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BIOLOGICAL ACTIVITIES AFFORDED BY THE EXTRACT FROM RARU BARK TO INHIBIT ACTION OF ALPHA- GLUCOSIDASE ENZYMES Pasaribu, Gunawan; Syafii, Wasrin; Darusman, Latifah K.
Indonesian Journal of Forestry Research Vol 8, No 1 (2011): Journal of Forestry Research
Publisher : Secretariat of Forestry Research and Development Agency

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Raru (Shoreabalanocarpoides Sym) signifies one of the tree species that grows widespread in Sumatra Island. Â Its bark portion is commonly used by local villagers as additional ingredient mixed to nira (sugar palm juice). Â This addition is intended to make the juice more durable and also to enrich its taste after the juice is previously fermented to become traditional toddy beverage or the so-call âtuakâ. Â Local villagers believe that raru bark can reduce the level of blood sugar. As the relevance, the research was conducted to confirm that the extract from raru bark could afford its biological activities to inhibit alpha-glucosidase enzyme through its characterization, quantification, and isolation of its boactive compound. The extraction was performed using two methods (i.e.reflux and maceration techniques). Result revealed that the bark extract obtained from both techniques contained polyphenol compounds: flavonoid, saponin and tannin. Further, raru-bark extract from the reflux and maceration techniques could inhibit the action of alpha glucosidase enzymes on carbohydrate substrate ( i.e. p -nitrophenil-Î±-D-glucopyranose), at respectively 90.67% and 97.33%. Meanwhile, the inhibition activities afforded by the patented drug as a control (i.e. glucobay) equaled to 97.05%. Â Assesment using UV-VIS spectroscopy, showed that the maximum spectrum of bioactive compound in the extract was at the wave length of 288.6 nm. Scrutiny using FTIR spectroscopy could identif y the presence of aromatic groups in the compound, containing -OH, C-H, C=C, C-O and C-H bond types. Analysis using GC-MS exhibited that the compound had molecular weight of 390 with molecular structure as C20H22O8. Ultimately, data analysis scrutiny with the aid of NMR judged the most plausible compound as bioactive was 4-Glucosyl-3, 4â, 5-trihydroxystilbene.

BIOLOGICAL ACTIVITIES AFFORDED BY THE EXTRACT FROM RARU BARK TO INHIBIT ACTION OF ALPHA- GLUCOSIDASE ENZYMES Pasaribu, Gunawan; Syafii, Wasrin; Darusman, Latifah K.
Indonesian Journal of Forestry Research Vol 8, No 1 (2011): Journal of Forestry Research
Publisher : Secretariat of Forestry Research and Development Agency

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20886/ijfr.2011.8.1.32-49

Raru (Shoreabalanocarpoides Sym) signifies one of the tree species that grows widespread in Sumatra Island. Â Its bark portion is commonly used by local villagers as additional ingredient mixed to nira (sugar palm juice). Â This addition is intended to make the juice more durable and also to enrich its taste after the juice is previously fermented to become traditional toddy beverage or the so-call âtuakâ. Â Local villagers believe that raru bark can reduce the level of blood sugar. As the relevance, the research was conducted to confirm that the extract from raru bark could afford its biological activities to inhibit alpha-glucosidase enzyme through its characterization, quantification, and isolation of its boactive compound. The extraction was performed using two methods (i.e.reflux and maceration techniques). Result revealed that the bark extract obtained from both techniques contained polyphenol compounds: flavonoid, saponin and tannin. Further, raru-bark extract from the reflux and maceration techniques could inhibit the action of alpha glucosidase enzymes on carbohydrate substrate ( i.e. p -nitrophenil-Î±-D-glucopyranose), at respectively 90.67% and 97.33%. Meanwhile, the inhibition activities afforded by the patented drug as a control (i.e. glucobay) equaled to 97.05%. Â Assesment using UV-VIS spectroscopy, showed that the maximum spectrum of bioactive compound in the extract was at the wave length of 288.6 nm. Scrutiny using FTIR spectroscopy could identif y the presence of aromatic groups in the compound, containing -OH, C-H, C=C, C-O and C-H bond types. Analysis using GC-MS exhibited that the compound had molecular weight of 390 with molecular structure as C20H22O8. Ultimately, data analysis scrutiny with the aid of NMR judged the most plausible compound as bioactive was 4-Glucosyl-3, 4â, 5-trihydroxystilbene.

