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Pengaruh Pemberian Aromaterapi Lavender secara Inhalasi terhadap Penurunan Intensitas Nyeri Persalinan Fisiologis pada Primipara Inpartu Kala Satu Fase Aktif di BPM “Fetty Fathiyah” Kota Mataram Karlina, Sisca Dewi; Reksohusodo, Subandi; Widayati, Aris
Majalah Kesehatan FKUB Vol 2, No 2 (2015)
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.01 KB)

Abstract

Nyeri merupakan perasaan sensorik dan emosional yang tidak menyenangkan. Pada persalinan nyeri  disebabkan kontraksi miometrium, regangan segmen bawah rahim dan serviks, serta iskemia otot rahim sebagai proses fisiologis yang menimbulkan rasa takut dan khawatir yang dapat berdampak pada ibu dan janin. Aromaterapi adalah salah satu metode nonfarmakologis untuk menangani nyeri dengan memproduksi   enkefalin. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pemberian aromaterapi lavender secara inhalasi terhadap penurunan intesitas nyeri persalinan fisiologis pada primipara inpartu kala I fase aktif. Desain penelitian ini adalah experimental dengan rancangan one group pretest-posttes without control. Jumlah sampel 20 orang yang ditentukan dengan metode purposive sampling. Variabel bebas adalah pemberian aromaterapi dan variabel terikatnya adalah nyeri persalinan. Uji statistik menggunakan paired t-test diperoleh nilaii p value = 0,000 (p value < 0,05) artinya pemberian aromaterapi lavender terbukti signifikan dapat menurunkan intensitas nyeri persalinan fisiologis kala satu fase aktif. Dapat disimpulkan bahwa terdapat pemberian aromaterapi lavender secara inhalasi mampu menurunkan intensitas nyeri persalinan fisiologis pada primipara inpartu kala satu fase aktif. Kata kunci: Aromaterapi Lavender, Nyeri persalinan, Primipara.
THE INFECTION EFFECT OF STRAIN H37Rv MYCOBACTERIUM TUBERCULOSIS ON APOPTOSIS OF MICE’S NEURON CELL BRAIN (MUS MUSCULUS) Kaspia, Rima Nor; Hidayati, Dwi Yuni Nur; Widayati, Aris
Malang Neurology Journal Vol 2, No 2 (2016): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (615.744 KB) | DOI: 10.21776/ub.mnj.2016.002.02.2

Abstract

Background. Ischemia on the cells and the lack of supply of glucose, will trigger a Ca2 + influx into the cell and increased expression of glutamate. Result in mitochondrial Ca2 + Influx be "overloaded". Glucose metabolism then switched to the anaerobic process that makes ATP increasingly depleted and there acidosis. This situation makes the neuron cell apoptosis triggered to occur. Apoptosis is programmed cell death. Neuron cell apoptosis is thought to have a strong connection to the tuberculosis infection in the brain.Objective. To determine the number of cells undergoing apoptosis neurons in brain tissue of mice.Methods. This study is a semiquantitative by comparing the number of cells undergoing apoptosis neurons in the three groups of samples. Observations apoptosis of neuronal cells in the brain tissue of mice was conducted using TUNEL staining technique (terminal deoxynucleotidyl transferase dUTP nick end labeling) are seen in a microscope with a magnification of 1000x.Results. The results showed that neuronal cells undergo apoptosis in brain tissue infected with M.tb for 8 and 16 weeks were marked with brown color in the cell nucleus. Neuron cell apoptosis were observed at M.tb-infected brain tissue for 16 weeks.Conclusion. The longer the M.tb infection can affect the increase in the number of neuronal cell apoptosis.
Swamedikasi di Kalangan Masyarakat Perkotaan di Kota Yogyakarta Widayati, Aris
Indonesian Journal of Clinical Pharmacy Vol 2, No 4 (2013)
Publisher : Indonesian Journal of Clinical Pharmacy

