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All Journal VALENSI Journal of Mathematical and Fundamental Sciences Al-Kimia Chimica et Natura Acta Indonesian Journal of Chemistry Molekul: Jurnal Ilmiah Kimia

Rani Maharani

Departemen Kimia Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Padjadjaran

Author-ID : 2589732

Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Environmental Science Materials Science & Nanotechnology Mathematics Physics

Published : 15 Documents Claim Missing Document

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Four Flavan-3-ol Compounds From The Stembark of Chisocheton balansae C.DC. (MELIACEAE) Unang Supratman; Mohamad Fajar; Supriatno Salam; Rani Maharani; Desi Harneti; Nur;lelasari Nurlelasari; Dewa Gede Katja; Agus Safari; Mohamad Nurul Azmi
Molekul Vol 16, No 1 (2021)
Publisher : Universitas Jenderal Soedirman

Chisocheton balansae C.DC., is one of the Meliaceae family plants which is the endemic plants from Soputan Mountain, North Sulawesi, Indonesia. This study was aimed to determine the chemical structure of flavan-3-ol compounds from ethyl acetate extract of C. balansae C.DC stembark. Dried powder of C. balansae C.DC stem bark was extracted consecutively with n-hexane, ethyl acetate, and methanol solvents. Four flavan-3-ol compounds, named catechin (1), epicatechin (2), epigallocatechin-3-O-gallate (3), and epicatechin-3-O-gallate (4) were successfully isolated from ethyl acetate extract. The chemical structure of these isolates was determined by spectroscopic methods (1H-NMR, 13C-NMR, DEPT, and 2D-NMR) and comparison with previous reported spectral data. These compounds are first time reported from this plant.

Cytotoxic Triterpenoids from the Stembark of Aglaia argentea (Meliaceae) Ace Tatang Hidayat; Kindi Farabi; Desi Harneti; Nurlelasari Nurlelasari; Rani Maharani; Ida Nurfarida; Unang Supratman; Yoshihito Shiono
Indonesian Journal of Chemistry Vol 18, No 1 (2018)
Publisher : Universitas Gadjah Mada

Four dammarane-type triterpenoid compounds, dammar-24-en-3a-ol (1), 3-epi-cabraleahydroxy lactone (2), (E)-25-hydroperoxydammar-23-en-3b,20-diol (3), and dammar-24-en-3β,20-diol (4), were isolated from the methanolic extract of the stembark of Aglaia argentea. Compounds 1-4 were isolated for first time from this plant. The structure of isolated compounds were elucidated by spectroscopic methods including one and two-dimensional NMR as well as mass spectrometric analysis. Compounds, 1-4, along with a known synthetic analog, 20-hydroxy-dammar-24-en-3-on (5), were evaluated their cytotoxic activity against P-388 murine leukemia cells in vitro. The IC50 values of compounds, 1-5 were 9.09 ± 0.10, 68.53 ± 0.08, 5.89 ± 0.08, 22.40 ± 0.11, and 11.53 ± 0.08 µg/mL, respectively. Among the dammarane-type triterpenoids, compounds 1, 3, 4 and 5 having opened side chain showed the stronger activity, wheres compound 2 with cyclic side chain showed weak or no activity. In addition, compound 3 showed strongest activity, indicate that hydroperoxy group at side chain increase cytotoxic activity.

Havanensin-type Limonoids from the Stem Bark of Chisocheton pentandrus (Meliaceae) Dudi Runadi; Purnama Purnama; Supriatno Salam; Nulelasari Nurlelasari; Desi Harneti; Tri Mayanti; Rani Maharani; Unang Supratman; Yoshihito Shiono
Journal of Mathematical and Fundamental Sciences Vol. 54 No. 3 (2023)
Publisher : Directorate for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2023.54.3.2

A new limonoid, belonging to the havanensin-type, called pentandricine E (1), alongside four other known types, i.e., trichilenone acetate (2), toonaciliatones C (3), 11α-acetoxyazadirone (4) and ceramicine I (5), were found in Chisocheton pentandrus stem bark. The structures of the isolated 1-5 were identified by NMR spectroscopy and HRTOFMS. Pentandricine E (1) displayed the highest cytotoxicity toward the MCF-7 breast cancer line with an IC50 value of 63.27 ± 0.21 mM.

