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All Journal Panrita Abdi - Jurnal Pengabdian pada Masyarakat Jurnal Surya Medika Indonesia Berdaya Dinamika Kesehatan: Jurnal Kebidanan dan Keperawatan Sains Medisina
Dyan Fitri Nugraha
Universitas Sari Mulia
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Pengaruh Ekstrak Etanol Rimpang Temu Mangga (Curcuma mangga Valeton and Zijp) Terhadap Berat Badan Tikus Putih (Rattus norvegicus) Yunisha Elzhi Adelin; Dyan Fitri Nugraha; Dede Mahdiyah
Sains Medisina Vol 1 No 1 (2022): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (287.502 KB)

Abstract

Berat badan lahir rendah hingga saat ini masih menjadi masalah kesehatan masyarakat di berbagai negara karena merupakan salah satu faktor penyebab kematian bayi. Berat badan lahir rendah pada anak-anak kerap diatasi oleh masyarakat dengan menggunakan sediaan-sediaan herbal seperti temu mangga. Temu mangga diduga mengandung senyawa metabolit sekunder yaitu Curcuminoid. Penelitian ini bertujuan untuk menganalisis pengaruh ektrak etanol rimpang temu mangga (Curcuma mangga Valeton and Zijp) terhadap berat badan tikus putih (Rattus norvegicus). Penelitian ini menggunakan true eksperimental design, dengan pendekatan Pre-Posttest control group. Melakukan uji fitokimia, uji penambahan berat badan dengan ekstrak etanol rimpang temu mangga dengan 3 kelompok (dosis 90mg/200gr, 180mg/200gr dan 360mg/200gr), kontrol positif( curcuma plus 5 ml) dan kontrol negatif (Na CMC 0,5%). Analisis data menggunakan Regresi Linier Sederhana. Pada hasil uji skrining fitokimia pada estrak etanol rimpang temu mangga didapatkan senyawa flavonoid, tanin dan saponin. Pada data berat badan rara-rata pada hewan uji dengan kontrol negatif 66.2gr, kelompok positif 52.8gr, ekstrak etanol dosis 1 28gr, dosis 2 8.8gr dan dosis 3 37.8gr berdasarkan analisis data regresi linier diperoleh nilai signifikan 0,757 > 0,05 yang artinya tidak ada pengaruh ekstrak etanol rimpang temu mangga terhadap berat badan. Pada kontrol positif curcuma plus tidak memiliki pengaruh terhadap berat badan hal ini dikarenakan suplemen makanan digunakan untuk memelihara kesehatan dan memenuhi kebutuhan vitamin selama masa pertumbuhan. Berdasarkan hasil maka dapat disimpulkan bahwa pada dosis 1, dosis 2 dosis 3 ektrak etanol rimpang temu mangga tidak memiliki pengaruh terhadap berat badan.
UJi Aktivitas Antidislipidemia Ekstrak Etanol Rimpang Temu Mangga (Curcuma mangga Valeton and Zijp) Alghafiqy Harya Evan Maulana; Dyan Fitri Nugraha; Putri Vidiasari D
Sains Medisina Vol 1 No 4 (2023): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

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Abstract

Dislipidemia merupakan salah satu penyebab penyakit kardiovaskular. Salah satu tanaman obat yang secara empiris dapat menurunkan kadar kolesterol yaitu Temu Mangga (Curcuma mangga Valeton and Zijp). Tujuan penelitian ini mengetahui aktivitas antidislipidemia dan dosis yang efektif pada ekstrak etanol rimpang temu mangga pada tikus putih jantan serta senyawa metabolit yang terkandung di dalamnya. Metode penelitian menggunakan hewan uji berupa 30 ekor tikus putih jantan yang dibagi menjadi 5 kelompok yaitu kontrol positif, kontrol negatif, dosis I, dosis II, dan dosis III. Tikus diberikan penginduksi berupa minyak jelantah selama 14 hari dan diberikan variasi dosis ekstrak selama 14 hari. Hasil dari penelitian ini senyawa yang terkandung di sediaan ekstrak etanol rimpang temu mangga dosis yaitu flavonoid, tannin dan saponin. Dosis II memiliki tidak memiliki perbedaan signifikan terhadap kontrol positif pada penurunan kolesterol total, trigliserida, dan peningkatan HDL. Namun, pada penurunan kadar LDL efektivitasnya masih rendah dibandingkan dengan kontrol positif. Simpulan penelitian ini senyawa metabolit yang terkandung pada sediaan ialah flavonoid, tannin, dan saponin. Dosis II ekstrak etanol rimpang temu mangga adalah dosis yang baik untuk terapi adjuvant antidislipidemia.
Aktivitas Anti Dislipidemia Ekstrak Etil Asetat Rimpang Temu Mangga (Curcuma mangga Valeton and Zijp): Antidyslipidemic Activity of Ethyl Acetate Extract of Temu Mangga Rhizome (Curcuma mangga Valeton and Zijp) Dyan Fitri Nugraha; Kunti Nastiti; Rahmayani Rahmayani
Jurnal Surya Medika (JSM) Vol. 9 No. 1 (2023): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v9i1.5193

