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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat JMM (Jurnal Masyarakat Mandiri) Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Medical Sains : Jurnal Ilmiah Kefarmasian
Tristiana Erawati
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Physics Social Sciences Other

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Characterization and Stability Test of Hydrolyzed Collagen Glyserosomes Safiul Fitria, Nur Indah; Erawati, Tristiana; Miatmoko, Andang; Soeratri, Widji
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.71-79

Abstract

Background: Hydrolyzed collagen is a protein obtained from enzymatic denaturation of collagen with a molecular weight of about 10 kDa, and it has been reported to produce anti-aging properties. Delivering hydrolyzed collagen into the dermis becomes a great challenge due to its large molecular weight, so glycerosome, a deformable vesicle containing glycerol as the edge activator, was developed to carry it into the dermis layer. Objective: The study aimed to determine the effect of increasing the concentration of glycerol and hydrolyzed collagen on the characteristics and stability of hydrolyzed collagen glycerosomes. Methods: Glycerosomes were composed of soy lecithin and prepared using a thin film lipid method. The lipid film was hydrated with phosphate-buffered saline pH 5 containing different glycerol concentrations (20% and 40%) and hydrolyzed collagen (2.5% and 5%). Then, characteristic tests and stability tests were carried out. Results: Hydrolyzed collagen glycerosomes had vesicle sizes of 170-180 nm, polydispersity index of 0.253-0.279, zeta potential values of -23.70 to -26.50 mV with deformability indexes of 2.25-3.49. The highest percentage of entrapment efficiency was 85.72%, achieved with a glycerol concentration of 40%. During the stability test at 25°C for 12 weeks, the hydrolyzed collagen glycerosomes did not experience pH and entrapment efficiency changes, but it increased the vesicle size. Conclusion: The use of 40% glycerol produced more deformable vesicles than 20% glycerol in hydrolyzed collagen glycerosomes; however, a formula improvement is required to improve the stability of glycerosomes.
Application of the Simplex Lattice Design Methode to Determine the Optimal Formula Nanoemulsion with Virgin Coconut Oil and Palm Oil Pradita Fiqlyanur Isna Primadana; Tristiana Erawati; Noorma Rosita; Hamdan, Siti Hartini
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 3 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i32024.395-401

Abstract

Background: The success of nanoemulsion preparation is characterized by characteristics such as small droplet size, polydispersity index (PDI), and % transmittance, which are close to 100%. One of these factors is the type of oil component used. The Simplex Lattice Design (SLD) method can be used to determine the ratio of oil combinations to obtain an optimal nanoemulsion formula. Objective: The application of the Simplex Lattice Design (SLD) method can help researchers speed up the acquisition of optimal formulas without trial and error so that nanoemulsion formulas that meet specifications can be obtained. Methods: This research uses the Simplex Lattice Design (SLD) method with Design of Expert Version 13 software, with an upper limit value for oil (VCO and Palm Oil) of 2.66% and a lower limit value for oil (VCO and Palm Oil) of 0, which then The results of several formulas come out and characterization testing is carried out to get the best formula from the recommendations produced by the software. Results: The results of the Simplex Lattice Design (SLD) showed that oil affected the droplet size and PDI (p <0.05). Six optimal formulas were obtained, and after testing in the laboratory, there was no significant difference between the results of the SLD program and those of the laboratory (Sig. <0.05). Conclusion: This study shows that the Simplex Lattice Design (SLD) method is very effective.
Stability and Antiaging Effectiveness Studies of Astaxanthin-Loaded Nanostructured Lipid Carriers Using a Combination of Cetyl Palmitate and Soybean Oil Zhihrotulwida, Dzakiya; Soeratri, Widji; Erawati, Tristiana; Rosita, Noorma
Science and Technology Indonesia Vol. 10 No. 2 (2025): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.2.473-481

