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All Journal Jurnal Veteriner Nusantara Medical Science Journal Jurnal Kesehatan Reproduksi JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Sri Sulistyowati
Bagian Obsteterik Dan Ginekologi, Fakultas Kedokteran, Universitas Sebelas Maret/ RSUD Dr. Moewardi Surakarta. Jl. Kolonel Sutarto 132, Surakarta, Jawa Tengah, Indonesia.
Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : Nusantara Medical Science Journal

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THE DIFFERENCE HUMAN LEUKOCYTE ANTIGEN-E (HLA-E) EXPRESSION AND NATURAL KILLER CELLS (NK CELLS) IN TROPHOBLAST BETWEEN INTRAUTERINE GROWTH RESTRICTION (IUGR) AND NORMAL PREGNANCY soetrisno soetrisno; Sri Sulistyowati; Supriyadi Hari Respati; Bambang Triono Cahyadi
Nusantara Medical Science Journal Volume 3 No. 1 Januari - Juni 2018
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v3i1.5781

Abstract

Background: Intrauterine growth restriction (IUGR) is still a major cause of perinatal morbidity and mortality. IUGR incidence ranged from 4.4 to 6.44% of pregnant women. Human Leukocyte Antigen - E and NK cells are thought to play an important role towards the process of IUGR.Objective: To determine aetiopathogenesis HLA-E expression and NK Cell in IUGR.Methods: An analytical observational study conducted through a cross-sectional approach. The research was conducted on March-October 2015 at the Obstetrics and Gynecology Department, Dr. Moewardi Hospital Surakarta and at of Laboratory of Pathology, Faculty of Medicine, Universitas Sebelas Maret Surakarta. Subjects who meet the inclusion and exclusion criteria consisted of 20 patients with IUGR and 20 normal pregnant patient. The researcher examined HLA-E Expression and NK cells in trophoblast using immunohistochemical method and statistical analysis using t test.Results: The average HLA-E expression in the trophoblast in IUGR group 17.80 ± 5.55, compared with normal pregnancy 66.23 ± 19.83, p value = 0.0001 (p <0.05). The average expression of NK cells in trophoblast in IUGR group 137.71 ± 28.09 compared with normal pregnancy 31.75 ± 14.77, p value = 0.0001 (p <0.05).Conclusion: HLA-E expression in normal pregnancy trophoblast is higher than pregnancies with IUGR. Expression of NK cells in pregnancy with IUGR is higher compared with normal pregnancy.
Co-Authors Aldi Firmansyah Bambang Triono Cahyadi Dewi Setiyawati Dympna Pramelita Eric Edwin Yuliantara Erindra Budi Cahyanto Hafi Nurinasari Hari Wujoso Lungguk Helen Alfian Tanjung Metharisa Sujana Muhammad Adrianes Bachnas Nutria Widya Purna Anggraini Rubin Enhui Tjiang Soetrisno Soetrisno Soetrisno Soetrisno Soetrisno Soetrisno soetrisno soetrisno Supriyadi Hari Respati Supriyadi Hari Respati Supriyadi Hari Respati Uki Retno Budihastuti Wisnu Prabowo