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VARIASI KOMPOSISI NANO HIDROKSIAPATIT PADA POLY(1,8-OCTANEDIOL-COCITRATE) (POC) SEBAGAI BIODEGRADABLE BONE SCREW Fitriyatul Qulub; Prihartini Widiyanti; Jan Ady
Jurnal Sains Materi Indonesia Vol 16, No 4: JULI 2015
Publisher : Center for Science & Technology of Advanced Materials - National Nuclear Energy Agency

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (172.915 KB) | DOI: 10.17146/jsmi.2015.16.4.4223

Abstract

VARIASI KOMPOSISI NANO HIDROKSIAPATIT PADA POLY(1,8-OCTANEDIOL-COCITRATE) (POC) SEBAGAI BIODEGRADABLE BONE SCREW . Tingginya kasus fraktur tulang sekitar 300-400 ditangani dengan metode fiksasi interna menggunakan bone screw. Diperlukan inovasi biomaterial yang memiliki sifat utama biodegradabel agar tidak memerlukan reoperation dan biokompatibel terhadap jaringan tubuh. Telah dilakukan penelitian mengenai variasi komposisi nano hidroksiapatit (HA) berasal dari ekstrak sisik ikan kakap pada Poly (1,8-octanediol-Co-Citrate) (POC) sebagai Biodegradable Bone Screw. Penelitian ini bertujuan mensintesis POC dan mengkarakterisasi pengaruh komposisi HA terhadap sifat mekanik dan biokompatibilitas komposit POC-HA. Sintesis POC dilakukan dengan metode polimerisasi kondensasi, terbentuk ikatan ester gugus C=O stretch pada 1731 cm-1 melalui uji gugus fungsi dari POC pra polimer. Pra polimer POC dikompositkan dengan nano-HA pada variasi komposisi 62%,65%,68%dan 71%, dilanjutkan perlakuan postpolymerization. Komposit POC-HA dilakukan karakterisasi uji kekerasan dan uji degradasi. Hasil pengujian menunjukkan komposisi nanopartikel HA memberikan pengaruh sifat mekanik dan biokompatibilitas. Seluruh sampel memiliki kuat tekan berkisar 3,64-9,56 MPa sesuai dengan kuat tekan tulang cancellous manusia (2-12 MPa). Melalui analisis Energy Dispersive X-Ray Spectroscopy (EDX), uji degradasi sampel terbukti kebioaktifitasan mineral apatit sebesar 7,5% (At%) dan terputusnya rantai C-X dari polimer POC sebesar 5,95% (At%) selama 4 minggu inkubasi dalam Simulated Body Fluid (SBF). Berdasarkan hasil karakteristik penelitian ini, komposit POC-HAberpotensi sebagai kandidat biodegradable bone screw.
Peningkatan Daya Tarik Desa Kare Kecamatan Kare Kabupaten Madiun melalui Pengembangan Ekowisata Berbasis Pasrtisipatif – Kolaboratif Prihartini Widiyanti; Fitriyatul Qulub; Akhmad Jayadi; Gadis Meinar Sari
I-Com: Indonesian Community Journal Vol 3 No 1 (2023): I-Com: Indonesian Community Journal (Maret 2023)
Publisher : Fakultas Sains Dan Teknologi, Universitas Raden Rahmat Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (545.649 KB) | DOI: 10.33379/icom.v3i1.2359