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Abstract

Penelitian observasional potong lintang ini bertujuan mengeksplorasi prevalensi dan pola swamedikasi di Kota Yogyakarta. Sejumlah 640 sampel di Kota Yogyakarta dipilih secara klaster acak pada periode Maret–Mei 2010. Data yang diperoleh kemudian dianalisis secara statistik deskriptif. Sebanyak 50% dari responden tersebut berswamedikasi satu kali, 33% dua kali dan 17% lebih dari dua kali. Responden yang membeli obat modern sebanyak 86% dan obat tradisional sebanyak 14%. Obat swamedikasi diperoleh dari apotek (42%), toko/warung kelontong (35%), toko obat (7%), dan kombinasi ketiganya (16%). Sebanyak 99% responden sembuh atau setidaknya berkurang keluhannya setelah berswamedikasi. Jika tidak sembuh setelah berswamedikasi, 45% responden menyatakan akan pergi ke dokter, sementara 20% lainnya ke puskesmas, 5% ke rumah sakit dan 5% kembali melakukan swamedikasi. Sumber informasi tentang obat mereka peroleh dari iklan (32%), dokter (17%), teman (17%), dan dari apotek (5%). Alasan mereka berswamedikasi antara lain pengalaman sembuh menggunakan obat tersebut sebelumnya (24%), berpersepsi bahwa penyakitnya ringan (22%), cepat dan praktis (17%) dan murah (13%). Temuan diatas mengindikasikan peluang dari aspek bisnis apotek sekaligus tantangan peningkatan peran profesi apoteker terutama di apotek dalam membantu masyarakat berswamedikasi secara tepat.Kata kunci: Swamedikasi, masyarakat perkotaanSelf-Medication among Urban Population in YogyakartaThis observational cross-sectional study is aimed at exploring prevalence and patterns of SM in Yogyakarta. A cluster random sampling technique was applied to select 640 adults in Yogyakarta between March and May 2010. From a total of 559 completed questionnaires, 247 (44%) respondents who had self-medicated during two previous weeks were included in subsequent analysis. Among these respondents, 50%had self-me-dicated once, 33% twice and 17% more than two times. Eighty-six percent of respondents had consumedmodern medicines while the rest 14% had used traditional ones. The drug for SM was obtained from pharmacies (42%), groceries (35%), drug stores (7%) and combination of those three sources (16%). Most of the respondents (99%) were recovered from their illnesses or at least experienced a symptom relieve after SMs. Forty-five percent respondents stated that they will visit a physician when they see no improvement after SM, while the rest said they will visit primary healthcenters (20%) and hospitals (5%) orrepeat their SM (5%). Information about the medicines areobtained from advertisements (32%), physicians (17%), friends (17%) and pharmacists (5%). The motivation for SM are previous experience of being relieved (24%), perception that they haveminor illnesses (22%), quick and easy (17%) and cheap (13%). Above findings indicate a business opportunityof pharmacies and a challenge to improve the role of pharmacists in assisting people regarding the selection of medicines for SM.Key words: Self-medication, urban people
Peningkatan Pelayanan Informasi Obat bagi Pasien Diabetes Melitus Hartayu, Titien S.; Widayati, Aris; Wijoyo, Yosef
Indonesian Journal of Clinical Pharmacy Vol 2, No 3 (2013)
Publisher : Indonesian Journal of Clinical Pharmacy

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Abstract

Penelitian ini ditujukan untuk meningkatkan pelayanan KIE melalui eksplorasi pandangan pasien DM terkait kebutuhan mendasar tentang informasi obat untuk penyakit DM dan pandangan apoteker terhadap peran dan tanggung jawabnya dalam layanan KIE bagi pasien DM.Jenis penelitian ini adalah observasional dengan pendekatan kualitatif. Penelitian dilakukan di Yogyakarta dengan responden pasien DM yang pernah menebus resep di apotek dan Apoteker Pengelola Apotek (APA) atau Apoteker pendamping(Aping). Pemilihan responden dilakukan dengan teknik non-random convenience. Data diambil dengan teknik wawancara mendalam terhadap responden yang memenuhi kriteria inklusi dan bersedia berpartisipasi dalam penelitian ini. Data kualitatif hasil wawancara dianalisis secara content-analysis. Wawancara dilakukan terhadap 17 pasien DM dan 7 Apoteker. Hasil wawancara terhadap pasien DM menunjukkan bahwa layanan KIE dari apotek selama ini belum optimal dan masih banyak informasi yang sebetulnya dibutuhkan dan diharapkanbelumdiperoleh. Dari pihak Apoteker, menyatakan bahwa belum optimalnya pelaksanaan KIE bagi pasien DM disebabkan oleh beban tugas pada aspek menejerial apotek dan kurangnya akses sumber informasi terkait DM untuk mendukung pelaksanaan layanan KIE.  Oleh karena itu, upaya peningkatan layanan KIE bagi pasien DM harus terus dilakukan.Kata kunci: Informasi obat, KIE, diabetes melitus, studi kualitatif Drug Information Service Improvement for Patients of Diabetes MellitusThe aim of the study is to explore the needs of patients regarding information about DMSM that will lead to improve patient’s knowledge, attitude and practice on DMSM and also to explore the view of pharmacists on their role and responsibility in providing patients information and education about DMSM. This is an observational study with a qualitative approach, which was conducted in Yogyakarta.People with DM and caregiver who purchased prescriptions in a pharmacy; and pharmacists who work in community pharmacy are involved in the study. They were selected using a non-random convenience sampling technique. Data were collected using in depth interviews and then were analysed using a content analysis technique. Seventeen DM patients and seven pharmacists were interviewed. The patients stated that DMSM information provided by pharmacist is not sufficient yet. They expected more indepthinformation regarding DMSM. Based on Pharmacist’s point of view, an overload of managerial works and lack of access on reliable sources of information of DMSM are seen as the main barriers to provide sufficient information and education on DMSM. In conclusion, efforts to improve quality ofinformation and education provision regarding DMSM for patients are urgently required.Key words: Information and education, KIE, diabetes mellitus, qualitative study
Korelasi Antropometri terhadap Profil Lipid pada Masyarakat Pedesaan Cangkringan, Kabupaten Sleman, Daerah Istimewa Yogyakarta Hendra, Phebe; Virginia, Dita Maria; Fenty, Fenty; Widayati, Aris
Indonesian Journal of Clinical Pharmacy Vol 6, No 2 (2017)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (612.501 KB) | DOI: 10.15416/ijcp.2017.6.2.107