Abstract

Astaxanthin is a potent antioxidant belonging to carotenoid compounds that is mainly produced from green microalgae Haematococcus pluvialis. Astaxanthin is beneficial for skin health as antiaging agent, but has limitations in its delivery through the skin. Astaxanthin could be formulated in nanostructured lipid carriers to improve its efficacy. The purpose of this study was to evaluate the stability and antiaging effectiveness of astaxanthin-loaded nanostructured lipid carriers (ASX-NLCs) with cetyl palmitate and soybean oil as lipid combinations at several ratios of 100:0, 90:10, 80:20, and 70:30. ASX-NLCs were synthesized using a high-shear homogenization technique. ASX-NLCs were characterized and stability evaluated after storage for 90 days. The antiaging effectiveness of ASX-NLCs was evaluated by in vitro release test using dialysis bag for 8 hours, as well as collagen density and fibroblast count evaluation on UV-induced skin aging mice for 28 days. After storage, all ASX-NLCs did not change significantly in organoleptic, pH, and particle size. However, other parameters including polydispersity index, viscosity, and entrapment efficiency experienced significant changes in some formulas. The release test showed that F4 (70:30) gave the highest cumulative release and was significantly different from F1 (100:0). The collagen density of the groups treated with ASX-NLC F3 (80:20) and F4 (70:30) increased significantly compared to the UVB control group, while the fibroblast count did not differ significantly in all groups. Overall, ASX-NLCs containing cetyl palmitate and soybean oil at ratios of 80:20 and 70:30 could improve the antiaging effect of astaxanthin which might be influenced by its better stability and release.
PERAN STRATEGIS PKK DALAM MENUNJANG PENINGKATKAN PEMAHAMAN MASYARAKAT TENTANG OBAT DAN SUPLEMEN MAKANAN Hendradi, Esti; Sari, Retno; Purwanti, Tutiek; Erawati, Tristiana; Miatmoko, Andang; Sugiyartono, Sugiyartono
JMM (Jurnal Masyarakat Mandiri) Vol 9, No 2 (2025): April
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v9i2.28739

Abstract

Abstrak: Pemahaman masyarakat tentang obat termasuk cara mendapatkan, menggunakan, menyimpan dan membuang serta penggunaan suplemen makanan masih perlu mendapat perhatian khusus, terutama untuk masyarakat perifer. Peran apoteker dibutuhkan dalam mengedukasi masyarakat dengan melibatkan gerakan Pemberdayaan dan Kesejahteraan Keluarga (PKK). Tujuan PKM ini adalah meningkatkan pengetahuan tentang obat dan suplemen makanan kepada masyarakat dengan memberdayakan PKK. Tim pengabdian kepada masyarakat Fakultas Farmasi Universitas Airlangga telah menyelenggarakan kegiatan bakti sosial bersama-sama IAI dan kader PKK di Kota Madya Tuban dalam bentuk penyuluhan atau sosialisasi terkait obat dan suplemen makanan. Sosialisasi dilakukan melalui Webinar via Zoom Meeting dalam bentuk seminar dan diskusi interaktif, karena aktivitas pengabdian dilaksanakan saat pandemi Covid-19. Sebagai mitra pada pengabdian masyarakat ini adalah Kader PKK dan Ketua Ikatan Apoteker Indonesia (IAI) Cabang Tuban dengan jumlah peserta yang hadir sejumlah 71 orang. Hasil evaluasi melalui pre-test dan post-test menunjukkan bahwa setelah mengikuti kegiatan rerata pemahaman peserta meningkat 7,04% dan 12,7% masing-masing untuk materi DAGUSIBU dan Probiotik. Diharapkan PKK secara aktif menyebar-luaskan kegiatan sosialisasi kepada masyarakat di seluruh desa.Abstract: Public understanding of medicines, including how to obtain, use, store and dispose of them as well as the use of food supplements, still needs special attention, especially for peripheral communities. The role of pharmacists is needed in educating the public by involving the Family Empowerment and Welfare (PKK) movement. The aim of this PKM is to increase knowledge about medicines and food supplements among the community by empowering PKK. The community service team at the Faculty of Pharmacy, Airlangga University has held social service activities together with IAI and PKK cadres in Tuban in the form of counseling or outreach regarding medicines and food supplements. Socialization was carried out through Webinar via Zoom Meeting in the form of seminars and interactive discussions, because service activities were carried out during the Covid-19 pandemic. As partners in this community service were PKK cadres and the Chair of the Indonesian Pharmacists Association (IAI) in Tuban city with a total of 71 participants attending. The evaluation results via pre-test and post-test showed that after participating in the activity the participants' average understanding increased by 7.04% and 12.7% for DAGUSIBU and Probiotic material, respectively. It is hoped that the PKK will actively spread outreach activities to communities throughout the village.
DESIGN AND OPTIMIZATION OF VCO AND OLEIC ACID FOR NLC QUERCETIN USING SIMPLE LATTICE DESIGN Cahyono, Definta Anisa Tamara; Rosita, Noorma; Erawati, Tristiana
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 3 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i3.1747