Abstract

Desa Kare adalah salah satu desa di wilayah Kabupaten Madiun yang potensial untuk pengembangan wisata dan produk alam. Pengabdian masyarakat bertema ekowisata bertujuan (1) mengembangkan kawasan wisata berbasis partisipatif-kolaboratif, (2) meningkatkan pola kesadaran masyarakat terhadap kesehatan, (3) memberikan fasilitas kesehatan sesuai protokol kesehatan, (4) menarik minat para wisatawan melalui promosi media sosial, (5) menambah wawasan tentang cara pengolahan limbah dan produk unggulan ciri khas Desa Kare. Pelaksanaan kegiatan berlangsung dalam tiga level tahapan yaitu perencanaan kegiatan, pelaksanaan kegiatan dan tindak lanjut acara. Ekowisata dijalankan menitikberatkan pada peran aktif masyarakat setempat dan dalam kegiatan Program Pengembangan Desa Binaan (PPDB) telah dilakukan pembinaan produk dan kemasan terstandar destinasi wisata pada Unit Mikro Kecil dan Menengah (UMKM). Melalui pengmas PPDB, masyarakat setempat diberikan edukasi untuk menyiapkan masyarakat supaya sadar akan potensi alam untuk ikut menjaga dan melestarikan. Kegiatan secara berkelanjutan diharapkan untuk meningkatkan kesejahteraan serta taraf hidup masyarakat Desa Kare.
Fast Microwave-Assisted Green Synthesis of Silver Nanoparticles Using Low Concentration of Seminyak (Champeria sp.) Leaf Extract Muhammad Bagas Ananda; Fathan Aditya Sanjaya; Tami Bachrurozy; Helmi Majid Ar Rasyid; Anggraini Barlian; Akfiny Hasdi Aimon; Fitriyatul Qulub; Prihartini Widiyanti; Arie Wibowo
Indonesian Journal of Chemistry Vol 23, No 2 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.78545

Abstract

Silver nanoparticles (AgNPs) are fascinating materials for biomedical applications thanks to their strong antibacterial activity and biocompatibility. This study applied the green synthesis method using 0.5 wt.% Seminyak leaf extract and assisted with one min microwave irradiation to enhance AgNPs formation. Extremely small sizes AgNPs with an average particle size of 9.1 ± 4.1 nm and spherical shapes were obtained. The synthesized AgNPs displayed potent antibacterial activity against Escherichia coli and Staphylococcus aureus bacteria with a zone of inhibition of 12.3 ± 0.1 and 13.7 ± 0.7 mm, respectively. The MTT assay results demonstrated that the cells’ viability of the obtained AgNPs was 88.5 ± 7.0 %, implying biocompatibility for biomedical applications.
Peningkatan Pengetahuan dan Ketrampilan dalam Bidang Bahasa dan Budaya di Desa Kare Kabupaten Madiun Akhmad Jayadi; Prihartini Widiyanti; Gadis Meinar Sari; Fitriyatul Qulub
I-Com: Indonesian Community Journal Vol 3 No 4 (2023): I-Com: Indonesian Community Journal (Desember 2023)
Publisher : Fakultas Sains Dan Teknologi, Universitas Raden Rahmat Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33379/icom.v3i4.3532

Abstract

Kare Village is one of the villages in Madiun Regency which has a variety of tourism potential, both natural and cultural. However, this tourism potential has not been utilized optimally. Ecotourism is carried out with a focus on increasing the active role of local communities. In the Assisted Village Development Program (PPDB) activities, seminars on local cultural potential identity and cultural preservation, English language training and draw pattern in piece of clothes (batik) making training were conducted for PKK women and Kare Village batik craftsmen. Community service with the topic of ecotourism aims to develop tourist village areas on the basis of participation and cooperation, increase understanding of tourism village marketing and realize sustainable tourism. This activity consists of three stages, namely preparation, implementation of activities, and follow-up activities. In its implementation, the community service program for the Assisted Village Development Program (PPDB) has held workshops with the theme of exploring local wisdom, applied tourism English language training with the aim of supporting sustainable ecotourism in Kare Village and batik batik training. This community service aims to make Kare Village ecotourism better and capable of international standards and can improve the welfare of the Kare Village community.
Solusi untuk Meningkatkan Kualitas Kerja dan Kesehatan di Desa Kare Kecamatan Kare Kabupaten Madiun melalui Manajemen Kelelahan Berbasis Audiovisual Prihartini Widiyanti; Fitriyatul Qulub; Akhmad Jayadi; Gadis Meinar Sari
I-Com: Indonesian Community Journal Vol 3 No 4 (2023): I-Com: Indonesian Community Journal (Desember 2023)
Publisher : Fakultas Sains Dan Teknologi, Universitas Raden Rahmat Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33379/icom.v3i4.3552