Abstract

Prevalensi abnormalitas profil lipid cukup besar pada masyarakat pedesaan. Pengukuran profil lipid (kolesterol total (KT), low density lipoprotein (LDL), high density lipoprotein (HDL), dan trigliserida (TG)) di laboratorium membutuhkan implementasi teknologi kesehatan sedangkan di daerah pedesaan kurang tenaga medis dan permasalahan ekonomi. Pengukuran antropometri yang mudah, tidak invasif, ekonomis, dan dapat dilakukan oleh tiap individu diharapkan dapat memprediksi abnormalitas profil lipid bagi masyarakat pedesaan. Penelitian ini bertujuan untuk mengobservasi korelasi pengukuran antropometri dengan abnormalitas profil lipid di daerah pedesaan. Penelitian ini merupakan penelitian observasional dengan desain potong lintang. Pengukuran antropometri meliputi Body Mass Index (BMI), lingkar pinggang (LP), dan rasio lingkar pinggang panggul (RLPP). Kriteria inklusi adalah penduduk Kecamatan Cangkringan, Sleman, DI Yogyakarta berumur 40–60 tahun, tidak ada riwayat penyakit kardiometabolik, tidak edema, dan konsumsi obat-obatan terkait kardiometabolik. Lokasi penelitian dipilih menggunakan klaster random sampling. Sampel penelitian dipilih secara purposive sampling dan diperoleh besar sampel 100 responden. Analisis data menggunakan Kolmogorov-Smirnov, Mann-Whitney, dan Spearman. Hasil penelitian ini menunjukkan korelasi antara BMI (r= –0,286; p=0,044), LP (r= –0,410; p=0,003), dan RLPP (r= –0,365; p=0,009) terhadap HDL pada kelompok wanita. Terdapat juga korelasi antara BMI (r=0,325; p=0,021), LP (r=0,394; p=0,005), dan RLPP (r=0,368; p=0,009) terhadap trigliserida pada kelompok wanita. Terdapat korelasi antara BMI terhadap KT (r=0,285;p=0,045), LDL (r=0,344;p=0,014), dan TG (r=0,446; p=0,001). Parameter LP pria memiliki korelasi terhadap HDL (r= –0,355; p=0,011) dan TG (r=0,488; p=0,000). Parameter RLPP pria memiliki korelasi terhadap seluruh profil lipid; terhadap KT (r=0,287; p=0,043), LDL (r=0,338; p=0,016), HDL (r=0,316; p=0,025), dan TG (r=0,359; p=0,011). Kesimpulan, pada kelompok wanita pengukuran anthropometri memiliki korelasi terhadap HDL dan TG, sedangkan parameter RLPP lebih sensitif pada kelompok pria.
PENINGKATAN EKSPRESI LAMININ NAMUN TIDAK VE-CADHERIN PADA SAWAR DARAH OTAK SETELAH INFEKSI Mycobacterium tuberculosis INTRAPULMONALIS Widayati, Aris; Wulandari, Laksmi; Riawan, Wibi
Majalah Kesehatan FKUB Vol 5, No 3 (2018): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (658.512 KB) | DOI: 10.21776/ub.majalahkesehatan.005.03.3

