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All Journal Farmaka Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology) Indonesian Journal of Pharmaceutical Science and Technology Acta Pharmaceutica Indonesia Indonesian Journal of Chemistry Journal of Global Pharma Technology
Danni Ramdhani
Universitas Padjadjaran
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Physics Public Health

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Journal : Journal of Global Pharma Technology

 1 
In Vitro Evaluation of Antibacterial Activity from Nephelium lappaceum L. Leaf Ethanolic Extract and Fraction against Some Foodborne Pathogens Imam Adi Wicaksono; Raden Bayu Indradi; Danni Ramdhani; Resmi Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Fooborne pathogens are causing foodborne illness with significant effects on human health. Some of the most common foodborne bacteria that cause foodborne illness are Bacillus cereus and Shigella dysenteriae. Nephelium lappaceum L. is known to have antibacterial potential because of these plants have secondary metabolites such as flavonoid and polyphenols. The ethanolic extract and fractions of Nephelium lappaceum L. was investigated for antibacterial activities including determine of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against foodborne pathogens. The extraction of N. lappaceum L. was done by maceration method with 70% ethanol and fractionationed by liquid-liquid extraction to obtain ethyl acetate, water, and n-hexane fractions. Secondary metabolite content and profile determination of N. lappaceum L. was done by phytochemical screening and thin layer chromatography. The antibacterial activities were determined using the agar diffusion method, MIC and MBC value determined by dilution method using the test tube. The results showed that the ethanolic extract, ethyl acetate fraction and water fraction of N. lappaceum L. had antibacterial activity against Bacillus cereus isolate and Shigella dysenteriae bacteria. The value of MIC and MBC of the extract in the concentration range between 0.08%(w/v) – 0.15%(w/v) against B. cereus isolate and 2.5%(w/v) – 5%(w/v) against S. dysenteriae, which the ethyl acetate fraction in concentration range between 0.04%(w/v) - 0.08%(w/v) against B. cereus isolate and 1.25%(w/v) – 2.50%(w/v) against S. dysenteriae bacteria. The ethyl acetate fraction is the most active fraction because it had the best activity, MIC and MBC values when compared to the results against both of test bacteria.
Antibiotics Treatment for Acute Respiratory Tract Infections (ARTIs): Evaluation of Doxycycline Resistance Cases at a Community Health Center in Urban Area of Indonesia. Danni - Ramdhani
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Abstract. Acute respiratory tract infections (ARTIs) are a major health problem in developing countries. This infection can occur in the upper or lower respiratory tract which is accompanied by inflammation. Doxycycline is highly recommended for the treatment of ARTIs patients allergic to penicillin. This study aimed to evaluate the effectiveness of doxycycline in the treatment of ARTIs through its antibiotic resistance rates, and identify bacteria that have been resistant to doxycycline antibiotics. This study consists of the stages of rejuvenation of clinical isolates from ARTIs patients at a community health center in the Urban Tasikmalaya area, identification of bacteria, and testing for antibiotic resistance using the paper-disk method. The results of resistance tests from 116 single clinical isolates showed that there had been resistance to doxycycline antibiotics in the treatment of ARTIs in the urban area of Tasikmalaya with a category of 64.29% being resistant; 14.29% intermediates and 21.42% are still sensitive. The results of bacterial identification showed that doxycycline was resistant to the Corynebacterium, Streptococcus, Staphylococcus, Haemophillus and Bordetella bacteria groups. Doxycycline treatment for ARTIs infection is considered not very effective. Another class of drugs as a substitute for doxycycline for patients allergic to penicillin is needed.
Co-Authors Abdul Mutalib Ade Suherman Ahmad Kurniawan Aliya Nur Hasanah Amir Musadad Miftah Anisa Desy Ariyanti Eva Maria Widyasari Henry Ng Henry Ibrahim Dalli Imam Adi Wicaksono Iswahyudi Iswahyudi Karen Low Ka Ling Maula Eka Sriyani Meti Kusmiati, Meti Miftah, Amir Musadad Mutalib, Abdul Nalia El-Huda Ismail Nyi Mekar Saptarini Raden Bayu Indradi Resmi Mustarichie Rusydina Sabila Shelvy Elizabeth Suherman SINTHA NUR FITRIANI Sri Agung Fitri Kusuma, Sri Agung Teguh Hafiz Ambar Wibawa