Abstract

Quercetin is a flavonoid compound that exhibits skin-brightening activity by inhibiting tyrosinase. However, its topical application is limited because of its low solubility. A Nanostructured Lipid Carrier (NLC) was selected as the delivery system to enhance the stability and topical efficacy of quercetin. This study aimed to optimize the combination ratio of oleic acid and Virgin Coconut Oil (VCO) as the liquid lipid phase in the NLC Blank Formulation using the Simplex Lattice Design (SLD) method. Eight blank NLC formulations were prepared using the high-shear homogenization method and were evaluated based on organoleptic properties, particle size, polydispersity index (PDI), pH, and real-time stability over 30 days. Eight blank NLC Blank Formulations showed that a balanced VCO to oleic acid ratio (5.5:4.5) produced small particle sizes (<160 nm), low polydispersity index (PDI <0.25), and good physical stability. Blank Formulations dominated by either VCO or oleic acid tended to have larger particles and lower stability, indicating that the liquid lipid ratio influenced the NLC characteristics. Optimization using the Simplex Lattice Design (SLD) method identified three optimal lipid ratios: B1 (4.86:5.31), B2 (2:8), and B3 (9:1), each with desirability values near 1. The model was validated by comparing the predicted (dry lab) and experimental (wet lab) data, which showed no significant differences in key parameters (p > 0.05), confirming the reliability of the SLD model. This approach effectively optimized quercetin-loaded NLC Blank Formulations, and the three selected Blank Formulas serve as a strong basis for developing topical quercetin NLC products.
PENDIDIKAN KOGNITIF DAN AFEKTIF DAGUSIBU UNTUK PENCEGAHAN RESISTENSI ANTIBIOTIK DI SMA SURABAYA Abhimata Paramanandana; Dini Retnowati; Andang Miatmoko; Dewi Isadiartuti; Sugiyartono1; Mohammad Agus Sjamsur Rijal; Dwi Setiawan; Esti Hendradi; Tutiek Purwanti; Noorma Rosita; Dewi Melani Hariyadi; Tristiana Erawati; Ardhani Dwi Lestari1; Helmy Yusuf; Retno Sari
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 1 (2019): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (620.49 KB) | DOI: 10.32734/abdimastalenta.v4i1.2395

Abstract

Antibiotics are not only used for humans, but also often used for cattle and livestock which are then been consumed by humans. This over prescribed and missed used of antibiotic is a major factor in antibiotic resistance. Antibiotic resistance is a condition where bacteria are unable to be treated with antibiotics. In fact, the use of antibiotics is the first response in curing infectious diseases (by bacteria) and preventing infectious diseases spreading. With antibiotic resistance, preventing infectious diseases by bacteria became harder. This community service activity came up with a slogan "Antibiotic Resistence Awareness Movement" was carried out in Surabaya 10 Public High Schools and Surabaya 17 Public High Schools with 60 students per school using several methods, namely: (a) giving lecture material using LCD projectors ) the implementation of poster making competitions, and (c) poster presentations that have been made that are accompanied by question and answer, and (d) evaluation activities in the form of written tests covering pre-test and post-test. Concerning the results of posters results, poster presentations and improving the results of this posttest can be concluded as a result of an increase in understanding and or knowledge of students of SMA 10 and SMA 17 Surabaya
Drug and cosmetic safety training for cadres of family welfare program Erawati, Tristiana; Hariyadi, Dewi Melani; Rosita, Noorma; Soeratri, Widji; Purwanti, Tutiek; Poerwono, Hadi; Rudyanto, Marcellino; Yusuf, Helmy; Purwanto, Djoko Agus; Wijaya, I Nyoman
Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Vol. 9 No. 2 (2024): May 2024
Publisher : University of Merdeka Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26905/abdimas.v9i2.11161

