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All Journal Folia Medica Indonesiana Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Wisnu Prabowo
Department Of Obstetrics And Gynaecology, Faculty Of Medicine, Universitas Sebelas Maret/Dr. Moewardi General Hospital, Surakarta
Health Professions Medicine & Pharmacology Nursing Public Health Other

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Hypoxia Inducible Factor-1-Alpha Expression on Preeclampsia Mice Model With L-Arginine Administration Nutria Widya Purna Anggraini; Sri Sulistyowati; Muhammad Adrianes Bachnas; Eric Edwin Yuliantara; Wisnu Prabowo; Uki Retno Budihastuti
Folia Medica Indonesiana Vol. 57 No. 3 (2021): September
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (430.04 KB) | DOI: 10.20473/fmi.v57i3.22733

Abstract

Preeclampsia is hypertension in pregnancy that affects 2% to 8% of pregnancies worldwide and causes significant maternal and perinatal morbidity and mortality. In the pathogenesis of preeclampsia, placental hypoxia plays an important role, associated with excessive trophoblast apoptosis resulting in decreased trophoblast and spiral arteries invasion. This placental hypoxic condition will induce increased expression of Hypoxia Inducible Factor -1-Alpha (HIF-1-A). L-Arginine is a potent vasodilator presumably to improve preeclampsia placental hypoxic conditions and reduce HIF-1-A expression. This study was an experimental study with a parallel-group post-test only design. Thirty-six preeclamptic mice models were divided into 2 groups. The control group (K1) 18 preeclamptic mice model without treatment and the treatment group (K2) 18 preeclamptic mice given L-Arginine. The independent variable was the administration of L-Arginine and the dependent variable is the placental HIF-1-A expression. Statistical analysis used unpaired t-test on normal data distribution, and Mann Whitney test on abnormal data distribution. The mean of placental HIF-1-A expression K1 was 2.47 ± 1.65 with a minimum value of 0.4 and a maximum value of 6.6. At K2 0.93 ± 0.55 with a minimum value of 0.0 and a maximum value of 2.0. Statistical tests showed that the placental HIF-1-A expression in the treatment group was significantly lower than that in the control group (p <0.001). In conclusion, the expression of HIF-1-A in preeclamptic mice model placenta decreased with L-Arginine administration.
THE EFFECT OF ABO BLOOD GROUP ON COVID-19 IN PREGNANCY Sri Sulistyowati; Nutria Widya Purna Anggraini; Soetrisno Soetrisno; Eric Edwin Yuliantara; Supriyadi Hari Respati; Muhammad Adrianes Bachnas; Wisnu Prabowo; Hafi Nurinasari; Dympna Pramelita; Dewi Setiyawati; Metharisa Sujana; Aldi Firmansyah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art6

Abstract

Background: The COVID-19 virus has spread throughout the world and has been declared as a global pandemic by WHO. Some population groups are more susceptible to COVID-19, and one of them is pregnant women. Pregnancy increases risks of the COVID-19, especially thrombotic complications. The SARS-CoV-2 infection may vary widely from asymptomatic to severe infection. Some studies have shown that ABO blood group can be a marker of susceptibility to some disease progression. Objective:This study aims to investigate relationships between the ABO blood group, the COVID-19 infection and its complications in pregnant women at Dr. Moewardi Hospital, Surakarta.Methods: This study was an observational analytic study with a cross-sectional study design involving 40 pregnant women infected with COVID-19 at Dr. Moewardi Hospital, Surakarta. COVID-19 PCR swabs on the women were administered on their oropharynx and nasopharynx, and laboratory examination of the ABO blood group in all samples was performed. Comparative data distribution of blood groups in the population and the global population distribution were calculated by Chi Square Goodness of Fit. Comparative data between ABO blood group distributions, blood parameters and complications (respiratory, thrombotic, other infections, and death) were calculated by Chi square test and then by One-Way ANOVA. Next, correlation tests for the complications of the blood group and the ages applied a multinomial regression.Results: There were significant differences of thrombotic complications on the blood group of pregnant women infected with COVID-19 (p=0.027). Blood type B significantly tended to experience thrombotic complications when compared to other blood groups (p=0.022).Conclusion: The ABO blood group could affect the complication levels in the pregnant women infected with the COVID 19.
LEARNING TO PREVENT AND BREAK THE CHAIN OF TRANSMISSION OF COVID-19 BY VACCINATE WOMEN, PREGNANT AND BREASTFEEDING MOTHERS THROUGH THE WEBINAR Muhammad Adrianes Bachnas; Nutria Widya purna Anggraini; Sri Sulistyowati; Eric Edwin Yuliantara; Wisnu Prabowo; Gagah B Adi Nugraha; Aldi Firmansyah; Dympna Prameilita
Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Vol 10, No 1 (2022): February
Publisher : Program Studi Kebidanan Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/placentum.v10i1.52880