Abstract

Kare Village is one of the Madiun Regency communities with the potential to become a tourist destination. The goal of community service with an ecotourism theme is to establish a tourist destination where people collaborate effectively, raise public knowledge about health, and provide health facilities that adhere to health protocols. Many advantages will accrue from effective ecotourism management. Kare Village has a lot of tourism potential because it is located on the slopes of Mount Wilis. The Kare Village community's active participation in the Assisted Village Development Program (PPDB) is highlighted through ecotourism. Local people are being trained on the sustainable management of occupational weariness with the assistance of the PPDB community, which will improve the health and living standards of the inhabitants of Kare Village.
Effect of Hydroxyapatite Filler on Mechanical Properties of PE/HAp Composite as a Candidate for Bone Repair Qulub, Fitriyatul; Wardhani, Inten Firdhausi
Indonesian Applied Physics Letters Vol. 4 No. 2 (2023): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iapl.v4i2.48649

Abstract

Polymer is one material that can be used as a fixation to repair fractured or broken bones. However, polymers are soft and ductile, so modifying them by adding hydroxyapatite as a filler is necessary. Polyethylene is a high density polymer with more potent material properties to be utilized as a matrix. The PE-HAp composites were synthesized by compacting and heating the composition percentage of Hap 25%, 35% and 45%. Based on the characterization results using XRD, FTIR, and hardness test instruments, it is concluded that the addition of HAp composition results in better composite mechanical properties. The material properties are improving, increasing the hardness value (shore A) by 63 shore A. The hardness value increases because the composite properties are more compact, and the PE matrix physically binds the HAp filler. This is reinforced by XRD and FTIR characterization results, with no new compounds formed and no new molecular vibrational patterns in the FTIR spectrum.
Design Of A Fiber Optic Sensor-Based Respiration Monitoring System Qulub, Fitriyatul; Alvie Aditya, Shabrina; Ama, Fadli; Pramudita Putra, Alfian
Jurnal Info Sains : Informatika dan Sains Vol. 14 No. 03 (2024): Informatika dan Sains , Edition July - September 2024
Publisher : SEAN Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Human breathing rate is an essential marker for assessing one's health, especially regarding respiratory issues. Precise breathing measurements are vital in medicine as they help detect problems early and devise effective treatment plans. The use of fiber optic sensors to monitor breathing offers excellent potential in health monitoring, both medically and independently. Such sensors have advantages such as ease of manufacturing, high sensitivity, compact size, and affordable cost. In this study, a Singlemode-Multimode-Singlemode (SMS) optical fiber-based breathing sensor was designed by fitting it as a belt around the abdomen to measure abdominal breathing. This SMS sensor has variations in multimode length and wavelength used. Tests were conducted in sitting and standing positions, and the results showed the best performance of the SMS sensor at a multimode length of 3.5 cm with an accuracy rate of 99.2525%, linearity of 0.9997, and sensitivity of 2.9725 Hz/dBm. In addition, the standing body position provides 96.5% accuracy with a multimode length of 3.5 cm, while the sitting position provides 96.8% accuracy with a multimode length of 2 cm.
Pemanfaatan Teknologi dalam Mewujudkan Sustainable And Productive Life Masyarakat Kelurahan Pradah Kalikendal, Kecamatan Dukuh Pakis, Surabaya Prihartini Widiyanti; Franky Chandra Satria Arisgraha; Fitriyatul Qulub
I-Com: Indonesian Community Journal Vol 4 No 4 (2024): I-Com: Indonesian Community Journal (Desember 2024)
Publisher : Fakultas Sains Dan Teknologi, Universitas Raden Rahmat Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70609/icom.v4i4.5536