KARAKTERISTIK HABITAT MIKRO TABAT BARITO (Ficus deltoidea Jack) PADA TUMBUHAN INANGNYA Agustina, Anisa; Zuhud, Ervizal A.M.; Darusman, Latifah K.
Jurnal Penelitian Hutan dan Konservasi Alam Vol 12, No 1 (2015): Jurnal Penelitian Hutan dan Konservasi Alam
Publisher : Pusat Penelitian dan Pengembangan Hutan

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Tabat barito (Ficus deltoidea Jack.) merupakan tumbuhan yang berpotensi sebagai obat dan memiliki sebaran luas Â di Indonesia, Â meliputiÂ Jawa Â Barat, Â Jawa Â Tengah, Â Sumatera, Â KalimantanÂ danÂ Sulawesi. Â Di Â Taman Nasional Gunung Gede Pangrango (TNGGP), tabat barito tumbuh sebagai epifit yang berpotensi sebagai sumber plasma nutfah bagi tujuan pengembangan budidaya. Tujuan dari penelitian ini adalah untuk memperoleh informasi tentang karakteristik habitat mikro tabat barito di Resort Mandalawangi TNGGP. Hasil penelitianÂ menunjukkanÂ bahwa Â sebaran tabat Â barito Â hingga elevasi 1.800 Â m dpl. Â Penelitian yang dilakukan memperoleh hasil, yaitu 178 individu tabat barito yang berasal dari 100 individu tumbuhan inang. Tabat barito terletak pada kisaran suhu 18,3Â°C-23,1Â°C, kelembaban udara relatif 80-84% dan kelerengan 4%-24% dengan arah lereng bervariasi. Tumbuhan inang memiliki karakteristik fisik yang bervariasi dalam hal tinggi pohon, diameter batang maupun luas tajuknya, namun memiliki persamaan dalam hal karakteristik kulit Â batangnya, Â yaitu Â memiliki Â permukaan Â yang Â kasar Â denganÂ kulit Â batang Â yang Â mengelupas Â maupun beralur. Â Media Â tumbuhÂ tabat Â barito Â pada Â tumbuhan Â inang Â bervariasi, Â mulaiÂ dariÂ akar Â yang Â menempel langsung pada kulit batang hingga media tumbuh berupa hasil dekompisisi

SINTESIS ADSORBEN ZEOLIT@AuNPs@MET MENGGUNAKAN EKSTRAK DAUN BINAHONG (Anredera cordifolia) SEBAGAI BIOREDUKTOR PREKURSOR Au DAN KARAKTERISASINYA (Synthesis Zeolite@AuNPs@MET Adsorbent by Binahong (Anredera cordifolia) Leaf Extract as Au Precursor Bioreduc Nurdiani, Nurdiani; Darusman, Latifah K.; Rohaeti, Eti
Jurnal Hasil Penelitian Industri Vol 28, No 1 (2015)
Publisher : Baristand Industri Banda Aceh

