penelitian Hutan dan Konservasi Alam Vol 12, No 1 (2015): Jurnal Penelitian Hutan dan Konservasi Alam
Publisher : Pusat Penelitian dan Pengembangan Hutan

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Abstract

Tabat barito (Ficus deltoidea Jack.) merupakan tumbuhan yang berpotensi sebagai obat dan memiliki sebaran luas  di Indonesia,  meliputi  Jawa  Barat,  Jawa  Tengah,  Sumatera,  Kalimantan  dan  Sulawesi.  Di  Taman Nasional Gunung Gede Pangrango (TNGGP), tabat barito tumbuh sebagai epifit yang berpotensi sebagai sumber plasma nutfah bagi tujuan pengembangan budidaya. Tujuan dari penelitian ini adalah untuk memperoleh informasi tentang karakteristik habitat mikro tabat barito di Resort Mandalawangi TNGGP. Hasil penelitian  menunjukkan  bahwa  sebaran tabat  barito  hingga elevasi 1.800  m dpl.  Penelitian yang dilakukan memperoleh hasil, yaitu 178 individu tabat barito yang berasal dari 100 individu tumbuhan inang. Tabat barito terletak pada kisaran suhu 18,3°C-23,1°C, kelembaban udara relatif 80-84% dan kelerengan 4%-24% dengan arah lereng bervariasi. Tumbuhan inang memiliki karakteristik fisik yang bervariasi dalam hal tinggi pohon, diameter batang maupun luas tajuknya, namun memiliki persamaan dalam hal karakteristik kulit  batangnya,  yaitu  memiliki  permukaan  yang  kasar  dengan  kulit  batang  yang  mengelupas  maupun beralur.  Media  tumbuh  tabat  barito  pada  tumbuhan  inang  bervariasi,  mulai  dari  akar  yang  menempel langsung pada kulit batang hingga media tumbuh berupa hasil dekompisisi
SINTESIS ADSORBEN ZEOLIT@AuNPs@MET MENGGUNAKAN EKSTRAK DAUN BINAHONG (Anredera cordifolia) SEBAGAI BIOREDUKTOR PREKURSOR Au DAN KARAKTERISASINYA (Synthesis Zeolite@AuNPs@MET Adsorbent by Binahong (Anredera cordifolia) Leaf Extract as Au Precursor Bioreduc Nurdiani, Nurdiani; Darusman, Latifah K.; Rohaeti, Eti
Jurnal Hasil Penelitian Industri Vol 28, No 1 (2015)
Publisher : Baristand Industri Banda Aceh

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Abstract

Modifying zeolite with Au nanoparticles and mercaptoethanol ligand(zeolite@AuNPs@MET) has been developed as an adsorbent of heavy metal ions. The preparation ofzeolite@AuNPs@MET composite material was done in three steps. Firstly, incorporating gold precursorin to zeolite cavity. Secondly, reduction of gold nanoparticles by binahong leaf extract. Thirdly, modifyingzeolite@AuNPs with mercaptoethanol ligand. Binahong was used as bioreductor agent in the synthesis ofAu nanoparticles since it has large contents of flavonoids, saponins, tannins, and steroids which containreducing functional group. The zeolite@AuNPs@MET composite material was characterized by XRD,EDX, PSA, TEM, FTIR and UV Visible Spectrophotometer. EDX measurements showed Au content of0.88%, TEM and PSA measurement showed Au nanoparticle size in the range of 7.12 nm to 14.45 nmwith an average size distribution of 110.6 nm while gold nanoparticles immobilized in the pores ofzeolites have sizes ranging from 4.98 nm to 9.50 nm with an average size distribution of 279 nm. UVVisible absorption spectrum revealed a new formed peak at 537 nm, indicating formation of AuNPs. The characteristic peaks (at 526 nm and 532 nm) were also found in the UV-Vis absorption spectrum ofAuNPs immobilized in the zeolite pores and AuNPs in the zeolite@AuNPs@MET composite, respectively.FTIR measurements of mercaptoethanol ligand showed the presence of a peak at 2550 cm-1 regionindicating SH functional groups, which disappeared after modification of zeolite@Au with MET ligand,indicated the –SH bond was broken and the remained –S was attached to AuNPs. All of thecharacterization revealed the success of the composite material preparation, which is an interestingmaterial expected to have highly potential as a heavy metal ion adsorbent.
HUBUNGAN KARAKTERISTIK SEDIMEN DASAR TERHADAP KANDUNGAN MERKURI AKIBAT PERTAMBANGAN EMAS TANPA IJIN (PETI) PONGKOR - KAB. BOGOR Nst, Hasmalina; Yoga, Gunawan Pratama; Darusman, Latifah K.
Sistem Informasi Vol 2 No 2 (2012): Jurnal Photon
Publisher : Fakultas MIPA dan Kesehatan Universitas Muhammadiyah Riau

