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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) As-syifaa Jurnal Farmasi Window of Health : Jurnal Kesehatan Jurnal Mandala Pharmacon Indonesia UMI Medical Journal Asy-Syariah ad-Dawaa : Journal of Pharmaceutical Sciences Borneo Journal Of Pharmascientech Jurnal Mandala Pengabdian Masyarakat Jurnal Kajian Ilmu Manajamen Journal of Global Pharma Technology Journal Microbiology Science Jurnal Indonesia : Manajemen Informatika dan Komunikasi Jurnal Pengabdian Masyarakat Journal of Pharmaceuticals and Natural Sciences KOPEMAS MPSJ Jurnal Ilmiah Nusantara Jurnal Balireso: Jurnal Pengabdian pada Masyarakat
Rizqi Nur Azizah
Fakultas Farmasi Universitas Muslim Indonesia
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Journal of Global Pharma Technology

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Antirheumatoid Artritis Effect of Purslane Herb Extract (portulaca oleracea l.) to Rat (rattus norvegicus) Induced by Complete Freuds Adjuvant Rizqi Nur Azizah
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Abstract

Rheumatoid arthritis is an autoimmune disease characterized by chronic inflammation of the joints of hands and feet. The research on antirheumatoid arthritis of ethanol extracts from Purslane (Portulaca oleracea L.) and effective doses of antirheumatoid arthritis. The research used 15 rats divided into 5 groups. Group 1 (1% Na-CMC); group 2 (prednisone) with the dose of 0.511 mg / kgBW; group III, IV and V were given ethanol extract of purslane doses of 100 mg / KgBW, 200 mg / KgBW and 400 mg / kgWW. The animal model of rheumatoid arthritis was made with intraplant injection of 0.1 mL Complete Freund's Adjuvant. The parameters observed were leg volume measurements and arthritis index. The leg volumes of data were analyzed by One Way Anova test followed by the L test while the arthritis index used the Kruskal-Wallis test followed by the Mann-Whitney test. In leg volume measurements, ethanol extract from the red root dose of 400 mg / kg reduced leg volume by 52.49% (p <0.05). Whereas in the arthritis index parameter, the ethanol extract from purslane dose of 400 mg / kg is significantly reduced the arthritis index (p <0.05) with arthritis index reduction by 50%. In conclusion, the ethanol extract from the purslane (Portulaca oleracea L.) with a dose of 400 mg/kg has better activity in treating rheumatoid arthritis in rats.Keywords: Antirheumatoid arthritis, Portulaca oleracea L., complete freund’s adjuvant.
Co-Authors , Faradiba A. Hudayah Abdul Malik Ahmad, Aktsar Roskiana Aisyah Alda, Alda Andi Clara Andi Maulana Kamri Annisyah, Nur Ardiansah Hasin Asriani Suhaenah Asrianto, La Ode Aulia Wati Awali, Muhammad Noer Bayu Putra Bayu Putra, Bayu Chikita Inaku Christiana Lethe Fadlina Chany Saputri Fitriana Fitriana Gemini Alam Hasanuddin, Asni Hendra Herman Irma Santi Irma Santi, Irma Iskandar , A. Nasyrah Iskandar Zulkarnain Karisa, Astuti Karyadi Marlian, Ayu Mirawati Mirawati Mudinillah, Adam Muhammad Irman Muhammad Yassir Mu’ammar Mu’ammar Nirma Kurriwati, Nirma Nopriyanti, Eka Maryam Nurwahida Nurwahida Rachmat Kosman Rachmat Kosman, Rachmat Rafika Tobis Rini Suwartika Kusumadiarti Ririn Ririn SALIM, MUH.AGUS Sukmawati Sukmawati Syarifah Khaerunnisa Ulupalu, Fadila Fauzia Mutmaina Yurniati Yusnita Rifai