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Modifying zeolite with Au nanoparticles and mercaptoethanol ligand(zeolite@AuNPs@MET) has been developed as an adsorbent of heavy metal ions. The preparation ofzeolite@AuNPs@MET composite material was done in three steps. Firstly, incorporating gold precursorin to zeolite cavity. Secondly, reduction of gold nanoparticles by binahong leaf extract. Thirdly, modifyingzeolite@AuNPs with mercaptoethanol ligand. Binahong was used as bioreductor agent in the synthesis ofAu nanoparticles since it has large contents of flavonoids, saponins, tannins, and steroids which containreducing functional group. The zeolite@AuNPs@MET composite material was characterized by XRD,EDX, PSA, TEM, FTIR and UV Visible Spectrophotometer. EDX measurements showed Au content of0.88%, TEM and PSA measurement showed Au nanoparticle size in the range of 7.12 nm to 14.45 nmwith an average size distribution of 110.6 nm while gold nanoparticles immobilized in the pores ofzeolites have sizes ranging from 4.98 nm to 9.50 nm with an average size distribution of 279 nm. UVVisible absorption spectrum revealed a new formed peak at 537 nm, indicating formation of AuNPs. The characteristic peaks (at 526 nm and 532 nm) were also found in the UV-Vis absorption spectrum ofAuNPs immobilized in the zeolite pores and AuNPs in the zeolite@AuNPs@MET composite, respectively.FTIR measurements of mercaptoethanol ligand showed the presence of a peak at 2550 cm-1 regionindicating SH functional groups, which disappeared after modification of zeolite@Au with MET ligand,indicated the âSH bond was broken and the remained âS was attached to AuNPs. All of thecharacterization revealed the success of the composite material preparation, which is an interestingmaterial expected to have highly potential as a heavy metal ion adsorbent.

HUBUNGAN KARAKTERISTIK SEDIMEN DASAR TERHADAP KANDUNGAN MERKURI AKIBAT PERTAMBANGAN EMAS TANPA IJIN (PETI) PONGKOR - KAB. BOGOR Nst, Hasmalina; Yoga, Gunawan Pratama; Darusman, Latifah K.
Sistem Informasi Vol 2 No 2 (2012): Jurnal Photon
Publisher : Fakultas MIPA dan Kesehatan Universitas Muhammadiyah Riau

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Aktivitas ekstraksi bijih emas dengan gelundungan yang menggunakan merkuri oleh Pertambangan Emas Tanpa Ijin (PETI) Pongkor di Sungai Cikaniki, Kab. Bogor telah menimbulkan dampak yang negatif terhadap ekosistem air tawar, akibat pembuangan limbah tailling merkuri secara langsung tanpa pengolahan terlebih dahulu ke lingkungan perairan sehingga mengakibatkan pencemaran air dan sedimen. Kandungan Merkuri total yang terlarut dalam sampel air sungai dan sedimen dianalisa dengan Atomic Absorption Spectroscopy (AAS), karakteristik sedimen dasar dilakukan dengan ayakan bertingkat, sedangkan hubungan kadar merkuri dengan karakteristik fraksi penyusun sedimen ditentukan dengan analisis korelasi. Hasil pengukuran kandungan merkuri dalam air sungai keempat lokasi sampling rata-rata berkisar ttd-0,265 ppm; dalam sedimen berkisar <0,0002-196 ppm dan karakteristik sedimen sungai Cikaniki rata-rata keempat lokasi terdiri dari pasir 73,9%; lumpur 4,8% ; liat 21,3%. Analisis korelasi menunjukkan adanya hubungan yang positif yang sangat erat antara fraksi halus (lumpur dan fraksi liat) sedimen dengan kadar merkuri dengan nilai koefesien korelasi (r) bulan Juni dan September berkisar antara 0.766 â 0.860, sebaliknya korelasi yang negatif antara fraksi kasar (pasir) sedimen dan kadar merkuri dengan nilai koefesien korelasi (r) bulan Juni dan Spetember berkisar antara -0.239 - -0.045.

UJI IN VITRO EKSTRAK AIR DAN ETANOL DARI BUAH ASAM GELUGUR, RIMPANG LENGKUAS, DAN KENCUR SEBAGAI INHIBITOR AKTIVITAS LIPASE PANKREAS Iswantini, Dyah; Darusman, Latifah K.; Fitriyani, Ana
Jurnal Sains dan Teknologi Indonesia Vol. 12 No. 1 (2010)
Publisher : Badan Pengkajian dan Penerapan Teknologi