Computational Study of Nocardiotide-A Analogues in the Development of Technetium-99m Radiopeptides for Cancer Imaging for Targeting Somatostatin Receptor 2 Rizky Juwita Sugiharti; Rani Maharani; Rahmana Emran Kartasasmita; Daryono Hadi Tjahjono
Journal of Mathematical and Fundamental Sciences Vol. 55 No. 1 (2023)
Publisher : Directorate for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2023.55.1.5

Nocardiotide-A (cWIWLVA) is a cyclic peptide with significant cytotoxicity against several cancer cells. The present research aimed to design a radiopeptide based on nocardiotide-A analogues to be labeled by technetium-99m targeting SSTR2, which is the most widely expressed receptor in several types of human cancers and used as radiopeptide target. Nocardiotide-A analogues were individually designed by replacing valine at the lead compound with lysine, arginine, histidine, asparagine, and glutamine, and this was simulated by molecular dynamics using AMBER18. A molecular docking using AutoDock 4.2 was performed and evaluated to understand the effect of chelation of technetium-99m on 99mTc-HYNIC-EDDA and 99mTc-HYNIC-tricine on the binding affinity of nocardiotide-A analogues. The molecular dynamics simulation confirmed that the designed nocardiotide-A-based peptides were stable in the binding pocket of SSTR2 for 200 ns. Moreover, the nocardiotide-A-based radiopeptides are able to interact with residues Q102, D122, Q126, and N276 by building hydrogen bonds, which are essential binding residues in SSTR2. The molecular docking simulation revealed that the best docking parameter is exhibited by 99mTc/EDDA/HYNIC-cWIWLNA and 99mTc/tricine/HYNIC-cWIWLNA with a binding free energy of –12.59 kcal/mol and –8.96 kcal/mol, respectively. Taken together, nocardiotide-A-based radiopeptides are prospective to be further developed for cancer imaging targeting SSTR2.

Steroid dari Kulit Batang Aglaia glabrata dan Aktivitas Sitotoksinya terhadap Sel Kanker Leukemia P-388 Risyandi Anwar; Desi Harneti; Vidia Afina Nuraini; Faizah Maira; Nurlelasari Nurlelasari; Tri Mayanti; Rani Maharani; Unang Supratman; Khalijah Awang
Chimica et Natura Acta Vol 11, No 2 (2023)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v11.n2.48980

Steroid saponin baru, b-sitosterol-3-O-beta-D-galaktopiranosil-(1-4)-beta-D-glukopiranosida (1), bersama dengan empat steroid yang diketahui (2-5) diisolasi dari kulit batang dari Aglaia glabrata. Struktur kimia senyawa baru dijelaskan berdasarkan data-data spektroskopi. Semua senyawa diuji aktivitas sitotoksiknya terhadap sel kanker leukemia murine P-388. Diantara senyawa yang diisolasi tersebut, stigmasterol (4) menunjukkan aktivitas sitotoksik terkuat dengan nilai IC50 sebesar 12.2 mg/mL.

Co-Authors Ace Tatang Hidayat Achmad Zainuddin Agus Safari Christina Marpaung Dadan Sumiarsa Daryono Hadi Tjahjono Deden Indra Dinata Desi Harneti Putri Huspa Dewa Gede Katja Dina Puspitasari Dudi Runadi Eka Fitri Yanti Faizah Maira Fauzan Zein Muttaqien Hersa Milawati Ida Nur Farida Ida Nurfarida Ika Wiani Kansy Haikal Khalijah Awang Kindi Farabi Kindi Farabi Mohamad Fajar Mohamad Nurul Azmi Mohamad Nurul Azmi Mohamad Nurul Azmi Muhammad Naufal Nulelasari Nurlelasari Nurlelasari Nurlelasari Nurlelasari Nurlelasari Purnama Purnama Rahmana Emran Kartasasmita Risyandi Anwar Rizky Juwita Sugiharti Siska Mulya Octavia Siska Mulya Octavia Siti Hani Pratiwi Supriatno Salam Taufiqqurahman Taufiqqurahman Tri Mayanti Tri Mayanti Unang Supratman Vidia Afina Nuraini Yoshihito Shiono Yoshihito Shiono Yoshihito Shiono Yoshihito Shiono

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