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All Journal Jurnal Keperawatan Biomedical Journal of Indonesia Jurnal Penelitian Kesehatan Suara Forikes Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Multidisciplinary Science Jurnal Ilmu Kesehatan Indonesia (JIKSI)
Avit Suchitra
Bagian Bedah Fakultas Kedokteran Universitas Andalas, RSUP Dr. M. Djamil, Padang 25163, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Journal : Majalah Kedokteran Andalas

 1 
Exploring the Link Between Oxidative Stress Reduction and Liver Function Improvement in Jaundiced Rats with Lactococcus lactis D4 Avit Su Suchitra
Majalah Kedokteran Andalas Vol 46, No 12 (2024): Online Oktober 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i12.p1948-1956.2024

Abstract

Objective: To explore the correlation between the reduction of oxidative stress and liver enzyme function in rats with obstructive jaundice, using malondialdehyde (MDA) levels as a biochemical marker, and its impact on serum glutamic oxaloacetic transaminase (SGOT) levels; Method: This experimental study used a post-test only randomized control group design in three groups of Rattus norvegicus strain Wistar rats with an obstructive jaundice model. The rats underwent biliary duct ligation and received Lactococcus lactis D4 starter fermented milk for 7 days. Oxidative stress was assessed by measuring MDA levels and Liver function was assessed by measuring levels of SGOT ; Result: The correlation analysis show an r-value of 0.886 revealed that there a very strong positive correlation between MDA and SGOT levels after LLD4 administration; Conclusion: Lactococcus lactis D4 starter fermented milk can improve liver function, indicated by decreased MDA levels and SGOT  levels in experimental animals.
Co-Authors Desmawati Desmawati Eka Nofita Fira Firdausia Hannan Khairu Anami Ilma Fitri Sakina Irwan Irwan Izzati, Ruhilda Julizar Julizar Juni Mitra Leni Merdawati M. Iqbal Rivai Malinda Meinapuri Muhammad Adzka Putra Anbiar Raditya Arya Dewanda Rizqy Tansa Rustam, Rony Selfi Renita Rusjdi Suswita, Rini Taufik Hidayat Yenita Afriyeni Yudi Ichsan Ramata Zikra Muhammad