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All Journal Jurnal Kedokteran Brawijaya EGALITA Journal of Innovation and Applied Technology Majalah Kesehatan FKUB E-Prodenta Journal of Dentistry Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Novi Khila Firani
Brawijaya University
Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Health Professions Medicine & Pharmacology Neuroscience Public Health

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HUBUNGAN OBESITAS DENGAN PENYAKIT PENYAKIT PERIODONTAL YANG DIUKUR MENGGUNAKAN COMMUNITY PERIODONTAL INDEX OF TREATMENT NEEDS (CPITN) Novi Khila Firani; Kurnia Putri Alvianti; Khusnul Munika Listari
E-Prodenta Journal of Dentistry Vol 5 No 2 (2021)
Publisher : Fakultas Kedokteran Gigi UB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.eprodenta.2021.005.02.5

Abstract

Latar belakang: Obesitas merupakan masalah kesehatan dunia dengan kecenderungan terjadi peningkatan tiap tahun. Obesitas adalah kelebihan berat badan akibat penimbunan lemak berlebih yang beresiko menimbulkan berbagai komplikasi penyakit sistemik, dan diduga juga menyebabkan gangguan kesehatan periodontal. Tujuan: Untuk mengetahui hubungan antara obesitas dan penyakit periodontal. Metode: Penelitian ini merupakan jenis penelitian observasional analitik dengan pendekatan cross sectional pada pasien di Puskesmas Janti, Kota Malang, dari Agustus hingga November 2019. Terdapat 107 responden obesitas dan non obesitas (21 laki-laki dan 86 perempuan), yang bersedia berpartisipasi dalam penelitian ini. Kriteria obesitas berdasarkan kriteria WHO Asia Pasifik yaitu indeks massa tubuh ≥25 kg/m2. Kriteria eksklusi adalah pasien dengan kelainan sistemik, merokok, menggunakan protesa atau alat ortodontik, hamil, menyusui, memiliki penyakit pada kelanjar saliva, dan pasien yang mengkonsumsi obat-obatan. Analisis statistik menggunakan chi-square dan Spearman's correlation test. Hasil: Terdapat perbedaan yang signifikan (p=0.002) pada skor keparahan indeks CPITN antara obesitas dan non obesitas. Uji korelasi spearman menunjukkan bahwa terdapat korelasi positif yang signifikan (p<0.01) antara obesitas dan skor CPITN. Kesimpulan: Obesitas memiliki hubungan dengan penyakit periodontal yang ditunjukkan dengan meningkatnya skor CPITNKeywords: CPITN, Obesity, Periodontal disease, Body mass index 
Role of Lactic Acid as Predictor of Mortality in Patients with Acute Myocardial Infarction Novi Khila Firani; Theresa Sugiarti Oetji
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 27 No. 2 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i2.1734

Abstract

The hypoxic-ischemic condition causes tissue metabolic abnormalities and organ dysfunction, characterized by elevated blood lactic acid levels. It is suspected that increased lactic acid in Acute Myocardial Infarction (AMI) patients could increase mortality risk. This study aimed to determine whether increased lactic acid levels could be used as a predictor of mortality in AMI patients. The analytical observational-cohort study was performed on AMI patients who were admitted to Dr. Saiful Anwar Malang Hospital from January 2018 to December 2019. Research subjects were divided into two groups, the group of deceased and living AMI patients, who were tested for lactic acid, troponin-I, CKMB, and creatinine levels at admission. Diabetes mellitus and septic patients were excluded. For analysis of lactic acid as a predictor of mortality, ROC curve analysis and odds ratio were used. There found that lactic acid levels in the deceased AMI patients group were higher compared to that of the living AMI patients (p < 0.05). The sensitivity and specificity values of lactic acid as a predictor of mortality in AMI patients at a cut-off of 3.5 mmol/L were 66.7% and 80%, respectively. Odds ratio analysis showed that AMI patients with lactic acid levels more than 3.5 mmol/L had 8 times greater mortality risk than those whose level less than 3.5 mmol/L. It was concluded that lactic acid level can be used as an indicator to predict the mortality of AMI patients.
Procalcitonin and Troponin-I as Predictor of Mortality in Acute Myocardial Infarction Patients Novi Khila Firani; Jennifer Prisilla
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 2 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i2.1817

