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All Journal Jurnal Ilmiah Farmasi ILMU KELAUTAN: Indonesian Journal of Marine Sciences Transformasi: Jurnal Pengabdian Masyarakat JURNAL PENGABDIAN KEPADA MASYARAKAT BERITA BIOLOGI Jurnal Kimia Riset Jurnal Biologi Tropis Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Agrotek UMMat JCES (Journal of Character Education Society) Jurnal Riset Akuakultur Scripta Biologica Jurnal Gema Ngabdi ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Abdi Insani Indonesia Natural Research Pharmaceutical Journal (INRPJ) Lumbung Farmasi : Jurnal Ilmu Kefarmasian Sasambo Journal of Pharmacy INDRA: Jurnal Pengabdian kepada Masyarakat Jurnal Pijar MIPA Jurnal Sains dan Kesehatan
Handa Muliasari
Department Of Pharmacy, Faculty Of Medicine, Universitas Mataram
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Social Sciences

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Journal : Lumbung Farmasi : Jurnal Ilmu Kefarmasian

 1 
Penetapan Kadar Fenolik Total Ekstrak Kulit Buah Kopi Robusta (Coffea canephora L.) Di Pulau Lombok Febriyanto Febriyanto; Nisa Isneni Hanifa; Handa Muliasari
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 2, No 2 (2021): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v2i2.5489

Abstract

ABSTRAKProduksi kopi robusta (Coffea canephora L.) menghasilkan limbah berupa kulit buah kopi dengan proporsi sebesar 40-45%. Kulit buah kopi dilaporkan mengandung senyawa fenolik yang berpotensi sebagai antioksidan. Kadar senyawa fenolik dapat dipengaruhi oleh faktor lingkungan. pulau Lombok memiliki perkebunan kopi yang tersebar hampir diseluruh penjuru pulau. Penelitian ini bertujuan menentukan kadar fenolik total kulit buah kopi robusta yang dikoleksi dari tiga lokasi berbeda di pulau Lombok. Sampel kulit buah kopi diekstraksi menggunakan metode sonikasi dengan pelarut etanol 70% selama 30 menit pada suhu ruang. Penentuan kadar fenolik total menggunakan metode Folin-Ciocalteu dengan standar asam galat. Kadar fenolik total dinyatakan dalam mg equivalent asam galat (GAE) per gram simplisia. Hasil analisis menunjukkan ekstrak kulit buah kopi dari lokasi desa Lamper memiliki kadar fenolik total sebesar 5.6252 ± 0.0658 mg GAE/g, kadar fenolik total ekstrak kulit buah kopi dari desa Keru sebesar 2.6626 ± 0.0892 mg GAE/g, dan kadar fenolik total kulit buah kopi dari desa Sajang sebesar 4.6757 ± 0.0528 mg GAE/g. Ekstrak dari ketiga lokasi berpotensi sebagai antioksidan dilihat dari kadar fenolik total yang berbeda. Berdasarkan hasil penelititan dapat diketahui bahwa kadar fenolik total ekstrak kulit buah kopi dari lokasi lamper lebih tinggi daripada lokasi Sajang dan Keru. Kata kunci: Kulit buah kopi; Kopi robusta (Coffea canephora L.); Kadar fenolik total.ABSTRACT Production of robusta coffee (Coffea canephora L.) produces coffee pulp waste  with proportion of 40-45%. Coffee pulp reported contain phenolic compounds that have antioxidants activity. Content of phenolic compounds can be influenced by environmental factors. Lombok Island has coffee plantations that scattered throughout the island. This study aims to determine the total phenolic content of robusta coffee pulp collected from three different locations on the island of Lombok. The coffee pulp samples extracted using the sonication method with 70% ethanol solvent for 30 minutes at room temperature. Determination of the total phenolic content of the extract using the Folin-Ciocalteu method with gallic acid standard. Total phenolic content  is expressed in mg equivalent gallic acid (GAE) per gram of simplicia. The results of the analysis showed total phenolic content coffee pulp from Lamper village was 5.6252 ± 0.0658 mg GAE/g, the total phenolic content coffee pulp from Keru village was 2.6626 ± 0.0892 mg GAE/g, and the total phenolic content coffee pulp from Sajang village was 4.6757 ± 0.0528 mg GAE/g. Extract from three different location have the potential as antioxidants. Based on the results of the study, it can be seen thatcoffee pulp extract from Lamper has highest total phenolic content than coffee pulp from Sajang and Keru.Keyword: Coffee pulp; Robusta coffee (Coffea canephora L.); Total phenolic content.
Formulasi Dan Uji Aktivitas Antioksidan Sediaan Masker Peel Off Ekstrak Etanol Daun Jambu Biji ( Psidium guajava L.) Risa Dwi Sosalia; Windah Anugrah Subaidah; Handa Muliasari
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 2, No 2 (2021): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v2i2.5498