Abstract

Tuberkulosis merupakan  masalah kesehatan utama di dunia. Pada tahun 2016, WHO menemukan angka kejadian TB kurang lebih 10,4 juta, dan untuk Indonesia dilaporkan sebesar 156.723 kasus. Meskipun penyebaran Mycobacterium tuberculosis di susunan saraf pusat tercatat hanya 1%, namun memiliki tingkat kecacatan dan kematian yang tinggi, sehingga menuntut adanya tatalaksana yang efektif untuk mengatasinya. VE-chaderin dan laminin merupakan protein adhesin yang berfungsi mengendalikan permeabilitas pembuluh darah dan mempertahankan integritas blood brain barrier, sehingga kedua protein adhesin tersebut dapat menjadi salah satu target terapi tuberkulosis otak. Penelitian ini bertujuan untuk mengetahui efek paparan M. tuberculosis secara inhalasi terhadap ekspresi laminin dan VE-chaderin pada sel endotel blood brain barrier. Penelitian ini menggunakan mencit Balb/c  (Mus musculus) yang diinfeksi oleh M.tuberculosis strain H37Rv secara inhalasi. Jaringan otak diperiksa menggunakan metode imunohistokimia dengan  antibodi mt-38, antibodi VE-chaderin dan laminin. Hasil penelitian menunjukkan adanya invasi M. tuberculosis pada  mikroglia jaringan otak mencit, diiketahui juga adanya peningkatan ekspresi laminin, sedangkan VE-chaderin tidak menunjukkan adanya perubahan. Proses masuknya M. tuberculosis ke otak diduga terjadi melalui proses diapedesis atau melalui peningkatan ekspresi laminin tanpa perubahan pada VE-chaderin dan reseptor laminin diduga sebagai tempat berikatan yang memungkinkan bakteri tersebut masuk ke jaringan otak. 
Reliability test of a questionnaire to investigate behaviour of using traditional medicines among urban students of Elementary School Cahyani, Riska; Widayati, Aris
Proceedings of Universitas Muhammadiyah Yogyakarta Graduate Conference Vol. 3 No. 2 (2024): Crafting Innovation for Global Benefit
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/umygrace.v3i2.604

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Introduction. The use of traditional medicine among the adult population is prevalent. Previous studies have explored the use of traditional medicine among adults. However, traditional medicine usage among adolescents is still rare, especially among elementary school students. Therefore the instruments for research on the use of traditional medicine among adolescents are also still limited. Objective. This study aims to calculate the reliability scale of a questionnaire based on the Theory of Planned Behavior. The questionnaire can be used to explore the behavior of using traditional medicine among elementary school students. Methods. The tested instrument has been assessed for its content validity using a professional judgement approach and language clarity. In this study, instrument reliability was calculated using Cronbach Alpha approach. The test respondents were elementary school students in Yogyakarta City namely SD Negeri Ungaran Yogyakarta. Fifty respondents were selected using purposive sampling and given a self-asministered questionnaire. Data were entered and calculated for Cronbach Alpha using SPSS software. Results. Twelve percent of the 50 data sets were ineligible for inclusion due to incomplete answers, resulting in 44 data sets (88%) being analysed. The analysis produces a Cronbach's Alpha scale of 0.840 with 24 items in the questionnaire. Conclusion. The conclusion is that the instrument is reliable because the scale of Cronbach's Alpha is more than 0.60 as the standard point. It can be used to investigate a behaviour regarding traditional medicines usage among Elementary Students in urban areas.
INTENSI SWAMEDIKASI DI KALANGAN MASYARAKAT KECAMATAN UMBULHARJO YOGYAKARTA PADA MASA PANDEMI COVID-19: TINJAUAN THEORY OF PLANNED BEHAVIOR De Karos, Vlorent Anggi; Widayati, Aris
Jurnal Kefarmasian Akfarindo Vol 7 No 2 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.155