Asam gelugur fruits of Garcinia often used to reduce body weight. Lengkuas and kencur are traditional herbal that potential for antiobesity because they could reduce the level of phospholipids, triglycerides, and cholesterol. The aim of the research was to evaluate the potencies of these herbal as antiobesity by measurement of their water and ethanol extracts capabilities as in vitro inhibitor of pancreatic lipase activity. The water and ethanol extracts of asam gelugur fruits contained saponins and alkaliods, respectively. The water extract of lengkuas rhizomes contained alkaloids, flavonoids, saponins, and quinones, while the ethanol extract contained alkaloids, flavonoids, saponins, and steroids. The water extract of kencur rhizomes contained saponins and quinones, while the ethanolextract contained alkaloids, flavonoids, steroids, and quinones. The highest inhibitory effect of all extracts was obtained from the ethanol extract of asam gelugur fruits with value of 86.3% at 150 ppm. The highest inhibitory effect of lengkuas extracts was from the ethanol extract at 200 ppm (56.2%). The highestinhibitory effect of kencur was showed by the ethanol extract with the value 37.6% at 300 ppm. These values were higher than the inhibitory effect of the positive control (Xenical®) at 100 ppm (10.6%).

Editorial dan Kelengkapan Jurnal Darusman, Latifah K.
Jurnal Jamu Indonesia Vol. 1 No. 1 (2016): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v1i1.7

Puji dan syukur kami ucapkan kepada Tuhan YME yang akhirnya di tahun 2016 ini, Pusat Studi Biofarmaka Tropika LPPM IPB telah menerbitkan Jurnal Jamu Indonesia sebagai media diseminasi penelitian terkait jamu Indonesia. Jurnal ini nantinya diharapkan dapat menambah informasi menyeluruh tentang jamu dari kegiatan hulu hingga hilirnya. Jamu merupakan warisan budaya Indonesia dan telah digunakan sejak berabad abad yang lalu. Jamu merupakan istilah lain dari obat herbal yang terbuat dari tumbuhan obat segar atau kering di Indonesia unruk kesehatan dan kecantikan. Penggunaannya saat ini menunjukkan kecenderungan yang semakin meningkat dan tren ini juga tampak dalam skala global. Lebih jauh, Sistem Kesehatan Nasional Indonesia menyatakan bahwa pengembangan dan peningkatan obat tradisional dalam hal ini jamu ditujukan agar diperoleh obat tradisional yang bermutu tinggi, aman, memiliki khasiat nyata yang teruji secara ilmiah dan dimanfaatkan secara luas, baik untuk pengobatan sendiri oleh masyarakat maupun digunakan dalam pelayanan kesehatan formal. Tiga isu kunci yaitu kualitas, keamanan dan khasiat untuk pengembangan produk jamu hanya dapat dicapai apabila prioritas diberikan sejak awal proses pengembangannya. Dalam beberapa tahun terakhir, isu kualitas, keamanan dan khasiat telah menjadi fokus perhatian para ilmuwan yang bekerja dalam keilmuan terkait. Seiring dengan banyaknya penelitian-penelitian pengembangan Jamu ini, hasil kajian yang didapatkan tentunya akan memerlukan wadah untuk diseminasi agar hasil kajian tersebut dapat diakses oleh para pihak yang memerlukan. Jurnal Jamu Indonesia dapat menjadi fasilitas bagi para peneliti dan ilmuwan untuk memudahkan pendistribusian informasi ilmu pengetahuan mengenai jamu melalui tulisan-tulisan yang dapat dipublikasi. Semua hasil karya tersebut akan diarsipkan sebagai dokumentasi berharga demi terjaganya informasi yang dapat menjadi sumber pengembangan ilmu pengetahuan di masa depan.Latifah K. DarusmanKetua Dewan Redaksi

Pertumbuhan, Produksi dan Kandungan Triterpenoid Dua Jenis Pegagan (Centella asiatica L. (Urban)) Sebagai Bahan Obat pada Berbagai Tingkat Naungan Kurniawati, Ani; Darusman, Latifah K.; Rachmawaty, Rani Yulie
Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) Vol. 33 No. 3 (2005): Jurnal Agronomi Indonesia
Publisher : Indonesia Society of Agronomy (PERAGI) and Department of Agronomy and Horticulture, Faculty of Agriculture, IPB University, Bogor, Indonesia

