Claim Missing Document
Check
Articles

Uji Aktivitas Antioksidan Kombinasi Infusa Daun Sirih (Piper betle L), Ekstrak Etanolik Tanaman Bundung (Actinuscirpus grossus) dan Kulit Jeruk Nipis (Citrus aurantifolia) Kunti Nastiti; Noval Noval; Darini Kurniawati
Jurnal Surya Medika (JSM) Vol 7 No 1 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i1.2647

Abstract

Piper betle L., the leaf, is the most often used for treatment and has been scientifically proven to have antibacterial activity. Actinuscirpus grossus plants are commonly found in Kalimantan and have antimicrobial properties. Citrus aurantifolia peel has antioxidant effects and nutritious chemical compounds in medicine. The purpose of this study was to determine the effect of antioxidant activity in a combination of Piper betle L., leaf infusion, ethanolic extract of Actinuscirpus grossus plant, and Citrus aurantifolia peel. The research method was experimental by making Piper betle L. leaves infused with water solvent. Simplisia powder of Actinuscirpus grossus plants and Citrus aurantifolia peel extracted by maceration with 95% ethanol solvent. The combination of the three plants was then tested for antioxidants by the DPPH method. Quercetin is used as a positive control. The results showed that the combination of the three plants had moderate antioxidant activity (IC50 128 ppm), but the antioxidant activity was smaller than quercetin (IC50 16.88 ppm). The combination of Piper betle L., leaf infusion, ethanolic extract of Actinuscirpus grossus plant, and Citrus aurantifolia peel has a moderate antioxidant category.
Uji Aktivitas Teh Celup Fraksi Metanol Rimpang Temu Mangga (Curcuma mangga Valeton and Zijp) sebagai Antihiperlipidemia Dyan Fitri Nugraha; Noval Noval; Kunti Nastiti
Jurnal Surya Medika (JSM) Vol 7 No 2 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i2.3199

Abstract

The high number of deaths from cardiovascular disease in the world makes cardiovascular drugs, such as antihyperlipidemic or dyslipidemia often used by patients in the whole world. Statins are first-line drugs that are often used, but have various side effects, such as myalgia, rhabdomyolysis, and are considered to trigger diabetes mellitus. Meanwhile, the use of traditional medicines such as the Temu mangga’s rhizome (Curcuma mangga Valeton and Zijp) is often used by the community as antihyperlipidemic therapy. The purpose of this study was to scientifically prove the antihyperlipidemic activity of teabags from the methanol fraction of Temu Mangga’s rhizome in reducing lipid profiles, namely total cholesterol, triglycerides, and LDL, as well as increasing HDL. This research method is experimental by measuring the parameters of total cholesterol, triglycerides, LDL, and HDL as well as the bodyweight of the test animals as additional parameters. The test group was divided into 3 doses, namely 0.35 mg, 0.7 mg, and 1.4 mg per 200 grams of test animals. The results showed that there was no significant difference between all groups, both in lipid profile and bodyweight of the test animals. However, a dose of 1.4 mg had better triglyceride lowering activity than the positive control, and the activity of the methanol fraction of the Temu Mangga’s rhizome was predicted to be similar to statins.
Aktivitas Antiinflamasi Ekstrak Kayu Bajakah (Spatholobus littoralis Hask) Kunti Nastiti; Dyan Fitri Nugraha
Jurnal Surya Medika (JSM) Vol 7 No 2 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i2.3202

Abstract

Bajakah wood (Spatholobus littoralis Hassk) is a native plant of Kalimantan which is widely used by the community to treat diarrhea, dysentery, aches, and pains, wound medicine and is even believed to be a cancer drug. Research on this plant is still very limited. The content of flavonoids is thought to act as an anti-inflammatory. The purpose of this study was to determine the effectiveness of Kayu Bajakah (Spatholobus littoralis Hassk) as an anti-inflammatory in male rats induced by carrageenin. The method used in this study was an experimental method using 21 male white rats aged 2-3 months weighing 150-250 grams which were divided into 7 groups, namely the normal group, the CMC Na group, the diclofenac sodium group 1.35 mg/day. 200 g BW and 4 doses of Kayu Bajakah ethanol extract: 50, 100, 200, and 400 mg/kg BW orally. Fifteen minutes after treatment, mice were injected with 1% carrageenin subplantar. The volume of edema was measured with a plestimometer every 60 minutes for 4 hours. Anti-inflammatory was measured by comparing the percentage value of edema inhibition in the control and treatment groups. The results showed that the four treatment groups had a significantly different total volume of edema at 240' minutes with a significance value less than 0.05. The greatest anti-inflammatory effect was at a dose of 400 mg/kg BW at the 240th minute with a percentage of 87.65%. Kayu Bajakah (Spatholobus littoralis Hassk) ethanol extract has anti-inflammatory activity.
Potentials of Betel Leaf Infusion (Piper betle L), Lime Peel Extract (Citrus aurantifolia) and Bundung Extract (Actinoscirpus grossus) as Candidiasis Therapy Darini Kurniawati; Kunti Nastiti
Berkala Kedokteran Vol 16, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (289.232 KB) | DOI: 10.20527/jbk.v16i2.9220