Abstract

In order to increase public understanding and awareness regarding the safety use of drugs and cosmetics, the Community Service Team of the Faculty of Pharmacy, Airlangga University has held community service in Jonggrangan Village, Klaten, Central Java. The community service was carried out on July 31, 2023, with approximately 60 family welfare programs or PKK cadres and health cadres participating through training, presentations, and discussions. The activity began with a pre-test, continued with training, a presentation of the material by three experts, and a discussion, then ended with giving a post-test to the participants. The results of the pre and post-test analysis showed that participants' understanding increased. The results of the analysis of the answers to the 15 questions given showed that the increase in participants' understanding ranged from  2.13-46.02 percent. The impact of these activities on society. The increase in participants' understanding of each topic is not the same depending on the initial understanding. However, the problem is that the level of public understanding after receiving training is still below 50 percent namely on topics about the stages of using cosmetic products and about drug classification. So it is necessary to deepen the material using other strategies (appropriate methods and media).
Molecular Docking of Flavan-3-Ol Compounds from Cocoa Beans Againts Matrix Metalloproteinases (MMPs) as Anti-Photoaging Agents Cindi Dia Annisa; Tristiana Erawati; Widji Soeratri; A'liyatur Rosyidah, M.Si., Ph.D
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.312-320

Abstract

Background: Premature aging of the skin is an abnormal aging process that is primarily triggered by UV exposure, which leads to increased production of matrix metalloproteinases (MMPs). These enzymes degrade skin collagen. The abundant flavan-3-ol content of cocoa beans has been demonstrated to possess antioxidant properties, thereby serving as a potential agent to impede premature aging. A molecular docking approach can facilitate the prediction of cocoa bean flavan-3-ols' capacity to impede MMP enzyme activity. Objective: This study aims to predict the interaction between cocoa bean flavan-3-ol compounds and MMP enzymes as potential photoaging inhibitors. Methods: Flavan-3-ol compounds from cocoa beans, including (-)-epicatechin, (+)-catechin, procyanidin B1, B2, and C1 were obtained from PubChem and modeled in 3D using ChemDraw 3D software. These compounds were docked into the collagenase (MMP-1), stromelysin (MMP-3), and gelatinase (MMP-9). The docking results were compared to native ligands of the proteins. AutoDock was used for docking, and the results were visualized using Biovia Discovery Studio. Results: Method validation confirmed that all proteins were suitable for docking. The docking results showed negative docking scores for all compounds, with each compound binding at least one amino acid residue similar to native ligands. Procyanidin B2 exhibited the best docking score and the smallest inhibition constant for collagenase and gelatinase 9. Conclusion: Cocoa bean flavan-3-ol compounds can inhibit collagenase, stromelysin, and gelatinase activity. Procyanidin B2 is the most effective compound among those tested. Consequently, further testing may be undertaken to generate supporting evidence for potential utilization of cocoa beans as an active compound in cosmetic formulations.
Co-Authors A'liyatur Rosyidah, M.Si., Ph.D Abhimata Paramanandana Andang Miatmoko Ardhani Dwi Lestari1 Cahyono, Definta Anisa Tamara Cindi Dia Annisa Dewi Isadiartuti Dewi Melani Hariyadi Dini Retnowati Djoko Agus Purwanto Dwi Setiawan Esti Hendradi Hadi Poerwono Hamdan, Siti Hartini I NYOMAN WIJAYA Marcellino Rudyanto Miatmoko, Andang Mohammad Agus Sjamsur Rijal Noorma Rosita Pradita Fiqlyanur Isna Primadana Retno Sari Retno Sari Safiul Fitria, Nur Indah Sugiyartono, Sugiyartono Sugiyartono1 Tutiek Purwanti Widji Soeratri Yusuf, Helmy Yusuf, Helmy Zhihrotulwida, Dzakiya