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Abstract

Aktivitas ekstraksi bijih emas dengan gelundungan yang menggunakan merkuri oleh Pertambangan Emas Tanpa Ijin (PETI) Pongkor di Sungai Cikaniki, Kab. Bogor telah menimbulkan dampak yang negatif terhadap ekosistem air tawar, akibat pembuangan limbah tailling merkuri secara langsung tanpa pengolahan terlebih dahulu ke lingkungan perairan sehingga mengakibatkan pencemaran air dan sedimen. Kandungan Merkuri total yang terlarut dalam sampel air sungai dan sedimen dianalisa dengan Atomic Absorption Spectroscopy (AAS), karakteristik sedimen dasar dilakukan dengan ayakan bertingkat, sedangkan hubungan kadar merkuri dengan karakteristik fraksi penyusun sedimen ditentukan dengan analisis korelasi. Hasil pengukuran kandungan merkuri dalam air sungai keempat lokasi sampling rata-rata berkisar ttd-0,265 ppm; dalam sedimen berkisar <0,0002-196 ppm dan karakteristik sedimen sungai Cikaniki rata-rata keempat lokasi terdiri dari pasir 73,9%; lumpur 4,8% ; liat 21,3%. Analisis korelasi menunjukkan adanya hubungan yang positif yang sangat erat antara fraksi halus (lumpur dan fraksi liat) sedimen dengan kadar merkuri dengan nilai koefesien korelasi (r) bulan Juni dan September berkisar antara 0.766 – 0.860, sebaliknya korelasi yang negatif antara fraksi kasar (pasir) sedimen dan kadar merkuri dengan nilai koefesien korelasi (r) bulan Juni dan Spetember berkisar antara -0.239 - -0.045.
UJI IN VITRO EKSTRAK AIR DAN ETANOL DARI BUAH ASAM GELUGUR, RIMPANG LENGKUAS, DAN KENCUR SEBAGAI INHIBITOR AKTIVITAS LIPASE PANKREAS Iswantini, Dyah; Darusman, Latifah K.; Fitriyani, Ana
Jurnal Sains dan Teknologi Indonesia Vol. 12 No. 1 (2010)
Publisher : Badan Pengkajian dan Penerapan Teknologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (70.299 KB) | DOI: 10.29122/jsti.v12i1.845

Abstract

Asam gelugur fruits of Garcinia often used to reduce body weight. Lengkuas and kencur are traditional herbal that potential for antiobesity because they could reduce the level of phospholipids, triglycerides, and cholesterol. The aim of the research was to evaluate the potencies of these herbal as antiobesity by measurement of their water and ethanol extracts capabilities as in vitro inhibitor of pancreatic lipase activity. The water and ethanol extracts of asam gelugur fruits contained saponins and alkaliods, respectively. The water extract of lengkuas rhizomes contained alkaloids, flavonoids, saponins, and quinones, while the ethanol extract contained alkaloids, flavonoids, saponins, and steroids. The water extract of kencur rhizomes contained saponins and quinones, while the ethanolextract contained alkaloids, flavonoids, steroids, and quinones. The highest inhibitory effect of all extracts was obtained from the ethanol extract of asam gelugur fruits with value of 86.3% at 150 ppm. The highest inhibitory effect of lengkuas extracts was from the ethanol extract at 200 ppm (56.2%). The highestinhibitory effect of kencur was showed by the ethanol extract with the value 37.6% at 300 ppm. These values were higher than the inhibitory effect of the positive control (Xenical®) at 100 ppm (10.6%).
Editorial dan Kelengkapan Jurnal Darusman, Latifah K.
Jurnal Jamu Indonesia Vol. 1 No. 1 (2016): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v1i1.7