Abstract

Self-medication is the first and most common effort made by the community to overcome their health complaints. During the COVID-19 pandemic, 70% of patients with chronic diseases were absent from routine control and 12% missed the treatment process, increasing the mortality rate by 1.3%. Some of the impacts that occurred due to the impact of the COVID-19 pandemic on changes in health seeking became the basis for conducting this research. The purpose of this study was to determine the factors that contributed to the intention of self-medication among the community during the COVID 19 pandemic. The intention factor will be reviewed using the theoretical framework of Theory of Planned Behavior (TPB). This research is an analytic observational study with a cross sectional design. The sample was selected using the Cluster Sampling with a total sample of 144 respondents. Data analysis was carried out descriptively followed by multiple linear regression. The results of this study, the attitude (p value ≤ 0,05) and perceived behavioral control (p value ≤ 0,05) showed a partial contribution to self-medication intentions. While subjective norm (p value ≥ 0,05) partially has no effect on self-medication intentions. The construct of perceived behavioral control was the most contributing factor to the self-medication intention (β= 0,017). The results of the F test showed that attitude, subjective norm, and perceived behavioral control simultaneously contributed 26.4% to self-medication intentions (p value 0,05, F count > F table, R Square = 0.264). The results of this study can be used as consideration for the Yogyakarta Public Health Office in preparing a health promotion program related to good self-medication to the community.
Pengaruh Intervensi Tenaga Kesehatan terhadap Kepatuhan Minum Obat pada Pasien Diabetes Mellitus Tipe 2 di Indonesia: Kajian Literatur Pratiwi, Fransiska Indah; Widayati, Aris
JSFK (Jurnal Sains Farmasi & Klinis) Vol 8 No 2 (2021): J Sains Farm Klin 8(2), Agustus 2021
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.8.2.107-115.2021

Abstract

Terapi penyakit Diabetes Mellitus (DM) bertujuan untuk mengontrol kadar glukosa darah dan mencegah komplikasi. Intervensi tenaga kesehatan mendukung kepatuhan penderita DM dalam menggunakan obatnya demi tercapainya keberhasilan terapi. Intervensi dapat berupa follow up, media pengingat, pillbox, pelatihan, media booklet, dan packaging obat khusus. Kajian literatur ini bertujuan memaparkan dampak intervensi tenaga kesehatan terhadap kepatuhan minum obat hipoglikemik pada pasien DM tipe 2 (DMT2). Metode pencarian literatur dilakukan melalui Google Scholar. Kriteria inklusi literatur yang dipilih yaitu artikel yang memuat: 1) intervensi tenaga kesehatan terhadap terapi pasien DMT2 di Indonesia, 2) desain studi intervensi dijelaskan secara rinci, 3) terdapat pengukuran parameter kepatuhan penggunaan obat hipoglikemik dan/atau kadar gula darah, sebelum dan setelah intervensi, 4) berupa artikel primer. Pemilihan literatur dilakukan oleh dua orang rater dengan nilai Kappa Cohen sebesar 0,939. Sejumlah 14 artikel terpilih dikaji. Hasil kajian literatur menunjukkan bahwa kejadian DMT2 banyak terjadi pada wanita, dewasa hingga lansia. Intervensi tenaga kesehatan yang dilakukan meliputi home care, pemberian informasi, konseling, maupun dengan alat bantu tertentu. Semua literatur yang dikaji menunjukkan peningkatan kepatuhan dan/atau perbaikan kadar gula darah. Oleh karena itu, dapat disimpulkan bahwa intervensi tenaga kesehatan berdampak pada peningkatan kepatuhan minum obat hipoglikemik dan berpengaruh terhadap kadar glukosa darah yang lebih baik pada pasien DMT2
Traditional medicines use among Indonesian young population: a Theory of Planned Behaviour study Widayati, Aris; Rahajeng, Bangunawati; Wulandari, Erna Tri; Abadi, Barnabas Bagus Aditya
Indonesian Journal of Pharmaceutical Science and Technology 2025: Vol. 12 Suppl. 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s1.57953

Abstract

Adolescents are a group that is very intensively exposed to changes from the Internet of Things, resulting in reduced exploration of nature, including medicinal plants. This study explores behavioral factors related to the use of herbals among Indonesian adolescents by applying the theory of planned behavior (TPB). The study was an analytic with a cross-sectional design. The independent variables were attitude, subjective norm, and perceived behavioral control. The dependent variable was behavioral intention. The samples were adolescents aged 10 to 19 years, determined from 200 samples in each of Indonesia's five major island groups, so 1,000 respondents were recruited. The instrument was a validated questionnaire that refers to the TPB constructs. Data were analyzed with a chi-square test and regression. 931 respondents participated in the research; the response rate was 93.1%. Approximately 85.1% of the participants expressed an intention to use traditional medicine. There is a statistically significant association between attitude, subjective norms, perceived behavioral control, and the purpose of using traditional medicine. The combined effect of the three constructs accounts for 25.9% of adolescents' propensity for using traditional medicines. All the factors contributed partially, with the subjective norm being the most significant contributor.