Abstract

Acute Myocardial Infarction (AMI) is known as one of the leading causes of death in the world as well as in Indonesia. Procalcitonin is a marker of inflammation that has been recognized as a predictor of mortality in sepsis patients. The role of procalcitonin as a predictor of mortality in AMI patients has not been widely studied. Troponin-I has been recognized as a biomarker of AMI. It is unclear whether Troponin-I can also act as a biomarker to predict the death of AMI patients. This study aim is to determine the role of procalcitonin and troponin-I as predictors of mortality in AMI patients. A 5-month analytical observational study was performed on AMI patients who were admitted to Dr. Saiful Anwar, Malang. Patients with sepsis or infection were excluded. There were 51 study subjects, of whom median procalcitonin and troponin-I levels of patients who died were significantly different from survivors (p<0.05). Procalcitonin level with a cut-off of 2.16 ng/mL had a sensitivity of 77% and specificity of 87%. Troponin-I level with a cut-off of 3.1 ng/mL had a sensitivity of 61% and specificity of 84%. Odds ratio of procalcitonin to mortality was 17.78 (p=0.001), while troponin-I was not significant. Procalcitonin correlated with mortality (r= 0.519, p= 0.005). The conclusion of this research is procalcitonin acts as a predictor of in AMI patients.
KORELASI PROFIL HEMATOLOGI DAN TROMBOPOIETIN DENGAN TERJADINYA PERDARAHAN PADA PASIEN SIROSIS HEPATIS Firani, Novi Khila; Fatonah, Siti; Wardhani, Shinta Oktya; Supriono; Gonius, Andry; Mustofa Aidid
Majalah Kesehatan Vol. 11 No. 3 (2024): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2024.011.03.2

Abstract

Sirosis hepatis adalah penyakit kronis hati yang ditandai adanya fibrosis hati yang dapat menyebabkan abnormalitas fungsi hati baik pada metabolisme maupun sintesis faktor koagulasi. Perdarahan akut saluran cerna atas merupakan akibat hipertensi portal dan kegagalan fungsi hati memproduksi faktor pembekuan darah pada sirosis hepatis. Belum diketahui bagaimana korelasi parameter hematologi dan trombopoietin dengan terjadinya perdarahan pasien sirosis hepatis. Tujuan penelitian ini untuk mengetahui korelasi kadar hemoglobin, leukosit, trombosit dan trombopoietin dengan terjadinya perdarahan pada pasien dengan sirosis hepatis. Desain studi ini adalah observasional analitik pada pasien sirosis hepatis yang dirawat di RSUD dr. Saiful Anwar Malang, yang memenuhi kriteria inklusi dan eksklusi. Analisis statistik menggunakan uji komparasi dan uji korelasi Spearman. Hasil penelitian didapatkan sejumlah 35 orang pasien sirosis hepatis. Kadar trombopoietin yang lebih tinggi pada pasien sirosis yang mengalami perdarahan dibandingkan pasien sirosis tanpa perdarahan. Kadar hemoglobin lebih rendah pada pasien sirosis yang mengalami perdarahan dibandingkan yang tanpa perdarahan. Terdapat ko relasi yang bermakna antara kadar hemoglobin (r = -0,653; p < 0,05) dan kadar trombopoietin (r = 0,355; p < 0,05) dengan terjadinya perdarahan pasien sirosis hepatis. Tidak ada perbedaan yang signifikan kadar leukosit dan trombosit pada pasien sirosis yang mengalami perdarahan dan tanpa perdarahan. Dari penelitian ini dapat disimpulkan bahwa kondisi perdarahan pada pasien sirosis hepatis berkorelasi dengan penurunan kadar hemoglobin dan peningkatan kadar trombopoietin.
Pencegahan Penyakit Diabetes Melitus pada Masyarakat Desa Ngadiwono Kecamatan Tosari Kabupaten Pasuruan dengan DEM (Deteksi, Edukasi, dan Monitoring) Firani, Novi Khila; Permatasari, Happy Kurnia; Wahono, Singgih Pudjo; Soraya, Mira; Purnamasari, Putri; Ningtyas, Denina Setya
Journal of Innovation and Applied Technology Vol 8, No 2 (2022)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jiat.2022.008.02.14