Abstract

One of the problems that exist in the community of Pradah Kalikendal Village, which is the largest sub-district in Dukuh Pakis District, Surabaya, is the waste of water that occurs during ablution and increasing chronic fatigue in the community which has an impact on reducing community productivity. Based on this, Airlangga University launched a community service program with the theme "Utilization of Technology in Realizing Sustainable and Productive Life in Pradah Kalikendal Village, Surabaya" which aims to increase water conservation and prevent fatigue and maintain community productivity through the application of technology, such as the use of automatic water taps. with a filter that can turn off when there is no object that stimulates the sensor and a fatigue detection tool to determine the individual's fatigue condition. This is necessary to prevent health problems and maintain the individual's fitness status. The program objectives are (1) water conservation: Using automatic sensor faucet technology to reducing water waste, especially in public service areas such as sub-districts, health centers and places of worship and (2) maintaining productivity: using a microcontroller-based fatigue detection tool to monitor the fatigue of people involved in intensive physical activity. This program involves Airlangga University students as part of the implementation of the Independent Learning Campus (MBKM) policy, which provides direct experience for students to interact with the community and solve real problems. This program takes the form of training on the use of technology-based tools in the form of filtered water taps for local residents, especially At-Taqwa mosque administrators and Dukuh Kupang Health Center medical personnel, for water conservation and the use of work fatigue detectors. Evaluation is carried out through questionnaires and community testimonials to measure the effectiveness of the program.
Measuring anxiety level on phobia using electrodermal activity, electrocardiogram and respiratory signals Ain, Khusnul; Rahma, Osmalina Nur; Purwanti, Endah; Varyan, Richa; Ittaqilah, Sayyidul Istighfar; Arfensia, Danny Sanjaya; Sosialita, Tiara Dyah; Qulub, Fitriyatul; Chai, Rifai
International Journal of Electrical and Computer Engineering (IJECE) Vol 15, No 1: February 2025
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijece.v15i1.pp337-348

Abstract

People with spider phobia experience excessive anxiety reactions when exposed to spiders that will interfere with daily life. Diagnosing and measuring anxiety levels in patients with spider phobia is a complex challenge. Conventional diagnosis requires psychological evaluations and clinical interviews that take time and often result in a high degree of subjectivity. Therefore, there is a need for a more objective and efficient approach to measuring anxiety levels in patients. This study performs anxiety level classification based on electrodermal activity, electrocardiogram (ECG) and respiratory signals using the dataset of Arachnophobia subjects. Each raw data is preprocessed using 24 types of features. Feature performance is processed using the recursive feature elimination method. Data processing was performed in 3 anxiety levels (high, medium, low) and two anxiety levels (high, low) with the support vector machine method and hold-out validation method (7:3). The performance of the model is evaluated by showing the accuracy, precision, recall and F1 score values. The polynomial kernel can perform optimal classification and obtain 100% accuracy in 2 classes and three classes with 100% precision, recall, and F1 score values. This result shows excellent potential in measuring anxiety levels that correlate with mental health issues.
EFFECT OF DEACETYLATION DEGREES VARIATION ON CHITOSAN NERVE CONDUIT FOR PERIPHERAL NERVE REGENERATION Qulub, Fitriyatul; Widiyanti, Prihartini; Maulida, Hendita Nur; Indrio, Ludita Woro; Wijayanti, Tia Rahayu
Folia Medica Indonesiana Vol. 53 No. 2 (2017): JUNE 2017
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (720.508 KB) | DOI: 10.20473/fmi.v53i2.6344

Abstract

Broken nerves could regenerate when exposed to simple injuries by using a nerve conduit that has appropriate physiological and mechanical ability to support the nerves regeneration around the fissure of trauma. One of the biopolymer for the conduit composition is chitosan because it is biocompatible, biodegradable, non-toxic, and has similarity structure as natural glycosaminoglycans. The aim of research is to synthesize chitosan with variation of Degrees of Deacetylation (DD) and characterize the DD influence on mechanical properties and biocompatibility. Research design is prospective observational. Chitosan was treated with a decrease in the DD method and an increase in the temperature with the strength of alkaline solution, which was NaOH solution with concentrations of 5%, 20%, 35%, and 50% within 2 hours with a heating temperature of 95°C. The results of each DD variation were 23.24, 46.55, 53.48, and 55.06. It was characterized by tensile test with tensile strength values of 0.25 - 1.18 MPa. The degradation test results tend to decrease with the increasing concentration of NaOH proving that samples are biodegradable. The surface morphology of samples shows a pore range of 61.52 μm - 220.3 μm. The best result is the chitosan sample with 35% NaOH because due to the tensile characteristic and a pore in accordance with normal standard. Tensile strength is around 0.41 MPa - 3.69 MPa and pore size around 40 μm – 250 μm to accelerate nerve regeneration. The results are expected to provide alternative solution of nerve conduit development for peripheral nerve defects.