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All Journal Jurnal Kedokteran Brawijaya The Journal of Experimental Life Sciences (JELS) Mutiara Medika: Jurnal Kedokteran dan Kesehatan MNJ (Malang Neurology Journal) Medical Laboratory Technology Journal Jurnal Ilmiah Farmako Bahari Jurnal Kebidanan Akademi Kebidanan Jember (JKAKJ) Indonesian Archives of Biomedical Research (InABR) Journal of Fisheries & Marine
Dwi Yuni Nur Hidayati
Program Studi Biomedik, Fakultas Kedokteran, Universitas Brawijaya, Malang
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Jurnal Kedokteran Brawijaya

 1 
IDENTIIFKASI PROTEIN IMUNOGENIK CHLAMYDIA PNEUMONIAE TERHADAP SERUM PENDERITA INFARK MIOARD AKUT Murwani, Sri; Hidayati, Dwi Yuni Nur
Jurnal Kedokteran Brawijaya Vol 23, No 2 (2007)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (661.466 KB) | DOI: 10.21776/ub.jkb.2007.023.02.6

Abstract

Chlamydia pneumoniae is human respiratory tract pathogen and recently investigated as pathogen causingatherosclerosis and acute myocardial infarction (AMI). This research was carrier out to detect proteinpattern of C. pneumoniae, and to study it relation to AMI throughdetection of immunogenic protein. Design research  was laboratory observational and analyzed descriptively. The subject was C. pneumoniae. Protein pattern the bacteria was detected by electrophoresis method, and to detect the immunogenic protein was done immunoblotting. Serum was obtained from AMI patients in Saiful Anwar and Lavallette hospitals.  The result showed, protein pattern C. pneumoniae wasprotein with molecular weight 117, 107, 97, 91, 86, 61, 58, 52, 46, 44, 34, 23, 19, 9, 5, 4 kDa. Immunogenic proteins vary between AMI patients was 117, 107, 86, 61, 58, 52, 46, 44,  34 kDa. Non immunogenic proteins were 97, 91, 23, 19, 9, 5 and 4 kDa. Protein 61 kDa react to all of patient’s serum. It was concluded, C. pneumoniae have protein fractions 117, 107, 97, 91, 86, 61, 58, 52, 46, 44, 34, 23, 19, 9, 5, and 4kDa. Immunogenic proteins vary between AMI patients was 117, 107, 86, 61, 58, 52, 46, 44, 34 kDa, and 61 kDa was the  immunodominant protein. The result proved C. pneumoniae as causative agent of atherosclerosis and acute myocardial infarction, in Indonesia particularly. Key words:C. pneumoniae, immunogenic, AMI
Comparison of Methanolic Extract of Piper Betle to Amikacin against the Growth of Pseudomonas aeruginosa Azalia Ayu Rysaputri; Hery Susilo; Dwi Yuni Nur Hidayati; Irene Ratridewi
Jurnal Kedokteran Brawijaya Vol. 32 No. 3 (2023)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2023.032.03.3

Abstract

Pseudomonas aeruginosa is one of the most common pathogens that cause Healthcare-Associated Infections (HAIs). A previous study stated that Piper betle L. extract has antibacterial activity against certain bacteria, including Pseudomonas aeruginosa. This study has the objective of comparing antibacterial activity of the methanolic extract of Piper betle L. and amikacin on the growth of Pseudomonas aeruginosa. This study used the tube dilution method with a sample of Pseudomonas aeruginosa from Microbiology Laboratory Dr. Saiful Anwar General Hospital, Malang. The results of this study showed that the value of MIC and MBC from the methanolic extract of the Piper betle L. treatment was 4800μg/mL. Meanwhile, the amikacin treatment resulted in 0.4μg/mL for MIC and 0.45μg/mL for MBC. From linear regression, it was found that the methanolic extract of Piper betle L. had a β-coefficient value closer to -1 compared to amikacin. Therefore, it can be concluded that the methanolic extract of Piper betle L. has a greater inhibiting effect on the growth of Pseudomonas aeruginosa.
Co-Authors Agustina Tri Endharti Andre William Tulle Aris Widayati Azalia Ayu Rysaputri Elisa Danik Kurniawati Eviana Norahmawati Hartono, Kevin Hening Ryan Aryani Hery Susilo Hidayat Sujuti Irene Ratridewi Istifadatul Ilmiya Ni Putu Sri Haryati Noorhamdani A.S. Noorhamdani Noorhamdani Nuning Winaris Nur Rohmah Prihantanti Nur Rohmah Prihatanti Prasetyo Adi Rima Nor Kaspia, Rima Nor Roekistiningsih Roekistiningsih Roekistiningsih Roekistiningsih Santoso, Giovani Anggasta Soeyati Poejiani Sri Andarini Sri Murwani Tanti Tri Lestary Tatit Nurseta Wening Prastowo Wiyasa, I Wayan Arsana