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Journal : VALENSI

Interkalasi Ion Mefenamat pada Host Mg/Al Hidrotalsit sebagai Rancangan Obat Lepas Lambat Fajar Indah Puspita Sari
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 4, No. 2, November 2018
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (831.864 KB) | DOI: 10.15408/jkv.v4i2.7600

Abstract

The aim of this study was to intercalate mefenamic ions in the interlayer structure of Mg/Al hydrotalcite and to test the release of mefenamic ion from host hydrotalcite interlays to determine its potential as a slow release drug design. Intercalation of mefenamic ions into interlayer structure of Mg/Al hydrotalcite by ion exchange has been studied. This success intercalation was confirmed by XRD data, diffractogram before and after intercalation showed a shift of d003, d006 and d009. The change of d003 from 8.717 Å to 22.017 Å indicates that the mefenamic ion has entered the interlayers of hydrotalcite. The FTIR analysis confirms that the nitrate ion was successfully replaced by mefenamic ions in the hydrotalcite interlayer. FTIR data indicate the absorption of symmetry and asymmetry of carboxylic groups in 1381 and 1612 cm-1 of the mefenamic ion. Have studied ion exchange kinetics and release of mefenamic ions from hydrotalcite hosts to determine their potential as a slow-release drug design. The result show mefenamic ion can be released from the hydrotalcite host for 6 hours. So that Mg / Al hydrotalcite has the potential to be used in slow release drug design.  
Sintesis, Karakterisasi Nanopartikel Magnetit, Mg/Al NO3 –Hidrotalsit dan Komposit Magnetit-Hidrotalsit Fajar Indah Puspita Sari
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 3, No. 1, Mei 2017
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1033.922 KB) | DOI: 10.15408/jkv.v3i1.4526

Abstract

Synthesis and characterization magnetite, Mg/Al NO3- hydrotalcite and magnetite-hydrotalcite have been done. The XRD and FTIR characterization result from third compound is used to assess the conformation of magnetite in the structure of hydrotalcite by comparison of spectra. Obtained that magnetite nanoparticles (10-20 nm) dispersed on octahedral lattice of hydrotalcite. The position investigation of magnetite particles in the hydrotalcite structure is very useful to determining applications of this composite in various fields, especially that involve ion exchange feature from hydrotalcite.DOI: http://dx.doi.org/10.15408/jkv.v0i0.4526