Abstract

Puji dan syukur kami ucapkan kepada Tuhan YME yang akhirnya di tahun 2016 ini, Pusat Studi Biofarmaka Tropika LPPM IPB telah menerbitkan Jurnal Jamu Indonesia sebagai media diseminasi penelitian terkait jamu Indonesia. Jurnal ini nantinya diharapkan dapat menambah informasi menyeluruh tentang jamu dari kegiatan hulu hingga hilirnya. Jamu merupakan warisan budaya Indonesia dan telah digunakan sejak berabad abad yang lalu. Jamu merupakan istilah lain dari obat herbal yang terbuat dari tumbuhan obat segar atau kering di Indonesia unruk kesehatan dan kecantikan. Penggunaannya saat ini menunjukkan kecenderungan yang semakin meningkat dan tren ini juga tampak dalam skala global. Lebih jauh, Sistem Kesehatan Nasional Indonesia menyatakan bahwa pengembangan dan peningkatan obat tradisional dalam hal ini jamu ditujukan agar diperoleh obat tradisional yang bermutu tinggi, aman, memiliki khasiat nyata yang teruji secara ilmiah dan dimanfaatkan secara luas, baik untuk pengobatan sendiri oleh masyarakat maupun digunakan dalam pelayanan kesehatan formal. Tiga isu kunci yaitu kualitas, keamanan dan khasiat untuk pengembangan produk jamu hanya dapat dicapai apabila prioritas diberikan sejak awal proses pengembangannya. Dalam beberapa tahun terakhir, isu kualitas, keamanan dan khasiat telah menjadi fokus perhatian para ilmuwan yang bekerja dalam keilmuan terkait. Seiring dengan banyaknya penelitian-penelitian pengembangan Jamu ini, hasil kajian yang didapatkan tentunya akan memerlukan wadah untuk diseminasi agar hasil kajian tersebut dapat diakses oleh para pihak yang memerlukan. Jurnal Jamu Indonesia dapat menjadi fasilitas bagi para peneliti dan ilmuwan untuk memudahkan pendistribusian informasi ilmu pengetahuan mengenai jamu melalui tulisan-tulisan yang dapat dipublikasi. Semua hasil karya tersebut akan diarsipkan sebagai dokumentasi berharga demi terjaganya informasi yang dapat menjadi sumber pengembangan ilmu pengetahuan di masa depan.Latifah K. DarusmanKetua Dewan Redaksi
Cellulolytic Yeast Isolated From Raja Ampat Indonesia Kanti, Atit; Sukarno, Nampiah; Sukara, Endang; Darusman, Latifah K.
Annales Bogorienses Vol. 16 No. 1 (2012): Annales Bogorienses
Publisher : BRIN

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Abstract

The objective of this study was to select and characterize three yeast isolates originating from soil of Raja Ampat region of Papua, Indonesia for its potential to produce cellulase . Selection and characterization of cellulolytic yeast was carried out by measuring cellulolytic Index (IS)with congo red method and measurement of Carboxy Methyl Cellulase (CMC-ase) activity through determination of reducing sugar with dinitrosalycilic methods. Cellulolytic Index (IS) of the isolates Sporobolomyces poonsookiae Y08RA07, Rhodosporidium paludigenum Y08RA29, and Cryptococcus flavescens Y08RA33 were 1.40, 2.60 and 1.66, respectively. CMC-ase produced optimum at pH 8 at 37ºC by isolate Y08RA07; whereas for Y08RA29 and Y08RA33 were at pH 6, at 28ºC. Paper waste was good substrate for cellulase enzyme production by isolate Y08RA07, while for two other isolates the best substrate was CMC. Isolate Y08RA29 having highest cellulase activities when grown in CMC, while isolates Y08RA07 and Y08RA33 achieved highest enzyme activity when grown in bamboo leaf. 
Co-Authors Ana Fitriyani Anisa Agustina, Anisa Atit Kanti Dyah Iswantini Endang Sukara Ervizal AMZU Eti Rohaeti Gunawan Pasaribu Gunawan Pratama Yoga, Gunawan Pratama Hasmalina Nst ISKANDAR ZULKARNAEN SIREGAR Mr. Kissinger Nampiah Sukarno Nurdiani Nurdiani, Nurdiani Wasrin Syafii