Abstract

Abstract: Candidiasis is an infection caused by the fungus Candida, especially Candida albicans. It often occurs in the mouth and sex organs, also in the nails, respiratory tract, digestive tract, and anus. Betel leaf stew is often used by people to gargle and clean the intimate organs. The nature of the betel leaf solution is easily oxidized and turns brown. Therefore, research needs to be done by mixing betel leaf (Piper betle L) with lime (Citrus aurantifolia) to maintain the color of betel leaf, coupled with natural ingredients that have antimicrobial properties, namely lime peel and bundung plants (Actinoscirpus grossus). With the hypothesis of the joining of three natural materials that have antimicrobial activity can strengthen the inhibitory activity of the fungus Candida albicans. This research was conducted by making a betel leaf infusion formulation, lime peel extract, and bundung extract with a concentration of 20%, 30%, 40%, and 50% which were then tested to determine the effect of the infusion formulation on the inhibitory activity of Candida albicans by the method spread on Saburoud Dextrose Agar media. Based on Zuraidah's research (2015), 80% and 100% betel leaf extraction has activity on Candida albicans. From the results of this study significant results were obtained at a concentration of 50% of a mixture of betel leaf infusion formulations, extracts of lime peel and bundung extract had the same inhibitory properties as the hand sanitizer antiseptic liquid against Candida albicans. Thus it can be concluded that the 50% test formulation of betel leaf infusion mixture with lime extract and bundung extract has greater potential than betel leaf extract alone as a candidiasis therapy. Keywords: Piper betle L, Citruss aurantifolia, Actinoscirpus grossus, Antiseptik, Kandidiasis, Candida albicans
PRODUK INOVASI HAND SANITIZER DARI AKAR BAJAKAH SEBAGAI UPAYA PENCEGAHAN DI MASA PANDEMI COVID-19 Noval Noval; Kunti Nastiti; Dyan Fitri Nugraha; Rahmadani Rahmadani; Tuti Alawiyah
LOGISTA - Jurnal Ilmiah Pengabdian kepada Masyarakat Vol 4 No 2 (2020)
Publisher : Department of Agricultural Product Technology, Faculty of Agricultural Technology, Universitas Andalas Kampus Limau Manis - Padang, Sumatera Barat Indonesia-25163