Abstract

Background: The incidence of Covid-19 in women, pregnant, and breastfeeding mothers is still high. Currently, the government is trying to prevent and break the chain of Covid-19 transmission by vaccination. However, knowledge about Covid-19 vaccination is still limited. Therefore, Indonesian Obstetrics and Gynecology Association/Perkumpulan Obstetri dan Ginekologi Indonesia  (POGI) members, as the spearhead of women's health, play an essential role in breaking the chain of transmission by providing knowledge about Covid-19 vaccination.Methods: All member of POGI and Youth POGI in Surakarta was educated by online method via the webinar zoom application. The level of knowledge was evaluated pre and post-webinar by using a questionnaire to see the significance.Result: Analysis of 110 participants with paired t-test obtained an average pretest value of 44.82 while the average post-test value was 57.45, with a significance value of p=0.001 (p<0.05). The results of the analysis with the Chi-square test obtained p = 0.002 (p <0.05) and OR = 23.40.Conclusion: There is an increased understanding of preventing and breaking the chain of transmission of Covid-19 in women, pregnant, and breastfeeding mothers by vaccinating youth POGI and POGI members after webinar and discussion, with a significance value of p=0.001 (p<0.05). Webinars and discussions on preventing and breaking the chain of transmission of Covid-19 to women, pregnant, and breastfeeding mothers with vaccination by researchers provided 23.40 times better understanding than before the webinar and discussions were given.   
Early Detection and Good Team Collaboration for Preventing Maternal Death Caused by Placenta Accreta Spectrum Disorder Eric Edwin Yuliantara; Muhammad Adrianes Bachnas; Nutria Widya Purna Anggraini; Wisnu Prabowo; Gagah Baskara Adi Nugraha; Meriska Dewi Chasanah; Fadel Muhammad S. Alim; Hikmah F. Merina
Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Vol 11, No 2 (2023): August
Publisher : Program Studi Kebidanan Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/placentum.v11i2.71047

Abstract

Background: Placenta accreta spectrum (PAS) is considered one of the most harmful pregnancy conditions, as it is strongly linked with maternal morbidity and mortality. An accurate and early prenatal diagnosis of PAS allows time for a multidisciplinary team to plan the best course of action for delivery management. The aim of this study is to describe placenta accreta spectrum management and outcomes with early detection and a multidisciplinary team approach.Method: A retrospective cohort study was conducted on 167 cases of placenta accreta from 2016 to 2021. Medical records were then reviewed, and data were collected for delivery management and maternal outcome, including estimated amounts of bleeding, urinary tract injury, delivery time, ICU referral, and maternal death.Result: Delivery management (hysterectomy and conservative management) and maternal bleeding were significantly associated with MAP score (p < 0.05), while urinary tract injury, delivery time, ICU admission, and maternal death were not significantly associated (p > 0.05). 55.1% of patients underwent hysterectomy, and the rest 44.9% underwent conservative surgery. Massive bleeding of more than 2500 mL happened in 54.5% of patients, and the rest 45.5% managed to bleed less than 45.5%. Preterm deliveries accounted for 29.9% of all deliveries, with the remaining 70.1% being term. 5.4% of patients experienced urinary tract injuries. 6.6% of patients were referred to the intensive care unit. The maternal mortality rate is 4.8%.Conclusion: Early detection of the placenta accreta spectrum, as well as good collaboration among members of a multidisciplinary team from various medical fields, are required to ensure the mother and baby's safety and survival.
Co-Authors Aldi Firmansyah Aldi Firmansyah Dewi Setiyawati Dympna Prameilita Dympna Pramelita Eric Edwin Yuliantara Fadel Muhammad S. Alim Gagah Baskara Adi Nugraha Gagah Baskara Adi Nugraha Hafi Nurinasari Hikmah F. Merina Meriska Dewi Chasanah Metharisa Sujana Muhammad Adrianes Bachnas Nutria Widya Purna Anggraini Soetrisno Soetrisno Sri Sulistyowati Sri Sulistyowati Supriyadi Hari Respati Uki Retno Budihastuti