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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Insan Farmasi Indonesia Jurnal Abdi Masyarakat Kita Jurnal Farmasi Sains dan Praktis Urecol Journal. Part G: Multidisciplinary Research Prosiding University Research Colloquium Borobudur Pharmacy Review
Widarika Santi Hapsari
Universitas Muhammadiyah Magelang, Indonesia
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Environmental Science Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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MODELING OF MICE AS TEST ANIMALS FOR A PRECLINICAL STUDY OF HYPOLIPIDEMIC AGENTS Setiyo Budi Santoso; Widarika Santi Hapsari; Renny Setyowati
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.8463

Abstract

Animal models suitable for preclinical research are necessary for the discovery of hypolipidemic agents. Various publications have presented alternative dyslipidemia animal models, but identifying a feasible and stable method would serve as a solid reference for researchers. This investigation aimed to establish a sustained dyslipidemia induction that persists after several days of intervention with a hypolipidemic agent. Six groups of mice, each consisting of five primary test animals and one reserve test animal, were used. After a seven-day acclimatization period, we induced each group for 14 days using three different methods: (1) 5% body weight of quail egg yolks (5% QEY), (2) 10% body weight of used cooking oil (10% UCOs), and (3) a combination of 5% QEY and 10% UCOs. Once all mice reached their peak lipid levels, we evaluated lipid performance through a seven-day intervention with simvastatin (0.026 mg/20-gram body weight) in one of the paired groups. A 14-day combined induction of 5% QEY and 10% UCOs resulted in a 39% elevation in mouse lipids compared to baseline levels. Our findings offer an alternative to traditional dyslipidemia models. However, the development of an animal model for dyslipidemia still poses challenges. Therefore, the identification of novel biomarkers capable of targeting dyslipidemia in humans is crucial.
Literature Review Analysis of the Side Effects of Chemotherapy in Cervical Cancer Patients in Southeast Asia Stephen Yustianto Pribadi; Fitriana Yuliastuti; Widarika Santi Hapsari
Urecol Journal. Part G: Multidisciplinary Research Vol. 2 No. 2 (2022): August-Dec
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53017/ujmr.207

Abstract

Cervical cancer is a cancer that occurs in the cervical part of the uterus that is the area in the female reproductive organs which is the entrance to the uterus located between the uterus and the burrow of intercourse. Cervical cancer treatment is known to be in several ways, one of which is by chemotherapy. Chemotherapy is a treatment using drugs both oral and intravenous that aim to inhibit or kill cancer cells, but treatment with chemotherapy has many side effects for people with cervical cancer. This study aims to analyze the side effects of chemotherapy in cervical cancer patients in Southeast Asia using the literature review method. The references used are literature obtained from Google Scholar and Pub Med from 2014 to 2020. After reviewing 15 journals it was stated that the side effects of chemotherapy on cervical cancer patients in Southeast Asia were nausea and vomiting (34.28%), anemia (14.28%), neurotoxins (14.28%), alopecia (11.42%), allergic reactions (8.57%), thrombocytopenia (8.57%), leukopenia (5.71%) and stomatitis (2.85%).
Co-Authors Adityawati, Rina Afif Tia Fatmawati Alfian Syariffudin Anggi Pratiwi Fatmawati, Afif Tia Fitriana Yuliastuti Heni Lutfiyati Herma Fanani Agusta Herma Fanani Agusta Lilik Kurniati Mia Annida Amalia Muhammad Khoirul Amin Ni Made Ayu Nila Septianingrum Ni Made Ayu Nila Septianingrum Prasojo Pribadi Puspite Septie Dinata Renny Setyowati Rifa Rizqi Azizah Rina Adityawati Setiyo Budi Santoso Stephen Yustianto Pribadi Viantika Meiliana Wulandari