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/logista.4.2.305-312.2020

Abstract

Wabah virus corona belakangan ini telah menyebar ke berbagai penjuru dunia. World Health Organization (WHO) telah menyatakan bahwa COVID-19 sebagai pandemi global. Penyebaran covid-19 di Kalimantan Selatan berdasarkan data dari Dinas Kesehatan Provinsi Kalimantan Selatan pada tanggal 12 April 2020 terdapat 1.184 Orang Dalam Pemantauan (ODP), 15 Pasien Dalam Pengawasan (PDP), dan 34 pasien positif covid-19 diantaranya ada 28 PDP, 4 pasien yang meninggal dan 2 pasien yang dinyatakan sembuh. Berdasarkan data tersebut kota Banjarmasin melaporkan ada sebanyak 232 ODP, 7 PDP, 14 pasien positif covid-19 sedang dalam perawatan dan 3 pasien meninggal. Hand Sanitizer digunakan sebagai salah satu alternatif jika tidak ditemukannya air untuk melakukan cuci tangan dalam rangka pencegahan dari virus corona. Produk hand sanitizer juga sangat dibutuhkan oleh masyarakat untuk bagian upaya dari menghindarkan paparan virus corona. Kurangnya ketersediaan hand sanitizer di pasaran dan meningkatnya harga jual hand sanitizer membuat masyarakat kesulitan mendapatkan dan sulit untuk membeli. Maka atas dasar tersebut, membuat produk inovaso hand sanitizer menggunakan bahan aktif dari bahan alam khas Kalimantan berupa akar bajakah (Littoralis hask) yang berfungsi untuk menghambat pertumbuhan virus dan bakteri. Serta pembagian produk dan langkah edukasi kepada masyarakat di tengah terjadinya pandemi virus corona. Kata kunci: Produk inovasi, Hand sanitizer, Akar bajakah, Covid-19 ABSTRACT The corona virus outbreak has recently spread to various parts of the world. The World Health Organization (WHO) has declared COVID-19 as a global pandemic. The infection number in South Kalimantan on April 12nd, 2020 were 1,184 people under monitoring (ODP), 15 patients under surveillance (PDP), and 34 positive patients for Covid-19, of whom 28 were PDP, 4 patients who died and 2 patients who were declared cured. Based on these data, the city of Banjarmasin reported that there were 232 ODP, 7 PDP, 14 positive patients with Covid-19 were being treated and 3 patients died. Hand Sanitizer is used as an alternative if water is not found for washing hands in order to prevent the corona virus. Hand sanitizer products are also very much needed by the community as part of the effort to avoid exposure to the corona virus. Lack of availability of hand sanitizers on the market and the increasing selling price of hand sanitizers have made it difficult for people to find and buy. So on this basis, making innovative hand sanitizer products uses active ingredients from natural ingredients typical of Kalimantan in the form of Bajakah roots (Littoralis hask) which functions to inhibit the growth of viruses and bacteria. As well as the distribution of products and educational steps to the public in the midst of the corona virus pandemic. Keywords: Innovation product, Hand sanitizer, Bajakah’s root, Covid-19
SKRINING SENYAWA INHIBITOR H2 DARI KAYU MANIS (Cinnamomum verum J.Presl) Samsul Hadi; Diah Aulia Rosanti; Desiya Ramayanti Azhara; Kunti Nastiti
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (291.519 KB) | DOI: 10.36387/jiis.v6i2.663

Abstract

Digestive tract disorders, especially gastric disorders, are often experienced by people. One drug to treat this disorder has a mechanism of blocking the H2 receptor. This research was conducted to find compounds from C.verum which have the stability of bind to H2 receptors. The method used is protein modeling with swiss-model, docking with PLANTS (CHEMPLP) and activity prediction. The test results obtained that the docking score was ?- amorphene (-65,79), ?-bergamotene (-65,48), ?-copaene (-66,62), ?-cubebene (-66,46), Cadinene (-64 , 79), Camphor (-52.15), Caryophyllene (-62.61), Cinnamaldehyde (-68.17), Epicatechin (-80.43), Ergosterol (-85.24), Eugenol (-67.35), Hydrocinnamaldehyde (-65,53), Quercetin (-74,38), Protocatechuic acid (-71,49), Stigmasterol (-88,88), 4- (2,3-dihydro-3- (hydroxymethyl) - 5- (3-hydroxypropyl) -7- (methoxy) benzofuranyl] -2-methoxyphenyl (-85,29). Combined with the probability activity of compounds that have the potential to be further developed are Epicatechin and urolignoside.
Terpenoid Isolation from Baccaurea Lanceolata Muell. Arg Fruit Kunti Nastiti; Samsul Hadi
International Journal of Clinical Inventions and Medical Sciences Vol 2 No 1 (2020)
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.ijcims-0201.79

Abstract

Fruits of Baccaurealanceolata is commonly used by tribe banjar in south Borneo to protect the skin damages due to sun light. People apply the pulverized fruits to the skin that will be exposed to sunlight. Antioxidant bioassay method (DPPH) is used to prove the effectiveness of the fruits.Baccaurea lanceolata fruitsvwere extracted by 70% ethanol, followed by fractionation with n-hexane, ether, ethyl acetate and methanol to give n-hexane (fr-H), ether (fr. Et2O), ethyl acetate (fr. EtOAc) and methanol (fr. MeOH) fractions respectively. Preparative TLC (SiO2) of the fr. EtOAc that showed the the highest antioxidant activity among those fractions. Based on spectroscopic data and comparison with reported data, the isolated compounds were identified as β-Sitosterol.
SKRINING SENYAWA AKTIF DARI BALIK ANGIN A. excels (Fenzl) Benth. TERHADAP RESEPTOR TNF-alpha convertase (TACE) DENGAN METODE DOCKING: Indonesia Samsul Hadi; Ana Maulana; Kunti Nastiti
Pharmacoscript Vol. 4 No. 2 (2021): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v4i2.727