Abstract

Statins are first-line drugs that are often used in the treatment of cardiovascular disease. It is noted that statins have various side effects, such as myalgia, rhabdomyolysis, and are considered to trigger diabetes mellitus. Meanwhile, the use of natural ingredients such as the rhizome of Intersection mango (Curcuma mango Valeton and Zijp) is often used empirically by the community in the treatment of dyslipidemia. The purpose of this study was to determine the effectiveness of anti-dyslipidemia and the dose of ethyl acetate extract of the temu mango rhizome which was effective as anti-dyslipidemia. This research method is a true experimental design with a pre-post test with control group on test animals with 5 test groups induced by cooking oil for 14 days, then given treatment for 14 days. Measurement of total cholesterol, triglyceride, LDL, and HDL parameters as well as body weight of test animals as additional parameters. The test group was divided into 3 doses, namely 90 mg, 180 mg, and 360 mg per 200 grams of test animals. The results showed that there was no significant difference between the extract groups, both in lipid profile and body weight of the test animals. However, a dose of 360 mg had the best activity, being able to lower cholesterol, triglycerides, and LDL, but was able to increase HDL levels.
Identifikasi Senyawa Aktif Antibakteri dari Ekstrak Bajakah (Spatholobus Littoralisk Hask) dengan GCMS (Gass Chromatography Mass Spectroscopy): Identification of Active Antibacterial Compounds from Spatholobus Littoralisk Hask Extract With GCMS (Gass Chromatography Mass Spectroscopy) Kunti Nastiti; Dyan Fitri Nugraha; Darini Kurniawati
Jurnal Surya Medika (JSM) Vol. 9 No. 1 (2023): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v9i1.5195

Abstract

Bajakah wood (Spatholobus Littoralisk Hask) is empirically used by the community to treat stomach pain, diarrhea and is even believed to be able to treat cancer. Several studies have shown its activity as an antibacterial. The purpose of this study was to identify compounds with antibacterial properties using Gas Chromatography Mass Spectroscopy (GCMS). The method used in this research is the experimental method. Bajakah plants were obtained from seven different areas, then extracted and fractionated. The fraction identified in this study was the n-hexan fraction. Preliminary tests were carried out using thin layer chromatography (TLC) bioautography for compounds that have the potential as antibacterial. Compounds in the n-Hexan fraction were further identified using Gass Chromatography Mass Spectroscopy (GCMS). The results showed Bajakah wood from seven regions had antibacterial activity seen from the formation of inhibition zones on compound spots on TLC that had been planted in agar media. There are 23 types of compounds identified by GCMS in this n-hexan fraction. In this study, the dominant compound seen from the largest area was Stigmast-5-en-3-ol, (3.beta.,24S)- (CAS) Clionaster (26.74%). The results of TLC bioautography of the n-Hexan fraction showed antibacterial activity and the dominant compound was Stigmast-5-en-3-ol, (3.beta.,24S)- (CAS) Clionaster.
Co-Authors Adhitama Ichsan Nugraha Alghafiqy Harya Evan Maulana Darini Kurniawati Dede Mahdiyah Fachry Abda El Rahman Helda Melati Kornelius Dena Lelu Kunti Nastiti Meida Rizki Putri Melviani Mohamad Rafi Nadya Novianty Noval Noval Putri Vidiasari Darsono Rahmayani Rahmayani Septyan Eka Prastya Theresia Carolina Tuti Alawiyah Umi Hanik Fetriyah Yunisha Elzhi Adelin Zulliati Zulliati