Abstract

Penyakit Diabetes Melitus merupakan penyakit metabolik yang ditandai  peningkatan kadar gula dalam darah. Penyakit ini merupakan penyakit degeneratif yang berlangsung kronis, sehingga seringkali menyebabkan berbagai komplikasi. Komplikasi akibat Diabetes Melitus dapat menyebabkan meningkatnya angka kematian.  Insiden penyakit Diabetes Melitus meningkat dengan bertambahnya usia. Skrining penyakit Diabetes Melitus dilakukan melalui pemeriksaan kadar gula darah sewaktu. Selanjutnya dilakukan edukasi dengan ceramah kesehatan dan pemberian brosur. Tahapan terakhir yaitu monitoring, dengan melakukan pemeriksaan kadar glukosa darah kembali di akhir program. Sasaran program pengabdian masyarakat ini adalah masyarakat usia lansia dan pralansia di Desa Ngadiwono, Kecamatan Tosari, Kabupaten Pasuruan. Hasil kegiatan pengabdian masyarakat ini menunjukkan bahwa terdapat penurunan persentase warga yang memiliki kadar gula darah kategori Diabetes Melitus.   
Pengaruh Pemberian Air Rebusan Bawang Putih (Allium Sativum) Terhadap pH Saliva Buatan yang Diinduksi Streptococcus mutans Secara In Vitro Firani, Novi Khila; Subandi, regian_fahmi02
E-Prodenta Journal of Dentistry Vol 9 No 1 (2025)
Publisher : Fakultas Kedokteran Gigi UB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.eprodenta.2025.009.01.7

Abstract

Saliva or spit is a complex fluid that plays an important role produced by the salivary glands to maintain the balance of the ecosystem in the mouth. The acidity in saliva is influenced by Streptococcus mutans because it can accelerate the process of creating an acidic environment in saliva. The infusion of garlic (Allium Sativum) contains allicin, ajoene, flavonoids, and essential oils that can inhibit the growth of the bacteria Streptococcus mutans. The aim of this research is to determine the effect of garlic (Allium Sativum) decoction on the pH of saliva artificially induced by Streptococcus mutans in vitro. This research employs a True Experimental Design, specifically the Pretest and Posttest Control Group Design. The concentrations used in this study are 25%, 50%, and 100%. The results indicate a difference in the pH levels of artificial saliva that has been induced by Streptococcus mutans and treated with garlic decoction in vitro. The data analysis utilized correlation and regression tests, showing an influence of 73.3% of garlic decoction on the pH of artificial saliva. Independent T-test showed a significant difference between the same groups with different observation times, namely in treatment 1 day 2 with treatment 1 day 3 of 0.013 (p<0.05). Based on this research, it can be concluded that garlic boiled water has an effect and relationship in increasing the pH of saliva artificially induced by Streptococcus mutans in vitro.
Co-Authors Agustin Iskandar Alvianti, Kurnia Putri Anik Widijanti Bambang Prijadi Gonius, Andry Happy Kurnia Permatasari Heri Kristianto Jennifer Prisilla Khusnul Munika Listari Kurnia Putri Alvianti listari, khusnul munika M Rasjad Indra Mustofa Aidid Nadie Fatimatuzzahro Ningtyas, Denina Setya Nonong Eriani Putri Purnamasari Putri, Fara Felisa Rahmad Rahmad Shinta Oktya Wardhani, Shinta Oktya Siti Fatonah Soraya, Mira Subandi, regian_fahmi02 Supriono Theresa Sugiarti Oetji Wahono, Singgih Pudjo Zulhaidah Arthamin, Maimun