Abstract

Tumor necrosis factor-alpha (TNF-α) merupakan sitokin proinflamasi yang terlibat dalam berbagai penyakit seperti radang selaput otak, rematik, asma, tuberkolosiS, periontitis kronis, crohn desease, hepatitis dan sinusitis hidung. Sehingga ekspresinya perlu dikontrol untuk mengatasi penyakit ini. Penelitian ini bertujuan melakukan skrining inhibitor reseptor TNF-alpha convertase (TACE) sehingga menurunkan ekspersi TNF-α. Dengan menurunnya produksi TNF-α maka dapat sebagai antiinflamasi atau imunosupresan. Salah satu tanaman yang dapat dipergunakan untuk skrining ini adalah A.excels. Metode yang dipergunakan untuk skrining melalui PASSonline dan Docking dengan PLANTS serta dilihat prediksi memasuki peredaran darah dengan SWISSADME. Berdasarkan PASSonline Senyawa yang memiliki skor probability to be active imunosupreasant tinggi adalah batulinic acid (0,724), alphitolic acid (0,763), cis-coumaroyl alphitolic acid (0,771). Sedangkan yang memiliki probability to be active antiinflamasi adalah batulinic acid (0,741) dan cis-coumaroyl alphitolic acid (0,783). Berdasarkan stabilitas interaksi, senyawa yang memiliki kemampuan minimal 80% terhadap ligand referensi adalah alphitonin (98,25%), alphitexolide (92,33%), cis-coumaroyl alphitolic acid (98,31%). Kesimpulannya senyawa yang berpotensi yang memiliki stabilitas interaksi yang bagus adalah cis-coumaroyl alphitolic acid dan alphitonin
PEMBUATAN LILIN AROMATERAPI UNTUK MENINGKATKAN KREATIVITAS KOMUNITAS PECINTA ALAM DI KABUPATEN BATOLA Melviani Melviani; Kunti Nastiti; Noval Noval
RESWARA: Jurnal Pengabdian Kepada Masyarakat Vol 2, No 2 (2021)
Publisher : Universitas Dharmawangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (447.663 KB) | DOI: 10.46576/rjpkm.v2i2.1112

Abstract

Aromaterapi merupakan metode pengobatan melalui media bau-bauan yang berasal dari bahan tanaman tertentu. Aromaterapi sering digabungkan dengan praktek pengobatan alternatif dan kepercayaan orang yang sudah ada sejak beberapa tahun yang lalu. Lilin aromaterapi adalah alternatif aplikasi aromaterapi secara inhalasi (penghirupan) dan akan menghasilkan aroma yang memberikan efek terapi bila dibakar seperti anti serangga, pengobatan alternatif, penghias, dan pengharum ruangan. Kegiatan pengabdian masyarakat ini bertujuan untuk memberikan transfer ilmu pengetahuan, keterampilan, kreatifitas, serta meningkatkan jiwa kewirausahaan remaja komunitas pecinta alam di Batola. Kegiatan telah dilaksanakan pada tanggal 1 Desember 2019 dengan jumlah peserta sebanyak 15 orang bertempat di Marabahan Kabupaten Barito Kuala Kalimantan Selatan. Metode yang digunakan dalam kegiatan ini adalah ceramah, diskusi, dan demonstrasi tentang cara pembuatan lilin aromaterapi, manfaat pengolahan kulit jeruk menjadi minyak atsiri sebagai bahan baku pembuatan lilin aroma terapi, serta kiat dalam melakukan wirausaha. Pelatihan dilaksanakan sesuai rencana dengan kegiatan berupa penyampaian materi terkait lilin aroma, manfaat, pembuatan, rencana keuangan serta pemasaran dan dilakukan praktek bersama tentang cara pembuatan lilin aroma terapi untuk meningkatkan kerjasama tim dan dapat membuat lilin aroma terapi sendiri. Peserta pelatihan sangat antusias dalam melakukan kegiatan pengabdian ini, terbukti dengan peran serta aktifnya selama kegiatan berlangsung. Selama ini, masyarakat belum mengetahui tentang lilin aromaterapi yang juga bisa menambah nilai ekonomi para peserta, Peserta juga berharap bahwa pembinaan yang dilakukan oleh Tim Pengabdian dari UNIVERSITAS SARI MULIA, dapat dilakukan secara terus-menerus.
POTENSI ANTISEPTIK POLIHERBAL DAUN SIRIH (Piper betle), KULIT JERUK NIPIS (Citrus aurantifolia) DAN TANAMAN BUNDUNG (Actinuscirpus grossus) PADA TINDAKAN KEPERAWATAN DAN KEBIDANAN Darini Kurniawati; Noval Noval; Kunti Nastiti
DINAMIKA KESEHATAN: JURNAL KEBIDANAN DAN KEPERAWATAN Vol 11, No 1 (2020): Dinamika Kesehatan Jurnal Kebidanan dan Keperawatan
Publisher : Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (200.566 KB) | DOI: 10.33859/dksm.v11i1.552