The research was aimed to determine the optimum shading level and effect two types of Indian Pennywort (Centella asiatica L. Urban)) on growth, production, and triterpernoid. The research was conducted on March until November 2004 at BIOFARMAKA Research Station, Darmaga and chemical analysis was conducted at Analytical Chemistry Laboratory, FMIPA, Baranangsiang. Split plot design with two factors was used in this experiment. The first factor was shading level as main plots consisting of 0, 25, 55, and 75% shading level. The second factor was type of Indian Pennywort as subplots consisting of big and small Indian Pennywort. Result of the reseach showed that shading effects decrease leaf area indeks, yield, and composition of triterpenoid content of Indian Pennywort. No shading treatment showed optimum growth and yield. The combination of 25% shading and small type of Indian Pennywort gave the highest triterpenoid content. Both types of Indian Pennywort showed best growth; the difference in length of petiole, number of leaf and shoots but the small one gave the best yield. Key words : Indian Pennywort type, shading level, triterpenoid

Pengaturan Pembungaan Tanaman Manggis (Garcinia mangostana L.) di Luar Musim dengan Strangulasi, serta Aplikasi Paklobutrazol dan Etepon Rai, I Nyoman; Poerwanto, Roedy; Darusman, Latifah K.; Purwoko, Bambang S.
Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) Vol. 32 No. 2 (2004): Buletin Agronomi
Publisher : Indonesia Society of Agronomy (PERAGI) and Department of Agronomy and Horticulture, Faculty of Agriculture, IPB University, Bogor, Indonesia

The objective of the research was to study the application of strangulation, packlobutrazol and ethephon to stimulate flowering of mangosteen trees. The experiment was conducted from June 2002 to September2 003, located at Farmer's Mangosteen Orchards, Leuwiliang, Bogor. A randomized block design with two factors was used in thisexperiment. The first factor was treatments to stimulate flowering consisted of three levels i.e strangulation (8), (S) application of paclobubtrazol (P) and control (K). The second factor was treatments for dormancy breaking consisted of two levels i.e without ethephon (Eo) and with ethephon (EiJ. Each treatment was replicated four times. The resultshowed that strangulation and application of paclobutrazol were effective in stimulating flowering of mangosteen trees. Those treatments decreased gibberellic acid content and increased total sugar and C: N ratio. Interaction effect was found between treatments to stimulate flowering and ethephon on number of flowers, number of fruits and weight of fruits per tree. The highest fruits weight (2.,50 kg/tree) was obtained on the combination of paclobutrazol with ethephon while the lowest was in control without ethephon( 6.05 kg/tree).Key words: Mangosteen, Strangulation, Paclobutrazol, Ethephon, Flowering;

Studies on Dormancy Periods and Growth Rhythm of Shoot and Root of Mangosteen (Garcinia mangostana L.) Hidayat, Ramdan; Surkati, Achmad; Poerwanto, Roedhy; Darusman, Latifah K.; Purwoko, Bambang S.
Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) Vol. 33 No. 2 (2005): Jurnal Agronomi Indonesia
Publisher : Indonesia Society of Agronomy (PERAGI) and Department of Agronomy and Horticulture, Faculty of Agriculture, IPB University, Bogor, Indonesia

Mangosteen has a good prospectus for international market. Many people in the world like this fruit because it is delicious, has high nutrient contents, and it can be consumed as a fresh fruit. The growth of mangosteen is very slow with a very long juvenile period because of its long dormancy period. The objective of this research was to study the dormancy periods and growth rhytm of shoot and root of young and adult mangosteen seedlings. The research used completely randomized design and consisted of two experiments. The first experiment was to study the dormancy and flushing periods. The second experiment was to study the growth patterns of shoot and root foom several ages of mangosteen seedlings. This research was conducted at Mekarsari Fruit Park, Cileungsi, Bogor. The result of the experiment showed that two years old of mangosteen seedling had 5 flushes per year, four years old of mangosteen had 3-4 flushes per year, and eight years old of mangosteen only had 2 flushes. Dormancy periods were significantly different between 2,4 and 8 year of mangosteen seedling. After the seedlings have branches, the dormancy periods become twice as many as that before branching. The roots grew rapidly two weeks before flush and slower after flush occurred. Key words: Garcinia mangostana, dormancy, flush, seedling

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