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All Journal HERBAPHARMA : Journal of Herb Farmacological Sainstech Farma: Jurnal Ilmu Kefarmasian Edu Masda Journal Medical Sains : Jurnal Ilmiah Kefarmasian Pharmaceutical Science Journal Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kefarmasian Indonesia
Sheila Meitania Utami
STIKES WIDYA DHARMA HUSADA TANGERANG
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : Pharmaceutical Science Journal

 1 
REVIEW ARTIKEL AKTIVITAS ANTIBAKTERI EKSTRAK RIMPANG KUNYIT (Curcuma domestica Val) TERHADAP BEBERAPA SAMPEL BAKTERI Sheila Meitania Utami; Diah Permata Sari; Nurwulan Adi Ismaya; Erwin Herdiawan
PHRASE (Pharmaceutical Science) Journal Vol 2, No 2 (2022): PHRASE (PHARMACEUTICAL SCIENCE) JOURNAL VOL 2 NO 2 (2022)
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v2i2.415

Abstract

The increase in antibiotic resistance is very fast throughout the world, this is a problem because it threatens human health globally. The increase in antibiotic resistance is due to overprescribing of antibiotics, as well as poor infection prevention and control. The use of traditional medicine can be used as an alternative treatment in overcoming health problems, prevention, and healing. Traditional medicine is considered safer than synthetic medicine, one of the plants that has antibacterial benefits is turmeric rhizome (Curcuma domestica Val). Turmeric rhizome has an antibacterial effect against gram negative and gram positive bacteria. This study aims to determine the antibacterial activity and active compounds contained in turmeric rhizome extract that can produce an antibacterial effect. The type of research used is descriptive using the Literature Review method by collecting various sources from 8 research journals that have been published and come from the internet. Turmeric rhizome extract is known to contain curcumin, alkaloids, flavonoids, essential oils, phenols, saponins, tannins, and terpenoids compounds that have antibacterial properties. The results of the literature review of the antibacterial activity test of turmeric rhizome extract showed that the antibacterial activity was classified as moderate to very strong against Escherichia coli (9 mm), Pseudomonas aeroginosa (7,8 mm), Bacillus cereus (11,1 mm), Salmonella typhi (12.1 mm), Staphylococcus aereus (10 mm), and Propionibacterium acnes (20.8 mm), while Bacillus subtilis (1.03 mm) was classified as weak.
Studi Literatur Uji Aktivitas Antibakteri Ekstrak Daun Sirsak (Annona muricata L.) Terhadap Berbagai Sampel Bakteri Sheila Meitania Utami
PHRASE (Pharmaceutical Science) Journal Vol 2, No 1 (2022): PHRASE (PHARMACEUTICAL SCIENCE) JOURNAL VOL 2 NO 1 (2022)
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v2i1.162

Abstract

Lingkungan yang tidak sehat adalah salah satu faktor penyebab penyakit infeksi. Tanaman obat terbukti efektif mengatasi penyakit bakteri salah satunya yaitu tanaman sirsak. Berbagai penelitian menunjukkan bahwa tanaman sirsak mengandung banyak khasiat sebagai obat. Terapi antibiotik secara irasional telah menimbulkan berbagai efek samping serta resistensi. Daun sirsak merupakan bahan alam yang dapat digunakan sebagai terapi alternatif yang mempunyai efek samping minimal dan diharapkan potensi yang lebih besar. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak daun sirsak (Annona muricata L.) yang diperoleh dari hasil maserasi simplisia daun sirsak menggunakan berbagai macam pelarut. Ekstrak daun sirsak mengandung senyawa aktif yang memiliki aktivitas antibakteri yaitu alkaloid, fenol, flavonoid, saponin dan tanin yang memiliki mekanisme kerja yang berbeda-beda. Metode Penelitian yang digunakan dalam penelitian ini yaitu studi literatur dengan mengumpulkan berbagai sumber yang didapat dari beberapa jurnal penelitian yang berasal dari internet baik jurnal nasional maupun internasional. Jumlah jurnal yang digunakan adalah 12 jurnal yang terdiri dari 7 jurnal utama dan 5 jurnal pendukung. Hasil studi literatur uji aktivitas antibakteri ekstrak daun sirsak menunjukkan aktivitas antibakteri yang tergolong kategori sedang-sangat kuat  terhadap Bacillus subtilis, Staphylococcus aureus, Propionibacterium acnes,Streptococcus mutans, Aggregatibacter actinomycetemcomitans, dan Pseudomonas aeruginosa, sedangkan pada bakteri Escherichia coli dikategorikan tergolong lemah.
FORMULASI DAN EVALUASI AKTIVITAS ANTIOKSIDAN SABUN CAIR BERBAHAN DASAR EKSTRAK DAUN KEMANGI DAN MADU Dewi, Bheta Sari; Utami, Sheila Meitania; Werawati, Ayu; Bachtiar, Wahyu; Dewantoro, Agung
PHRASE (Pharmaceutical Science) Journal Vol 4, No 2 (2024): Pharmaceutical Science Journal Vol 4 No 2
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v4i2.903

Abstract

Basil leaves  (Ocimum sanctum L.) and honey contain flavonoids and polyphenol compounds such as methyl eugenol, which are known to have antioxidant activity. Liquid soap is a form of pharmaceutical product that is often used to cleanse the body and provide additional protection to the skin. Objective: The aim of this study was to obtain the best physical formulation of a liquid soap combination of basil leaf extract and honey and its antioxidant activity. Method: Liquid soap preparations were made by adding basil leaf extract with various concentrations of 2g (FI), 4g (FII) and 8g (FIII) and honey, namely 5g (FI), 5g (FII) and 5g (FIII). Evaluation of liquid soap preparations included organoleptic, pH, and homogenity, as well as antioxidant activity test using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method with a wavelength of 516 nm. Results: The results showed that Formula III (FIII) had the best results, namely organoleptic milk chocolate color, pH preparation (9.71-9.89), homogeneous preparation, stable preparation in storage for 12 days and showed the best IC50 value of 118.39 ppm. Conclusion: In conclusion, the combination of basil leaf extract and honey can be formulated as a liquid soap preparation with a concentration of 8g basil leaf extract and 5g honey in formula III (FIII) showing the effectiveness as the best formulation.
Co-Authors Agung Dewantoro Ahmad Sopian, Ahmad Alamsyah, Salwa Season Angraeni, Lutfiah Aprilivani, Saskia Nur Ayu Indayanti Ismail Ayu Werawati Bachtiar, Wahyu Beny Maulana Satria Bheta Sari Dewi Diah Permata Sari Diah Permata Sari Erwin Herdiawan Gina Aulia Holidah Holidah Humaira Fadhilah Ignesia Rara Denanti Imansari, Aulia Nadya Rizki Intan Tsamrotul Fu’adah Liswati Friana Sipayung Mita Nur Malasari Nanang Yunarto Nanang Yunarto Neneng Sri Purwaningsih Nur Hasanah Nur Hasanah Nurwulan Adi Ismaya Oktavendriyastuti Tabrani Pomalingo, Dwina Ramadhani Rahmadani, Novita Tri Santoso, Pugoh Sayyidah, Sayyidah Silvester Maximus Tulandi Tifani Monika Tri Okta Ratnaningtyas Widia Apriandini