Abstract

Latar Belakang: Antiseptik adalah senyawa kimia yang digunakan untuk membunuh atau menghambat pertumbuhan mikroorganisme pada jaringan yang hidup seperti permukaan kulit dan membran mukosa. Daun sirih, jeruk nipis, bundung sudah banyak digunakan masyarakat untuk obat. Antiseptik dari poliherbal diyakini lebih aman dari pada zat kimia sintetis.Tujuan: Tujuan penelitian ini untuk mengetahui kemampuan antiseptik terhadap bakteri Staphylococcus aureus dari campuran ekstrak daun sirih, jeruk nipis dan bundung sebagai pengganti antiseptic dari bahan zat kimia sintetis pada tindakan keperawatan dan kebidanan.Metode: Metode penelitian adalah eksperimental dengan membuat formulasi uji konsentrasi F1 20%, F2 30%, F3 F4 40% dan F5 50% dan diujikan terhadap bakteri Staphylococcus aureus dengan metode difusi disk.Hasil: Hasil penelitian menunjukkan bahwa daya antiseptik Daun Sirih, Jeruk Nipis dan  Bundung efektif sebagai antiseptic pada konsentrasi 40%  dengan efektifitas yang sama dari bahan antiseptic zat kimia sintetis. Konsentrasi  F1 20% tidak ada daya hambat dengan nilai yang sama pada kontrol negatif, pada F2 30% terdapat daya hambat lemah sebesar 7 mm, pada F3 40% terdapat daya hambat kuat sebesar 23 mm sama dengan kontrol positif, dan pada F4 50% terdapat daya hambat sangat kuat lebih besar dari kontrol positif yaitu 40 mm.Simpulan: Antiseptik dari bahan alam kombinasi Daun Sirih, Jeruk Nipis dan Bundung pada konsentrasi 40% mempunyai efektifitas antiseptic yang sama dari antiseptic dengan bahan zat kimia sintetis. Antiseptik poliherbal ini bisa digunakan untuk keperluan tindakan keperawatan dan kebidanan. Kata Kunci: Daun sirih-kulit jeruk nipis-tanaman bundung, antiseptik, tindakan keperawatan dan kebidananAbstractBackground: Antiseptic is a chemical compound used to kill or inhibit the growth of microorganisms in living tissues such as the surface of the skin and mucous membranes. Betel leaf, lime, bundung have been widely used by the community for medicine. Antiseptics from polyherbal are believed to be safer than synthetic chemicals.Purpose: The purpose of this study was to determine the antiseptic ability of Staphylococcus aureus bacteria from a mixture of betel, lime, and bundung extracts as an antiseptic substitute for synthetic chemicals in nursing and obstetrics.Methods: The research method was experimental by making test formulations with concentrations of F1 20%, F2 30%, F3 F4 40%, and F5 50% and tested against Staphylococcus aureus bacteria using the disk diffusion method.Results: The results showed that the antiseptic power of Betel, Lime and Bundung leaves was effective as an antiseptic at a concentration of 40% with the same effectiveness of synthetic chemical antiseptic substances. The concentration of F1 20% has no inhibitory power with the same value in the negative control, at F2 30% there is a weak inhibitory power of 7 mm, at F3 40% there is a strong inhibitory power of 23 mm, the same as the positive control, and at F4 50% there is Very strong inhibition power is greater than the positive control, which is 40 mm.Conclusion: Antiseptic made from natural ingredients a combination of Betel, Lime, and Bundung Leave at a concentration of 40% has the same antiseptic effectiveness as antiseptic with synthetic chemical substances. This polyherbal antiseptic can be used for the purposes of nursing and midwifery action.Keywords: Betel leaf-lime peel-bundung plant, antiseptic, nursing and obstetrics measures