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All Journal Medula The Indonesian Biomedical Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Acta Biochimica Indonesiana Poltekita : Jurnal Ilmu Kesehatan Jurnal Gema Ngabdi NURSING UPDATE JURNAL ILMIAH ILMU KEPERAWATAN JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Borneo Journal of Pharmacy
Tien Tien
Departemen Biokimia, Fakultas Kedokteran, Universitas Halu Oleo
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)

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Inhibition of HMG-CoA Reductase Activity by Kersen Leaves (Muntingia calabura L.) to Prevent Hypercholesterolemia: Inhibisi HMG-CoA Reduktase Menggunakan Ekstrak Daun Kersen (Muntingia calabura L) Untuk Mencegah Hiperkolesterolemia Tien Tien; Nishar Rakhman Ardiansyah; Carla Wulandari Sabandar; Laode Kardin; Pranita Aritrina
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 9 No. 1 (2023): (March 2023)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2023.v9.i1.16086

Abstract

Background: Hypercholesterolemia is a condition of total cholesterol level >200 mg/dL and LDL >130 mg/dL. HMG-CoA (3-hydroxy-3-ethylglutaryl-coenzyme A) reductase is an enzyme that has a role in cholesterol biosynthesis. Hence, inhibition of this enzyme led to the decrement of cholesterol level. The extract of Kersen leaves (Muntingia calabura L.) is known to contain flavonoids, terpenoids, steroids, tannins, phenolic, and alkaloids. Flavonoids work by inhibiting the HMG-CoA reductase activity, so that mevalonate cannot be formed and thus decrease the cholesterol synthesis. Objectives: The present study aimed to determine the effect of Kersen leaves extract (M. calabura L.) in inhibiting the HMG-CoA reductase activity in vitro. Material and Methods: The study is a true experimental study with a post-test-only control group design. The independent variables were ethanol, methanol, and n-hexane extracts of Kersen leaves. Moreover, the percentage inhibition of the enzyme was the dependent variable. The test was conducted in vitro using UV-Vis spectrophotometry with pravastatin as a positive control. Results: The inhibitory effects of ethanol, methanol, n-hexane extracts of Kersen leaves, and pravastatin towards HMG-CoA reductase activity were 85.56%, 59.75%, 92.03%, and 99.58%, respectively. Post Hoc One-Way ANOVA showed that the p-values of pravastatin with ethanol, methanol, and n-hexane extracts were 0.687, 0.048, and 0.931, respectively. The n-hexane and ethanol extracts were potent for inhibiting the enzyme activity (p>0.05) comparable to pravastatin. Conclusion: The n-hexane and ethanol extracts of Kersen leaves could serve as a natural source of HMG-CoA reductase inhibitor to prevent hypercholesterolemia.
Co-Authors A Kadir La Ode Adellya Febriyani Hadini Adry Leonardy Tendean Agus Chahyadi Agussalim Ali Ardiansyah Ardiansyah Arimaswti Arimaswati Carla Wulandari Sabandar Dionisius Excelsis Deo Sombolinggi Gustavita Maria Bandong Hartati Hartati Haryati Haryati I Putu Sudayasa Juminten Saimin Kamaruddin, Harni Sartika Laode Kardin Laode Kardin Laode Kardin Mulyawati, Sufiah Asri Nina Indriyani Nina Indriyani Nasruddin Nur Rahmi Pranita Aritrina Pranita Aritrina Pranita Aritrina Pranita Aritrina Pranita Ayitrina Raja Al fath Widya Iswara Rana Triana Amin Reskiya Nur Insani Ririn Afrianto Sapto Raharjo Sukurni Syarifin, Andi Noor Kholidha Tety Yuniarty Sudiro Tomy Nurtamin Tri Wistya Utami Yenti Purnamasari Zulkifli Zulkifli