Abstract

ABSTRAKRadikal bebas merupakan substansi yang sangat reaktif dapat menyebakan kerusakan sel kulit sehingga dapat menghilangkan elastisitas kulit serta menyebabkan penuaan dini. Penuaan dini merupakan kondisi penuaan yang terjadi secara cepat. Keadaan ini dapat dicegah dengan senyawa antioksidan yang berasal dari tanaman salah satunya yaitu ekstrak etanol daun jambu biji (Psidium guajava L.) yang mengandung senyawa metabolit sekunder seperti flavonoid, fenolik, dan tanin. Penggunaan ekstrak akan lebih mudah dalam bentuk sediaan seperti masker peel off. Tujuan dari penelitian ini yaitu mengetahui aktivitas antioksidan ekstrak etanol daun jambu biji dan formulasinya sebagai sediaan masker peel off. Daun jambu biji diekstraksi menggunakan metode maserasi dengan pelarut etanol 70%, kemudian dilakukan skrining fitokimia pada ekstrak meliputi flavonoid, fenolik, dan tanin selanjutnya diuji aktivitas antioksidan pada ekstrak dengan metode DPPH. Ekstrak diformulasi menjadi sediaan masker peel off F0 (0%) dan F1(2%)lalu kedua formula diuji sifat fisik (uji organoleptis, pH, homogenitas, viskositas, daya sebar, daya lekat, dan waktu sediaan kering) serta diuji  aktivitas antioksidan sediaan dengan metode DPPH. Hasil yang diperoleh menunjukan bahwa ekstrak etanol daun jambu biji  positif mengandung flavonoid, tanin dan fenolik serta  memiliki aktivitas antioksidan yang sangat kuat dengan nilai IC50 sebesar 23,29±0,2 μg/mL. Uji sifat  fisik sediaan masker peel off ekstrak daun jambu biji F0 dan F1 telah memenuhi syarat pH, homogenitas, viskositas, daya sebar, waktu sediaan kering dan daya lekat yang baik. Pengujian aktivitas antioksidan sediaan masker peel off ekstrak etanol daun jambu biji F0 dan F1 diperoleh IC50 berturut-turut yaitu 953,87±6,4 μg/mL dan 79,56±12,1 μg/mL dimana aktivitas antioksidan F0 masuk kategori sangat lemah dan F1 masuk kategori. Hasil aktivitas antioksidan yang diperoleh berbeda signifikan antara ekstrak daun jambu biji dengan sediaan masker peel off ekstrak daun jambu biji berdasarkan uji Anova dengan nilai p>0.05 (p=0,00). Kata kunci: Radikal bebas; Antioksidan; DPPH; Daun Jambu Biji; Masker Peel OffABSTRACTFree radicals are highly reactive substances that can cause skin cell damage so that they can eliminate skin elasticity and cause premature aging. Premature aging is a condition of aging that occurs rapidly. This situation can be prevented by antioxidant compounds derived from plants, one of which is ethanol extract of guava leaves (Psidium guajava L.) which contains secondary metabolites such as flavonoids, phenolics, and tannins. The use of extracts will be easier in dosage forms such as peel off masks. The purpose of this study was to determine the antioxidant activity of guava leaf ethanol extract and its formulation as a peel off mask preparation. Guava leaves were extracted using the maceration method with 70% ethanol solvent, then phytochemical screening was carried out on the extract including flavonoids, phenolics, and tannins and then tested for antioxidant activity in the extract using the DPPH method. The extract was formulated into F0 (0%) and F1 (2%) peel off mask preparations, then both formulas were tested for physical properties (organoleptic test, pH, homogeneity, viscosity, spreadability, adhesion, and dry preparation time) and were tested for antioxidant activity. with the DPPH method. The results showed that the guava leaf ethanol extract was positive for flavonoids, tannins and phenolics and had a very strong antioxidant activity with an IC50 value of 23.29±0,2 μg/mL. Physical properties test of guava leaf extract peel off mask preparations F0 and F1 met the requirements for pH, homogeneity, viscosity, dispersion, dry preparation time and good adhesion. Testing the antioxidant activity of the peel-off mask preparation of guava leaf ethanol extract F0 and F1 obtained IC50 of 953.87±6,4 μg/mL and 79.56±12,1 μg/mL where the antioxidant activity of F0 was in the very weak category and F1 was in the category. The antioxidant activity results obtained were significantly different between guava leaf extract and guava leaf extract peel off mask preparations based on the Anova test with p>0.05 (p=0.00).Keyword: Free radicals; Antioxidants; DPPH; Guava leaves; Peel Off Mask
Co-Authors Agus Dwi Ananto, Agus Ahmad Wirahadi Aliefman Hakim Anggit Listyacahyani Sunarwidhi Baiq Handayani Rinuastuti Baiq Ressa Puspita Rizma Baiq Sofianti Annisa Bayu Priyambodo Bela Azkiana Candra D. Hamdin Candra Dwipayana Hamdin Candra Dwipayana Hamdin Candra Dwipayana Hamdin Candra Dwipayana Hamdin Candra Eka Puspitasari Dani Syaiful Akbar Devy Shandra Purwati Dhony Hermanto Diva Almira Edi M Jayadi Elliya Rosyada Emmy Yuanita Ernin Hidayati Fahrurazi Fahrurazi Febriyanto Febriyanto Hidayati, Agriana Rosmalina I Made Sudarma Ima Arum Lestarini Indah Permata Sari Lalu Husnul Hidayat Luh Putu Intan Paramitha Sari M. Elyadi Mahacita Andanalusia Muhsinul Ihsan Muhsinul Ihsan Muhsinul Ihsan Muhsinul Ihsan Mujiburrohman Mujiburrohman Ni Kadek Intan Wulan Sinta Dewi Ni Luh Arisa Prahastuti Winastri Nisa Isneni Hanifa Novita Eliya Wardani Novita Eliya Wardani Nur Nadhifah Zahra Qurnia Aini Regita Pramesti Retno Zahara Reza Sagista Risa Dwi Sosalia Riza Rusyiana Rizqa Fersiyana Deccati Rizqa Fersiyana Deccati Romi Juniawan Suhirman suhirman Ulul Khairi Zuryati Ulul Khairi Zuryati Virnia Wanda Utami Wahida Hajrin Wahida Hajrin Wahyu Bintang Ilahi Windah Anugrah Subaidah Yayuk Andayani Yohanes Juliantoni Yuli Eka Hardianti